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All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Heart Science Journal Solo Journal of Anesthesi, Pain and Critical Care Journal of Mechanical Design and Testing (JMDT) Berita Kedokteran Masyarakat Indonesian Journal of Biomedicine and Clinical Sciences

Budi Yuli Setianto

Departemen Kardiologi Dan Kedokteran Vaskular, Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan, Universitas Gadjah Mada, Jalan Farmako Sekip Utara,Yogyakarta 55281 Telp. +62 274 560300

Author-ID : 2970799

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Role of Non-Vitamin K Oral Anticoagulants for Prevention of Stroke in Renal Impaired Atrial Fibrillation Patients Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 5, No 1 (P) (2019): Proceedings Jogja Cardiology Update 2019 (JCU2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Atrial fibrillation (AF) and chronic kidney disease (CKD) are highly prevalent, particularly with increasing of age and associated comorbidities, such as hypertension, diabetes, heart failure, and vascular disease. The relationship between AF and CKD seems to be bidirectional. CKD predisposes to AF while onset of AF seems to lead to progression of CKD. Stroke prevention is the cornerstone of AF management, and AF patients with CKD are at higher risk of stroke, mortality, cardiac events, and bleeding. Stroke prevention requires use of oral anticoagulants, which are either vitamin K antagonists (e.g. warfarin), or the non-vitamin K antagonist oral anticoagulants (NOAC). While NOAC have been shown to be effective in mild-to-moderate renal dysfunction, there are a paucity of data regarding NOAC in severe and end-stage renal dysfunction. The followingwill discuss the evidence for NOAC in CKD, and summarize the current knowledge regarding the efficacy and safety of NOAC to prevent AF-related stroke and systemic embolism in severe and end-stage renal disease.

Navigating Your Acute Heart Failure Patient in Emergency and Pre-Discharge Phase Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 5, No 1 (P) (2019): Proceedings Jogja Cardiology Update 2019 (JCU2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Heart failure (HF) leads to frequent hospitalizations. The presence of re-hospitalization risk among patientshospitalized for heart failure is important, especially hemodynamic instability and neurohormonal over activation. ARNI is needed to restore the balance of neurohormonal system in HF. PARADIGM-HF study provide insight on long term benefit of ARNI (i.e. sacubitril/valsartan) in ambulatory setting. How is the evidence of ARNI use for in hospitalization phase of HF? PIONEER and TRANSITION showed that initiation of sacubitril/valsartan shortly after an ADHF event is feasible and well tolerated. In-hospital initiation of sacubitril/valsartan is associated with early and sustained improvements in biomarkers of cardiac wall stress and myocardial injury, indicating pathophysiological benefits in a wide range of HFrEF patients.

Transmisi infeksi Helicobacter Pylori di antara anggota keluarga Susanna Hilda Hutajulu, Budi Yuli Setianto dan Siti Nurjanah
Berita Kedokteran Masyarakat (BKM) Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.3698

Background: The transmission of Helicobacter pylon (H. pylon) infection between family members plays important role in the spreading of infection. Many factors have been known to affect the transmission. Objective: This study aimed at determining whether an existence of infected chronic dyspepsia patient in the family will increase infection prevalence of the other family members, and assessing risk factors well known to increase infection transmission in the family. Methods: This study was cross sectional and was conducted in Yogyakarta. Anti-H. pylon serology was performed to determine the infection status of family members of infected chronic dyspepsia patients compared to family members of uninfected ones. A questionnaire was used to assess the risk factors. Results: There were 118 subjects who met the eligibility criteria. The infection prevalence among all subjects was 38,1%. There were 16 families (76,19%) from infected patients and 13 families (61,90%) from uninfected ones proven seropositivity among the members. The prevalence ratio was 1,23 and the difference was not statistically significant (p= 0,317, 95% Confidence Interval 0,82-1,86). Univariate analysis for the variables suspected to increase seropositivity prevalence in the family was not statistically significant. Conclusion: The infection prevalence of H. pylon was higher among family members of infected chronic dyspepsia patients than among family members of uninfected ones, but it was not statistically different. All of well known risk factors did not seem to affect the prevalence rate. Keywords: Helicobacter pylori, transmission, family members, seropositivity

