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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Journal Pharmaceutical Science and Application (JPSA) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Farmasi Udayana

N. L. P. V. Paramita

Program Studi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana

Author-ID : 2921941

Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Perbandingan Aktivitas Antibakteri Ekstrak kaya antosianin dari Kulit Ubi Jalar Ungu (Ipomoea batatas L.) dan Kulit Buah Anggur Hitam (Vitis Vinifera L.) terhadap Isolat Bakteri Propionibacterium acnes Paramita N.L.P.V.; Rasmita, L.D.; Putri I G.A.A.R.C.; Utami N.P.P.; Budiningrum, N.W.; Suastini I G.A.N.; Wintari L.K.S.; Yustiantara P.S; Wirasuta I M.A.G
Jurnal Farmasi Udayana Vol. 5 No. 2 Tahun 2016
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Acne dipengaruhi perkembangannya oleh karena peningkatan sebum, kolonisasi bakteri Propionibacterium acnes yang menyebabkan inflamasi, dan adanya ROS. Senyawa yang diperlukan untuk mengontrol acne yaitu senyawa yang memiliki aktivitas antibakteri, antiinflamasi, antilipase dan antioksidan. Kulit ubi Jalar ungu (Ipomoea batatas L.) dan kulit buah anggur hitam (Vitis vinifera L.) telah dilaporkan memiliki aktivitas antioksidan, namun aktivitas antibakteri terhadap P. acnes belum pernah dilakukan. Tujuan penelitian ini untuk mengetahui kemampuan kulit ubi jalar ungu dan kulit buah anggur hitam dalam menghambat isolat bakteri P. acnes. Uji aktivitas antibakteri menggunakan metode difusi disk. Sampel uji adalah empat variasi konsentrasi ekstrak kulit ubi jalar ungu (250, 500, 1000, dan 2000 mg/mL ) dan ekstrak kulit buah anggur hitam dengan 5 variasi konsentrasi (12.5, 25, 50, 100, 200 mg/mL), kontrol negatif (CMC-Na 0,5% b/v), kontrol positif (Doksisiklin 30 ?g/disk). Aktivitas antibakteri ditandai dengan munculnya daerah zona hambatan disekitar disk uji (ukuran 6 mm). Nilai diameter zona hambatan dianalisa secara deskriptif berdasarkan kategori respon hambat dari CSLI yaitu resistent (? 14 mm), intermediate (15 – 19 mm), susceptible (? 20 mm) Berdasarkan penelitian ini, Ekstrak kulit ubi jalar ungu mampu menghambat isolat bakteri P. acnes mulai pada konsentrasi 1000 mg/mL dengan nilai diameter zona hambatan yaitu 10.3 ± 0.03 mm dan termasuk dalam kategori resisten. Sedangkan ekstrak kulit buah anggur hitam tidak mampu menghambat bakteri P. acnes pada 5 variasi konsentrasi yang dipaparkan.

Uji Aktivitas Antibakteri Ekstrak Terpurifikasi Daun sirih hijau (Piper betle L.) Terhadap Bakteri Propionibacterium acnes Widyaningtias N. M. S. R; Yustiantara P. S.; Paramita N. L. P.V.
Jurnal Farmasi Udayana Vol. 3, No. 1, Tahun 2014
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Daun sirih hijau (Piper betle L.) merupakan tanaman yang telah terbukti secara ilmiah memiliki aktivitas sebagai antibakteri. Ekstrak terpurifikasi merupakan ekstrak yang telah terbebas dari komponen zat ballast yang dapat mengganggu suatu matriks bahan alam dalam menghasilkan aktivitas biologi. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak terpurifikasi daun sirih hijau hijau (EPS) terhadap bakteri Propionibacterium acnes (P. acnes). Uji aktivitas antibakteri menggunakann metode difusi disk. Sampel uji adalah empat variasi konsentrasi EPS (2,5 mg/mL; 5 mg/mL; 10 mg/mL; 20 mg/mL), kontrol negatif (CMC-Na 0,5% b/v), kontrol positif(Doksisiklin 30 ?g/disk). Berdasarkan penelitian ini, EPS memiliki kemampuan menghambat pertumbuhan bakteri P. acnes. Berdasarkan kategori kekuatan, EPS memiliki aktivitas antibakteri yang kuat terhadap P. acnes pada konsentrasi 20 mg/mL. Sehingga, proses purifikasi terhadap daun sirih hijau hijau tidak menghilangkan kemampuannya dalam menghasilkan aktivitas antibakteri

