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All Journal Vegetalika Journal of Mathematical and Fundamental Sciences Jurnal Biologi Universitas Andalas Indonesian Journal of Chemistry Martabe : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Jurnal Mandala Pharmacon Indonesia Jurnal Review Pendidikan dan Pengajaran (JRPP) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks
Nova Syafni
Fakultas Farmasi, Universitas Andalas
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Essential Oils from Etlingera elatior Inflorescence against α-Amylase and α-Glucosidase Inhibition Syafni, Nova; Nofrizal, Nofrizal; Ismed, Friardi; Putra, Deddi Prima
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.812

Abstract

The increasing number of diabetes mellitus cases every year is alarming for every country. More than 90% of the cases are type-2 diabetes mellitus. The range of diabetes mellitus patients is at a productive age, including in Indonesia. Type-2 diabetes mellitus can be managed by reducing postprandial glucose levels. The approach inhibits α-amylase and α-glucosidase enzymes. A preliminary study on the local edible plants in Solok district, Etlingera elatior, showed potential against the α-glucosidase enzyme by TLC-bioautography screening. The essential oils from the inflorescence of E. elatior were extracted by hydro-distillation. The analysis of components from the essential oils identified 20 compounds. GC-MS data showed that the highest abundance percentages were 1-dodecanol (39.79%), dodecanal (28.20%), α-pinene (13.11%), decanal (4.16%), and dodecanol acetate (2.75%). The inhibition against the α-glucosidase enzyme obtains the IC50 value of 73.95 and 67.55 ?g/mL for the essential oils and acarbose, respectively. The inhibition against the α-amylase enzyme obtains the IC50 value of 70.87 and 12.28 ?g/mL for the essential oils and acarbose, respectively. The essential oils from the inflorescence of E. elatior could inhibit α-amylase and α-glucosidase enzymes, even though the potential was lower than that of acarbose as a positive control.
Formulation of Anti-Blackhead Rubber Mask from Purified Gambier (Uncaria gambir [Hunter] Roxb.) Agustin, Rini; Akrami, Hafizatul; Syafni, Nova
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.340-347.2023

Abstract

The purified was isolated from  Uncaria gambir [Hunter] Roxb. that contains more than 90% of catechins. Its antioksidant  and antibacterial properties have  potential to  formulate  as cosmetics. Dry form formulation of cosmetic was one approach to minimize cathecins degradation in a product.  In this study, three formulation of rubber mask containing 5% of purified gambier was done. . Each formulation was formulated with calcium sulfate, propylene glycol, magnesium carbonate, citrus essential oil and variation of HPMC and chitosan as film former. The three formulas had  a brown color, smooth textures, the gambier odor, visually homogeneous, particle sizes at 112.24 – 116.39 µm, moisture values at 3.9 – 7.04%, pH of 6, drying times of 8 to 15 minutes, adhesive power of > 10 seconds and remained stable for 21 days at 4±2°C and 27±2°C. The actual catechin content in formula I, II, and III were 0.89%, 1.09%, and 1.39%, respectively. The best formula was formula III, which contained 40% HPMC and 10% chitosan due to the fastest drying time of 8.36 minutes ± 19 seconds and the highest catechins content at 1.39%.The purified was isolated from  Uncaria gambir [Hunter] Roxb. that contains more than 90% of catechins. Its antioksidant  and antibacterial properties have  potential to  formulate  as cosmetics. Dry form formulation of cosmetic was one approach to minimize cathecins degradation in a product.  In this study, three formulation of rubber mask containing 5% of purified gambier was done. . Each formulation was formulated with calcium sulfate, propylene glycol, magnesium carbonate, citrus essential oil and variation of HPMC and chitosan as film former. The three formulas had  a brown color, smooth textures, the gambier odor, visually homogeneous, particle sizes at 112.24 – 116.39 µm, moisture values at 3.9 – 7.04%, pH of 6, drying times of 8 to 15 minutes, adhesive power of > 10 seconds and remained stable for 21 days at 4±2°C and 27±2°C. The actual catechin content in formula I, II, and III were 0.89%, 1.09%, and 1.39%, respectively. The best formula was formula III, which contained 40% HPMC and 10% chitosan due to the fastest drying time of 8.36 minutes ± 19 seconds and the highest catechins content at 1.39%.
Inhibition of Edible Plant Torch Ginger (Etlingera elatior (Jack) R. M. Sm.) against α-Glucosidase and α-Amylase Syafni, Nova; Fakhriadi, Athallah; Nofrizal, Nofrizal; Ismed, Friardi; Putra, Deddi Prima
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.348-352.2023

