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All Journal Journal of Food and Pharmaceutical Science e-Journal Pustaka Kesehatan Indonesian Journal of Pharmaceutical Science and Technology JOPS (Journal Of Pharmacy and Science) Abdimasku : Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences. Journal of Food and Pharmaceutical Sciences Journal of Agropharmacy
Tanfidz Alishlah, Tanfidz
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : e-Journal Pustaka Kesehatan

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Pengaruh Trietanolamin terhadap Karakteristik Fisika Kimia dan Laju Pelepasan Ibuprofen dalam Sediaan Gel Dispersi Padat Ibuprofen-PEG 6000 (Effect of Triethanolamine on Physicochemical Characteristic and Dissolution Rate of Ibuprofen in Ibuprofen-PEG 600 Tanfidz Alishlah; Budipratiwi Wisudyaningsih; Lidya Ameliana
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The present research has been undertaken with the aim to develop a topical gel formulation of ibuprofen which would avoid side effects of ibuprofen in oral administration. In this study, ibuprofen was made in solid dispersion form with PEG 6000 polymer composition 1 : 1.5 by fusion method. Solid dispersions aims to improve the solubility of ibuprofen. Triethanolamine as an alkalizing agent was added with different concentration in each gel formula which are 1 %, 2 %, and 4 %. They were evaluated for physicochemical properties such as organoleptic, pH, viscosity and in vitro drug release. Based on this research, it can be concluded that the different concentration of triethanolamine doesn’t give the significant effect on viscosity, nonetheless there is a significant effect on pH and dissolution rate of ibuprofen. It is obtained that the highest dissolution rate is F3 with a flux as 216.93 μg/cm2.minutes. Keywords: gel, ibuprofen, solid dispersion, PEG 6000, triethanolamine
Co-Authors Ameliana, Lidya Arif Rahman Hakim Balqis, Aura Inzalna Claudia Fortunata, Florensia Grace Diana Holidah Dianasari, Dewi Eka Putri, Khilwiyah Endah Puspitasari Eryani, Mikhania Christiningtyas Lestyo Wulandari Mahdi Jufri Mun’im, Abdul Muthi'atul, Bannan Nia Kristiningrum Nina Wijiani Nuri Nuri Putri Aditama, Tiara Sagita Sattya Arimurti Ulfah, Evi Umayah Umayah Ulfa, Evi Zulvania, Clarissa Najwa