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All Journal VALENSI BioWallacea Journal of Biological Research KOVALEN: Jurnal Riset Kimia Indonesian Journal of Health Sciences Research and Development (IJHSRD) Current Research on Biosciences and Biotechnology Hydrogen: Jurnal Kependidikan Kimia Jurnal Akademika Kimia Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat

Imran Imran

Chemistry Department, Faculty Of Mathematics And Natural Sciences, Halu Oleo University

Author-ID : 3080351

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Articles

Bioaktivitas Metabolit Sekunder Batang Kayu Paliasa (Kleinhovia hospital Linn) dengan Uji BST (Brine Shrimp Lethality Test) dan Daya Hambatnya Pada Sel Leukimia P-388 Imran Imran; A. Noor; N.H. Soekamto; Megawati Megawati; Laode Abdul Kadir
BioWallacea : Jurnal Penelitian Biologi (Journal of Biological Research) Vol 7, No 2 (2020): Biodiversitas on Asian Wallacea
Publisher : University of Halu Oleo

This research aimed to find out the isolates of secondary metabolites in stem wood of paliasa (Kleinhovia hospital Linn) and their bioactivities with brine shrimp test (BST) and growth inhibition of leukemia murine cell P-388. Sample was macerated by methanol solvent and evaporated till concentration. Furthermore, macerate then was extracted by using n-hexane, and methylene chloride solvent. For finding pure compound, fraction component was purified with FCC and recrystallization methods. Determination of compound used analysis of IR spectroscopy. Bioactivity test was determined toward fifty percent lethality concentration (LC50) of brine shrimp (Artemia salina) and growth inhibition (IC50) of leukemia murine cell tumor P-388. The secondary metabolite of compounds (1) have LC50 112,2 µg/ml and IC50 0 µg/ml, compounds (2) LC50 54,74 µg/ml and IC50 56,0 µg/ml, compounds (3) LC50 9,50 µg/ml and IC50 14,2 µg/ml, and compounds (4) LC50 37,99 µg/ml and IC50 76,0 µg/ml and compound. This results showed that all compounds have moderate bioactivity against both test materials. This indicates that the compounds found can be useful as anti-tumor leukemia P-388. Kata kunci: Kleinhovia hospital Linn, secondary metabolite, bioactivities ABSTRAK Penelitian ini bertujuan untuk mengetahui isolat metabolit sekunder pada batang kayu paliasa (Kleinhovia hospital Linn) dan bioaktifitasnya dengan Brine shrimp test (BST) dan daya hambanya terhadap pertumbuhan sel leukemia P-388. Sampel dimaserasi dengan pelarut metanol dan diuapkan sampai terkonsentrasi. Selanjutnya maserat diekstraksi menggunakan pelarut n-heksana dan metilen klorida. Untuk mencari senyawa murni, komponen fraksi dimurnikan dengan FCC dan metode rekristalisasi. Penentuan senyawa menggunakan analisis spektroskopi IR. Uji bioaktivitas ditentukan terhadap konsentrasi letalitas lima puluh persen (LC50) udang air asin (Artemia salina) dan daya hambat pertumbuhan (IC50) tumor sel leukemia tikus P-388. Metabolit sekunder senyawa (1) memiliki LC50 112,2 µg / ml dan IC50 0 µg / ml, senyawa (2) LC50 54,74 µg / ml dan IC50 56,0 µg / ml, senyawa (3) LC50 9, 50 µg / ml dan IC50 14,2 µg / ml, dan senyawa (4) LC50 37,99 µg / ml dan IC50 76,0 µg / ml. Hasil penelitian ini menunjukkan semua senyawa memiliki bioaktivitas yang moderat terhadap kedua bahan uji. Hal ini mengindikasikan bahwa senyawa hasil temuan dapat bermanfaat sebagai anti tumor leukemia P-388. Key words: Kleinhovia hospital Linn, metabolit sekunder, bioaktivitas

Potensi Antibakteri Ekstrak Metanol dan Senyawa Aromatik dari Buah Wualae (Etlingera elatior) Sahidin Sahidin; Syefira Salsabila; Wahyuni Wahyuni; Fristiohady Adryan; Imran Imran
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 1, May 2019
Publisher : Syarif Hidayatullah State Islamic University