Uji Aktivitas Antibakteri Ekstrak Etanol Buah Cabe Jawa (Piper retrofractum Vahl.) Terhadap Bakteri Propionibacterium acnes Wulansari, I. A. R.; Yustiantara, P. S.; Paramita, N. L. P.V.; Wirasuta, I M.A.G.
Jurnal Farmasi Udayana Vol. 3, No. 2, Tahun 2014
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Jerawat merupakan salah satu penyakit kulit yang dikenal sebagai acne vulgaris. Salah satu bakteri penyebab jerawat adalah bakteri gram positif Propionibacterium acnes yang bersifat anaerob. Cabe jawa (Piper retrofractum Vahl.) telah terbukti secara ilmiah memiliki aktivitas antibakteri terhadap bakteri gram positif Staphylococcus aureus. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol buah cabe jawa (Piper retrofractum Vahl.) terhadap bakteri P. acnes. Uji aktivitas antibakteri dilakukan dengan metode difusi cakram. Sampel adalah 5 variasi konsentrasi dari ekstrak etanol buah cabe jawa dalam CMC-Na 0,5% b/v (1 - 10.000 ppm) dengan kontrol positif Doksisiklin. Media uji adalah Mueller-Hinton Agar. Suspensi bakteri dengan kekeruhan 108 CFU/mL. Hasil penelitian menunjukan bahwa 5 variasi konsentrasi ekstrak etanol buah cabe jawa tidak menghambat pertumbuhan bakteri P. acnes, sehingga dapat disimpulkan bahwa ekstrak etanol buah cabe jawa tidak memiliki aktivitas antibakteri terhadap bakteri P. acnes. Hal ini dapat saja dimungkinkan adanya perbedaan karakter struktur dinding sel dari bakteri P. acnes dan bakteri gram positif lainnya.

Pengaruh Perbedaan Metode Ekstraksi Terhadap Fingerprint HPTLC Ganja Ni Luh Putu Vidya Paramita; I Made Agus Gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 3 (2013): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

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Effect of Extraction Systems of Cannabinoid From Cannabis Sp on TLC Densitometric Chromatogram Pattern N.M.P. Susanti; M.A.G. Wirasuta; I. N. K. Widjaja; K.W. Astuti; N.L.P.V. Paramita
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Optimization studies of cannabinoid extraction method of Cannabis sp have been conducted. The aim of this study was to find a marijuana extraction method to identify cannabinoid compounds using TLC–Spectrophotodensitometry technique. This study covers the process of maceration and soxhlet extraction to extract cannabinoid content in marijuana flowers and seeds using methanol PE, and ether as a solvent, followed by a screening test using the TLC- Spectrophotodensitometry method. Confirmation test used Fast Blue B salt to visualize color of the spots. CBN, THC, and CBD can be separated by either using the stationary phase of Al-TLC SI G60 F254 with a mobile phase of hexane - diethylether with the color visualization and Rf value after spraying with Fast Blue B Salt are the CBN will provide the purple-pink color with the HRF 59, THC will provide the purple color with the HRF 66, and the CBD will give orange color with the HRF 73 [1,2]. These results indicate that CBN, THC and CBD can be separated by either using the Al-TLC SI G60 F254 system with a mobile phase of hexanediethylether (80: 20, v / v). Differences in extraction methods affect the pattern of TLCDensitometry chromatogram peak. This effect on the profiling of simplicia. Keywords: extraction, cannabinoid, Al-TLC, Spectrophotodensitometry

EFFECT OF METHANOL CONCENTRATION AS A SOLVENT ON TOTAL PHENOLIC AND FLAVONOID CONTENT OF BELUNTAS LEAF EXTRACT (Pulchea indica L.) Ni Putu Sinta Mahasuari; N. L. P. Vidya Paramita; A.A Gede Rai Yadnya Putra
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p05

