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All Journal HAYATI Journal of Biosciences Journal of Medicine and Health Majalah Kedokteran Neurosains Neurona
Johan Lucianus
Departemen Mikrobiologi FK Universitas Kristen Maranatha, Bandung
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : HAYATI Journal of Biosciences

 1 
Potential of Clitoria ternatea L. Extract Towards Insulin Receptor Expression and Marker of Inflammation in Diabetes Mellitus Rats Model Rusmana, Djaja; Tiono, Hartini; Widowati, Wahyu; Lucianus, Johan; Darsono, Lusiana; Onggowidjaja, Philips; Tjokropranoto, Rita; Vera, Vera; Setiabudi, Edwin; Obeng, Selonan; Kusuma, Hanna Sari Widya; Novianto, Agung
HAYATI Journal of Biosciences Vol. 31 No. 4 (2024): July 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.4.803-810

Abstract

Metabolic abnormalities caused by the accumulation of human, environmental, genetic and lifestyle variables can be found in diabetes mellitus (DM). An increase in blood glucose carried on by a reduction in insulin production can also result in DM. Insulin resistance often occurs as a result of obesity and a lack of physical activity and aging. Telang flower extract (Clitoria ternatea L.) is reported to have several qualities such as being able to treat DM, chronic bronchitis, goiter, mucosal disorders and leprosy. This study’s objective was to elucidate anti-dibetic effect of C. ternatea extract (CTE) in rats with diabetic complications related to dyslipidemia. Rats suffering from diabetes will be examined after being given oral doses of Simvastatin 0.9 mg/kg BW, Glibenclamide 0.45 mg/kg BW, and 200, 400, and 800 mg/kg BW CTE, model induced by streptozotocin. The expression of the insulin gene (INS-1) was investigated by qRTPCR, Tumor Necrosis Factor-α (TNF-α), and Interleukin-1β (IL-1β) pancreatic DM rats model using the Immunohistochemistry (IHC) test. Both descriptive and quantitative data were acquired for the data. After utilizing ANOVA to evaluate quantitative data, the Tukey post hoc test was used to analyze the data, the expression of TNF-α and IL-1β was found to decrease while INS-1 expression increased in response to CTE. This effect was attributed to the modulation of TNF-α, IL-1β, and INS-1 expression. These findings suggest that CTE possesses antidiabetic properties.
Anti-Aging and Antioxidant Activities of Clitoria ternatea L. Flower Extract Lucianus, Johan; Adhika, Oeij Anindita
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.508-517

Abstract

Aging is influenced by several factors, including Reactive Oxygen Species (ROS). An imbalance of higher ROS and lower antioxidants may lead to oxidative stress in cells that is manifested as wrinkles, dark spots, and fine lines. Antioxidants can prevent the effects of ROS. Safe and abundant sources of antioxidants can come from natural ingredients. One of the natural ingredients widely studied is Clitoria ternatea flower extract (CFE). This study aims to report the CFE potential as an anti-aging and antioxidant agent. Gallic acid and quercetin standards were used to measure the total flavonoid and phenolic content. Antioxidant activity was evaluated by hydroxyl (OH) and Nitric Oxide (NO) scavenging, while anti-aging activity was evaluated by collagenase and elastase inhibition tests. CFE showed high phenol and flavonoid content (14.49 μg GAE/mg and 9.00 μg QE/mg). CFE also has OH and NO scavenging activity with IC50 18.39 and 31.11 μg/mL, which exhibited antioxidant potential. CFE also showed potential to inhibit collagenase (IC50 = 177.48 μg/mL) and inhibit elastase (IC50 = 30.88 μg/mL). CFE may serve as a promising candidate with antioxidant and anti-aging properties.
Co-Authors Agung Novianto, Agung Azalia Rahmanita Erman Budi Widyarto Lana Danny R Garna, Danny R Djaja Rusmana Edwin Setiabudi Hanna Sari Widya Kusuma, Hanna Sari Widya Hartini Tiono July Ivone Lusiana Darsono Obeng, Selonan Oeij Anindita Adhika Philips Onggowidjaja Rita Tjokropranoto vera vera, vera WAHYU WIDOWATI Winda Permata Sari Yenni Limyati