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Ni Luh Putu Eka Kartika Sari
Department Of Physiology And Biochemistry, Faculty Of Medicine And Health Sciences, Warmadewa University
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Journal : Aesculapius Medical Journal

 1 
Prevalensi Ekspresi Epidermal Growth Factor Receptor (EGFR) pada Karsinoma Penis Gede Khrisnanda Arya Dharma; Desak Putu Oki Lestari; Ni Wayan Armerinayanti; Ni Luh Putu Eka Kartika Sari
AMJ (Aesculapius Medical Journal) Vol. 1 No. 1 (2021): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

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Abstract

Abstrak Kanker penis merupakan penyakit keganasan pada laki laki yang ditemukan paling tinggi di Bali dibandingkan dengan daerah lain di Indonesia. Sekitar 95% keganasan pada penis adalah jenis karsinoma sel skuamosa (KSS). Perkembangan terapi kanker saat ini telah mencapai targeted terapi, sedangkan belum banyak penelitian pada kanker penis. Perkembangan targeted terapi berdasarkan overekspresi EGFR telah banyak berkembang dan telah dipakai sebagai individual terapi terutama pada kanker paru. Penelitian ini bertujuan untuk mengetahui ekspresi EGFR pada KSS penis. Penelitian ini merupakan penelitian deskriptif observasional untuk mengetahui prevalensi ekspresi EGFR dari pemeriksaan imuno histokimia, sel tumor terpulas positif berwarna coklat kuat mengelilingi seluruh membran sel tumor. Hasil penelitian dari 141 sampel karsinoma sel skuamosa penis yang diambil dari biopsi, operasi penektomi parsial, dan operasi penektomi total didapat prevalensi ekspresi EGFR yang terpulas positif pada sel tumor kanker penis sebanyak 8 kasus (5,7%) dengan distribusi umur tertinggi pada kelompok umur 41-60 tahun sebanyak 66 kasus (46,8%). Pengetahuan tentang overekspresi EGFR pada kanker penis dapat dijadikan dasar rujukan pemberian anti EGFR terutama pada kanker penis dengan stadium lanjut.
Hubungan Tingkat Kecemasan dengan Kualitas Tidur pada Mahasiswa Tahap Pre-Klinik dalam Menghadapi Ujian Blok di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa Ni Made Aninda Febriyanti; Putu Asih Primatanti; Ni Luh Putu Eka Kartika Sari
AMJ (Aesculapius Medical Journal) Vol. 3 No. 2 (2023): June
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

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Abstract

Anxiety is a mental problem that is often experienced by medical students which can be interpreted as feeling worried and unable to perform obligations. The academic obligations that medical students have to perform such as block exams encountered are the initial triggers for anxiety that affect sleep quality. Sustained anxiety will affect the quality of student sleep, resulting in impaired physiological and psychological balance. This research aims to analyze the correlation between anxiety level and sleep quality of pre-clinical students when facing block exams in the Faculty of Medicine and Health Science of Warmadewa University. This research applied analytical study design using cross-sectional approach. The sampling technique was using proportional random sampling approach. The sample of the research covered 227 students of medical education. The instruments of this research were Hamilton Anxiety Rating Scale (HARS) dan Pittsburgh Sleep Quality Index (PSQI). The data analysis techniques employed within this research were univariate and bivariate analyses using the Rank Spearman test. The result of the analysis shows that out of the 227 samples; 146 respondents (64.3) indicated no anxiety, 44 respondents (19.4%) indicated mild anxiety, 19 respondents (9.3%) indicated moderate anxiety, and 14 respondents indicated (6.2%) severe anxiety. In terms of sleep quality; 67 respondents (29.5%) indicated good sleep quality and 160 respondents (70.5%) indicated poor sleep quality. The results of the Rank Spearman test analysis showed the value of p = 0.006 which means that p<0.05. So it can be concluded that there is a significant correlation between anxiety level and sleep quality of pre-clinical students when facing block exams.
Hubungan antara Durasi Penggunaan Komputer dengan Kelelahan Mata pada Pegawai Bank BPD Cabang Utama Denpasar Ni Made Adinda Sadhana Pramadani; Ni Wayan Rusni; Ni Luh Putu Eka Kartika Sari
Aesculapius Medical Journal Vol 4 No 1 (2024): February
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.4.1.2024.9-15

Abstract

[Correlation between Duration of Computer Use and Eye Fatigue in Employees of BPD Bank Main Branch Denpasar] Eye fatigue is a condition when the eye muscles are overworked beyond their capacity, especially when looking at close objects for a long time. According to data from the World Health Organization (WHO), the incidence of eye fatigue in the world ranges from 40% to 90%. One activity that often causes eyestrain is computer use. This condition can be affected by individual and environmental factors, and will induce the symptoms such as headaches, blurry vision, sore eyes, and other related symptoms. The purpose of this research is to investigate the correlation between the duration of computer use and eye fatigue among the employees of the BPD Bank Main Branch in Denpasar. This research was held from November 2022 until February 2023. The method used for this research was the cross-sectional analytic method. Purposive sampling was used to collect samples, and 88 samples were obtained from employees of the BPD Bank Main Branch in Denpasar. The data collection that used was the Visual Fatigue Index (VFI) questionnaire. The data were analyzed using a chi-square test (p < 0.05). The result showed that the prevalence of computer use duration was ≤ 4 hours (12,5%) and > 4 hours (87,5%). The prevalence of eye fatigue was 67%. The chi-square test results obtained a p-value = 0.021, indicating a significant correlation between the duration of computer use and eye fatigue in employees of the BPD Bank Main Branch in Denpasar. Based on the results obtained, the company needs to conduct an evaluation regarding the duration of work to minimize eye fatigue and improve working comfort for employees.
Co-Authors Anak Agung Gede Budhitresna, Anak Agung Gede Ayu Savitri Siskayani Desak Putu Oki Lestari Erly Sintya Gede Khrisnanda Arya Dharma Hegard Sukmawati, Ni Made I Putu Jaya Suputra K Tangking Widarsa Meilla Ayu Suryaningsih Ni Ketut Witri Cahyani Ni Made Adinda Sadhana Pramadani Ni Made Aninda Febriyanti Ni Wayan Armerinayanti Ni Wayan Rusni Ni Wayan Widhidewi Pande Ayu Naya Kasih Permatananda Putu Asih Primatanti Sri Ratna Dewi Witari, Ni Putu Diah