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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Jurnal Media Hukum Jurnal Hukum IUS QUIA IUSTUM Undang: Jurnal Hukum Jurnal Ilmu Kefarmasian Indonesia Istinbath : Jurnal Hukum
Ari Wibowo
Department Of Pharmacy, Universitas Islam Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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ANALISIS RESIDU ANTIBIOTIK KLORAMFENIKOL DALAM DAGING IKAN GURAMI (Osphronemus gouramy, Lac) MENGGUNAKAN METODE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Ari Wibowo; Lukysanita Muliana; M. Hatta Prabowo
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penggunaan kloramfenikol (CAP) pada hewan produksi untuk tujuan non-terapetik berpotensi menimbulkan akumulasi residu CAP pada jaringan dan organ hewan tersebut. Manusia yang mengkonsumsi produk ternak yang mengandung residu CAP dapat berdampak buruk bagi kesehatannya, karena berpotensi menimbulkan reaksi hipersensitivitas, deperesi sumsum tulang belakang (anemia aplastik), bahkan resistensi CAP pada manusia. Komoditi perikananan yang sering menggunakan antibiotik untuk meningkatkan produksinya adalah ikan gurami (Osphronemus gouramy, Lac). Penelitian ini bertujuan untuk menganalisis kadar residu antibiotik CAP dalam daging ikan gurami dengan metode HPLC (High Performance Liquid Chromatography), kemudian kadar yang diperoleh dibandingkan dengan BMR (Batas Maksimum Residu) antibiotik pada bahan makanan asal hewan (SNI 01-6366-2000). Kurva kalibarsi menunjukkan linieritas yang baik pada range 5 – 40 ng/ml (r = 0,9995). Hasil penelitian menunjukkan ikan gurami yang dijual diketiga pasar tradisional yaitu sebesar 0,276; 0,281; 1,168 ng/g. Kadar residu CAP yang diperoleh tidak melebihi BMR berdasarkan batasan pada Standar Nasional Indonesia (0,01 mg/kg), namun kadar CAP dari salah satu pasar tidak memenuhi persyaratan oleh European Union (0,3 μg/kg). 
PENGEMBANGAN DAN VALIDASI METODE ANALISIS RIFAMPICIN ISONIAZID-PIRAZINAMID DALAM FIXED DOSE COMBINATION DENGAN METODE KROMATOGRAFI LAPIS TIPIS-DENSITOMETRI Muhammad Hatta Prabowo; Ari Wibowo; Laily Fauziyah
Jurnal Ilmiah Farmasi Vol. 9 No. 2 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss2.art4

