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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Acta Pharmaciae Indonesia : Acta Pharm Indo JSFK (Jurnal Sains Farmasi & Klinis) Mandala of Health : A Scientific Journal Jurnal Tumbuhan Obat Indonesia Jurnal Sains dan Kesehatan
Tuti Sri Suhesti
Jurusan Farmasi, Fakultas Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Formulation of Gel Hand Sanitizer of Nagasari Leaf Extract (Mesua ferrea L.) Tuti Sri Suhesti; M. Mudrik H. Rohman; Sunarto Sunarto
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36465

Abstract

Nagasari (Mesua ferrea L.) is one of the biodiversity to be developed as an antiseptic preparation. These plants are known to contain flavonoid compounds, tannins, and terpenoids that act as antibacterial. Hand sanitizer gel preparations can increase the effectiveness of topically. The physical properties of a good gel depend on a gelling agent, one of which is HPMC. The purpose of this study was to determine the effect of variations in HPMC levels on physical properties and antibacterial activity. Gels were prepared with various HPMC levels of 1%, 2%, and 3%. The gel was tested for physical properties and stability. All formulas produced preparations that met the requirements for good physical properties and stability. Testing of antibacterial activity against Staphylococcus aureus showed that an increase in HPMC levels could decrease the ability to release the active substance of the preparation. The diameter of the inhibition zone obtained was 10.0 mm (HPMC 1%); 9.5 mm (2% HPMC) and 8.0 mm (3% HPMC). Increasing the concentration of HPMC will increase the viscosity and adhesion but decrease the spreadability. The three formulas had antibacterial activity against Staphylococcus aureus with moderate criteria.Keywords: Extract of nagasari leaf, Gel, HPMC, Staphylococcus aureus
Nanoemulsion of Nagasari (Mesua ferrea L.) Leaf and Its Activity Against Staphylococus aureus Suhesti, Tuti Sri; Muslimah, Annisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49866

Abstract

Nagasari leaves (Mesua ferrea L.) contain special chemicals to fight S. aureus. Nanoparticle technology can improve the solubility, stability, and bioavailability of the phytochemicals found in herbal medicines. The nanoemulsion produces small particle sizes. It has a large surface area. This research aims to determine the physical stability of Nagasari leaf ethanol extract nanoemulsion (EDN) with variations of Virgin Coconut Oil (VCO) as the oil phase during storage and its activity. Nanoemulsions were produced using 1%, 2%, and 3% VCO concentrations. The physical properties and stability of the preparations were characterised. The nanoemulsion was tested for activity against S. aureus. Chloramphenicol was used as a positive control. The results showed that the nanoemulsion containing 1% VCO produced the best physical properties: a particle size of 23.137 ± 7.63 nm, a polydispersity index (PDI) of 0.203 ± 0.013, and a zeta potential of -18.9 ± 0.086. A VCO concentration of 1% produces good nanoemulsion stability. The F1 nanoemulsion exhibited an average inhibition zone diameter of 16.75 mm (strong), the EDN provided an inhibition zone diameter of 8.70 mm (medium), and the positive control exhibited an inhibition zone diameter of 24.30 mm (very strong).
Co-Authors A Haris Budi Widodo Achmad Fudholi Amatullah Syarifah Amilia Ramadhani Arifa Aldi, Nisa Ario Ditto Primandaru Christiana Cahyani Prihastuti Diah Nurpratami Diani Mentari Eka Prasasti Nur Rachmani Esti Dyah Utami Fanni Kusuma Djati Gratiana Ekaningsih Wijayanti M. Mudrik H. Rohman Muhammad, Katon Muslimah, Annisa Ni Ken Ritchie Nurmahmudah, Nurmahmudah Nurmahmudah, Nurmahmudah Nuryanti Nuryanti Pitra Wulandari Rahmahwati, Devita Sukma Rehana Rinawati Satrio Sunarto Sunarto Utami, Vitis Vini Vera Ratna Warsinah Warsinah Warsinah Warsinah Wulandari, Pitra