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All Journal Berkala Ilmiah Pendidikan Biologi (BioEdu) Biota BIOEDUKASI Stigma : Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa Baktimu : Jurnal Pengabdian Kepada Masyarakat Baktimu : Jurnal Pengabdian Kepada Masyarakat
Erlix Rakhmad Purnama
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Biota

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DOCKING MOLEKULER SENYAWA METABOLIT SEKUNDER Lantana camara SEBAGAI ANTIINFLAMASI TERHADAP ENZIM COX-1 Atim Febry Masula; Dian Puspitasari; Eili Supriatin S.W; Khoirul Ummah; Dinik Rokhmatin; M. Musthofa Mubarrok; Ajheng Triyuni Hariza; Isnawati Isnawati; Erlix Rakhmad Purnama
Biota Vol 4 No 2 (2018): Jurnal Biota 2018
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v4i2.2172

Abstract

Lantana camara contains several types of flavonoids such as Umuhengerin, Lantadene A, Lantadene B, Icterogenin.One of the mechanisms of action of flavonoids as antiinflammatoryis by inhibiting cyclooxygenase receptor (COX). This study aims to determine the affinity of flavonoid compounds contained in L. camara with COX-1 receptors as antiinflammatory and to know the hydrogen bonds that can be formed by using molecular docking method. Testing in silico is done based on computer-aided drug design method. The tools used in this study, the PyRx software, PyMol software, Pubchem (database compound), PDB (Protein Data Bank), and PoseView. Based on the results of the docking and discussion above it can be concluded that the Icterogenin compound and Umuhengerin compound is the most effective compound in antiinflamasi process, Icterogenin compound has a value RMSD 41.1 Å and the value of binding afinity -8.8 and the Umuhengerin compound has value RMSD 1, 61 Å and value of binding affinity -8.0. It shows that the Umuhengerin compound has a resemblance percentage with the target protein because it has a smaller RMSD value than the Icterogenin compound. However, Icterogenin compounds have stronger and more efficient hydrogen bonds than the Umuhengerin compound because of the lowest value of binding affinity.
Identification of Anticancer Active Compound from GC-MS Test Results of Zodia Leaves (Evodia suaveolens) Ethanol Extract Ghea Dionita Sanora; Elly Yana Mastura; Muhammad Ongky Muji Handoyo; Erlix Rakhmad Purnama
Biota Vol 5 No 2 (2019): Jurnal Biota 2019
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v5i2.3374

Abstract

Cancer is estimated to be the second leading cause of death globally in 2018. The background of the study was the prevalence of cancer in Indonesia in 2018 reaching 775.120 people. Treatments such as surgery, chemotherapy, radiotherapy, immunotherapy, and hormone therapy have negative side effects. Herbal medicine is an alternative treatment with lower side effects that can reduce the side effects of existing treatments. The aim of this study was to identify the results of GC-MS active compounds from ethanol extract of zodia leaves which have the potential as anticancer. The method of this research was observational research through scientific literature. GC-MS results showed 22 active compounds contained in ethanol extract of zodia leaves. Based on the literature searching, there are 17 active compounds that have potential to be anticancer. Menthofuran; evodone; Bicyclopentene; Delta-Selinene; 3,5,7-Octatrien-2-Ol, 2,6-Dimethyl; Aromadendrene oxide 2; Alpha-bisabolol; 2,4-Dimethyl-2,4-Heptadienal; Phytol; Squalene; Beta-Tocopherol; D-alpha-Tocopherol; Stigmasta-5,23-dien-3.beta.-ol; (23S)-ethylcholest-5-en-3.beta.ol; 24,25-Dihydrolanosterol; Lanosterol; and Obtusifoliol. The compounds are targeted in breast, lung, and ovarian cancer.
Co-Authors Ajheng Triyuni Hariza Anisa Maryam Atim Febry Masula Boni Herdiawan Debby Verama Sari Dewi Putriarti Dian Puspitasari Dinik Rokhmatin Dwi Rulitasari Dyah Hariani Eili Supriatin S.W Ella Triana Aprilianty Elly Yana Mastura Erma Sukmawati Ghea Dionita Sanora Hidayatul Lailiyyah Huzaimatul Khalisah Isnawati Isnawati Jauzaa Dyah Imtiyaz Khaleyla, Firas Khoirul Ummah M. Musthofa Mubarrok Muhammad Ongky Muji Handoyo Nur Ducha Nur Fatichah Choirudiniyah Nur Haniyyah Muslimah Nur Kuswanti Prastyaningtias, Sisca Desi Raharjo Raharjo Rizki Nur Wijayanti Widowati Budijastuti