Buah tanaman wualae (bahasa Tolaki) atau Etlingera elatior digunakan oleh masyarakat Tolaki (Sulawesi Tenggara) sebagai bumbu masak dan obat tradisional. Untuk mengungkap potensi tersebut, khususnya buah wualae, dilakukan kajian fitokimia dan farmakologi buah wualae. Kajian fitokimia meliputi isolasi dan penentuan struktur dikerjakan dengan metode kromatografi (kromatografi vakum cair dan kromatografi radial) dan spektroskopi (1H dan 13C NMR). Kajian farmakologi meliputi uji aktivitas biologi terhadap enam jenis bakteri (Bacillus subtilis FNCC 0060, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella enterica ATCC 14028, Staphylococcus aureus ATCC 25923, dan Streptococcus mutans ATCC 25175). Hasilnya menunjukkan tiga senyawa fenolik telah berhasil diisolasi dan diidentifikasi dari buah wualae yaitu asam vanilat (1), asam p-hidroksibenzoat (2), dan asam kumarat (3). Ketiga senyawa tersebut pertama kali dilaporkan berhasil diisolasi dari buah E. elatior. Aktivitas antibakteri ekstrak metanol buah wualae dan tiga senyawa hasil isolasi menunjukkan bahwa sampel tersebut paling aktif terhadap bakteri S. mutans. Dengan demikian aktivitas senyawa-senyawa hasil isolasi dari buah E. elatior berkorelasi dengan aktivitas ekstrak metanol buah E. elatior terhadap S. mutans, dimana senyawa paling aktif adalah asam vanilat. Ekstrak yang dominan mengandung asam vanilat dari tanaman ini dapat dikembangkan sebagai herbal antibakteri S. mutans seperti herbal karies gigi dan obat kumur. Kata kunci: Etlingera elatior, wualae, buah, senyawa aromatik, antibakteri. The fruits of wualae (Tolakinese) or Etlingera elatior is utilized by Tolakinese (Sulawesi Tenggara) as spices and traditional medicine. To reveal the potencies, a study on phytochemical and pharmacological aspects have been carried out. The phytochemical study includes isolation and structure determination used chromatography methods (vacuum liquid chromatography and radial chromatography) and spectroscopy methods (1H NMR and 13C NMR). Biological activity was evaluated against some bacteria that are Bacillus subtilis FNCC 0060, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella enterica ATCC 14028, Staphylococcus aureus ATCC 25923, and Streptococcus mutans ATCC 25175). The results showed that three aromatic compounds had been isolated and identified that are vanillic acid (1), p-hydroxybenzoic acid (2) and coumaric acid (3). All compounds are firstly reported that successfully isolated from fruits of Wualae. Antibacterial potency indicated that the methanol extracts and the isolated compounds are the most active towards S. mutans and have good activity correlation between the extracts and the compounds. Vanillic acid is the most active compound from E. elatior fruits. Thus, the extracts contain dominantly vanillic acid from E. elatior fruits can be developed to be antibacterial herbals caused by S. mutans. Keywords: Etlingera elatior, wualae, fruits, aromatic compounds, antibacterial activity.

Penyarian Konstituen Organik Daging Buah Gaharu (Aquilaria malaccensis Lamk.) dengan Metode Maserasi Berbantu Microwave dan Uji Aktivitas Sebagai Antioksidan: Organic Constituent Extraction of Gaharu Fruit (Aquilaria malaccensis Lamk.) Using Microwave Assisted Maseration Method and Activity Test as Antioxidant Imran; Nurlian; L.A. Kadir; La Agusu; Ruslan
KOVALEN: Jurnal Riset Kimia Vol. 7 No. 1 (2021): Edisi April
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2021.v7.i1.15478