Outcome Comparison Between Insulin-Dependent and Non Insulin-Dependent Patients after Open Adult Cardiac Surgery Juni Kurniawaty; Budi Yuli Setianto; Supomo Supomo; Yunita Widyastuti; Cornelia Ancilla; Cindy Elfira Boom
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 3, No 1 (2023): April 2023
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v3i1.66306

Background: Insulin-dependent diabetic patients usually have poor glycemic control and higher risk of complications than non-insulin-dependent diabetic patients. However, the difference in clinical outcomes between these two groups of patients who underwent open cardiac surgery was not established. Therefore, this study compares the short-term outcome of insulin vs non-insulin-dependent diabetic patients after open cardiac surgery in a large-scale study.Methods: The study design was a retrospective cohort. All adults who underwent open cardiac surgery between January 1st 2016-December 31st 2020 in 4 tertiary hospitals in Indonesia were included in the study. From a total of 4.931 samples included in the study, 3.753 patients were non-diabetic (Group I) and 1.178 were diabetic (Group II). Group II was divided into subgroup IIA (930 non-insulin-dependent) and subgroup IIB (248 insulin-dependent). The main outcome was in-hospital mortality of open cardiac surgery patients.Result: In-hospital mortality between group I and II had no significant difference (6.8% vs 5.7%; p = 0.188), as well as IIA and IIB (5.6% vs 6%; p = 0.782). Multivariate analysis demonstrated that diabetes did not increase mortality of open cardiac surgery (OR 0.665; p = 0.021). In-hospital mortality of subgroup IIB was higher than subgroup IIA, but insulin therapy did not increase the risk of in-hospital mortality (OR 1.259; p = 0.464).Conclusion: Both insulin-dependent and non-insulin-dependent diabetes mellitus were not the predictors of poor short-term outcomes for open adult cardiac surgery patients.

The impact of COVID-19 pandemic on decreasing hospitalization rates and management of acute coronary syndrome: a study from single centre hospital in Yogyakarta, Indonesia Hendry Purnasidha Bagaswoto; Ferdinandus Bayu Satria; Hani Khairina; Nahar Taufik; Budi Yuli Setianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202303

The Corona virus disease-2019 (COVID-19) pandemic has an impact on the medical field, one of which is service for patients with acute coronary syndrome (ACS). Studies in other countries showed a sudden decrease in admission rates, and percutaneous coronary intervention (PCI), one of ACS treatments, has an impact due to this pandemic. This study aimed to ascertain the effect of COVID-19 on the admissions and management of patients with ACS in Yogyakarta, Indonesia. It was an observational single center study conducted by collecting data for ACS patients at Dr. Sardjito General Hospital, Yogyakarta. Admission data for March 2019 to February 2020 were pre pandemic data, while those gathered from March to December 2020 were pandemic data. Data from 864 (pre pandemic period) and 338 patients (during the pandemic period) were further analyzed. The results showed a decrease in ACS patients’ admission during the pandemic. The most remarkable reduction occurred in those with ST-segment elevation myocardial infarction (STEMI), followed by non-STEMI (NSTEMI) and unstable angina pectoris (UAP) (63.4, 61.4, and 40.9%, respectively). Furthermore, the PCI procedure decreased compared to the period before the pandemic. No significant differences in patients’ characteristics was observed (p>0.05), except for the incidence of pneumonia (p <0.001). Finally, the mortality rate was higher during the pandemic than before (14.8 vs 13.2%), although it was not significant (p>0.05). This study showed that COVID-19 caused a sensible reduction in the admission rates for ACS patients and the number of PCI procedures have been performed. On the other hand, their mortality rate did not increase significantly. However, it is essential to improve healthcare services for ACS patients considering the uncertainty of ending the COVID-19 outbreak.

