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All Journal Jurnal Ilmu Pertanian Indonesia Current Biochemistry Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Warta IHP (Warta Industri Hasil Pertanian) Pharmascience FITOFARMAKA: Jurnal Ilmiah Farmasi Indonesian Journal of Applied Research (IJAR) Borneo Journal of Pharmacy
Husnawati, .
Department Of Biochemistry, Faculty Of Mathematics And Natural Sciences, IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Industrial & Manufacturing Engineering Medicine & Pharmacology

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Antiproliferative Potency of God’s Crown Fruit (Phaleria macrocarpa) Extract Against Breast Cancer Cell Hasim Hasim; Yonathan Arderian Mantik; Husnawati Husnawati; Bambang Pontjo Priosoeryanto; Ratna Puspita
Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i4.2822

Abstract

Breast cancer is a sickness caused by abnormal cell growth in the breast. Mahkota Dewa fruit or god’s crown fruit products (Phaleria macrocarpa) contain flavonoids, alkaloids, polyphenols, and tannins associated with active compounds. This work directs to influence the potency of P. macrocarpa fruit as an antiproliferative agent against breast cancer cells (MCF-7 cells). The antiproliferative potency of P. macrocarpa fruit was proved by extracting and fractionating P. macrocarpa fruit using maceration. The cytotoxicity of extracts and fractions was determined using Brine Shrimp Lethality Test (BSLT). The antiproliferative potency against MCF-7 cells was tested using the hemacytometer approach. This work demonstrates the crude ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction. The LC50 values in crude ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction were 13.72 ppm, 147.55 ppm, 405.81 ppm, and 149. 07 ppm severally. Phaleria macrocarpa fruit has shown antiproliferation potency against MCF-7 cells. The maximum part of crude ethanol extract antiproliferative potency (56 ppm) effectively suppressed MCF-7 cell growth by 70. 9% while doxorubicin (100 ppm) by 46. 92%. This work confirms that crude ethanol extract of P. macrocarpa fruit interacts synergistically as an antiproliferative compound against MCF-7 cells.
Co-Authors Agus Setiyono Akhmad Endang Zainal Hasan Aldi Fadilah Amrista Fanzani Kananga Aziz Syamsul Huda Bambang Pontjo Priosoeryanto Chintia Ayu Puspita Danty Oktiana Prastiwi DIMAS ANDRIANTO Elgiani Yassifa Yulia Nur Insari Eny Ida Riyanti Faisal Rahman Galuh Rizal Prayoga Gina Oktaviani Sabrina Hanif Alamudin Manshur Hasim Hasim Hasim Hasim Heddy Julistiono Ika Yuni Astutik Imelia Dewi Irmanida Batubara LAKSMI AMBARSARI Latifah Kosim Darusman Mega Safithri Muhammad Farhan Muhammad Irfansyah Pradika Nurliani Bermawie Ratna Puspita Safira Rahmadanti Santi Nuraeni Siti Wachidatun Zulaikha Slamet Hamzah Sri Wahyuni Syndilona Br Sitepu Tohru Mitsunaga Tommy Abrar Yonathan Arderian Mantik Zulfikar Muchammad