This study was conducted to determine the organic constituents and to test the antioxidant activity and toxicity of gaharu fruit pulp extract (Aquilaria malaccensis Lamk.). Gaharu fruit pulp extract was obtained through Microwave Assisted Extraction (MAE) method and then extracted with a solvent with different polarity, namely ethyl acetate and n-hexane. The obtained yield of ethyl acetate extract of the gaharu fruit pulp was 40.827% w/v, whereas 0% w/v in n-hexane extract, therefore, no further test for n-hexane extract, so that the n-hexane extract was not tested for the next stage. The results of the organic constituents of the ethyl acetate extract of gaharu fruit pulp showed flavonoids, saponins, glycosides, phenols and tannins. Antioxidant activity testing was carried out using the DPPH method with vitamin C as a positive control. The results of the antioxidant activity test showed that IC50 of ethyl acetate extract of gaharu fruit pulp and vitamin C were 143.789ppm and 13.797ppm, respectively. Extracts from microwave-assisted maceration that were partitioned with ethyl acetate solvent were categorized into moderate antioxidants because the IC50 value was between 101-150ppm, while vitamin C was categorized as a strong antioxidant because the IC50 value was between 0-100ppm. Toxicity testing was also carried out on ethyl acetate extract of gaharu fruit pulp using the BSLT method. The results of the toxicity test of the ethyl acetate extract of gaharu fruit pulp showed activity with an LC50 value of 11.282ppm. Based on this research, the ethyl acetate extract of gaharu fruit pulp is considered to have an anticancer potential.

Antibacterial and antioxidant potentials of methanol extract and secondary metabolites from Wualae rhizome (Etlingera elatior) Wahyuni; Sri Hutami Lety Grashella; Wa Ode Ida Fitriah; Muhammad Hajrul Malaka; Adryan Fristiohady; Imran; Sahidin
Current Research on Bioscences and Biotechnology Vol. 1 No. 1 (2019)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2019.1.1/IHHZ547

The rhizome of Etlingera elatior or Wualae (Tolakinese) has many advantages on traditional remedies and cooking in Sulawesi Tenggara. To support those advantages, two secondary metabolites derived from steroid and phenylpropanoic acid classes, stigmast-4-en-6β-ol-3-one (1) and p-coumaric acid (2), respectively, have been firstly isolated and identified from the E. elatior rhizome. Isolation of these two compounds was performed using several chromatography techniques, including thin layer chromatography (TLC), vacuum liquid chromatography (VLC) and radial chromatography (RC). Identification of isolates was carried out using 1 H and 13C NMR spectroscopy and comparing the spectroscopy data with the library. The potency of antibacterial of the methanol extract of Wualae rhizome and the isolates were evaluated against Pseudomonas aeruginosa ATCC 27853, Bacillus subtilis FNCC 0060, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Salmonella enterica ATCC 14028, and Streptococcus mutans ATCC 25175 using agar diffusion method. Antioxidant activity was evaluated against DPPH radicals (2,2-diphenyl-1-picrylhydrazyl). The results show that the antibacterial potential of Wualae methanol extract is better than compound 1 and 2. Furthermore, the antioxidant properties of Compound 2 (IC50 159.47 μg/mL) was stronger than the antioxidant properties of Compound 1 (IC50 219.95 μg/mL) and the methanol extract (IC50 586.38 μg/mL).

Uji Aktivitas Antibakteri Staphylococcus aureus dan Salmonella typhi dari Hasil Mikroenkapsulasi Minyak Atsiri Rogo (Premna Serratifolia Linn) Nursin Nursin; Laily Nurliana; Imran Imran; Rustam Musta
Hydrogen: Jurnal Kependidikan Kimia Vol 7, No 2 (2019): Hydrogen: Jurnal Kependidikan Kimia
Publisher : Universitas Pendidikan Mandalika

Antibacterial activity test Staphylococcus aureus and Salmonella typhihas been performed by microencapsulation product of rogo essential oil (Premnaserratifolia Linn). This study aims to determine rogo oil activity test and microencapsulation results as antibacterial S. aureus and S. typhi. The results of antibacterial activity of rogo liquid oil to S. aureus and S. Typhi bacteria showed different inhibitory power of each concentration variation of 12.5%, 25%, 50% and 100% with 100% concentration as the best inhibitor for both bacteria. While the antibacterial activity test of S. aureus and S. typhi from microencapsulated rogo oil: maltodextrin showed the difference of each variation of concentration 1:10; 1:12; 1:14; 1:16 and 1:18 with a 1:14 composition of S. aureus and 1:18 in S. typhi as the best ratio of activity power. The antibacterial activity test between liquid rogo oil and microencapsulated result shows the difference, but it can be concluded that the inhibitory power of rogo oil from microencapsulation is more inhibited than 100% rogo oil.