Abstract

Indonesia's diabetes cases were in the top ten list globally, with 90% of the patients being type-2 diabetes mellitus (T2DM).  An approach for screening the local edible plants is made for managing or treating T2DM by inhibiting α-glucosidase and α-amylase enzymes. Results showed that inflorescence of Etlingera elatior inhibition toward both enzymes. TLC-autography and IC50 value of fractions from E. elatior were used to identify the potential fractions and possible compounds for the activity. The non-polar fraction was spotted in the active substances based on TLC-autography. Then, the targeted compounds were separated by column chromatography to obtain stigmasterol as one of the active compounds. The IC50 values of total extract, n-hexane, EtOAc, BuOH, and isolated compound against α-glucosidase were 16.0, 7.5, 13.5, 9.7, and 2.0 ppm, respectively. The IC50 values for α-amylase inhibition were respectively 88.6, 48.6, 23.2, 29.1, and 27.5 ppm. The positive control (acarbose) against α-glucosidase and amylase exhibited IC50 values of 153.2 and 12.3 ppm. The inhibition of E. elatior against the two enzymes could be an alternative to delay carbohydrate absorption.
Ethnobotanical Study of Ferns as Traditional Medicine in Central Siberut, Mentawai Island Syafni, Nova; Bakhtiar, Amri
Jurnal Biologi Universitas Andalas Vol 10 No 1 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jbioua.10.1.10-14.2022

Abstract

West Sumatra Province has two ethnicities, namely Minangkabau and Mentawai. Both ethnicities have the capability to apply plants in folk medicine. This ethnobotanical study was conducted in Saibi Simokop village in three hamlets namely Sirisurak, Simoilaklak, and Saibi. The study was focused on the use of ferns in traditional medicine. Data collection was carried out using the snowball sampling method to seek the traditional healers (sikerei). The results showed that seven species of ferns were used for treatment of fever, inflammation, and poisoning. The ferns were included Cephalomanes javanicum (Blume) Bosch, Angiopteris evecta (G. Forst.) Hoffm., Dicranopteris linearis (Burm. F.) Underw., Diplazium esculentum (Retz.) Sw., Phymatosorus membranifolium (R. Br.) S.G. Lu, Lecanopteris sp., and Asplenium nidus L. The application of ferns in concoctions was administered topically and some were combined with oral administration.
SKRINING PENGHAMBATAN AKTIVITAS ENZIM Α-AMILASE SECARA IN-VITRO DARI REMPAH-REMPAH PADA MAKANAN TRADISIONAL SUKU MINANGKABAU, SUMATERA BARAT Nofrizal, Nofrizal; Syafni, Nova; Putri, Lusia Eka; Huljanah, Mifta
Jurnal Review Pendidikan dan Pengajaran Vol. 8 No. 1 (2025): Volume 8 No. 1 Tahun 2025
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jrpp.v8i1.41435

