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All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Heart Science Journal Solo Journal of Anesthesi, Pain and Critical Care Journal of Mechanical Design and Testing (JMDT) Berita Kedokteran Masyarakat Indonesian Journal of Biomedicine and Clinical Sciences

Budi Yuli Setianto

Departemen Kardiologi Dan Kedokteran Vaskular, Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan, Universitas Gadjah Mada, Jalan Farmako Sekip Utara,Yogyakarta 55281 Telp. +62 274 560300

Author-ID : 2970799

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Ventricular Septal Defect Closure with Perforated Patch in Large Ventricular Septal Defect with Severe Pulmonary Hypertension and Non Reactive Oxygen Test Budi Yuli Setianto; Hariadi Hariawan; Rano Imawan
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17813

Management of ventricular septal defect (VSD) with severe pulmonary hypertension (PH) had not been extensively studied and is still challenging. The closure of VSD in patients with high pulmonary vascular resistance (PVR) and severe PH is highly risk procedure. If high PVR and severe PH still persist after closure procedure, the patients have poor prognosis. We reported a 24-year-oldwoman whom was diagnosed with large VSD, bidirectional shunt with L to R dominance, dilatation of left ventricle, and mild to moderate mitral regurgitation, mild tricuspid regurgitation and severe PH. Right heart catheterization showed pre-oxygen test: mean aorta pressure 85 mmHg, mean pulmonary artery pressure 65 mmHg, fl ow ratio 5,4, PVR 2,3 WU and pulmonary vascular resistance index (PVRI) 3,22 WU/m2. The results of post-oxygen test: mean aorta pressure 83 mmHg, mean pulmonary artery pressure 63 mmHg, fl ow Ratio 2,2, PVR 0,3 WU and PVRI 0,42 WU/m2. Patient had been performed VSD closure with perforated patch 3 mm. Three month evaluation by echocardiography showed residual VSD 3 mm, L to R shunt, moderate tricuspid regurgitation and mild PH (TVG 36 mmHg). In Baumgartner criteria of VSD operability, this patient was not operable because the ratio of mean pulmonary and systemic circulation more than 2/3, but in Lopez criteria, patient is operable because PVRI below 6 WU/m2. Patient with high and moderate PH and PVR which is still operable, VSD can be closed partially. Partially VSD closure can be performed by transcatheter procedure after PH decrease and stable.Keyword: VSD closure- perforated patch – PH severe

Correlation between Small Dense Low Density Lipoprotein Level with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients Maria Debby Maharatno; Hariadi Hariawan; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 2, No 1 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17817

Background: Cardiovascular disease is one of major problems in developed and developing countries. Atherosclerosis process begins with endothelial dysfunction. Lipoprotein is important factor in atherogenesis. Previous study stated that about 50% of cardiovascular events happened in individuals with normal or low LDL, therefore LDL plasma level alone is not enough to identifyindividuals with major adverse cardiac events. Individuals with small dense LDL predominant have 3 times fold to have cardiovascular risk. The goal of this study is to know whether the level of sdLDL has impact on in hospital major adverse cardiac events (MACE) of acute coronary syndrome patients. Methods: This was a cross sectional study, enrolling patients with acute coronary syndrome admitted and hospitalized in ICCU of Dr.Sardjito Hospital since September of 2013 until June 2015. The small dense LDL (sdLDLD) level was measured with previous formula using routine blood lipid component. Major adverse cardiac events (MACE) were determined upon observation during horpitalisation and defi ned as death, reinfarction, cardiogenic shock, acute heart failure, ventricular tachycardia or ventricular fi brillation, prolonged angina pain, and the need for immediate coronary intervention. Results: There were 159 patients with mean age 60.80 ± 9.8 years involved in this study. Onehundred eighteen (118) or 73% of patients were male. The mean of sdLDL level in patients with MACE was 108.34 ± 37.94 g/dl and mean sdLDL level in patients without MACE was 105.54 ± 43.10 g/dl. The level of sdLDL in patients without MACE was lower than patients with MACE (p=0.705). In this study we found the cut- off sdLDL level is ≥ 108.085 for higher sdLDL level and < 108.085 for lower sdLDL level. The higher sdLDL level have the prevalence ratio of 1.25 to develop MACE, however the value was not statistically signifi cant.Conclusion: The sdLDL level did not correlate with MACE in hospitalised patients with acute coronary syndrome.Keywords: small dense LDL, acute coronary syndrome, MACE