Equilibrium and Adsorption Kinetic Study of Metal Ni(II) using Persimmon Tannin Gel La O. Ahmad; Ulfa H. Syam; Laode A. Kadir; Nohong Nohong; Muh Natsir; Nasriadi Dali; Imran Imran; Tahril Tahril; Thamrin Azis
Jurnal Akademika Kimia Vol. 11 No. 2 (2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2022.v11.i2.pp111-116

Heavy metal concentration exceeding the threshold amount is hazardous to the environment, so it needs some treatment. The study aimed to know the capacity and kinetics of adsorption. This study used the adsorption method to remove the heavy metal ion Ni(II) using persimmon tannin gel. Influences of time contact, pH, and ion concentration in the adsorption process were also investigated. Results showed optimum adsorption at 60 minutes of time contact and pH 5. Variation of concentration made the adsorption decrease as metal ion Ni(II) concentration increased. The maximum adsorption capacity was 23.14 mg/g by using pseudo-second-order adsorption kinetic model.

Efektivitas Fotodegradasi Lignin dari Limbah Ampas Sagu (Metroxylon sagu Rottb.) Menggunakan Katalis TiO₂: The Effectiveness of the Photodegradation of Lignin from Sago (Metroxylon sagu Rottb.) Waste Using TiO₂ Catalyst Muh. Natsir; Aden Mula Pratiwi; Thamrin Azis; Nohong; Imran; Wa Ode Harlis; Alimin; La Ode Kadidae; Ruslan; C Bijang; La Ode Abd Kadir; Laily Nurliana
KOVALEN: Jurnal Riset Kimia Vol. 8 No. 3 (2022): December Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2022.v8.i3.16149

Lignin degradation from sago (Metroxylon sagu Rottb.) waste has been carried out using a TiO2 catalyst. This research aims to determine the effectiveness of lignin degradation from sago waste using a TiO2 catalyst. Lignin from sago pulp was isolated using 10% NaOH and characterized using Fourier Transform Infra Red (FTIR) spectroscopy. The results of the characterization using FTIR show that the absorption at wave number 2937.59 cm-1 is the -C-H stretching vibration of the alkane functional groups, the absorption at wave number 2360.87 cm-1 is the vibration of the C≡C triple bond, the wave numbers 1795.73 cm-1 and 1637.56 cm-1 are associated with the stretching of the carbonyl group. The absorption at wave number 1427.32 cm-1 is a C-H vibration connected to an unsaturated bond in an aromatic ring. Absorptions at wave number 1105.21 cm-1, 1128.36 cm-1, 1153.43 cm-1 were the stretching vibration of -C-H on the guaiasil ring, and the absorption at wave number 1022.27 cm-1 was the stretching vibration of C-O-C ether. From this spectrum, it can be seen that lignin is not completely pure because it is probably still mixed with cellulose. The results of the effectiveness test of lignin degradation using a TiO2 catalyst with the help of UV light were able to degrade the lignin isolated by 31.43%, for 3 hours at a lignin concentration of 40 ppm.

Sosialisasi dan Pelatihan Pembuatan Camilan Kripik Kelapa Sebagai Upaya Peningkatan Pendapatan Ibu-Ibu Rumah Tangga Thamrin Azis; Maulidiyah Maulidiyah; Muhammad Nurdin; M. Natsir; Nasriadi Nasriadi; Nohong Nohong; Muhammad Zakir Muzakkar; Ratna Ratna; Imran Imran; La Ode Santiaji Bande; Halimatussaddiyah R; La Ode Abd Kadir; Aceng Haetami
Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2022): Edisi November 2022
Publisher : FKIP Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/amalilmiah.v4i1.23