Abstract

Diabetes melitus (DM) merupakan penyakit metabolik degeneratif yang ditandai dengan kondisi hiperglikemia yang tidak terkontrol. Kondisi ini disebabkan oleh resistensi insulin dan kurangnya produksi insulin pada sel beta pancreas. Tujuan dari kajian ini adalah untuk menilai penghambatan aktivitas enzim α-amilase dari rempah-rempah yang digunakan dalam makanan tradisional suku Minangkabau, Sumatera Barat. Metode penelitian ini yaitu 20 Jenis rempah-rempah dimaserasi menggunakan pelarut etanol 70%. Masing-masing ekstrak dilarutkan dalam DMSO 10% dalam dapar fosfat pH 6,9. Masing-masing larutan diuji daya penghambatannya terhadap aktivitas enzim α-amilase dengan menggunakan pati sebagai substrat. Absorbansi dibaca pada l 540 nm menggunakan microplate reader. Hasil dianalisa menggunakan metoda Probit analysis untuk menentukan nilai IC50 dengan standar pembanding akarbosa. Hasil bahwa Ekstrak buah lada hitam menunjukkan penghambatan aktivitas tertinggi dengan IC50 sebesar 10,35 ppm (1,2 kali lebih kuat dari akarbosa). Tiga sampel lainnya, ekstrak kulit batang kayu manis, buah cabai, dan buah ketumbar menunjukkan aktivitas sedang dengan IC50 secara berturut-turut 40,17; 84,96 dan 97,42 ppm. Kesimpulan menunjukkan bahwa beberapa rempah-rempah yang digunakan dalam makanan tradisional Minangkabau berpotensi sebagai agen penghambat aktivitas enzim α-amilase
OPTIMALISASI FARMAKOTERAPI: IDENTIFIKASI DAN EDUKASI TENTANG ADRs DAN DRPs PADA PESERTA PROLANIS WILAYAH PUSKESMAS SURIAN, KABUPATEN SOLOK, SUMATERA BARAT Gumala, Azhoma; Armenia, Armenia; Prima Putra, Deddi; Syafni, Nova; Handayani, Fitri; Eka Putri, Desi; Furqan, Mainal; Sentat, Triswanto; Gusnelti, Yessi; Lucida, Henny
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.%p

Abstract

Peningkatan risiko reaksi obat yang tidak diinginkan (adverse drug reactions/ADRs) dan masalah terkait obat (drug-related problems/DRPs) pada pasien penyakit kronis, khususnya peserta Program Pengelolaan Penyakit Kronis (PROLANIS), sangat membutuhkan informasi dan edukasi intensif terkait optimalisasi terapi. Kegiatan pengabdian ini bertujuan untuk mengidentifikasi insiden ADRs dan DRPs pada kelompok PROLANIS di Puskesmas Surian dan memberikan edukasi yang terfokus untuk meminimalkan risiko, demi mencapai terapi optimal. Kegiatan diawali dengan wawancara dan pengumpulan data kuesioner dari 30 responden (semua perempuan). Hasil demografi menunjukkan mayoritas responden (70,00%) berusia 45–64 tahun, dan dua pertiga (66,67%) mengalami polifarmasi (menderita 3–7 penyakit kronis). Empat penyakit utama yang diderita adalah artritis, hipertensi, hiperurisemia, dan dislipidemia. Penting untuk dicatat, 60% responden melaporkan keluhan yang mengindikasikan ADRs dan DRPs. Sebagian besar subjek memperoleh obat dari tenaga kesehatan formal (86,67%). Tindak lanjut kegiatan mencakup pemeriksaan kesehatan gratis (tekanan darah, gula darah, kolesterol, dan asam urat) serta konseling langsung. Pasien PROLANIS menerima edukasi mendalam tentang cara penggunaan obat yang benar, terutama dalam terapi polifarmasi, untuk meminimalkan masalah terkait obat. Disimpulkan bahwa edukasi intensif dan berkelanjutan mengenai obat-obatan, pengobatan alternatif, dan suplemen kesehatan kepada komunitas PROLANIS sangat penting. Intervensi ini secara signifikan berkontribusi pada keselamatan pasien dan meningkatkan pemahaman masyarakat dalam pengelolaan penyakit kronis.
Monitoring Ekspresi Gen Chalcone Synthase dan Respon Pertumbuhan Lobak Singgalang (Brassica oleracea L.) Akibat Paparan Ultraviolet-B Ekstrem Puti Khairunnajwa Amar; Mansyurdin Mansyurdin; Nova Syafni; Ersa Nur Syafia; Muhammad Idris
Vegetalika Vol 14, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/veg.103190

