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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Kebidanan Dan Kesehatan Tradisional Jurnal Ilmiah Kedokteran Wijaya Kusuma Herb-Medicine Journal Journal of Pharmaceutical and Sciences. Journal of Innovative and Creativity Jurnal Sains dan Kesehatan
Muflihah Rizkawati
Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Potential of Tithonia diversifolia Hemsley A. Gray (Kembang Bulan) Leaf Extract as Anti-Cancer Agents Muflihah Rizkawati
Biology, Medicine, & Natural Product Chemistry Vol 10, No 2 (2021)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2021.102.87-91

Abstract

The main objective of this review is to explain the great potential of herbal plants as anticancer agents. Cancer is a disease caused by abnormal cell growth in the body. The high number of cancer incidents still become a global concern because of the high mortality rate. The treatments of cancer such as chemotherapy can cause serious side effects by killing the normal cells. This is the reason why it is necessary to develop an alternative treatment of cancer. I discussed a plant that is believed to has health benefit. Many studies have showed the positive effect of Tithonia diversifolia plant for health. After 2000, the researchers discovered a new potential through its cytotoxicity to neoplastic cells. This plant needs to be developed sustainably. However, in the future this plant might become an effective alternative to treat cancer with lower side effects.
Potensi Diet Soybean (Glycine max) Sebagai Alternatif Terapi Obesitas Dengan Dislipemia Muflihah Rizkawati
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 2 (2022): Herb-Medicine Journal April 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.13713

Abstract

ABSTRACTBackground : Obesity is becoming a major health problem in the world. Obesity rates are increasing in each country with a high risk of complications associated with the metabolic syndrome, such as hypertension, diabetes mellitus, dyslipidemia, and the risk of cardiovascular disease. Therapeutic management in cases of obesity with dyslipidemia through lifestyle modification approaches, dietary interventions, and drugs. However, long-term use of the drug is concerned about the possible side effects. Therefore, alternative dietary intervention and non-pharmacological therapy can be a better choice for treating obese patients with dyslipidemia.Methods: This research method is a literature review study. Database searches were performed via PubMed, ScienceDirect, and Google Scholar with keywords ((soybean or glycine max) AND (dyslipidemia or hypercholesterolemia)) AND (obesity) published in 2012-2022. Based on the search results, found 7 matching articles.Results: Based on a review of 7 articles, we found the benefits of soybeans (Glycin Max) in lowering total cholesterol (TC), lowering triglycerides (TG), increasing HDL-C levels, and lowering LDL level. The effect of long-term consumption of soybeans (Glycin Max) shows the potential effect of lowering MAD and increasing SOD due to long-term complications of oxidative stress from hypercholesterolemic conditions.Conclusion : There is a positive effect of soybeans consumption in obese patients with dyslipidemia and the literature also shows the potential for preventing complications on the risk of oxidative stress hypercholesterolemia.Keywords : Soybean; Glycin Max; Obesity; Hipercholesterolemia;Dyslipidemia; Review  AbstrakLatar belakang : Obesitas telah menjadi masalah kesehatan utama di dunia. Angka obesitas terus meningkat pada setiap negara disertai peningkatan resiko komplikasi yang dapat muncul terkait sindrom metabolik, seperti hipertensi, diabetes melitus, dislipidemia, dan risiko penyakit kardiovaskular. Manajemen terapi pada kasus obesitas dengan dislipidemia yang lebih kompleks harus dilakukan melalui pendekatan modifikasi gaya hidup, intervensi diet, dan obat-obatan. Akan tetapi, penggunaan obat-obatan jangka panjang banyak memunculkan kecemasan terhadap efek samping yang dapat muncul. Sehingga alternatif intervensi diet dan terapi non farmakologi dapat menjadi pilihan yang lebih baik dalam penanganan pasien obesitas dengan dislipidemia.Metode : Metode penelitian ini adalah studi literatur review. Penelusuran databaase dilakukan melalui Pubmed, Sciencedirect, dan Google Scholar dengan kata kunci ((soybeans or glycine max) AND (dyslipidemia or hypercholesterolemia)) AND (obesity) yang dipublikasikan tahun 2012-2022. Berdasarkan hasil penelusuran didapatkan 7 artikel yang sesuai.  Hasil : Berdasarkan telaah 7 artikel didapatkan hasil bahwa terdapat manfaat dari Soybean (Glycin Max) atau kedelai terhadap penurunan  kadar Kolesterol total (TC), penurunan kadar trigliserid (TG), peningkatan kadar HDL-C, penurunan kadar LDL. Efek konsumsi jangka panjang dari Soybean (Glycin Max) juga menunjukkan efek potensial dalam menurunkan MAD dan meningkatkan SOD sebagai akibat komplikasi jangka panjang dari munculnya stres oksidatif dari kondisi hiperkolesterolemia.Kesimpulan : Terdapat efek positif konsumsi soy bean atau kedelai pada pasien obesitas dengan dislipidemia dan literatur juga menunjukkan adanya potensi pencegaham komplikasi terhadap resiko stres oksidatif hiperkolesterolemia.Kata kunci : Soybean; Glycin Max; Obesitas;  Hiperkolesterolemia;  Dislipidemia;  Review
Antiobesity Potential of Butterfly Pea Flower (Clitoria Ternatea): A Literature Review Nur Aini Djunet; Muflihah Rizkawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2670

