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Khaula Karima
Pusat Kajian Gizi dan Kesehatan, Fakultas Kesehatan Masyarakat, Universitas Indonesia, Depok 16424, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Public Health

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Thyroid Cancer : an Overview of Epidemiology, Risk Factor, and Treatment Arista, Rida Dwi; Khaula Karima; M. Fardi Anugrah; Puji Widyastuti; Eva Triani
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2791

Abstract

Thyroid cancer is the most common cancer of the endocrine glands with a prevalence of approximately 95% of all malignancies. Its incidence has increased more rapidly since the 1990s than any other cancer. Thyroid cancer is divided into 4 types based on its histopathology. The nature of this cancer varies, ranging from slow progressive to aggressive. Like other cancers, thyroid cancer if left untreated will invade other organs of thebody. We collect several reading journals that discuss epidemiology, risk factors, management for thyroid gland cancer and present them descriptively. The purpose of writing this article is to discuss the latest epidemiology and risk factors that influence the incidence of thyroid cancer as well as the old and newest treatments in treating thyroid cancer. The results of this article found several risk factors thought to influence prevalence, namely radiation exposure, genetic mutation, heredity, iodine deficiency, increased TSH, autoimmune, thyroid nodules, environment, lifestyle, and estrogen. Treatments that need to be carried out are surgery, RAI therapy, thyroid hormone therapy, external radiation, systemic chemotherapy, and combination therapy. Through this discussion, it is hoped that it can become material for analysis and reference in the treatment of thyroid gland cancer. Keyword : Thyroid cancer, epidemiology, risk factor, and treatment
The Article Review Penggunaan Aspirin sebagai Faktor Pemicu Sindrom Reye Radwa, Ghaniyyah Atifah; Fatikha Rudia Ahda; Indri Setiawati; Khaula Karima; Ni Made Ayu Shinta Dewi; Arif Zuhan
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.3174

Abstract

Reye syndrome (RS) is a rare metabolic disorder which primarily affects children. The disease is generally characterized by acute encephalopathy and fatty degeneration of several parenchymes, especially the liver. Aspirin or acetylsalicylic acid is an over-the-counter drug as a solution to viral infection that would be the trigger for developing this syndrome. Reye syndrome is most commonly caused by viral pathogens like influenza A and B and varicella. Reye syndrome presents signs and symptoms of continued vomiting with or without dehydration, encephalopathy and, in 50% of patients, hepatomegaly. According to the clinical stage developed and modified by Hurwitz, the clinical stage of Reye syndrome is divided in 0-5, including the non-clinical stage (stage 0). The pathophysiological profile of Reye syndrome is unknown. However, it appears to be associated with mitochondrial dysfunction caused by the use of aspirin resulting in impaired fatty acid metabolism, reduced excretion, and impaired hepatic metabolism. A case-control study suggested a strong association between aspirin-taking behavior and the development of Reye's syndrome. A case-control study suggested a strong association between aspirin-taking behavior and the development of Reye's syndrome. This literature will present a discussion of the relationship of aspirin as a trigger for Reye syndrome based on the etiology, pathophysiology, and pharmacodynamics of aspirin.
Thyroid Cancer : an Overview of Epidemiology, Risk Factor, and Treatment Arista, Rida Dwi; Khaula Karima; M. Fardi Anugrah; Puji Widyastuti; Eva Triani
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2791