Coronary Circulation and Hemodynamics Hendry Purnasidha Bagaswoto; Erika Maharani; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 2, No 1 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17819

Coronary circulation is the circulation of blood in the blood vessels of the heart muscle (myocardium). The vessels that deliver oxygenrich blood to the myocardium are known as coronary arteries. The vessels that remove thedeoxygenated blood from the heart muscle are known as cardiac veins.

Prediction of Failed Fibrinolytic Using Scoring System in ST Elevation Myocardial Infarction Patients Satria Mahendra; Budi Yuli Setianto; Hariadi Hariawan
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22601

Background: ST elevation myocardial infarction (STEMI) is the most common acute coronary syndrome in adults, and requiring immediate reperfusion. Primary percutaneous coronary intervention (PCI) is the main reperfusion therapy, but because of many limitations, fibrinolytic is often chosen. Fibrinolytic have high failure risk, so it is important to be able to predict whether this therapy will fail or not. This research aim to create a scoring system to predict failed fibrinolytic in STEMI patients. Methods: This is retrospective cohort study using medical records data from Dr. Sardjito General Hospital in Yogyakarta, recorded in June 2014-December 2015. The population was STEMI patients that reperfused with streptokinase regiment. Determination of failed fibrinolytic was using the difference in the ST segment elevation of the pre and post fibrinolytic electrocardiogram (ECG). The clinical variables of subjects were recorded. The statistical analysis was done and scoring system was constructed. Results: A total of 105 patients with mean age of 57.82±9.59 years were included in this study. Subjects with failed fibrinolytic was 53 patients (50.5%). Several variables were independently associated with failed fibrinolytis, i.e. the onset of ≥ 6 hours, hyperglycemia, and the location of anterior infarction (OR = 11.3, p = 0.000; OR = 6.11, p = 0.003 and OR = 10.5, p = 0.001, respectively). After scoring system was constructed, it was found that score ≥ 2 predict failed fibinolytic, with 53% sensitivity and 94% specificity. Conclusions : Scoring system consisting of onset ≥ 6 hours, hyperglycemia in arrival, and anterior infarct location, can be used to predict failed fibrinolytic in STEMI patients using streptokinase with 53% sensitivity and 94% specificity. Keywords: failed fibrinolytic scoring; fibrinolytic; STEMI; streptokinase

The Prevalence and Impact of Body Mass Index Category in Patients with Acute Myocardial Infarction Anggoro Budi Hartopo; Vina Yanti Susanti; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22604

Background: Body mass index is widely recognized as a tool to classify obesity and adiposity. In Asian population, body mass index category can be divided as underweight, normal, overweight and obese. The prevalence of this categorisation is varied among patients with acute myocardial infarction. Furthermore, there is a J and U curve relationship between body mass index category with outcome in acute myocardial infarction. This research aims to investigate the prevalence of body mass index category and its impact on patients with acute myocardial infarction.Methods: The research design is a cross sectional study. The subjects of this research are patients hospitalised with acute myocardial infarction. Subjects are categorised as underweight, normal, overweight and obese, based on Asian body mass index categorisation. The demography, clinical and laboratory data is compared among categories and statistically analysed. The major adverse cardiac events occuring during hospitalisation are recorded and its incidence is compared among group. A p value < 0.05 is statistics limit for significance.Results: We analyse 375 subjects hospitalised with acute myocardial infarction. The most prevalence BMI category is overweight (47.7 %), the second most common category is normal (33.1 %), followed by obese (15.5 %) and the least common category is underweight (3.7 %). No significant difference is observed in respect of gender and cardiovascular risk factors. The underweight subject is significantly older as compared to other categories. The glucose level and atherogenic lipid tend to be higher in underweight subject as compared with normal subject. There is no difference in the incidence of major adverse cardiac events among body mass index categorisation.Conclusion: The overweight is the most common body mass index category in acute myocardial infarction. The underweight subject is significantly older and tend to have worse biochemical parameters as compared to other categories. The incidence of MACE is not associated with the body mass index category.Keywords: body mass index; overweight; underweight; acute myocardial infarction