Abstract

Obesity is a health problem with an increasing prevalence every year in many countries including Indonesia.  Obese patients are at risk for complications related to some non-communicable diseases. The difficulty of losing weight in obese patients is due to low awareness of a good lifestyle, appropriate dietary patterns, and discipline in taking drugs to prevent complications. However, the need for drug consumption takes a long time. The risk of side effects arising from long-term drug use needs to be considered. Using herbal plants as an additional dietary intervention could be a better choice. This review described the benefits of the butterfly pea (Clitoria ternatea) flower as antiobesity. This study is a literature review by searching preceding published articles in Pubmed, ScienceDirect, Cochrane, and Google Scholar journals. The keywords used are (Clitoria ternatea) OR (Bunga Telang) OR (Butterfly pea) AND (Obesity) OR (Antiobesity). Articles are limited by publication period from 2012 to 2022 and then selected based on the criteria. This literature review concluded that the administration of Clitoria ternatea extracts (CTE) can become an alternative antiobesity by inhibiting weight gain, increasing adipose lipolysis, and decreasing the expression of adipogenic and lipogenic proteins.
Potensi Aktivitas Antibakterial Ekstrak Bunga Telang (Clitoria Ternatea): Potential Antibacterial Activity of Telang Flower Extract (Clitoria Ternatea) Muflihah Rizkawati; Leonny Dwi Rizkita
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1512

Abstract

High burden rate of antimicrobial resistance (AMR) worldwide encourages for more new studies of therapeutic strategies to minimize the further morbidities and mortalities, especially in country with heavy prevalence of infection disease. One of the alternative approach is through the nature. Butterfly pea (Clitoria ternatea) or Asian Pigeonwing is indigenous decorative plant commonly found in tropical region of the world, such as Pacific Asia, South America and Madagascar. The bright purple colour is notably utilized as natural food colouring in many Asian cuisine. The particular plant has been used for years as medicinal plant in various preparations, mostly as decoction for herbal drink/tea. However, scientific analysis to identify the possible health benefits are required to support the vaguely empirical testimony. The antibacterial component owned by butterfly pea plant is not limited by its flower petals only, but also the rest of the body, from the roots to the stem. The extraction process of butterfly pea plant shows myriad of phytochemical compounds with high pharmacological activity, especially as antibacterial against various bacteria such as E. coli and Bacillus cereus. Thus, this review compiles the recent ten years original article reported the antibacterial activities of Clitoria ternatea. Keywords: telang flower, Clitoria ternatea, butterfly pea, antibacterial Abstrak Angka beban global yang diakibatkan oleh kejadian resistensi antimikroba mendorong untuk dilakukan lebih banyak studi yang menelusuri strategi terapi terbaru guna mengurangi penambahan angka morbiditas dan mortalitas terutama pada negara dengan kasus penyakit infeksi yang sering. Salah satu pendekatan yang dapat dilakukan ialah melalui pengamatan terhadap potensi alam. Bunga telang (Clitoria ternatea) merupakan tanaman hias yang banyak ditemukan di negara tropis seperti Asia Pasifik, Amerika Selatan dan Madagaskar. Warna ungu terang yang menjadi khas tanaman tersebut sudah banyak dimanfaatkan sebagai pewarna makanan alami di beragam masakan Asia. Selain itu, tanaman ini juga telah digunakan sejak lama sebagai obat tradisional dalam berbagai sediaan, terutama seduhan rebusan. Namun, pendekatan saintifik diperlukan untuk mendukung pernyataan berbasis empiris. Komponen antimikroba milik bunga telang tidak hanya terbatas pada bagian kelopak bunganya saja namun semua bagian tubuhnya, mulai dari akar hingga batang. Proses ekstraksi tanaman bunga telang menunjukkan komponen fitokimia yang berkhasiat terutama sebagai antimikroba melawan E. coli dan Bacilus cereus. Oleh karena itu, ulasan ini dibuat guna mengkompilasi berbagai penelitian yang melaporkan aktivitas antibakteri Clitoria ternatea. Kata Kunci: Bunga telang, Clitoria ternatea, Antibakteri
The Problematic of Medicinal Plant: Negative effect of Catha Edulis (Khat) Abuse and Its Potential Benefits Muflihah Rizkawati; Ulfatun Nisa; Widhi Astana; Leonny Dwi Rizkita
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1756