Abstract

Rifampicin, isoniazid (INH) dan pirazinamid merupakan Obat Anti Tuberkulosis (OAT) yang tersedia dalam bentuk Fixed Dose Combination (FDC). Sediaan FDC ini lebih praktis dalam penggunaannya sehingga dapat meningkatkan kepatuhan pasien Tuberkulosis (TB) dalam mengkonsumsi obat. Namun pada beberapa penelitian masih ditemukan FDC yang subdosis yang dapat mengakibatkan pengobatan TB menjadi kurang optimal dan meningkatnya risiko resistensi OAT. Tujuan penelitian ini adalah mengembangkan metode analisis baru yaitu Kromatografi Lapis Tipis (KLT)-Densitometri yang memiliki validitas baik sehingga dapat menjadi alternatif metode analisis yang lebih mudah, cepat, murah dan praktis. Validasi metode yang dilakukan meliputi pengukuran linieritas, presisi, akurasi, batas deteksi dan batas kuantitasi. Parameter hasil validasi metode dibandingkan dengan persyaratan yang ada di Association of Official Analytical Chemist (AOAC) dan United States Pharmacopeia (USP) untuk penetapan kadar FDC. Sampel FDC yang mengandung rifampicin, INH dan pirazinamid dapat dipisahkan dengan fase gerak berupa n-heksan: 2-propanol: aseton: amonia: asam format dengan perbandingan 3:3,6:3:0,3:0,1 (v/v/v/v) dan nilai Rf yang diperoleh untuk rifampicin adalah 0,85, INH 0,6 dan pirazinamid 0,7. Hasil penelitian menunjukkan bahwa metode KLT-Densitometri dapat dikembangkan dan semua parameter validasinya memenuhi persyaratan AOAC. Hasil koefisien korelasi (r) rifampicin 0,999, INH 0,999 dan pirazinamida 0,999, perolehan kembali rifampicin 101,00 %, INH 94,36 % dan pirazinamid 95,69 %; nilai % RSD presisi rifampicin 0,55 %, INH 0,96 %, dan pirazinamid 0,98 %; nilai batas deteksi rifampicin 10,91 ppm, INH 10,38 ppm dan pirazinamid 42,14 ppm; nilai batas kuantitasi rifampicin 33,07 ppm, INH 31,45 ppm dan pirazinamid 127,7 ppm. Kadar terukur (mg) rifampicin, INH, dan pirazinamid per tablet adalah 157,37 mg, 75,26 mg dan 400,79 mg yang berarti sesuai dengan standar yang ditetapkan oleh USP.Kata kunci: KLT-Densitometri, rifampicin-INH-pirazinamid, validasiABSTRACTRifampicin, isoniazid (INH) and pyrazinamide are anti tuberculosis drugs (ATD) available in fixed dose combination (FDC) form. The FDC is more practical in usage so can improve tuberculosis patient obedience in consuming the drug. However, in some researches, there are still found subdose of FDC. Subdose of FDC that effected in less optimal TB medication and increase risk of ATD resistance. The high TB case in developing countries such as Indonesia require test of FDC drug dose evaluation. Objective of this research was to develop new analytical method, Thin Layer Chromatography (TLC)-densitometry having good validity so it may be easier, faster, cheaper and more practical analytical method alternative. Validation parameters consist of linearity, precision, accuracy, Limit Of Detection (LOD), and Limit Of Quantitation (LOQ). Parameter of method validation results was compared with requirement in Association of Official Analytical Chemist (AOAC) and United States pharmacopeia (USP) for determine active ingredient in sample. FDC sample containing rifampicin, INH and pyrazinamide can be separated with n-hexane: 2-propanol: acetone: ammonia: formic acid with proportion of 3:3.6:3:0.3:0.1 (v/vv/v) as mobile phase and Rf value for rifampicin, INH, and pyrazinamide were 0.85, 0.6, and 0.7, respectively. The results indicated that TLC-densitometry can be developed and all validation parameters complied with AOAC requirements. The correlation coefficient (r) of rifampicin 0.999, INH 0.999 and pyrazinamide 0.999; recovery of rifampicin, INH and pyrazinamide were 101.00 %, 94.36 % and 95.69 %, respectively. In addition, precision, % RSD for rifampicin, INH and pyrazinamide were 0.55 %, 0.96 %, and 0.98 % respectively; LOD for rifampicin, INH and pyrazinamide were 10.91 ppm, 10.38 ppm and 42.14 ppm, respectively; LOQ for rifampicin, INH and pyrazinamide were 33.07 ppm, 31.45 ppm and 127.7 ppm, respectively. Concentration of rifampicin, INH and pyrazinamide in a tablet were 157.37 mg, 75.26 mg and 400.79 mg that comply with USP standard.Keywords: rifampicin-isoniazid-pyrazinamide, TLC-densitometry, validation
IDENTIFIKASI DAN ANALISIS AKRILAMIDA DALAM KOPI SERBUK (TUBRUK) DAN KOPI INSTAN DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI M Hatta Prabowo; Ari Wibowo; Fitri Yuliani
Jurnal Ilmiah Farmasi Vol. 9 No. 1 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss1.art1

