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All Journal Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal Sari Pediatri Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Agnes Rengga Indrati
Departemen Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Characteristics of Immunological Non-Responders in People Living with HIV at Abepura Hospital Papua Justina Berry Sembiring; Agnes Rengga Indrati; Widya Amalia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2210

Abstract

Infection of Human Immunodeficiency Virus (HIV) lowers the body's immune system, especially CD4+ cells, making it more susceptible to opportunistic infections. Approximately 10-40% of People Living with HIV/AIDS (PLHIV) fail to achieve normal levels of CD4+ T cells despite continued virological suppression, a condition called Immunological Non-Responders (INR). Previous studies have shown that INR is considered a predictor of disease progression in people with HIV receiving antiretroviral (ARV)s through various mechanisms of suppression of the immune system that increases morbidity and mortality. Papua is an HIV epidemic area with a prevalence of 2.3%. This research is a cohort study conducted at Abepura Hospital from June 2019 to February 2023, which aims to identify the factors that influence the occurrence of INR in PLHIV receiving ARV therapy. There were 123 research subjects consisting of 55 people (44.7%) in the INR group and 68 people (55.3%) in the non-INR group. The results showed that the incidence of INR was higher in males than females (p=0.019), INR was significantly associated with increasing age (p=0.013), and CD4 count was low at the start of ARVs (p=0.002). There was a significant difference in CD4 counts between INR and non-INR (p<0.001). Oral candidiasis as a common opportunistic infection is more common in people with INR than in non-INR. (p=0.037). This study suggested that it is necessary to carry out a CD4 examination at the start of therapy and monitoring every 6 months to detect possible INR to prevent an increased risk of AIDS and non-AIDS, which increases mortality.
Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients Nurmin, Rahmawati; Lismayanti, Leni; Rostini, Tiene; Indrati, Agnes Rengga; Amalia, Lisda
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.2777

Abstract

One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level. The end result of platelet activation is platelet aggregation. However, it is unknown whether the beginning of platelet activation ends with platelet aggregation. This study aimed to discover the correlation between P-selectin level and platelet aggregation in CVST. This study used a cross-sectional escriptive observational correlative approach. Subjects were the CVST outpatients visiting the Neurology Department of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from July to September 2021. A total of 49 subjects met the inclusion and exclusion criteria. This study used citrate plasma samples for platelet aggregation and serum for P-selectin assessment. Platelet aggregation were assessed using the light transmission platelet aggregation method while P-selectin was assessed using Enzyme-linked immunosorbent assay (ELISA). Platelet aggregation median was 10.6% (range 0.2–82.4%), which reflected normoaggregation. Platelet hyperaggregation were seen in 9 samples (8.4%). Median of P-selectin was 2.4 ng/mL (range 0.1–10.1 ng/mL) which were normal. High P-selectin level was observed in 16 (32.7%) with 4/16 (25%) experiencing platelet hyperaggregation. Statistical analysis showed a weak negative correlation between P-selectin and platelet aggregation (r=-0.012; p=0.467). In conclusion, no correlation is seen between P-selectin and platelet aggregation, which may be due to the fact that platelets are influenced by many factors that are not examined in this study.
Co-Authors Adhi Kristianto S Adhi Sunjaya, Al Farizi Ahmad Rizal Ganiem Ahmad Rizal Ganiem, Ahmad Rizal Amaylia Oehadian Andre van der Venn Anggraini Alam Anggraini Alam Ani Melani Maskoen Bachti Alisjahbana Cissy Kartasasmita Coriejati Rita Delita Prihatni Dewi Kartika Turbawaty Djatnika Setiabudi Edhyana Sahiratmadja Edhyana Sahiratmadja Hartanto Bayuaji Hendro Hendro Hendro Hendro Herry Garna Heti Kus Erni Hilda Marsela Hinta Meijerink Ida Parwati Ida Parwati Indri Handayani Ines Atmosukarto Jane Haryanto Justina Berry Sembiring Lazuardi Dwipa Leni Lismayanti Lisda Amalia Maenaka Smaratungga Hendrajaya Maenaka Smaratungga Hendrajaya, Maenaka Smaratungga Marsela, Hilda Maya Marinda Montain Mohammad Ghozali, Mohammad Mustari, Asri Dini Neni Nurainy Nida Suraya Nina Tristina Nurmin, Rahmawati Ratu Purwanti Reinout van Crevel Rudi Wisaksana Stevi Dwiyani Sylvia Rachmayati Tiene Rostini, Tiene Tonggo Gerdina Panjaitan Wahyuningrum, Woro Hapsari Widya Amalia Yanti Yanti Yehezkiel Yonathan Yehezkiel Yonathan Yulia Hayatul Aini