Abstract

Catha edulis (khat), belongs to a group of psychotropic plants, which has an amphetamine-like structure and contains many catin and cation. The plant contains hallucinogenic compounds and known for its calming effect. The excessive catin contained inside the fresh leave of khat could potentially induce a plenty of side effects especially when the leaves are directly consumed and uncooked. The side effects vary according to how long the plant has been consumed, started from local organ disruption to cardiovascular complication such as increased blood pressure to myocardial infarction. In the contrary, positive effects of the composition of khat have also been reported such as anti-inflammatory effect, antidiabetic, anticancer, immunomodulatory and increased improvement in respiratory diseases. Although myriad studies have been conducted to examine the best benefit obtained from the such plant, the legal issue on its utilization is still questionable. Therefore, khat consumption must be maintained with a proper and strong regulation to lessen the negative impacts. However, studies on the potency of khat are still ongoing. The literature review was written based on various books, journals, and search databases in Pubmed, Medline, Cochrane and Google Scholar to show the positive and negative effects of the habit in consuming khat.
Optimalisasi Pencapaian Kompetensi Peresepan melalui Integrasi Gamifikasi dalam Learning Management System (LMS) dan Pemanfaatan e-Portfolio pada Tahap Pendidikan Klinis: Analisis Konseptual dan Tinjauan Naratif Yaltafit Jeem; Diani Puspa Wijaya; Muflihah Rizkawati; Isnatin Miladiyah; Riana Rahmawati; Sufi Desrini; Umatul Khoiriyah; Fuad Khadafianto; Yeny Dyah Cahyaningrum
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.5866

Abstract

Latar Belakang: Kompetensi peresepan merupakan pilar fundamental dalam pendidikan kedokteran di Indonesia, namun insiden kesalahan peresepan yang berdampak pada kesalahan pengobatan (medication errors) masih sangat tinggi, terutama di kalangan dokter muda. Kesalahan ini sering kali dikaitkan dengan pendidikan farmakologi klinis yang tidak adekuat, beban kognitif yang tinggi, dan kurangnya kesiapan dalam lingkungan klinis nyata. Tujuan: Studi ini bertujuan untuk mengonseptualisasikan bagaimana model pembelajaran yang mengintegrasikan Pembelajaran Berbasis Kasus (Case-Based Learning/CBL) yang diperkaya gamifikasi dalam Learning Management System (LMS) dan Portofolio Elektronik (e-Portfolio) dapat mengoptimalkan pencapaian kompetensi peresepan pada tahap pendidikan klinis. Metode: Studi ini menggunakan pendekatan analisis konseptual dan tinjauan naratif. Studi ini mensintesis literatur mengenai kesalahan peresepan, mekanika gamifikasi, dan teori pembelajaran mandiri (self-regulated learning) untuk membangun kerangka pedagogis yang dapat diterapkan pada pengaturan klinis. Hasil: Analisis menunjukkan bahwa gamifikasi mengatasi hambatan motivasi dan keterlibatan dalam latihan peresepan yang repetitif melalui mekanisme seperti pemantauan kemajuan dan umpan balik real-time. Secara bersamaan, e-Portfolio memfasilitasi pembelajaran mendalam dengan mendukung Self-Regulated Learning (SRL), pemantauan kompetensi longitudinal, dan praktik reflektif. Kesimpulan: Potensi integrasi CBL dengan gamifikasi dengan e-Portfolio menciptakan ekosistem pendidikan komprehensif yang mengatasi tantangan kognitif dan struktural pendidikan peresepan, yang pada akhirnya bertujuan untuk memenuhi standar kompetensi nasional dan meningkatkan keselamatan pasien.
Uji Larvasida Seduhan Teh Bunga Telang (Clitoria Ternatea L.) Terhadap Larva Nyamuk Aedes Aegypti Instar III Muflihah Rizkawati; Marlina Anggraeni; Ernadita Budiastuti; Riana Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1092

