Muflihah Rizkawati
Departemen Farmakologi Fakultas Kedokteran, Universitas Islam Indonesia

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Potential of Tithonia diversifolia Hemsley A. Gray (Kembang Bulan) Leaf Extract as Anti-Cancer Agents Muflihah Rizkawati
Biology, Medicine, & Natural Product Chemistry Vol 10, No 2 (2021)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2021.102.87-91

Abstract

The main objective of this review is to explain the great potential of herbal plants as anticancer agents. Cancer is a disease caused by abnormal cell growth in the body. The high number of cancer incidents still become a global concern because of the high mortality rate. The treatments of cancer such as chemotherapy can cause serious side effects by killing the normal cells. This is the reason why it is necessary to develop an alternative treatment of cancer. I discussed a plant that is believed to has health benefit. Many studies have showed the positive effect of Tithonia diversifolia plant for health. After 2000, the researchers discovered a new potential through its cytotoxicity to neoplastic cells. This plant needs to be developed sustainably. However, in the future this plant might become an effective alternative to treat cancer with lower side effects.
Potensi Diet Soybean (Glycine max) Sebagai Alternatif Terapi Obesitas Dengan Dislipemia Muflihah Rizkawati
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 2 (2022): Herb-Medicine Journal April 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.13713

Abstract

ABSTRACTBackground : Obesity is becoming a major health problem in the world. Obesity rates are increasing in each country with a high risk of complications associated with the metabolic syndrome, such as hypertension, diabetes mellitus, dyslipidemia, and the risk of cardiovascular disease. Therapeutic management in cases of obesity with dyslipidemia through lifestyle modification approaches, dietary interventions, and drugs. However, long-term use of the drug is concerned about the possible side effects. Therefore, alternative dietary intervention and non-pharmacological therapy can be a better choice for treating obese patients with dyslipidemia.Methods: This research method is a literature review study. Database searches were performed via PubMed, ScienceDirect, and Google Scholar with keywords ((soybean or glycine max) AND (dyslipidemia or hypercholesterolemia)) AND (obesity) published in 2012-2022. Based on the search results, found 7 matching articles.Results: Based on a review of 7 articles, we found the benefits of soybeans (Glycin Max) in lowering total cholesterol (TC), lowering triglycerides (TG), increasing HDL-C levels, and lowering LDL level. The effect of long-term consumption of soybeans (Glycin Max) shows the potential effect of lowering MAD and increasing SOD due to long-term complications of oxidative stress from hypercholesterolemic conditions.Conclusion : There is a positive effect of soybeans consumption in obese patients with dyslipidemia and the literature also shows the potential for preventing complications on the risk of oxidative stress hypercholesterolemia.Keywords : Soybean; Glycin Max; Obesity; Hipercholesterolemia;Dyslipidemia; Review  AbstrakLatar belakang : Obesitas telah menjadi masalah kesehatan utama di dunia. Angka obesitas terus meningkat pada setiap negara disertai peningkatan resiko komplikasi yang dapat muncul terkait sindrom metabolik, seperti hipertensi, diabetes melitus, dislipidemia, dan risiko penyakit kardiovaskular. Manajemen terapi pada kasus obesitas dengan dislipidemia yang lebih kompleks harus dilakukan melalui pendekatan modifikasi gaya hidup, intervensi diet, dan obat-obatan. Akan tetapi, penggunaan obat-obatan jangka panjang banyak memunculkan kecemasan terhadap efek samping yang dapat muncul. Sehingga alternatif intervensi diet dan terapi non farmakologi dapat menjadi pilihan yang lebih baik dalam penanganan pasien obesitas dengan dislipidemia.Metode : Metode penelitian ini adalah studi literatur review. Penelusuran databaase dilakukan melalui Pubmed, Sciencedirect, dan Google Scholar dengan kata kunci ((soybeans or glycine max) AND (dyslipidemia or hypercholesterolemia)) AND (obesity) yang dipublikasikan tahun 2012-2022. Berdasarkan hasil penelusuran didapatkan 7 artikel yang sesuai.  Hasil : Berdasarkan telaah 7 artikel didapatkan hasil bahwa terdapat manfaat dari Soybean (Glycin Max) atau kedelai terhadap penurunan  kadar Kolesterol total (TC), penurunan kadar trigliserid (TG), peningkatan kadar HDL-C, penurunan kadar LDL. Efek konsumsi jangka panjang dari Soybean (Glycin Max) juga menunjukkan efek potensial dalam menurunkan MAD dan meningkatkan SOD sebagai akibat komplikasi jangka panjang dari munculnya stres oksidatif dari kondisi hiperkolesterolemia.Kesimpulan : Terdapat efek positif konsumsi soy bean atau kedelai pada pasien obesitas dengan dislipidemia dan literatur juga menunjukkan adanya potensi pencegaham komplikasi terhadap resiko stres oksidatif hiperkolesterolemia.Kata kunci : Soybean; Glycin Max; Obesitas;  Hiperkolesterolemia;  Dislipidemia;  Review