Abstract

Singgalang cabbage (Brassica oleracea L.) is a local vegetable native to West Sumatra, cultivated in highlands around Mount Singgalang, Tanah Datar. Vegetables from Brassica genus are recognized for their high nutritional value and potential as functional foods. Key secondary metabolites in Brassica species, i.e., phenolic compounds and their derivatives, play a crucial role in antioxidant activity and are essential in promoting health. Light exposure, particularly ultraviolet-B (UV-B, 280-315 nm), can enhance biosynthesis of these compounds. UV-B intensity affects various process in plants including the phenylpropanoid pathway involved in secondary metabolite production. This study aimed to assess the expression of the CHALCONE SYNTHASE (CHS) gene under different UV-B intensities (0.3–3.0 µmol·m-2·s-1, 4 h) and examine the effects of two extreme UV-B intensities (0.3 and 3.0 µmol·m-2·s-1, 4h.d-1) in a controlled environment for 14 days. The results showed that increasing UV-B intensity enhanced CHS expression (1.0 and 3.0 µmol·m-2·s-1 showed thicker bands compared to 0.3 µmol·m-2·s-1, with a faint band in the control). Extreme UV-B exposure reduced chlorophyll content by 35–37% compared to the control, while carotenoids remained unaffected. Anthocyanin accumulation increased under low-intensity UV-B, whereas flavonoid levels were higher under high-intensity UV-B, suggesting different functional roles. UV-B exposure also influenced stomatal number and density in leaf. This preliminary study highlights the significant role of UV-B in enhancing specific metabolites in Singgalang cabbage, supporting its potential as a functional food.
Essential oils from Homalomena aff. pendula (Blume) Bakh F. and Its Antioxidant Activities Rifaldi Harfiyantama; Nurainas Nurainas; Deddi Prima Putra; Nova Syafni
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.21-27.2026

Abstract

Homalomena is a genus from the family Aracaceae that is characterized by scent. Most Homalomena species from Indonesia have limited information on the chemical components of their essential oils, including those found in West Sumatra Province. The species of Homalomena aff. pendula (Blume) Bakh. F. is found in large amounts in Padang city, and it has the potential to explore its profile of essential oil substances in its leaves, petioles, and rhizomes. In this research, the antioxidant activity of the essential oils was screened using three methods: DPPH, ABTS, and FRAP. The essential oils are extracted through hydro-distillation, and their components are analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The results show that the three major components in the leaves and petioles were β-bisabolene, α-selinene, and α-bergamotene with different percentages. The rhizomes had the same higher component as β-bisabolene, followed by trans-caryophyllene and α-bergamotene. The antioxidant activity, as measured by DPPH and ABTS, showed an IC50 greater than 200 μg/mL. That result is also supported by the FRAP value of leaves, petioles, and rhizomes, 0.165±0.0081;  0.168±0.0019;  0.191±0.0003 µmol Fe(II)/mg sample and 0.013±0.0006; 0.014±0.0001; 0.015±0.0001 µmol trolox/mg sample, respectively. Although the essential oils from H. aff. pendula do not exhibit antioxidant activity, the primary compound, β-bisabolene, has been shown to possess other potential activities.
PELATIHAN PEMBUATAN JAMU JAHE MERAH INSTAN DI PASIE JAMBAK KOTA PADANG Nova Syafni; Wiwik Hanifah; Ryan Fajri Kurniawan; Lili Fitriani; Suryati Suryati
Jurnal Hilirisasi IPTEKS Vol. 6 No. 3 (2023)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v6i3.675