Abstract

ABSTRAKAkrilamida merupakan salah satu zat yang dapat menyebabkan kanker pada manusia dan bersifat neurotoksik. Akrilamida dapat terbentuk akibat pemanasan suhu tinggi terhadap makanan yang mengandung karbohidrat dan asam amino. Karbohidrat dan asam amino merupakan senyawa utama yang terkandung dalam biji kopi. Penelitian ini bertujuan untuk mengetahui jumlah akrilamida pada serbuk kopi dan kopi instan yang beredar di masyarakat. Metode analisa akrilamida dilakukan dengan metode KCKT menggunakan fase gerak asam fosfat:asetonitril:akuabides (1:5:94 v/v/v), fase diam kolom Sunfire C18 (150 x 4,6 mm id, 5μm), dan laju alir 0,15 mL/menit dengan detektor UV 202 nm. Hasil uji validasi metode yang dilakukan memberikan linearitas 0,999 (range 2-20 μg/mL), LOD 0,94 g/mL dan LOQ 2,86 μg/mL, presisi dengan RSD 0,47 %, dan akurasi serbuk kopi 91-94% serta kopi instan 99-102%. Kadar yang diperoleh menunjukkan kadar akrilamida pada serbuk kopi dan kopi instan masing-masing sebesar 7,03 ± 0,01 μg/g dan 5,71 ± 0,03 μg/g. Kadar akrilamida dalam serbuk kopi dan kopi instan dinyatakan aman berdasarkan FDA apabila konsumsi kopi tidak melebihi 16 g/hari.Kata kunci: akrilamida, serbuk kopi, kopi instan, KCKT, validasiABSTRACTAcrylamide is a substance that can cause cancer on human and is neurotoxic. Acrylamide is formed due to high temperature heating of foods that contains carbohydrates and amino acids. Carbohydrates and amino acids are the major compounds that contained in coffee beans. This study aims to determine the levels of acrylamide in ground coffee and instant coffee that have different process of manufacture. Method of analyze of acrylamide were perfomed by HPLC (High Performance of Liquid Chromatography) method using mobile phase that consists of phosphoric acid : acetonitrile : aquabides (1:5:94 v/v/v), the stationary phase was Sunfire C18 column (150 x 4.6 mm, 5μm), and the flow rate was 0-15 mL/minute and the detection using UV 202 nm. The result of the study was validation of method that provide the linearity 0.999 (range 2-20 μg/mL), LOD of 0.94 μg/mL and LOQ of 2.86 μg/mL, the precision with RSD of 0.47%, and accuracy for ground coffee of 91-94% and instant coffee of 99-102%. The study found acrylamide levels in ground coffee and instant coffee were 7.03 ±0.01 μg/g dan 5.71 ± 0.03 μg/g respectively. These levels were considered safe for up to 16 g for consume of coffee.Keywords : acrylamide, ground coffee, instant coffee, HPLC, validation
Validasi Metode Bioanalisis Vankomisin HCl dalam Spiked-plasma Manusia Menggunakan KCKT-UV untuk Aplikasi PKOD Ari Wibowo; Damas Inggil Maulidina; Wahyuni Shalatan Fitri; Vitarani Ningrum
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 19, ISSUE 1, February 2019
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/eksakta.vol19.iss1.art6

Abstract

As the first-line antibiotic for the treatment of infections caused by methicillin-resistant Staphylococcus aureus  (MRSA), vancomycin has  a narrow therapeutic index with high pharmacokinetic   variability. Therefore, it is deemed necessary to examine its concentration in the blood as a strategy to monitor the fulfillment of therapeutic levels  in patients receiving vancomycin. This study aimed to validate vancomycin bioanalysis  in  spiked-human  plasma  for  the  applications  of  therapeutic  drug  monitoring  (TDM).
SUMBANGAN PEMIKIRAN HAK ASASI MANUSIA TERHADAP PEMBAHARUAN KITAB UNDANG-UNDANG HUKUM ACARA PIDANA(KUHAP) Ari Wibowo
Jurnal Media Hukum Vol 23, No 2 (2016): December
Publisher : Fakultas Hukum Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmh.2016.0074.128-136