Abstract

Thyroid cancer is the most common cancer of the endocrine glands with a prevalence of approximately 95% of all malignancies. Its incidence has increased more rapidly since the 1990s than any other cancer. Thyroid cancer is divided into 4 types based on its histopathology. The nature of this cancer varies, ranging from slow progressive to aggressive. Like other cancers, thyroid cancer if left untreated will invade other organs of thebody. We collect several reading journals that discuss epidemiology, risk factors, management for thyroid gland cancer and present them descriptively. The purpose of writing this article is to discuss the latest epidemiology and risk factors that influence the incidence of thyroid cancer as well as the old and newest treatments in treating thyroid cancer. The results of this article found several risk factors thought to influence prevalence, namely radiation exposure, genetic mutation, heredity, iodine deficiency, increased TSH, autoimmune, thyroid nodules, environment, lifestyle, and estrogen. Treatments that need to be carried out are surgery, RAI therapy, thyroid hormone therapy, external radiation, systemic chemotherapy, and combination therapy. Through this discussion, it is hoped that it can become material for analysis and reference in the treatment of thyroid gland cancer. Keyword : Thyroid cancer, epidemiology, risk factor, and treatment
The Article Review Penggunaan Aspirin sebagai Faktor Pemicu Sindrom Reye Radwa, Ghaniyyah Atifah; Fatikha Rudia Ahda; Indri Setiawati; Khaula Karima; Ni Made Ayu Shinta Dewi; Arif Zuhan
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.3174

Abstract

Reye syndrome (RS) is a rare metabolic disorder which primarily affects children. The disease is generally characterized by acute encephalopathy and fatty degeneration of several parenchymes, especially the liver. Aspirin or acetylsalicylic acid is an over-the-counter drug as a solution to viral infection that would be the trigger for developing this syndrome. Reye syndrome is most commonly caused by viral pathogens like influenza A and B and varicella. Reye syndrome presents signs and symptoms of continued vomiting with or without dehydration, encephalopathy and, in 50% of patients, hepatomegaly. According to the clinical stage developed and modified by Hurwitz, the clinical stage of Reye syndrome is divided in 0-5, including the non-clinical stage (stage 0). The pathophysiological profile of Reye syndrome is unknown. However, it appears to be associated with mitochondrial dysfunction caused by the use of aspirin resulting in impaired fatty acid metabolism, reduced excretion, and impaired hepatic metabolism. A case-control study suggested a strong association between aspirin-taking behavior and the development of Reye's syndrome. A case-control study suggested a strong association between aspirin-taking behavior and the development of Reye's syndrome. This literature will present a discussion of the relationship of aspirin as a trigger for Reye syndrome based on the etiology, pathophysiology, and pharmacodynamics of aspirin.
Trauma Vaskular: Patofisiologi, Manifestasi Klinis, Diagnosis dan Penatalaksanaan Palna, Zhayyin; I Gede Aditya Satrya Bhuwana Cakra; Irsyadina Hasana Bharata; Khaula Karima; Salsabila Chauna; Wina Arsylia Fakar; Maz Isa Anshori Arsatt
Lombok Medical Journal Vol. 3 No. 2 (2024): Lombok Medical Journal Volume 3 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i2.3381

Abstract

Vascular trauma is an injury involving the circulatory system, particularly blood vessels, disrupting the body's balance and being a leading cause of morbidity and mortality. The extremities are the most common locations for vascular trauma, especially the femoral artery, popliteal artery, and brachial artery. Signs and symptoms of vascular trauma in body limbs are described as hard and soft signs. Hard signs found in patients indicate the need for surgical intervention, while patients with soft signs require further diagnostic imaging for confirmation. Management should consider the golden period (6 to 8 hours) by controlling bleeding with resuscitative endovascular balloon occlusions (REBOA), minimizing ischemic events in the distal part of the trauma, and preventing compartment syndrome. Surgical intervention is performed to achieve functional recovery and salvage the affected vascular area. Surgical procedures that can be performed in cases of vascular trauma include vascular grafting, vascular ligation, and temporary intravascular shunt (TIVS).
Co-Authors Arif Zuhan Arista, Rida Dwi Eva Triani Fatikha Rudia Ahda I Gede Aditya Satrya Bhuwana Cakra Indri Setiawati Irsyadina Hasana Bharata M. Fardi Anugrah Maz Isa Anshori Arsatt Ni Made Ayu Shinta Dewi Palna, Zhayyin Puji Widyastuti Radwa, Ghaniyyah Atifah Salsabila Chauna Wina Arsylia Fakar