Simplified Selvester QRS Score as an Infarct Size Parameter in STEMI Patients Undergoing Pharmacoinvasive or Primary Percutaneous Coronary Intervention Prasetia, Arif Eka; Hartopo, Anggoro Budi; Taufiq, Nahar; Bagaswoto, Hendry Purnasidha; Setianto, Budi Yuli
Jurnal Kardiologi Indonesia Vol 43 No 4 (2022): Indonesian Journal of Cardiology: October - December 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1186

Background:Cardiovascular disease especially acute myocardial infarct (AMI) is one of the highest cause of mortality worldwide. Majority of AMI comes in the form of ST elevation myocardial infarct (STEMI) that requires timely diagnosis and revascularization management to restore myocardial circulation. The simple method to estimate infarct size is by using simplified Selvester QRS Score to electrocardiogram records, which is a tested method that have good correlation with gold standard, namely cardiac magnetic resonance imaging. Objectives : To investigate difference of infarct size with simplified Selvester QRS score parameter between STEMI patients undergoing pharmacoinvasive compared to primary PCI. Methods: Eighty-two STEMI patients, 41 of pharmacoinvasive and 41 of primary PCI was scored with simplified Selvester QRS score from electrocardiogram recording. Patient data are retroactively taken form Sardjito Cardiovascular Intensive Care (SCIENCE) registry. Scoring of simplified Selvester QRS Score was done by two experienced cardiologist blinded to patient procedure, and results then measured for interobserver agreement with Bland-Altman test. Comparison of QRS Score in pharmacoinvasive and primary PCI group was done with independent sample T test followed with multivariable linear regression test. Results: The means of simplified Selvester QRS score in pharmacoinvasive and primary PCI group is 7.240±3.015 and 8.900±4.188, p=0.043, respectively. Independent sample T test shows significant difference in the simplified Selvester QRS score in pharmacoinvasive and primary PCI group. The multivariable analysis shows that variables other than revascularization method independently influences QRS score are onset, anterior segment ST elevation and ST segment elevation in more > 3 leads in electrocardiogram. Conclusion: There is significant difference in infarct size measured by simplified Selvester QRS score betweem STEMI patient undergoing pharmacoinvasive method compared to primary PCI procedure, which is lower in the pharmacoinvasive group

Predictors of Acute Kidney Injury in Critically Ill Patient at Intensive Cardiac Care Unit Jauhari, Haris; Bagaswoto, Hendry Purnasidha; Setianto, Budi Yuli
Jurnal Kardiologi Indonesia Vol 43 No 4 (2022): Indonesian Journal of Cardiology: October - December 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1322

Background: Acute kidney injury (AKI) occurs frequently in the intensive cardiac care unit (ICCU) and is recognized as a heterogeneous syndrome with variable etiology and clinical presentation that affects acute morbidity and mortality. AKI needs to be identified early and underlying causes must be treated Method: We performed a retrospective analysis of patient registry from Sardjito Cardiovascular Intensive Care (SCIENCE) between January 2021 and December 2021. This registry provided demographic data, risk factors, comorbidities, laboratory findings and survival outcomes. The KDIGO criteria were used to define AKI characterized by an increase in serum creatinine more or equal to 0.3 mg/dL in 48 hours, or an increase in serum creatinine more or equal to 1.5 times than previous value, or urine volume less than 0.5 mL/kg BW/hour for 6 hours. Univariate and multivariate data analyses were carried out. Results: This study included 428 patients with an incidence of AKI was 14,3 %. Univariate analysis showed that AKI was related to diabetes, acute heart failure, sepsis, APACHE score, SAPS, Sardjito score, MCARS, hemoglobin, leukocyte, and plasma albumin concentration. Furthermore, we did multivariate analysis and showed the independent predictor of AKI at ICCU admission is acute heart failure (OR 3.90; 95% CI 1.95–7.77; p <0.001), sepsis (OR 3.02; 95% CI 1.03-8.90; p 0.045) and high APACHE II score (OR 0.33; 95% CI 0.13-0.80; p 0.015). Conclusions: Acute heart failure, sepsis and high APACHE score at admission is independent predictors of AKI among critically ill in ICCU Sardjito General Hospital. The results of this study may contribute to the implementation of targeted therapies.