Abstract

The idea of renewal of the Criminal Procedure Code can not be separated from the contribution of human rights concept. This contribution has been explicitly included in the preamble of the Draft of Criminal Procedure Code. Although the current Criminal Procedure Code already provides protection to the rights of the defendant, but the implementation is still not optimal. Therefore, in the Draft of Criminal Procedure Code there is a new institution called the Rechter-Commissaris to replace the function of Pretrial Institutions. It has far wider powers of Pretrial Institution, so that the protection of the rights of defendant in any stage of the judicial process will be more secure fulfillment. The development of human rights concept also contributed to the idea to regulate the rights of victims, both associated with involvement in all stages of judicial proceedings and the right to sue for damages.
Justifikasi Hukum Pidana terhadap Kebijakan Kriminalisasi Pelanggaran Hak Cipta, serta Perumusan Kualifikasi Yuridis dan Jenis Deliknya Ari Wibowo
Jurnal Hukum IUS QUIA IUSTUM Vol. 22 No. 1: Januari 2015
Publisher : Fakultas Hukum Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/iustum.vol22.iss1.art3

Abstract

This study focuses on a policy of criminalization of copyright infringement through Law No. 19 of 2002 on Copyright, as well as policy formulation on juridical qualification and the type of the offense. This research includes the study of normative law with legal materials obtained through document study or literature. From the analysis, it was concluded that the theory justiying criminalization of copyright infringement is a liberalindividualistic theory which is based on social harm, as well as a moral theory that makes morality as a parameter. Moreover, no judicial qualifications emphasized the offense, as well as the determination of the crime of copyright as an ordinary offense can lead to legal problems in practice.
Pertimbangan Hakim dalam Penjatuhan Pidana di Bawah Minimum Khusus: Studi Perkara Tindak Pidana Narkotika Ari Wibowo; Ivan Agung Widiyasmoko
Undang: Jurnal Hukum Vol 4 No 2 (2021)
Publisher : Fakultas Hukum Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ujh.4.2.345-369

Abstract

This article discusses two issues, firstly, judges’ considerations (ratio decidendi) in deciding cases of narcotics crimes with punishment below a special minimum, and secondly, the theories of the punishment purpose used by judges in deciding cases of narcotics crimes with punishment below a special minimum. This article concludes that judges' considerations in deciding ten cases of narcotics crimes with punishment below a special minimum are based on certain criteria in the form of conditions related to the crime and the defendant. In addition, the judges' considerations are also based on SEMA No. 3 of 2015 and SEMA No. 4 of 2010. Meanwhile, there are 6 out of 10 court decisions used the relative or utilitarian theory, and others used the absolute or retributive theory. Justice is the basis used by judges in deviating from special minimum provisions, so that the use of relative theory as a punishment purpose shows the inconsistency of judges. This is because justice in punishment is proportionality which is part of modern absolute theory. Judges may use a combined theory of absolute theory and relative theory. Abstrak Artikel ini membahas dua permasalahan, pertama, pertimbangan hukum hakim (ratio decidendi) dalam memutus perkara tindak pidana narkotika dengan pidana di bawah minimum khusus, dan kedua, teori tujuan pemidanaan yang digunakan oleh hakim dalam memutus perkara tindak pidana narkotika dengan pidana di bawah minimum khusus. Berdasarkan hasil penelitian dan pembahasan terhadap 10 putusan pengadilan diperoleh kesimpulan bahwa pertimbangan hukum hakim dalam memutus perkara tindak pidana narkotika dengan pidana di bawah minimum khusus didasarkan pada kriteria-kriteria tertentu berupa keadaan-keadaan baik yang berhubungan dengan tindak pidana maupun terdakwanya. Selain itu pertimbangan hukum hakim juga didasarkan pada SEMA No. 3 tahun 2015 dan SEMA No. 4 Tahun 2010. Adapun terkait dengan teori tujuan pemidanaan, sebanyak enam dari 10 putusan pengadilan yang di dalamnya digunakan teori relatif atau tujuan, sementara sebanyak lima putusan di dalamnya digunakan teori absolut atau pembalasan. Dasar yang digunakan hakim dalam menyimpangi ketentuan pidana minimum khusus adalah keadilan, sehingga penggunaan teori relatif sebagai tujuan pemidanaan menunjukkan ketidakkonsistenan hakim. Hal ini karena keadilan dalam pemidanaan adalah proporsionalitas yang merupakan bagian dari teori absolut modern. Hakim bisa saja menggunakan teori gabungan teori absolut dan teori relatif.
INDEPENDENSI KEJAKSAAN DALAM SISTEM PERADILAN PIDANA INDONESIA Ari Wibowo
Istinbath : Jurnal Hukum Vol 12 No 1 (2015): Istinbath Jurnal Hukum
Publisher : Institut Agama Islam Negeri Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.485 KB)

