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All Journal Vegetalika Journal of Mathematical and Fundamental Sciences Jurnal Biologi Universitas Andalas Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Jurnal Mandala Pharmacon Indonesia Jurnal Review Pendidikan dan Pengajaran (JRPP) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks
Nova Syafni
Fakultas Farmasi, Universitas Andalas
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Essential Oils from Etlingera elatior Inflorescence against α-Amylase and α-Glucosidase Inhibition Syafni, Nova; Nofrizal, Nofrizal; Ismed, Friardi; Putra, Deddi Prima
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.812

Abstract

The increasing number of diabetes mellitus cases every year is alarming for every country. More than 90% of the cases are type-2 diabetes mellitus. The range of diabetes mellitus patients is at a productive age, including in Indonesia. Type-2 diabetes mellitus can be managed by reducing postprandial glucose levels. The approach inhibits α-amylase and α-glucosidase enzymes. A preliminary study on the local edible plants in Solok district, Etlingera elatior, showed potential against the α-glucosidase enzyme by TLC-bioautography screening. The essential oils from the inflorescence of E. elatior were extracted by hydro-distillation. The analysis of components from the essential oils identified 20 compounds. GC-MS data showed that the highest abundance percentages were 1-dodecanol (39.79%), dodecanal (28.20%), α-pinene (13.11%), decanal (4.16%), and dodecanol acetate (2.75%). The inhibition against the α-glucosidase enzyme obtains the IC50 value of 73.95 and 67.55 ?g/mL for the essential oils and acarbose, respectively. The inhibition against the α-amylase enzyme obtains the IC50 value of 70.87 and 12.28 ?g/mL for the essential oils and acarbose, respectively. The essential oils from the inflorescence of E. elatior could inhibit α-amylase and α-glucosidase enzymes, even though the potential was lower than that of acarbose as a positive control.
Formulation of Anti-Blackhead Rubber Mask from Purified Gambier (Uncaria gambir [Hunter] Roxb.) Agustin, Rini; Akrami, Hafizatul; Syafni, Nova
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.340-347.2023

Abstract

The purified was isolated from  Uncaria gambir [Hunter] Roxb. that contains more than 90% of catechins. Its antioksidant  and antibacterial properties have  potential to  formulate  as cosmetics. Dry form formulation of cosmetic was one approach to minimize cathecins degradation in a product.  In this study, three formulation of rubber mask containing 5% of purified gambier was done. . Each formulation was formulated with calcium sulfate, propylene glycol, magnesium carbonate, citrus essential oil and variation of HPMC and chitosan as film former. The three formulas had  a brown color, smooth textures, the gambier odor, visually homogeneous, particle sizes at 112.24 – 116.39 µm, moisture values at 3.9 – 7.04%, pH of 6, drying times of 8 to 15 minutes, adhesive power of > 10 seconds and remained stable for 21 days at 4±2°C and 27±2°C. The actual catechin content in formula I, II, and III were 0.89%, 1.09%, and 1.39%, respectively. The best formula was formula III, which contained 40% HPMC and 10% chitosan due to the fastest drying time of 8.36 minutes ± 19 seconds and the highest catechins content at 1.39%.The purified was isolated from  Uncaria gambir [Hunter] Roxb. that contains more than 90% of catechins. Its antioksidant  and antibacterial properties have  potential to  formulate  as cosmetics. Dry form formulation of cosmetic was one approach to minimize cathecins degradation in a product.  In this study, three formulation of rubber mask containing 5% of purified gambier was done. . Each formulation was formulated with calcium sulfate, propylene glycol, magnesium carbonate, citrus essential oil and variation of HPMC and chitosan as film former. The three formulas had  a brown color, smooth textures, the gambier odor, visually homogeneous, particle sizes at 112.24 – 116.39 µm, moisture values at 3.9 – 7.04%, pH of 6, drying times of 8 to 15 minutes, adhesive power of > 10 seconds and remained stable for 21 days at 4±2°C and 27±2°C. The actual catechin content in formula I, II, and III were 0.89%, 1.09%, and 1.39%, respectively. The best formula was formula III, which contained 40% HPMC and 10% chitosan due to the fastest drying time of 8.36 minutes ± 19 seconds and the highest catechins content at 1.39%.
Inhibition of Edible Plant Torch Ginger (Etlingera elatior (Jack) R. M. Sm.) against α-Glucosidase and α-Amylase Syafni, Nova; Fakhriadi, Athallah; Nofrizal, Nofrizal; Ismed, Friardi; Putra, Deddi Prima
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.348-352.2023

