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All Journal JBIO: jurnal biosains (the journal of biosciences) Saintia Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Prosiding Seminar Biologi Best Journal (Biology Education, Sains and Technology) IJOEP : International Journal of Ecophysiology
Salomo Hutahaean
Departemen Biologi Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Sumatera Utara.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Saintia Biologi

 1 
KELAINAN PERKEMBANGAN KRANIOFACIAL FETUS MENCIT (Mus musculus L.) Strain DDW SETELAH PEMBERIAN EKSTRAK N-HEKSAN BUAH ANDALIMAN (Zanthoxylum acanthopodium DC.) Mai Sarah; Emita Sabri; Salomo Hutahaean
Saintia Biologi Vol 1, No 1 (2012)
Publisher : Saintia Biologi

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Abstract

The purpose of this study is  to investigate the effect of n-hexane extract of andaliman (Zanthoxylum acanthopodium DC.) fruit on craniofacial development of DDW Mice (Mus musculus L.). Experiment was carried out using Completely Randomized Design (CRD) with 5 treatments and 6 replicates. Treatments  consist  of a blank control, vehicle control (1% CMC) and 3 concentrations of andaliman extract (2%, 4% and 6%). All treatments were administered by oral gavage (0.1 ml/10 g bw) once  daily from day 0 to day 10 of gestation.  N-hexane extract of andaliman fruit induced developmental abnormalities in craniofacial structures i.e. increased the incidence of microphthalmia (P <0.05), and hydrocephalus (P <0.05). In conclusion, we suggested that andaliman fruit may have fetotoxic effects.   Keyword: andaliman (Zanthoxylum acanthopodium DC.), micropthalmia, hydrocephalus
GAMBARAN HISTOLOGIS PULMO MENCIT JANTAN (Mus musculus L.) SETELAH DIPAPARI ASAP ROKOK ELEKTRIK Nanin Triana; Syafruddin Ilyas; Salomo Hutahaean
Saintia Biologi Vol 1, No 2 (2013)
Publisher : Saintia Biologi

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The effects of electric cigarette exposure on lung tissue of mice were studied. The experiments using completely randomized design (CRD) with 3 treatments, i.e.  treatment of electric cigarette with strawberry flavour, tobacco flavour, and control treatment that was not exposed by cigarette smoke. Eight male mice were used for each group. Exposure treatment was done every day for 2 consecutive weeks with dosage 20 times suction using syringe of 60 mL. After receiving treatment for 2 weeks, the mice were killed by cervical dislocation. The lungs were isolated and prepared histologically using paraffin method and then stained with by haematoxylin and eosin  (HE). The results showed that, smoke treatment mice lose weight significantly (p< 0.05). In gross anatomy, electric cigarrete smoke affect lung feature, but histological observation on  membrane damage, damage to the lumen and the relationship between alveoli the smoke effect were statistically unsignificant (p>0.05).. In summary short period exposure to electric  cigarette smoke  tends affect lung damage in anatomy, but statistically has no effect of the damage to the lung tissue.   Keywords: alveolar lumen, alveolar membrane, electric cigarettes
PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS HEPAR MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG) Ahri Maulida; Syafruddin Ilyas; Salomo Hutahaean
Saintia Biologi Vol 1, No 2 (2013)
Publisher : Saintia Biologi

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This study aimed to determine the effects of vitamin C and E on liver microstructure of mouse exposed to monosodium glutamate (MSG) for 30 days. The experiment used completely randomized design which consists of 6 treatments and  5 replications. Mice were treated daily by oral gavage with 4 mg MSG (P1),  4 mg MSG + 0.26 mg  vitamin C (P2),  4 mg MSG + 0.026 vitamin E (P3), or  4 mg  MSG + 0.26 mg  vitamin C + 0.026 mg vitamin E (P4). All dosages were based on mg/g body weight. Two control groups K- and K+ were treated with water and castor oil respectively. The mice liver tissue slide was prepared by the paraffin method and stained with haematoxylin-eosin (HE). The results showed that MSG caused cell degeneration and necrosis in liver tissue. Vitamin C and E was  able to recover  liver cell damage induced by MSG.  The highest result was found in P3 and combination treatment (P4) where the recovery effect reaches 64% and 80% respectively. Keywords : Liver, Monosodium glutamate (MSG), Vitamin C, Vitamin E.
PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS GINJAL MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG) Zulfiani Zulfi; Syafruddin Ilyas; Salomo Hutahaean
Saintia Biologi Vol 1, No 3 (2013)
Publisher : Saintia Biologi

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The aim of this research is to study the effect of vitamin C and E on kidney microstructure of mouse exposed to monosodium glutamate for 30 days. This research used complete randomized design which consisted of 6 treatments and 5 replications. The control consisted of  K-, and K+ (castor oil 0.3 ml). The treatments were MSG 4 mg/g BW, P1 (only MSG), P2 (MSG plus vitamin C 0.26 mg/g BW), P3 (MSG plus vitamin E 0.026 mg/g BW) and P4 (MSG plus vitamin C and E). After treatments were completed, the mice were sacrificed by cervical dislocation, and kidney tissue section was prepared by  the paraffin method and  stained with Haematoxylin and Eosin staining. Microstructure damage of kidneys showed a significant difference between control and treatments. In P1, the proximal tubule damage was 69.95%±5 and in P4 was 47.22%±3. In summary MSG can cause damage in the form of a narrowing of the lumen of the proximal tubules of the kidney. A combination of vitamins C and E can reduce the effect of MSG on the kidney.   Keywords: kidney, Monosodium glutamat (MSG), Vit C, Vit E.
PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS TESTIS MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG) Ummi Kalsum; Syafruddin Ilyas; Salomo Hutahaean
Saintia Biologi Vol 1, No 3 (2013)
Publisher : Saintia Biologi

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The aim of this study is to determine the effect of vitamin C and E on  testicular histology of mice following exposure to monosodium glutamate (MSG) for 30 days. Completely Randomized Design (CRD) consisting of 6 treatments and 5 replications was used in this experiment. Mice were treated daily by oral gavage with 4 mg MSG (P1),  4 mg MSG + 0,26 mg  vitamin C (P2),  4 mg MSG + 0,026 vitamin E (P3), and  4 mg  MSG + 0,26 mg  vitamin C + 0,026 mg vitamin E (P4). All dosages (mg/g) were given based on body weight. Two control groups K- and K+ treated with water and castor oil respectively. The results showed that MSG decrease testis weight and its volume (P<0,05), MSG also decrease the diameter of seminiferous tubule and the number of spermatogenic cells. Vitamin C recovers testis weight (P<0,05), but cannot recover its volume, diameter of seminiferous tubules and the number  spermatogenic cells (P>0,05). Vitamin E increases the weight and volume of the testes and spermatogenic cells (P<0,05), but unable to recover diameter of the seminiferous tubules (P>0,05). The combination of vitamin C and E recover testis weight and its volume, seminiferous  tubule  diameter  and number  of  spermatogenic  cells (P<0,05). Keywords: Monosodium Glutamate, Vitamin C, Vitamin E, Testis
Co-Authors Ahri Maulida Elizabeth, Fitri Emita Sabri Ibezaro Zega Ilyas, Syarifuddin Maelani, Imelda Mai Sarah Mammed Sagi Mangkoewidjojo , Soesanto Nanin Triana Nursal Putri, Syarifah Riska Mela Ronald Pasaribu Sagi , Mammed Soesanto Mangkoewidjojo Syafruddin Ilyas Syafruddin Ilyas Syahfitri, Widya Tambunan, Christoper Arata Ummi Kalsum Widya Asmara Zulfiani Zulfi