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All Journal Science and Technology Indonesia IJECS: Indonesian Journal of Empowerment and Community Services Jurnal Medicare
Dian Susanti
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Health Professions Materials Science & Nanotechnology Nursing Physics Public Health Social Sciences

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Phytochemical Profile, Antioxidant Activity and Anticancer Activity of Gamma-Irradiated Black Rice Bran (Oryza sativa L.) Ethanolic Extract: In-Vitro and In-Silico Study Rukmana, Rizal Maarif; Silfarohana, Rantika; Putra, Aditya Dwi Permana; Devi Safrina; Dian Susanti; Nur Rahmawati Wijaya; M Bakti Samsu Adi; Muhammad Evy Prastiyanto; Yanuar Ashari Cahyaningrum; Rina Nurmaulawati; Weka Sidha Bhagawan
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.628-643

Abstract

Black rice is a food crop with black pigments, which helps reduce the risk of various diseases and improve health. One way to improve food quality and avoid food contaminants is by irradiating. This study evaluated the phytochemical profile, antioxidant activity, and anticancer activity of irradiated black rice bran extract (IBRBE) in vitro and in silico. Black rice was irradiated with a Gamma cell 220 type irradiator at a 7.5 kGy/hour dose rate. Extraction of irradiated black rice bran was carried out using the maceration method. Phenolic and flavonoid components were quantified using the Folin–Ciocalteau and AlCl3 methods, respectively. Phytochemical compounds were identified by liquid chromatography-high-resolution mass spectrometry (LC HRMS). The antioxidant activity of IBRBE was carried out against 2,2-diphenyl-1picrylhydazyl (DPPH). The cytotoxic activity of IBRBE against WiDr cells (colorectal cancer) and Vero (nonhuman cell lines) used the MT test method. Prediction of the inhibitory mechanism of compounds in the extract against target proteins EGFR and GPX7 was carried out in silico. Total phenolics and flavonoids were 2.57 ± 0.28 mg GAE/g and 19.12 ± 0.18 μg QE/ml, respectively. Twenty-four types of active compounds were obtained in IBRBE. The results of antioxidant activity obtained an IC50 value of 1198.45 ± 92.86 μg/ml. IC50 in WiDr cells and Vero cells were obtained at 36.08 ± 11.71 μg/ml and 570.58 ± 130.25 μg/ml, respectively. In silico results, the compound 4 Dodecylbenzene sulfonic acid has the highest binding affinity to the EGFR protein, with a value of -5.9. Meanwhile, the Monoolein compound has the highest binding affinity to the GPX7 protein, with a value of -5.4.
PENGARUH PEMBERIAN INFUSED WATER KURMA PADA IBU HAMIL TRIMESTER III DENGAN ANEMIA Agi Yulia Ria Dini; Yosi Yusrotul Khasanah; Heny Puspasari; Siti Nurdiyana; Dian Susanti; Fitri Setiawati
Jurnal Medicare Vol. 4 No. 2: APRIL 2025
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/jurnalmedicare.v4i2.185

Abstract

Anemia in pregnant women is a condition of low hemoglobin levels in pregnant women which is a common health problem and can affect both the mother and the fetus. One potential non-pharmacological method to overcome anemia is giving date infused water. Dates are rich in iron, vitamin B complex, and vitamin C which support the formation of hemoglobin and iron absorption. This study aims to analyze the effect of giving date infused water on hemoglobin levels in pregnant women. This study used a quasi-experimental design with a one-group pretest-posttest approach. The study population was all pregnant women in the third trimester with anemia at TPMB Mintarsih, S.SiT., Bd in the month of 33 people. The sampling technique was carried out using the total sampling technique. The results of the study showed that giving date palm infused water significantly increased hemoglobin levels in pregnant women with anemia in the third trimester. The Paired Samples Test statistical test produced a p value = 0.003 (p < 0.05), which indicates a significant effect of giving date palm infused water on increasing hemoglobin levels. This study recommends date infused water as a non-pharmacological intervention that can be used to support the health of pregnant women.
Empowerment of Persons with Disabilities with Blind Jatabek through Tuina Chuzhen Massage Therapy Training Japaries, Willie; Wijono Sukaputra Agussalim; Hedi Suanto Tjong; Metta Sari; Erni Chrisilia Suhendry; Aditya Prabowo Audisapta; Ony Susita; Adrianus Suyadi, S.J.; Anastasia S.P; Dian Susanti; Sutrisno; R.M. Alfian
IJECS: Indonesian Journal of Empowerment and Community Services Vol. 6 No. 2 (2025)
Publisher : Universitas Veteran Bangun Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32585/ijecs.v6i2.7240

Abstract

ABSTRACT Background: People with disabilities, especially the blind, are members of society who have limited vision. Therefore, they require specific methods to learn certain skills to earn a living. One such skill suitable for the blind is massage therapy, which can be learned without relying on sight, but relying on the sense of touch. Purpose: This paper aims to describe the experience of training blind people to perform a special massage treatment called Tuina Chuzhen. Methods: The experience of training blind people to perform Tuina Chuzhen massage is described chronologically and systematically from facts and primary data collected during six training sessions at the Daya Dharma Institute of the Archdiocese of Jakarta, with support from traditional Chinese medicine experts from the Nalanda Institute. Main Results: The Tuina Chuzhen massage training for 20 blind people went smoothly during six sessions over a period of one month. The training participants successfully mastered the Tuina Chuzhen method using the provided short wooden rods. Mastery of these skills was evident in the participants' recognition and their ability to pass the competency test conducted by the Nalanda Institute's assessment team after the training. Conclusion: Tuina Chuzhen massage training can bring tangible benefits to the visually impaired. Keywords: Massage, tuina Chuzhen, disability, visual impairment.
Co-Authors Aditya Prabowo Audisapta Adrianus Suyadi, S.J. Agi Yulia Ria Dini Anastasia S.P Devi Safrina Erni Chrisilia Suhendry Fitri Setiawati Hedi Suanto Tjong M Bakti Samsu Adi Metta Sari Muhammad Evy Prastiyanto Nur Rahmawati Wijaya Ony Susita Puspasari, Heny Putra, Aditya Dwi Permana R.M. Alfian Rina Nurmaulawati Rizal Maarif Rukmana, Rizal Maarif Silfarohana, Rantika Siti Nurdiyana SUTRISNO Weka Sidha Bhagawan Wijono Sukaputra Agussalim Willie Japaries Yanuar Ashari Cahyaningrum Yosi Yusrotul Khasanah