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All Journal Indonesian Journal of Applied Sciences Majalah Kedokteran Bandung Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Pharmaceutical Science and Technology Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Reti Hindritiani
Departemen Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health

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Successful Combination Therapy of Acne Keloidalis Nuchae Kartika Ruchiatan; Erfina Rohana Sormin; Reti Hindritiani; Asmaja Soedarwoto; Hendra Gunawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.999 KB) | DOI: 10.20473/bikk.V29.3.2017.260-263

Abstract

Background: Acne keloidalis nuchae (AKN) is a chronic, inflammatory, idiopathic disorder of hair follicle, characterized by keloidal papules or plaques on the nape and occipital scalp. Various therapies have been reported to treat AKN with various results. Purpose: To observe the efficacy of combination therapy for AKN. Case report: A 19-year-old man presented with multiple pruritic papules, 0.1–0.3 cm in diameter on the nape and occipital area. The histopathological examination revealed neutrophil, eosinophil, and plasma cell infiltration in infundibulum, which was consistent with AKN pathological patterns. Discussion: Combination therapy consisted of 0.025% tretinoin cream, 0.1% mometasone furoate cream, intralesional triamcinolone acetonide 5 mg/ml, and doxycycline 2x100 mg. The improvement was initially observed on 2nd week of follow up, as the lesions had reduced in size and number, and the improvement became more significant on 4th week of follow up. Conclusion: Combination therapy of topical tretinoin, topical and intralesional steroid, and systemic doxycycline shows good result and can be considered in the management of AKN.
A Split-Face Comparative Study in Efficacy and Safety between the Combination of 4% Niacinamide and 4% Kojic Acid Cream versus 4% Hydroquinone Cream for Epidermal Melasma Hindritiani, Reti; Nazlia, Felly; Octavia, Nadia; Rizqandaru, Trustia; Puspitosari, Diah; Ruchiatan, Kartika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.93-99

Abstract

Background: Melasma is a hyperpigmentation disorder that affects the quality of life, especially in women. Hydroquinone has remained the mainstay of melasma treatment. However, its safety for long-term usage became a great concern. Combination therapy, such as niacinamide and kojic acid, can be used as an alternative melasma treatment due to different mechanisms of action and synergism. Purpose: The aim of this study was to compare the efficacy and safety of a combination of 4% niacinamide and 4% kojic acid (N-K) vs. 4% hydroquinone (HQ) in epidermal melasma. Methods: This was a randomized, double blind, clinical study on 13 female epidermal melasma patients at the Cosmetic Dermatology Outpatient Clinic of Dr. Hasan Sadikin Hospital, Bandung. Patients received two creams, a combination of N-K and HQ, for split-face therapy, regardless of the sides of the face. All patients were followed up at 4 and 8 weeks. The clinical efficacy was assessed for skin lightening effects using a spectrophotometer (L* value) and the melasma area severity index (MASI). Adverse effects were assessed in all patients. Result: Both the N-K and HQ groups showed significant improvement in skin lightening and MASI scores on week 8 (p <0.05). There was no statistically significant difference in efficacy between the N-K and HQ groups (p >0.05). None of the patients in the N-K group complained of any adverse effects. Whereas in the HQ group, 23.07% presented with pruritus and mild erythema.
Co-Authors - Setiawan, - Abdasah, Marline Asmaja Soedarwoto Ayu Adzani Sabila Diah Dhianawaty Diah Puspitosari Dimas Erlangga Luftimas Dimas Erlangga Luftimas Endang Sutedja Endang Sutedja Erfina Rohana Sormin Febrina, Dia Hendra Gunawan Hermin Aminah Usman Hindun, Siti Jessica Oktavianus Trisaputra Kartika Ruchiatan Marline Abdasah Maulinda, Shinta MUCHTAN SUJATNO MUCHTAN SUJATNO Nazlia, Felly Octavia, Nadia Oki Suwarsa Rizqandaru, Trustia Ruchiatan, Kartika Sabila, Ayu Adzani Setiawan . Siti Hindun Taofik Rusdiana Trisaputra, Jessica Oktavianus