Abstract

The majority of the population in the Pasie Jambak area depends on fishing as their livelihood, which requires them to be in excellent physical condition to carry out their work. Red ginger is one of the most commonly found plants in the market and is known to have benefits in maintaining bodily stamina. Therefore, the Student Executive Board of the Faculty of Pharmacy, Andalas University, in collaboration with faculty members and students, conducted training in the production of instant red ginger herbal drinks with the aim of making it a convenient health beverage for the fishing community, suitable for consumption during their fishing trips. This training was attended by a large number of women residing in the vicinity of Pasie Jambak, Padang City. The training process consisted of several stages. The first stage involved an explanation of the benefits of red ginger, followed by the second stage, which was a practical session on the production of instant red ginger herbal drinks using red ginger rhizomes, sugar, and water. The subsequent stage focused on the packaging of the red ginger product and the proper method of preparing the beverage. The training activities concluded with a discussion session and the completion of questionnaires regarding the implementation of the training. The results of this training demonstrated that the participants were able to smoothly produce and package instant red ginger herbal drinks. The questionnaire results also indicated that overall, all participants were satisfied with the training activities. Therefore, it is expected that this training will provide significant benefits to the community in the Pasie Jambak area, helping to improve their health and offering a practical solution for fishermen who require good physical stamina to carry out their work.
Utilization Of Moringa Leaves As A Nutrient to Prevent Stunting In Children In Gantiang Village, Padang Panjang City Meri Susanti; Annisa Fauzana; Yoneta Srangenge; Nova Syafni; Najmiatul Fitria
Warta Pengabdian Andalas Vol 33 No 2 (2026)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.33.2.166-172.2026

Abstract

Stunting is a critical public health issue in Indonesia. Despite various nutrition programs, the utilization of nutritious local foods, such as Moringa oleifera leaves, has not been maximized due to limited public awareness and inadequate education. This activity aims to increase public knowledge of the nutritional content and benefits of Moringa leaves for preventing stunting, and to provide training in processing Moringa into healthy foods. Methods: The activity was conducted on October 4, 2025, in Gantiang Village, Padang Panjang City. The target group comprised housewives, health care workers, and caregivers of toddlers. Data were collected through pre- and post-tests, as well as surveys of participant satisfaction and interest. Results: Following the educational and processing demonstration, participants' knowledge increased significantly; the program was deemed highly beneficial, and most expressed interest in incorporating Moringa leaf preparations into their family menus. Conclusion: Education and training in Moringa leaf processing have been effective in increasing public knowledge and interest in using Moringa as a nutritious food, thereby potentially supporting efforts to prevent stunting. For sustainability, it is recommended that this program be integrated into integrated health posts (Posyandu) and that further training be conducted to ensure that Moringa leaf consumption becomes a regular part of family eating habits.
Co-Authors Adhitya Jessica Akrami, Hafizatul Amar, Puti Khairunnajwa Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Annisa Fauzana Armenia, Armenia Azhoma Gumala DAYAR ARBAIN Deddi Prima Putra Eka Putri, Desi Erizal Zaini Ersa Nur Syafia Fakhriadi, Athallah Faroliu, Goldha Fitri Handayani Friardi Ismed Furqan, Mainal Gusnelti, Yessi Henny Lucida Huljanah, Mifta Lili Fitriani Mansyurdin Meri Susanti Muhammad Idris Muhammad Idris Najmiatul Fitria Nanda Putra Nofrizal Nurainas Nurainas Prima Putra, Deddi Puti Khairunnajwa Amar Putri, Lusia Eka Rahmi Yosmar Rahmi Yosmar Rifaldi Harfiyantama Rini Agustin Rini Agustin Ryan Fajri Kurniawan Ryan Fajri Kurniawan Saafrida Saafrida Saafrida Saafrida Suryati Suryati Suryati Suryati Syafia, Ersa Nur Triswanto Sentat Try Andy Sahputra Try Andy Sahputra Uswatul Hasanah Wiwik Hanifah Wiwik Hanifah Yoneta Srangenge Yori Yuliandra, Yori