Program Kemitraan Masyarakat Internal Universitas Halu Oleo (PKMI-UHO) merupakan kegiatan pengabdian pada masyarakat yang diharapkan memberikan model untuk mengatasi berbagai masalah dengan memberikan solusi terutama pengelolaan sumber daya alam menjadi produk bernilai jual tinggi dengan memanfaatkan teknologi sederhana. Tujuan kegiatan pengabdian kepada masyarakat adalah sosialisasi dan pelatihan tentang pengolahan kelapa menjadi keripik kepada masyarakat Kelurahan Petoahaa. Meningkatkan keterampilan masyarakat melalui transfer pengetahuan dalam mengelolah potensi lokal tanaman kelapa menjadi keunggulan lokal melalui produksi olahan kripik kelapa dan membantu menambah sumber pendapatan dalam mencapai taraf kehidupan yang lebih baik. Metode pendekatan yang dilakukan dengan cara edukasi dan pelatihan. Hasil kegiatan ini menunjukkan bahwa masyarakat terutama dari ibu-ibu rumah tangga mitra kerja memperoleh keterampilan dalam membuat keripik kelapa yang bernilai jual dan memasarkaan produk keripik kelapa agar dikenali oleh masyarakat luas.

Early Detection Patterns Of Chronic Kidney Disease Based On Differences In Individual Health Status In Kendari City: Chronic Kidney Disease Tasnim Tasnim; Sugireng Sugireng; Imran Imran; Nur Illiyyin Akib
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 5 No. 2 (2023): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol5.Iss2/190

Background: The prevalence of chronic kidney disease (CKD) was small but it continued to increase every year in Kendari City. The patients were difficult to monitor. The aim of this research is to formulate an early detection pattern for CKD based on differences in individual health status in Kendari City. Methods: This quantitative research used a cross sectional study design which was conducted at 4 Community Health Centers and 3 Hospitals in Kendari City, Southeast Sulawesi, Indonesia. Recruited 136 respondents aged between 24-70 years. Data collection by interviews with questionnaires. The dependent variable is health status, and the independent variables include behavior, psychological environment, stress and genetics. Data analysis used chi square statistical tests, crosstabulation and multinomial logistic regression. Results: There is a significant difference in drinking water consumption behavior of less than 1000 ml a day (p<0.0001, OR=1.56, B=-20.276), calorie intake of less than 1534 calories a day (p<0.05, OR=2.13, B=-19.969 ), physical activity (p<0.05, OR=5.7, B=1.735), medication adherence (P<0.01, OR=0.4,B=1.999) and psychological stress environment (p<0.0001,OR=8.6, B=2.151 ) with the respondent's health status. Meanwhile, herbal consumption behavior (p=0.195) and genetic factors (p=0.813) did not show significant differences with individual health status. Conclusion: Early detection patterns for CKD can use the variable such as less drinking water consumption in healthy people and no obedient medication in single disease group. Using variables of less daily drinking water consumption and heavy physical activity in multiple diseases group, and less drinking water consumption, less physical activity, and moderate stress in CKD group.

Co-Authors A. Noor Aceng Haetami Aden Mula Pratiwi Adryan Fristiohady Alimin C Bijang Fristiohady Adryan Halimatussaddiyah R Kadir, Laode A. L.A. Kadir La Agusu La O. Ahmad La Ode Abd Kadir La Ode Abd Kadir La Ode Kadidae, La Ode La Ode Santiaji Bande Laily Nurliana Laily Nurliana Laode A. Kadir M. Natsir MAULIDIYAH MAULIDIYAH Megawati Megawati Muh Natsir Muh. Natsir Muhammad Hajrul Malaka Muhammad Nurdin Muhammad Zakir Muzakkar N.H. Soekamto Nasriadi Dali Nasriadi Nasriadi Nohong Nohong Nohong Nohong Nohong Nur Illiyyin Akib Nurlian Nursin Nursin Ratna Ratna Ruslan Ruslan Rustam Musta Sahidin Sahidin Sahidin Sri Hutami Lety Grashella Sugireng Sugireng Syefira Salsabila Tahril Tasnim Tasnim THAMRIN AZIS Ulfa H. Syam Wa Ode Harlis Wa Ode Ida Fitriah Wahyuni Wahyuni

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