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All Journal Jurnal Penelitian Pascapanen Pertanian Science and Technology Indonesia
Devi Safrina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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PENGARUH KETINGGIAN TEMPAT TUMBUH DAN PENGERINGAN TERHADAP FLAVONOID TOTAL SAMBANG COLOK (Iresine herbstii) Devi Safrina; Wahyu Joko Priyambodo
Jurnal Penelitian Pascapanen Pertanian Vol 15, No 3 (2018): Jurnal Penelitian Pascapanen Pertanian
Publisher : Balai Besar Penelitian dan Pengembangan Pascapanen Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/jpasca.v15n3.2018.147-154

Abstract

Sambang Colok (Iresine herbstii) merupakan salah satu tanaman obat yang memberikan efek diuretik, anti-inflamasi, dan antipiretik. Sambang Colok merupakan tanaman yang dapat hidup dari dataran rendah sampai dataran tinggi. Pertumbuhan dan perkembangan tanaman sangat dipengaruhi oleh lingkungan termasuk ketinggian. Proses pembuatan bahan jamu harus memenuhi beberapa kriteria parameter kualitas simplisia diantaranya flavonoid total. Kandungan kimia simplisia sangat dipengaruhi oleh proses pembuatan simplisia salah satunya adalah proses pengeringan. Penelitian ini bertujuan mengetahui pengaruh ketinggian tempat tumbuh dan cara pengeringan terhadap kandungan flavonoid tanaman Sambang Colok. Penelitian yang dilakukan menggunakan variasi ketinggian (1800 mpdl, 1200 mdpl, 600mdpl, dan 200mdpl) serta metode pengeringan (sinar matahari, oven dan kombinasi). Simplisia yang diperoleh selanjutnya dianalisis biomasa dan kadar flavonoid totalnya. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan pada perlakuan ketinggian dan pengeringan, dimana perlakuan terbaik adalah pada tempat tumbuh dengan ketinggian 1200 mdpl dan pengeringan dengan menggunakan kombinasi sinar matahari dan oven atau pengeringan menggunakan oven Effect of Altitude and Drying Method on Flavonoid of Sambang Colok (Iresine herbsti)Sambang colok (Iresine herbstii) is one of the medicinal plants which has diuretic, anti-inflammatory, and antipyretic properties. Sambang colok can live inlowlands and highlands. Plant growth and development is strongly influenced by the environment, including altitude. The process of making herbal medicine materials must meet the quality parameters of simplicia, i.e. total flavonoid content. Chemical content of simplicia is strongly influenced by the manufacturing process, one of which is the drying process. The aim of this research was to study the influence of altitude of planting land and drying methods on flavonoid content of sambang colok. The research was conducted using variations of altitude planting land (1800 masl, 1200 masl, 600masl, and 200masl) as well as the drying method (sun drying, oven drying and combination). Simplicia then analyzed for total biomass and flavonoid content. The result showed that altitude and drying methods gave significant effect on simplicia sambang colok, where the best result for flavonoid content obtained with altitude of 1200 masl and oven drying and combination of drying methods.
Phytochemical Profile, Antioxidant Activity and Anticancer Activity of Gamma-Irradiated Black Rice Bran (Oryza sativa L.) Ethanolic Extract: In-Vitro and In-Silico Study Rukmana, Rizal Maarif; Silfarohana, Rantika; Putra, Aditya Dwi Permana; Devi Safrina; Dian Susanti; Nur Rahmawati Wijaya; M Bakti Samsu Adi; Muhammad Evy Prastiyanto; Yanuar Ashari Cahyaningrum; Rina Nurmaulawati; Weka Sidha Bhagawan
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.628-643

Abstract

Black rice is a food crop with black pigments, which helps reduce the risk of various diseases and improve health. One way to improve food quality and avoid food contaminants is by irradiating. This study evaluated the phytochemical profile, antioxidant activity, and anticancer activity of irradiated black rice bran extract (IBRBE) in vitro and in silico. Black rice was irradiated with a Gamma cell 220 type irradiator at a 7.5 kGy/hour dose rate. Extraction of irradiated black rice bran was carried out using the maceration method. Phenolic and flavonoid components were quantified using the Folin–Ciocalteau and AlCl3 methods, respectively. Phytochemical compounds were identified by liquid chromatography-high-resolution mass spectrometry (LC HRMS). The antioxidant activity of IBRBE was carried out against 2,2-diphenyl-1picrylhydazyl (DPPH). The cytotoxic activity of IBRBE against WiDr cells (colorectal cancer) and Vero (nonhuman cell lines) used the MT test method. Prediction of the inhibitory mechanism of compounds in the extract against target proteins EGFR and GPX7 was carried out in silico. Total phenolics and flavonoids were 2.57 ± 0.28 mg GAE/g and 19.12 ± 0.18 μg QE/ml, respectively. Twenty-four types of active compounds were obtained in IBRBE. The results of antioxidant activity obtained an IC50 value of 1198.45 ± 92.86 μg/ml. IC50 in WiDr cells and Vero cells were obtained at 36.08 ± 11.71 μg/ml and 570.58 ± 130.25 μg/ml, respectively. In silico results, the compound 4 Dodecylbenzene sulfonic acid has the highest binding affinity to the EGFR protein, with a value of -5.9. Meanwhile, the Monoolein compound has the highest binding affinity to the GPX7 protein, with a value of -5.4.
Co-Authors Dian Susanti M Bakti Samsu Adi Muhammad Evy Prastiyanto Nur Rahmawati Wijaya Putra, Aditya Dwi Permana Rina Nurmaulawati Rizal Maarif Rukmana, Rizal Maarif Silfarohana, Rantika Wahyu Joko Priyambodo Weka Sidha Bhagawan Yanuar Ashari Cahyaningrum