Impact of multivessel coronary artery disease on early and late clinical outcome in ST-Segment elevation myocardial infarction patients who underwent percutaneous coronary intervention: insight from Indonesia Damarkusuma, Arditya; Taufiq, Nahar; Bagaswoto, Hendry Purnasidha; Saputra, Firandi; Sukmadja, Daniel; Setianto, Budi Yuli
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.12536

It is estimated that 15 people for every 1000 Indonesian residents suffer from cardiovascular disease (CVD) including ST-segment elevation myocardial infarction (STEMI). Percutaneous coronary intervention (PCI) is often performed in patients with STEMI. Several factors affect clinical outcome after PCI procedure including multivessel coronary artery disease. This study aimed to measure the impact of multivessel coronary artery disease on the early and late outcomes of STEMI patients undergoing PCI procedures. This was a prospective cohort study on STEMI patients undergoing PCI procedures from the period of August to December 2021. Two expected cohorts were performed i.e. patients who suffered from single-vessel disease (SVD) and patients who suffered from multivessel disease (MVD). Forty six patients with STEMI were enrolled in this study consisting of 24 (52.17%) patients with MVD and 22 (47.83%) patients with SVD. No significant difference in baseline characteristics between MVD and SVD groups was observed (p > 0.05). The MVD group (91.67%) used a more radial percutaneous approach compared with the SVD group (54.55%; p = 0.04). In addition, no significant difference between the SVD group and the MVD group in major adverse cardiovascular events (MACE) and echocardiographic outcome after 90-d follow up was observed (p > 0.05). In conclusion, MVD has similar impacts on early and late clinical outcomes compared with SVD in STEMI patients undergoing PCI procedures.

Tekanan darah sistolik, indeks kardiak dan sindrome Eisenmenger merupakan prediktor kematian pada pasien hipertensi arteri pulmonal terkait penyakit jantung bawaan: analisis dari register COHARD-PH Rochmat, Muflihatul Baroroh; Setianto, Budi Yuli; Anggrahini, Dyah Wulan; Dinarti, Lucia Kris; Hartopo, Anggoro Budi
Jurnal Kardiologi Indonesia Vol 45 No 3 (2024): July - September, 2024
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1623

Background: Pulmonary arterial hypertension (PAH) is a complication of left-to-right intracardiac shunt congenital heart disease (LtR-shunt CHD). There are several known predictors of mortality in PAH patients, however predictors of mortality in LtR-shunt CHD-associated PAH need to be validated. Objectives: We aimed to investigate the predictors of mortality among adult LtR-shunt CHD-associated PAH patients. Methods: This research was a retrospective cohort study that included adult patients with LtR-shunt CHD-associated PAH retrieved from the COHARD-PH registry. Several baseline variables were selected as potential predictors of mortality, namely (1) clinical data: WHO-functional class, SaO2, 6-min walking distance, systolic blood pressure, and Eisenmenger syndrome; (2) laboratory data: hemoglobin and NT-pro BNP levels; (3) echocardiography data: pericardial effusion, defect size, and TAPSE; and (4) hemodynamic data: right atrial pressure, cardiac output and index, SvO2, and flow ratio. The mortality outcome was assessed from the cohort registry. Results: A total of 124 subjects with LtR-shunt CHD-associated PAH were included. Sixteen subjects (12.9%) died during the follow-up period. The baseline variables which showed significant association with mortality were lower systolic blood pressure, Eisenmenger syndrome, higher NT-pro BNP level, and lower cardiac output. The multivariable analysis showed that systolic blood pressure <100 mmHg (OR 10.99; 95% CI 2.54-47.51, p=0.001), cardiac index <2.5 L/min/m2 (OR 8.13; 95% CI: 1.59-42.28, p=0.011) and Eisenmenger syndrome (OR 3.87; 95%CI: 1.06-14.07) were the independent predictors for mortality. Conclusions: The systolic blood pressure <100 mmHg, cardiac index <2.5 L/min/m2, and Eisenmenger syndrome were independent predictors of mortality among adults with LtR-shunt CHD-associated PAH.