Abstract

Lawyer is one of the important institutions in law enforcement, so that in carrying out its functions it should be independent. In Indonesia it is positioned under the executive power where it is considered as vulnerable toward the intervention of executive power in carrying out law enforcement functions. To ensure its independence, the lawyer must be participated in the judicial power. Furthermore, it should be given legitimacy by explicitly stated in the Constitution to ensure the independence of both institutional and functional . The sistem of criminal justice which is applied as the law enforcement system doesn’t not run optimally even become a ruler tool due to its position is subordinated by the executive power. The court Sub-system is structurally and functionally under the authority of the executive, so that its role as law enforcement authorities seems as only serve the interest of ruler. The Sub-systems within the criminal justice system (sub-system investigation, prosecution, and criminal executor) is functionally and institutionally not showed any independence because it is structurally under the executive control. While prosecuting authority (court) has been placed as an independent authority from the executive dominance, either institutional organization, budgets, personnel or kerier systems under one roof (one-roof system) under the Supreme Court. The dependence dominance which is caused as by the dependent institutions, confusion or overlapping law substance and law cultural factors of sub-system of criminal justice executor that tends to be arrogant, ego centric, commercial and serve pragmatic interests beyond the law enforcement purposes.
Standardization of the Extract of Cultivated Ipomoea reptans Poir. Leaves from Sardonoharjo, Sleman and Its Potency as Antioxidant FARIDA HAYATI; ARI WIBOWO; PINUS JUMARYATNO; ARDE TOGA NUGROHO; DIAN AMALIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Telah dilakukan penelitian untuk mengetahui nilai parameter spesifik dan nonspesifik standardisasi ekstrak kangkung darat hasil budidaya di wilayah Sardonoharjo, Sleman serta potensinya sebagai antioksidan. Sampel yang digunakan dipanen pada saat usia kangkung darat ±25-30 hari setelah penanaman. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Parameter spesifik terdiri dari uji organoleptik, pola kromatografi, kadar senyawa marker dan parameter nonspesifik terdiri dari uji bobot jenis,uji kadar air, uji kadar abu total, uji kadar abu tidak larut asam, uji cemaran logam, uji cemaran mikroba, uji cemaran kapang dan khamir, perkiraan angka koliform, dan uji sisa pelarut etanol. Hasil standardisasi ekstrak menunjukkan nilai pengukuran berturut-turut untuk parameter kadar air 16,45±0,05%, bobot jenis ekstrak 3,26±3,37x10-3 g/mL, kadar abu total 4,52± 0,77%. Tidak terdapat sisa pelarut etanol di dalam ekstrak, serta angka cemaran mikroba, angka kapang dan khamir, angka koliform, serta cemaran logam timbal (Pb) dan kadmium (Cd), di dalam ekstrak di bawah standar batas maksimal yang ditetapkan BPOM. Hasil pengukuran dengan KLT densitometri menunjukkan nilai kadar β-karoten di dalam ekstrak sebesar 5,7% (b/b). Hasil Uji aktivitas antioksidan dengan menggunakan 2,2-diphenyl-1- picrylhydrazyl (DPPH) menunjukkan nilai IC50 ekstrak daun kangkung sebesar 178,3 μg/ mL.
Co-Authors Arde Toga Nugraha Damas Inggil Maulidina DIAN AMALIA Fitri Yuliani Hayati, Farida Ivan Agung Widiyasmoko Laily Fauziyah Lukysanita Muliana M Hatta Prabowo M. Hatta Prabowo Muhammad Hatta Prabowo Pinus Jumaryatno Vitarani Ningrum Wahyuni Shalatan Fitri