Surgical and Non Surgical Interventions in Adult Congenital Heart Disease: Our Experience from COHARD registry Budi Yuli Setianto; Dyah Wulan Anggrahini
ACI (Acta Cardiologia Indonesiana) Vol 3, No 2(S) (2017): Supplement, Abstracts of Jogja INternational CARdiovascular TOpic Series (JIN
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.28012

Surgical and Non Surgical Interventions in Adult Congenital Heart Disease:Our Experience from COHARD registry

Prognostic Factor of Soluble ST2 Serum on 90 Days-Major Cardiovascular Events in ST-Elevation Acute Myocardial Infarction Patients with Reperfusion Therapy Pamrayogi Hutomo; Anggoro Budi Hartopo; Indah Sukmasari; Ira Puspitawati; Putrika Prastuti Ratna Gharini; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29680

Background: Soluble ST2 (sST2) is released by strained myocardial. High baseline sST2 levels have been shown to be a predictor of mortality and heart failure in STEMI patients within 30 days and within 1 year, but its effect on medium-term events has not been widely investigated. Aims: To assess the prognostic factor of sST2 levels during admission with major cardiovascular events in the form of cardiovascular death and heart failure due to left ventricular dysfunction within 90 days of observation. Methods: A retrospective cohort study was conducted on STEMI patients with an onset of ≤ 24 hours undergoing reperfusion therapy from April 2014 - June 2015 in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The sST2 sample of venous blood was performed at admission. Primary outcomes for this analysis included cardiovascular death and congestive heart failure (CHF) through 90 days of follow-up. Assessment of major cardiovascular events was based on medical record data. Bivariate analysis were conducted on demographic and clinical factors related to sST2 and major cardiovascular events. A multivariate analysis was then conducted to determine the independent factors that influenced the emergence of major cardiovascular events. Results: Of the 107 patients who met the subject criteria, there were 33 (30.8%) subjects withmajor cardiovascular events and 74 subjects (69.2%) without major cardiovascular events in 90 days of observation. Of the 33 subjects with major cardiovascular events, there were 10 subjects (9.3%) died and 23 subjects (21.5%) with heart failure. The sST2 levels did not have a significant relationship with the incidence of mortality (p=0.617), heart failure (p=1.000), orboth combined (p = 1.000) in 90 days of observation. Conclusion: High serum sST2 levels during admission in STEMI patients who had undergonereperfusion therapy were not associated with increased incidence of major cardiovascular events (either the incidence of mortality or heart failure alone or both combined) in 90 days observation.

The Past, Present, and Future of Myocardial Revascularization Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 3, No 2 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.33550

One of the important diagnostic modalities in cardiology is cardiac catheterization, which is onetool for myocardial revascularization. This examination is particularly useful in the aspect ofcardiac hemodynamic evaluation, among other utilities. This review describes the advance ofcardiac catheterization from the beginning of its discovery to future development.