Abstract

Indonesia's diabetes cases were in the top ten list globally, with 90% of the patients being type-2 diabetes mellitus (T2DM).  An approach for screening the local edible plants is made for managing or treating T2DM by inhibiting α-glucosidase and α-amylase enzymes. Results showed that inflorescence of Etlingera elatior inhibition toward both enzymes. TLC-autography and IC50 value of fractions from E. elatior were used to identify the potential fractions and possible compounds for the activity. The non-polar fraction was spotted in the active substances based on TLC-autography. Then, the targeted compounds were separated by column chromatography to obtain stigmasterol as one of the active compounds. The IC50 values of total extract, n-hexane, EtOAc, BuOH, and isolated compound against α-glucosidase were 16.0, 7.5, 13.5, 9.7, and 2.0 ppm, respectively. The IC50 values for α-amylase inhibition were respectively 88.6, 48.6, 23.2, 29.1, and 27.5 ppm. The positive control (acarbose) against α-glucosidase and amylase exhibited IC50 values of 153.2 and 12.3 ppm. The inhibition of E. elatior against the two enzymes could be an alternative to delay carbohydrate absorption.
Ethnobotanical Study of Ferns as Traditional Medicine in Central Siberut, Mentawai Island Syafni, Nova; Bakhtiar, Amri
Jurnal Biologi Universitas Andalas Vol 10 No 1 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jbioua.10.1.10-14.2022

Abstract

West Sumatra Province has two ethnicities, namely Minangkabau and Mentawai. Both ethnicities have the capability to apply plants in folk medicine. This ethnobotanical study was conducted in Saibi Simokop village in three hamlets namely Sirisurak, Simoilaklak, and Saibi. The study was focused on the use of ferns in traditional medicine. Data collection was carried out using the snowball sampling method to seek the traditional healers (sikerei). The results showed that seven species of ferns were used for treatment of fever, inflammation, and poisoning. The ferns were included Cephalomanes javanicum (Blume) Bosch, Angiopteris evecta (G. Forst.) Hoffm., Dicranopteris linearis (Burm. F.) Underw., Diplazium esculentum (Retz.) Sw., Phymatosorus membranifolium (R. Br.) S.G. Lu, Lecanopteris sp., and Asplenium nidus L. The application of ferns in concoctions was administered topically and some were combined with oral administration.
SKRINING PENGHAMBATAN AKTIVITAS ENZIM Α-AMILASE SECARA IN-VITRO DARI REMPAH-REMPAH PADA MAKANAN TRADISIONAL SUKU MINANGKABAU, SUMATERA BARAT Nofrizal, Nofrizal; Syafni, Nova; Putri, Lusia Eka; Huljanah, Mifta
Jurnal Review Pendidikan dan Pengajaran Vol. 8 No. 1 (2025): Volume 8 No. 1 Tahun 2025
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jrpp.v8i1.41435

Abstract

Diabetes melitus (DM) merupakan penyakit metabolik degeneratif yang ditandai dengan kondisi hiperglikemia yang tidak terkontrol. Kondisi ini disebabkan oleh resistensi insulin dan kurangnya produksi insulin pada sel beta pancreas. Tujuan dari kajian ini adalah untuk menilai penghambatan aktivitas enzim α-amilase dari rempah-rempah yang digunakan dalam makanan tradisional suku Minangkabau, Sumatera Barat. Metode penelitian ini yaitu 20 Jenis rempah-rempah dimaserasi menggunakan pelarut etanol 70%. Masing-masing ekstrak dilarutkan dalam DMSO 10% dalam dapar fosfat pH 6,9. Masing-masing larutan diuji daya penghambatannya terhadap aktivitas enzim α-amilase dengan menggunakan pati sebagai substrat. Absorbansi dibaca pada l 540 nm menggunakan microplate reader. Hasil dianalisa menggunakan metoda Probit analysis untuk menentukan nilai IC50 dengan standar pembanding akarbosa. Hasil bahwa Ekstrak buah lada hitam menunjukkan penghambatan aktivitas tertinggi dengan IC50 sebesar 10,35 ppm (1,2 kali lebih kuat dari akarbosa). Tiga sampel lainnya, ekstrak kulit batang kayu manis, buah cabai, dan buah ketumbar menunjukkan aktivitas sedang dengan IC50 secara berturut-turut 40,17; 84,96 dan 97,42 ppm. Kesimpulan menunjukkan bahwa beberapa rempah-rempah yang digunakan dalam makanan tradisional Minangkabau berpotensi sebagai agen penghambat aktivitas enzim α-amilase
Co-Authors . Mansyurdin Adhitya Jessica Akrami, Hafizatul Amar, Puti Khairunnajwa Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar DAYAR ARBAIN Deddi Prima Putra Erizal Zaini Fakhriadi, Athallah Faroliu, Goldha Friardi Ismed Huljanah, Mifta Lili Fitriani Muhammad Idris Nanda Putra Nofrizal Nofrizal Nofrizal Putri, Lusia Eka Rahmi Yosmar Rahmi Yosmar Rini Agustin Rini Agustin Ryan Fajri Kurniawan Saafrida Saafrida Saafrida Saafrida Suryati Suryati Syafia, Ersa Nur Try Andy Sahputra Try Andy Sahputra Uswatul Hasanah Wiwik Hanifah Yori Yuliandra, Yori