Abstract

Aedes aegypti is a mosquito species capable of transmitting dengue fever to humans. Vector control aimed at disrupting the mosquito life cycle is an effective strategy for preventing dengue fever. Larvicides are a class of pesticides used to kill insects at the larval stage. Butterfly pea flowers (Clitoria ternatea L.) contain active compounds such as flavonoids, which have potential larvicidal properties. This study aimed to determine the larvicidal effect of butterfly pea flower infusion (Clitoria ternatea L.). Telang flower tea was prepared at concentrations of 10%, 5%, 2.5%, and 1.25% for the treatment groups, while abate powder was used as the positive control. The study employed a completely randomized design by placing Aedes aegypti larvae into plastic cups divided into six groups with three replications, each containing 25 larvae. The treatment groups received telang flower tea at concentrations of 10%, 5%, 2.5%, and 1.25%. Larval mortality was observed over a 24-hour period. The results demonstrated larvicidal activity, as indicated by larval mortality. The effective concentration causing 50% larval mortality was 10% after 6 hours of observation, and 5% and 10% after 12 hours. In conclusion, telang flower tea (Clitoria ternatea L.) has been proven to exhibit larvicidal activity against instar III Aedes aegypti larvae at concentrations of 10% and 5%. The phytochemical compounds present in butterfly pea flowers—namely saponins, flavonoids, and tannins exert a rapid effect on larval mortality by damaging cell membranes or disrupting larval metabolic processes.
Effectiveness of Antidepressants and Telehealth-Based Interpersonal Psychotherapy for Postpartum Depression: A Scoping Review Tasya Azzahra Laila Mardhotillah; Muflihah Rizkawati
Jurnal Kebidanan dan Kesehatan Tradisional Jurnal Kebidanan dan Kesehatan Tradisional Volume 11 Number 2 Year 2026
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jkkt.v11i2.657

Abstract

Background: Postpartum depression (PPD) is a common mental health issue that occurs after childbirth and can negatively impact the health of mothers and the development of their children. Addressing PPD requires a practical approach that includes the use of antidepressant therapy with Telehealth Interpersonal Psychotherapy (IPT), which is expected to enhance post partum recovery. This review explores the comparative effectiveness of using antidepressants and implementing IPT in the recovery process from postpartum depression. Methods: This study reviewed and analyzed scientific articles from databases such as PubMed, ScienceDirect, Springer Link, and Google Scholar using PRISMA-ScR framework. A total of 14 original articles were selected based on inclusion and exclusion discussing the effectiveness of antidepressants and IPT. Results: The evidence demonstrated that antidepressant interventions, including conventional antidepressants and newer neuroactive steroid therapies, were generally associated with improvements in depressive symptoms. Telehealth IPT also demonstrated improvements in depressive outcomes and may provide an accessible alternative. However, substantial heterogeneity was observed in study designs, intervention characteristics, treatment duration, outcome measures, and follow-up periods, limiting direct comparison between pharmacological and telehealth-based IPT interventions. Conclusion: Both antidepressants and telehealth IPT effectively reduce PPD symptoms and enhance maternal well-being. However, further research is needed to understand these interventions' long-term impacts and explore the various types of available antidepressants.
Co-Authors Ernadita Budiastuti Fuad Khadafianto Isnatin Miladiyah Leonny Dwi Rizkita Marlina Anggraeni Nur Aini Djunet Riana Rahmawati Sufi Desrini Tasya Azzahra Laila Mardhotillah Ulfatun Nisa Umatul Khoiriyah Widhi Astana Wijaya, Diani Puspa Yaltafit Jeem Yeny Dyah Cahyaningrum