Mean Platelet Volume as a Predictor of Atherosclerotic Severity in Non ST Elevation Acute Myocardial Infarction Yuli Astuti; Budi Yuli Setianto; Nahar Taufiq
ACI (Acta Cardiologia Indonesiana) Vol 5, No 1 (2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Background: Acute myocardial infarction (AMI) is the leading cause of death in the world. AMI is classified into ST-elevation myocardial infarction (STEMI) and Non-ST elevation myocardial infarction (NSTEMI). Diagnosis and prediction of severity of atherosclerotic in NSTEMI is a challenge. Despite the risk stratification, 14-20% of patients that undergo coronary angiography have normal or non significant coronary artery disease. The role of platelet and the extent of atherotrombosis in patients with NSTEMI are interesting field of research. Mean platelet volume (MPV) reflects platelet size and reactivity. It can be used as a diagnostic marker and may have predictive value. This study aims to prove the role of MPV as a predictor of the degree of atherosclerotic based on Syntax score in patients with NSTEMI undergoing coronary angiography.Methods: This is a cross sectional study enrolled 86 subjects with NSTEMI. Blood samples were taken at the time of admission to the hospital. An MPV was measured by automated machine. Subsequent coronary angiography was performed using standardized method. Syntax score was determined to reflect the atherosclerotic severity. Statistical analysis was used to assess whether an MPV as a predictor of atherosclerotic severity based on Syntax score.Results: The chi-square analysis showed that high MPV could not be used as a predictor of the atherosclerotic severity based on Syntax score in NSTEMI patients (p value =0.5, prevalence ratio 1.15 (95% CI: 0.755-1.753). From multivariate analysis, only smoking factor had an independent relationship with Syntax score (p value =0.047; Odds ratio 2.531(95% CI: 1.012-6.328).Conclusions: High MPV cannot be used as a predictor of atherosclerotic severity based on Syntax score in NSTEMI patients.

Successful Balloon Mitral Valvuloplasty in 21-week Pregnant Patient with Severe Mitral Stenosis: A Case Report and Literature Review Cynthia Yosephine Silitonga; Nahar Taufiq; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 5, No 1 (2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Mitral stenosis is the most common manifestation of rheumatic heart disease. Hemodynamic changes during pregnancy increase the burden of the heart in pregnant women with cardiac abnormalities. A 33 years old woman, G3P1A1 is 21 weeks pregnant came to our hospital with a shortness of breath during daily activity, which was worsened since 3 months of pregnancy. The patient has been diagnosed with severe mitral stenosis. The results of echocardiography examination was left atrial dilatation, normal global function and left ventricular with ejection fraction 51%, severe mitral stenosis Wilkin Score 8 with Mitral Valve area 0.53 cm2 and Mitral Valve Gradient 33 mmHg. Subsequently, Balloon Mitral Valvuloplasty was successfully performed. During and after the procedure there was no complication. The fetus was considered in stable condition.

Co-Authors . Supomo Abdus Samik Wahab Ahmad Hamim Sadewa Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Cindy Elfira Boom Cornelia Ancilla Cynthia Yosephine Silitonga Damarkusuma, Arditya Daniel Daniel Dyah Wulan Anggrahini Erdiansyah Zulyadaini Erika Maharani Ferdinandus Bayu Satria Firandi Saputra Firandi Saputra, Firandi Gharini, Putrika Prastuti Ratna Gumilang, Rizki Amalia Hani Khairina Hariadi Hariawan Hendry Purnasidha Bagaswoto Heri Hernawan Heri Hernawan, Heri Indah Sukmasari Ira Puspitawati Irsad Andi Arso, Irsad Andi Jauhari, Haris Julia Sari Juni Kurniawaty Muhdar Abubakar Djayanti Sari Lucia Kris Dinarti Lucia Krisdinarti Lucia Krisdinarti Maria Debby Maharatno Martalena Br Purba, Martalena Br Miftakhudin Miftakhudin Muhamad Taufik Ismail Muslim Mahardika Nahar Taufik Nahar Taufiq Nahar Taufiq Nahar Taufiq Nahar Taufiq Nahar Taufiq, Nahar Pamrayogi Hutomo Pradhana, Aditya Prasetia, Arif Eka Putrika Prastuti Ra Gharini Putrika Prastuti Ra Gharini Rahadiyanti, Ayu Rano Imawan Rochmat, Muflihatul Baroroh Ruchanihadi Ruchanihadi Sasongko Hadi Purnomo Satria Mahendra Sukmadja, Daniel Vina Yanti Susanti Yuli Astuti Yunita Widyastuti

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