The effect of invasive strategy versus conservative strategy on mortality in patients with non-ST-elevation myocardial infarction at Sardjito Hospital Yogyakarta Pradhana, Aditya; Bagaswoto, Hendry Purnasidha; Saputra, Firandi; Setianto, Budi Yuli
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.14

BACKGROUND: Acute myocardial infarction (AMI) causes high hospital admission rates and mortality in Indonesia. Previous studies showed that invasive strategies on non-ST-elevation myocardial infarction (NSTEMI) patients can provide more benefit in clinical outcomes, particularly in high- and very high-risk groups. However, this strategy cannot be implemented due to transportation limitations or a lack of available catheterization facilities in some regions. Recent meta-analyses suggested that early invasive strategies (≤24 hours), delayed strategies (>24 hours), or conservative showed no differences significantly in mortality rates from any cause, stroke or cardiovascular death in NSTEMI patients. OBJECTIVES: This study aims to define the impact of invasive strategies on in-hospital mortality in high and very high-risk NSTEMI patients at Sardjito Hospital. METHODS: A retrospective cohort study utilized data from 326 NSTEMI patients who satisfied the inclusion and exclusion criteria, obtained from the Sardjito Cardiovascular Intensive Care (SCIENCE) registry between January 2023 and June 2024. RESULTS: The invasive and conservative method groups did not substantially differ in in-hospital mortality among NSTEMI patients in either unadjusted (p=0.09) or adjusted analysis (p=0.071, OR 2.251, 95% CI [0.932–5.434]). However, a significant difference was found in the high-risk group (p=0.042) but not in the very-high-risk group (p=0.525). Multivariate analysis confirmed Killip classification (p=0.000, OR 4.449, 95% CI [2.195–9.016]) and hs-Troponin T levels (p=0.006, OR 1.000, 95% CI [1.000–1.000]) as independent mortality predictors. CONCLUSION: Invasive management gave high-risk NSTEMI patients a survival advantage over conservative therapy at Sardjito Hospital, but not in the very-high-risk population.

Co-Authors . Supomo Abdus Samik Wahab Ahmad Hamim Sadewa Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Cindy Elfira Boom Cornelia Ancilla Cynthia Yosephine Silitonga Damarkusuma, Arditya Daniel Daniel Dyah Wulan Anggrahini Erdiansyah Zulyadaini Erika Maharani Ferdinandus Bayu Satria Firandi Saputra Firandi Saputra, Firandi Gharini, Putrika Prastuti Ratna Gumilang, Rizki Amalia Hani Khairina Hariadi Hariawan Hendry Purnasidha Bagaswoto Heri Hernawan Heri Hernawan, Heri Indah Sukmasari Ira Puspitawati Irsad Andi Arso, Irsad Andi Jauhari, Haris Julia Sari Juni Kurniawaty Muhdar Abubakar Djayanti Sari Lucia Kris Dinarti Lucia Krisdinarti Lucia Krisdinarti Maria Debby Maharatno Martalena Br Purba, Martalena Br Miftakhudin Miftakhudin Muhamad Taufik Ismail Muslim Mahardika Nahar Taufik Nahar Taufiq Nahar Taufiq Nahar Taufiq Nahar Taufiq Nahar Taufiq, Nahar Pamrayogi Hutomo Pradhana, Aditya Prasetia, Arif Eka Putrika Prastuti Ra Gharini Putrika Prastuti Ra Gharini Rahadiyanti, Ayu Rano Imawan Rochmat, Muflihatul Baroroh Ruchanihadi Ruchanihadi Sasongko Hadi Purnomo Satria Mahendra Sukmadja, Daniel Vina Yanti Susanti Yuli Astuti Yunita Widyastuti

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