Background: Beluntas (Pluchea indica L.) is an Indonesian plant that grows wild and is used as traditional medicine. Beluntas leaves are reported to contain phenolic, and flavonoid is a part of phenolic compounds. Phenolic compounds other than flavonoids include 1,3,4,5-tetra-O-caffeoylquinic acid, 3,4,5-tri-O-caffeoylquinic acid, chlorogenic acid, and ferulic acid. Flavonoid compounds in beluntas leaves are quercetin, apigenin, luteolin and chrysoeriol. Methanol solvents are reported to be able to extract higher polyphenol and flavonoid contents than other solvents. Objective: The purpose of this study is to determine the effect of 20%, 50% and 75% solvent concentration of methanol on total phenol and total flavonoid levels of beluntas leaf extract. Methods: In this study, the extraction process was carried out by maceration, the determination of total phenol content was carried out by the Follin-Ciocalteu method. Determination of total flavonoid levels was carried out by the Colorimetric method. Data on phenol and flavonoid levels were analyzed statistically. Results: The yield of beluntas leaf extract in this study was respectively from the lowest methanol concentration of 24.094% w/w, 31.126% w/w, 24.838% w/w. The value of total phenol levels increased with increasing methanol concentration, namely 124.84 mg GAE/g, 138.3 mg GAE/g, and 147.91 mg GAE/g. The highest total flavonoid value in 75% methanol extract is 69.72 mg QE/g, followed by 20% methanol extract at 46.29 mg QE/g and the lowest is found in 50% methanol extract at 32.80 mg QE/g. The results of statistical analysis using the Kruskal-Wallis test showed that there were significant differences (p<0.05) in the value of total phenol levels and total flavonoids of the three extracts. Conclusion: The difference in the concentration of methanol solvents affects the value of total phenol levels and total flavonoids with the highest value produced by a 75% methanol solvent. Keywords: Beluntas Leaves (Pluchea indica L.), Total Phenol Content, Total Flavonoid Content, Gallic Acid, Quercetin.

PENGOLAHAN HASIL PERTANIAN BUNGA GEMITIR SEBAGAI MASKER WAJAH KAYA ANTIOKSIDAN L.P.F. Larasanty; N.L.P.V. Paramita; N.P.E. Leliqia; N.P.L. Laksmiani
Buletin Udayana Mengabdi Vol 22 No 4 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i04.p05

Gemitir flower cultivation is one of the agricultural commodities in Apuan village, Susut district, Bangli. The demand for gemitir flowers fluctuates from time to time. When prices are low, farmers will generally experience losses. It is necessary to carry out community service activities that aim to diversify gemitir flower agricultural products into cosmetic products in the form of natural face masks with high antioxidant content. Gemitir flower petals are known to contain tagetin and hydroxyflavones which are naturally antioxidants and are useful in the process of skin regeneration. This face mask product can become a processed product that provides more economic value for farmer groups in Apuan Bangli Village. Community service activities are carried out in stages starting with a survey at the location of the service to see when the gemitir flowers are harvested. At harvest time, the flowers that have bloomed are then collected as needed to be used as samples for processing into face masks. In the first step, the activities carried out were the process of selecting and drying flowers in a natural way and with the help of an oven, then they were made into powder. Product manufacturing activities begin with the pre-formulation of mask preparations. Then with the existing formula, training activities on how to make masks were carried out, including mask packaging. The results of monitoring and evaluation activities showed an increase in public knowledge with an initial average value of 28 to 71 after the final monitoring evaliation was carried out. Keywords: gemitir flower, face mask, natural, antioxidant, training.

Co-Authors A. A. R. Y. Putra A.A.G.R.Y. Putra Adiluhur M. A. Anak Agung Gede Rai Yadnya Putra Budiningrum, N.W. Coky N. W. C. Dewantari A. A. I. S. H Dewi L. R. Diarini A. S. I G.A.A. Trisnadewi I Made Agus Gelgel Wirasuta I. A. P. Y. Putri I. N. K. Widjaja I. P. S. T. Lova Ketut Widyani Astuti L.P.F. Larasanty N. K. S. Indriyani N. M. D. Andani N. M. D. Andani N. M. P. Susanti N. M. P. Susanti N. P. T. W. Andari N.L.P.P. Ardiyanti N.M.P. Dwijayanti N.M.P. Susanti N.P.C. Pratiwi Ni Made Pitri Susanti Ni Putu Eka Leliqia Ni Putu Linda Laksmiani Ni Putu Sinta Mahasuari Oka M. Putra, I.M.D.S Putri I G.A.A.R.C. Rasmita, L.D. Sari, D. R. A. P. Suastini I G.A.N. Utami N.P.P. W. A. Wijaya W. A. Wijaya Widyaningtias N. M. S. R Wintari L.K.S. Wulansari, I. A. R. Yustiantara, Putu Sanna

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