Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Science and Technology Indonesia Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Rina Nurmaulawati
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Efek Penambahan Substrat Madu Hutan Baduy Pada Fermentasi Kombucha Bunga Telang (Clitoria ternatea L) Dalam Menurunkan Kolesterol Ayam Broiler (Gallus galus) Sebagai Inovasi Produk Bioteknologi Konvensional Terkini Kuncara Nata Waskita; Rina Nurmaulawati; Firman Rezaldi
Jurnal Ilmiah Kedokteran dan Kesehatan Vol 2 No 1 (2023): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3974.816 KB) | DOI: 10.55606/klinik.v2i1.883

Abstract

Kombucha bunga telang pada konsentrasi madu hutan baduy berkolerasi secara positif dalam menurunkan kolesterol pada ayam broier. Penelitian ini bertujuan untuk menghasilkan daging ayam yang rendah kolesterol. Penelitian ini menggunakan ayam broiler sebanyak 20 ekor yang berusia 3 bulan serta diberi perlakuan larutan fermentasi kombucha bunga telang dengan konsentarsi madu hutan baduy meliputi 20%, 30%, dan 40% sebagai substratnya untuk difermentasi selama 14 hari pada suhu 260C. Metode penelitian ini adalah RAL (Rancangan Acak Lengkap) pada 4 perlakuan dalam waktu 30 hari disertai pengulangan sebanyak 5 kali. Perlakuan pemberian terhadap hewan uji meliputi T0 yaitu kontrol berupa air putih/minum. T1 berupa larutan fermentasi kombucha bunga telang pada konsentrsi madu hutan baduy sebesar 20%. T2 berupa larutan fermentasi kombucha bunga telang pada konsentrasi madu hutan baduy sebesar 30%. T3 berupa larutan fermentasi kombucha bunga telang pada konsentrasi madu hutan baduy sebesar 40%. Parameter peneltian yang diuji meliputi kadar kolesterol, berat/bobot tubuh, dan konsumsi air minum. Hasil penelitian ini datanya dioleh melalui ANOVA dan dilakukan analisis lanjut berupa uji Duncan dengan taraf kepercayaan sebesar 95%. Hasil penelitian ini membuktikan bahwa kombucha bunga telang pada konsentrasi madu hutan baduy memiliki aktivitas farmakologi sebagai penurun kolesterol secara nyata sehingga dapat disimpulkan bahwa konsentrasi 40% pada madu hutan baduy fermentasi kombucha buna telan merupakan perlakuan yang terbaik dalam menurunkan kolesterol ayam broiler pada seluruh parameter uji.
Phytochemical Profile, Antioxidant Activity and Anticancer Activity of Gamma-Irradiated Black Rice Bran (Oryza sativa L.) Ethanolic Extract: In-Vitro and In-Silico Study Rukmana, Rizal Maarif; Silfarohana, Rantika; Putra, Aditya Dwi Permana; Devi Safrina; Dian Susanti; Nur Rahmawati Wijaya; M Bakti Samsu Adi; Muhammad Evy Prastiyanto; Yanuar Ashari Cahyaningrum; Rina Nurmaulawati; Weka Sidha Bhagawan
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.628-643

Abstract

Black rice is a food crop with black pigments, which helps reduce the risk of various diseases and improve health. One way to improve food quality and avoid food contaminants is by irradiating. This study evaluated the phytochemical profile, antioxidant activity, and anticancer activity of irradiated black rice bran extract (IBRBE) in vitro and in silico. Black rice was irradiated with a Gamma cell 220 type irradiator at a 7.5 kGy/hour dose rate. Extraction of irradiated black rice bran was carried out using the maceration method. Phenolic and flavonoid components were quantified using the Folin–Ciocalteau and AlCl3 methods, respectively. Phytochemical compounds were identified by liquid chromatography-high-resolution mass spectrometry (LC HRMS). The antioxidant activity of IBRBE was carried out against 2,2-diphenyl-1picrylhydazyl (DPPH). The cytotoxic activity of IBRBE against WiDr cells (colorectal cancer) and Vero (nonhuman cell lines) used the MT test method. Prediction of the inhibitory mechanism of compounds in the extract against target proteins EGFR and GPX7 was carried out in silico. Total phenolics and flavonoids were 2.57 ± 0.28 mg GAE/g and 19.12 ± 0.18 μg QE/ml, respectively. Twenty-four types of active compounds were obtained in IBRBE. The results of antioxidant activity obtained an IC50 value of 1198.45 ± 92.86 μg/ml. IC50 in WiDr cells and Vero cells were obtained at 36.08 ± 11.71 μg/ml and 570.58 ± 130.25 μg/ml, respectively. In silico results, the compound 4 Dodecylbenzene sulfonic acid has the highest binding affinity to the EGFR protein, with a value of -5.9. Meanwhile, the Monoolein compound has the highest binding affinity to the GPX7 protein, with a value of -5.4.
Co-Authors Devi Safrina Dian Susanti Firman Rezaldi Kuncara Nata Waskita M Bakti Samsu Adi Muhammad Evy Prastiyanto Nur Rahmawati Wijaya Putra, Aditya Dwi Permana Rizal Maarif Rukmana, Rizal Maarif Silfarohana, Rantika Weka Sidha Bhagawan Yanuar Ashari Cahyaningrum