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All Journal e-Journal Pustaka Kesehatan Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Indonesia Journal of Agropharmacy
Eka Deddy Irawan
Fakultas Farmasi Universitas Jember
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Library & Information Science Medicine & Pharmacology

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet Irawan, Eka Deddy; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.204 KB) | DOI: 10.14499/indonesianjpharm0iss0pp231-238

Abstract

Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg).Key words : mucoadhesive, factorial design, DE480 , chitosan, CMC Na, Mg stearat, contour plot
Optimization of chitosan and sodium carboxymethylcellulose as mucoadhesive system in theophylline tablet Irawan, Eka Deddy; ., Farhana
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.37 KB) | DOI: 10.14499/indonesianjpharm0iss0pp92-97

Abstract

Mucoadhesive  tablet  for  asthma  treatment  were  prepared  by  mixing theophylline  with  two  variations  of  polymers.  The  purpose  of  this  research  was to  controlled  drug  release  from  the  dosage  form.  Theophylline  mucoadhesive tablets  were  prepared  by  direct  compression  using  chitosan  and  sodium carboxymethylcellulose  as  mucoadhesive  polymers.  Mucoadhesive  strength measured  using  rabbit  gastric  mucosa  and  in  vitro  drug  dissolution  was subjected  in  a  hydroclorid  acid  buffer  pH  1.2  for  10  hours.  The  optimized formula  was  obtained  by  analyzing   both  evaluation  using  factorial  design. Formula  with  5.4  %  of  chitosan  and  14.5  %  of  sodium carboxymethylcellulose followed zero order kinetics. The optimized formulation showed by 8.38-10.91% of  chitosan  and  28.84-29.09%  of   sodium  carboxymethylcellulose  with mucoadhesive strength between 25-40 gram and 43.5%-55% drug was released in 10 hours.Key words: Mucoadhesive, chitosan, CMC Na, E, factorial design. 
Co-Authors ., Farhana Achmad Fudholi Amalia Fadila Ameliana, Lidya Barikah, Kuni Zu’aimah Cahyaningrum, Nitta Christyn Novita S Dwi Nurahmanto Eryani, Mikhania Christiningtyas Eunike Aprilianio Eva Setyorini Farkha, Fara Sukma Firdatus Sholehah Hanif, Mohammad Ainul Fakhruddin Hery Diar Febryanto Laily, Aisyah Prida Lina Winarti Lusia Oktora Ruma K. S. Lusia Oktora Ruma Kumala Sari Ninda Sukmaningrum Siti Munawaro Siti Munawaro, Siti Sri Untari Sukmaningrum, Ninda Taffana Windy Hananta Tiara Berlianti Tintia Lintang Pratiwi Viddy Agustian Rosyidi Yudi Wicaksono Yudistirawati Khusna