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All Journal Science and Technology Indonesia Jurnal Medicare Indonesian Journal of Jamu
Dian Susanti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Pengaruh Naungan dan Variasi Sumber Pupuk Organik Cair terhadap Kadar Flavonoid Daun Bangun Bangun (Plectranthus amboinicus (Lour) Spreng) Sofa Farida; Dian Susanti; Alifia Yuniarachma
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i3.152

Abstract

Bangun-bangun [Plectranthus amboinicus (Lour.) Spreng] termasuk famili Lamiaceae yang memiliki aktivitas sebagai urolithiasis, fungitoxic, anti-bakteri, anti-malaria dan anti-radang. Lingkungan tumbuhan dan sistem budidaya bangun-bangun dapat mempengaruhi kadar senyawa metabolit sekunder terutama flavonoid. Penelitian ini bertujuan untuk mengetahui kandungan flavonoid total daun bangun-bangun dengan perlakuan naungan dan pupuk organik cair. Desain eksperimen menggunakan rancangan acak kelompok faktorial. Faktor pertama adalah variasi pupuk organik cair (0% / tanpa pupuk organik cair, 100% daun kedelai, 100% batang pisang, jerami: sayuran 30%: 70%), sedangkan faktor kedua adalah empat tingkat persentase naungan (0 % / tanpa naungan, 40%, 60%, dan 80%). Oleh karena itu, terdapat 16 kombinasi perlakuan dengan masing-masing perlakuan diulang tiga kali, sehingga terdapat 48 unit percobaan. Penelitian dilakukan di Laboratorium Terpadu dan Kebun Produksi Karangpandan B2P2TO-OT selama bulan Juli-Oktober 2018. Perhitungan total flavonoid dilakukan dengan menggunakan metode spektrofotometri. Hasil penelitian menunjukkan bahwa tidak ada interaksi antara kedua faktor tersebut dan flavonoid total tidak berbeda nyata antar kelompok perlakuan. Namun, kelompok pupuk batang pisang dengan naungan 80% menghasilkan flavonoid total tertinggi.
Phytochemical Profile, Antioxidant Activity and Anticancer Activity of Gamma-Irradiated Black Rice Bran (Oryza sativa L.) Ethanolic Extract: In-Vitro and In-Silico Study Rukmana, Rizal Maarif; Silfarohana, Rantika; Putra, Aditya Dwi Permana; Devi Safrina; Dian Susanti; Nur Rahmawati Wijaya; M Bakti Samsu Adi; Muhammad Evy Prastiyanto; Yanuar Ashari Cahyaningrum; Rina Nurmaulawati; Weka Sidha Bhagawan
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.628-643

Abstract

Black rice is a food crop with black pigments, which helps reduce the risk of various diseases and improve health. One way to improve food quality and avoid food contaminants is by irradiating. This study evaluated the phytochemical profile, antioxidant activity, and anticancer activity of irradiated black rice bran extract (IBRBE) in vitro and in silico. Black rice was irradiated with a Gamma cell 220 type irradiator at a 7.5 kGy/hour dose rate. Extraction of irradiated black rice bran was carried out using the maceration method. Phenolic and flavonoid components were quantified using the Folin–Ciocalteau and AlCl3 methods, respectively. Phytochemical compounds were identified by liquid chromatography-high-resolution mass spectrometry (LC HRMS). The antioxidant activity of IBRBE was carried out against 2,2-diphenyl-1picrylhydazyl (DPPH). The cytotoxic activity of IBRBE against WiDr cells (colorectal cancer) and Vero (nonhuman cell lines) used the MT test method. Prediction of the inhibitory mechanism of compounds in the extract against target proteins EGFR and GPX7 was carried out in silico. Total phenolics and flavonoids were 2.57 ± 0.28 mg GAE/g and 19.12 ± 0.18 μg QE/ml, respectively. Twenty-four types of active compounds were obtained in IBRBE. The results of antioxidant activity obtained an IC50 value of 1198.45 ± 92.86 μg/ml. IC50 in WiDr cells and Vero cells were obtained at 36.08 ± 11.71 μg/ml and 570.58 ± 130.25 μg/ml, respectively. In silico results, the compound 4 Dodecylbenzene sulfonic acid has the highest binding affinity to the EGFR protein, with a value of -5.9. Meanwhile, the Monoolein compound has the highest binding affinity to the GPX7 protein, with a value of -5.4.
PENGARUH PEMBERIAN INFUSED WATER KURMA PADA IBU HAMIL TRIMESTER III DENGAN ANEMIA Agi Yulia Ria Dini; Yosi Yusrotul Khasanah; Heny Puspasari; Siti Nurdiyana; Dian Susanti; Fitri Setiawati
Jurnal Medicare Vol. 4 No. 2: APRIL 2025
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/jurnalmedicare.v4i2.185

Abstract

Anemia in pregnant women is a condition of low hemoglobin levels in pregnant women which is a common health problem and can affect both the mother and the fetus. One potential non-pharmacological method to overcome anemia is giving date infused water. Dates are rich in iron, vitamin B complex, and vitamin C which support the formation of hemoglobin and iron absorption. This study aims to analyze the effect of giving date infused water on hemoglobin levels in pregnant women. This study used a quasi-experimental design with a one-group pretest-posttest approach. The study population was all pregnant women in the third trimester with anemia at TPMB Mintarsih, S.SiT., Bd in the month of 33 people. The sampling technique was carried out using the total sampling technique. The results of the study showed that giving date palm infused water significantly increased hemoglobin levels in pregnant women with anemia in the third trimester. The Paired Samples Test statistical test produced a p value = 0.003 (p < 0.05), which indicates a significant effect of giving date palm infused water on increasing hemoglobin levels. This study recommends date infused water as a non-pharmacological intervention that can be used to support the health of pregnant women.
Co-Authors Agi Yulia Ria Dini Alifia Yuniarachma Devi Safrina Fitri Setiawati M Bakti Samsu Adi Muhammad Evy Prastiyanto Nur Rahmawati Wijaya Puspasari, Heny Putra, Aditya Dwi Permana Rina Nurmaulawati Rizal Maarif Rukmana, Rizal Maarif Silfarohana, Rantika Siti Nurdiyana Sofa Farida Weka Sidha Bhagawan Yanuar Ashari Cahyaningrum Yosi Yusrotul Khasanah