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PEMBUATAN GEL HIDROKSIAPATIT CANGKANG KERANG-SIMPING (Amusium pleuronectes) DAN PENGARUHNYA SETELAH APLIKASI DI LESI WHITE-SPOT EMAIL GIGI Rizki Amalina; Dewi Monica; Anggun Feranisa; Firda Yanuar Syafaat; Mona Sari; Yusril Yusuf
Cakradonya Dental Journal Vol 13, No 2 (2021): Agustus 2021
Publisher : FKG Unsyiah

Masalah kesehatan gigi tertinggi di Indonesia adalah karies yaitu rusaknya jaringan keras gigi. Pencegahan karies dapat dilakukan dengan meningkatkan remineralisasi. Cangkang kerang-simping merupakan limbah industri kaya kalsium yang dapat menjadi prekursor hidroksiapatit yaitu kristal penyusun gigi. Penelitian ini bertujuan untuk mensintesis gel hidroksiapatit dari cangkang kerang- simping dan mengetahui pengaruh gel hidroksiapatit terhadap remineralisasi email gigi. Metode penelitian merupakan eksperimental laboratoris 2 tahap. Pertama adalah sintesis hidroksiapatit dan evaluasi fisikokimia menggunakan SEM-EDX dan XRD. Hidroksiapatit kemudian dibuat menjadi sediaan gel dan diuji secara organoleptik. Tahap kedua adalah penelitian pre dan post-test control group design menggunakan 16 sampel gigi premolar satu rahang atas post ekstraksi yang terbagi menjadi 2 kelompok yaitu kelompok gel hidroksiapatit 20%, dan kelompok kontrol. Uji kekerasan email gigi menggunakan Vickers microhardness tester sebanyak 2 kali, yaitu sebelum dan setelah aplikasi gel. Hasil menunjukkan bahwa hidroksiapatit cangkang kerang simping berukuran nano, berbentuk granular dengan rasio molar Ca:P 3,22. Konsistensi gel hidroksiapatit homogen, sedikit berbau dan berwarna putih krem. Pada hasil uji kekerasan email terdapat perbedaan signifikan sebelum dan sesudah aplikasi (p0,05) dan terdapat signifikansi perbedaan peningkatan kekerasan antar kelompok (p0,05). Peningkatan kekerasan email kelompok gel hidroksiapatit lebih tinggi daripada kelompok kontrol. Kesimpulannya adalah gel hidroksiapatit cangkang kerang-simping berpotensi sebagai agen remineralisasi email gigi

Evaluation of Physical Stability of Phaleria Macrocarpa’s Leaf Extract Formulated in Nanoemulgel Rosa Pratiwi; Anggun Feranisa; Elsa Yuliana Sukmawati
Denta Journal Kedokteran Gigi Vol 17 No 1 (2023): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v17i1.2

Background: Phaleria macrocarpa’s leaf contains alkaloids, saponins, phenols, tannins, and flavonoids which have antioxidant, anti-inflammatory, and antibacterial activities. The nanoemulgel preparation was chosen because it can penetrate well and quickly into the mucosa thereby increasing absorption. Physical stability tests need to be carried out to ensure the quality, safety and benefits of the gel meet the expected specifications and stable during storage. Objective: This study aims to determine which concentration has the most stable physical stability of pH and viscosity which were observed for 28 days. Materials and Methods: This was an experimental laboratory design, with 30 preparation divided into 3 groups, group of 30%, 40%, and 50% concentration preparation of nanoemulgel leaves of Phaleria macrocarpa. which were tested for pH tests and viscosity tests for 28 days which was observed every 7 days in climatic chamber. The pH and viscosity tests among groups were compared and analyzed by the Repeated Anova and Pos Hoc test. Results: Average pH test and viscosity test 30% concentration with the average baseline and h+28 pH values were 5,02 and 4,97 and the baseline and h+28 viscosity values were 1610 cPas and 1520 cPas. The results of the average concentration of 50% pH value at baseline = 4,65 and h+28 = 4,60. The mean baseline viscosity value=1290 cPas and h+28=1170 cPas. The results of the post-Wilcoxon test showed p>0.05 in the 30% concentration group for pH and viscosity tests showed that there was no significant difference in pH and viscosity values at a concentration of 30%, It means the pH value and viscosity of the 30% concentration preparation of nanoemulgel were relatively constant from baseline to h+28. Conclusion: It can be concluded that the pH and viscosity test of the preparation of nanoemulgel leaves of Phaleria macrocarpa at a concentration of 30% was the most stable pH and viscosity compared to concentrations of 40% and 50%.

KOMPARASI ANTARA POLYMERASE CHAIN REACTION (PCR) DAN LOOPMEDIATED ISOTHERMAL AMPLIFICATION (LAMP) DALAM DIAGNOSIS MOLEKULER Anggun Feranisa
Odonto : Dental Journal Vol 3, No 2 (2016): December 2016
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Molecular diagnostic is an emerging diagnostic method inpersonalized medicine/dentistry era. Usually, it uses nucleic acid amplificationmethod to detect various diseases. PCR is conventional nucleic acid amplification method. However, due to an urgency in infectious diseases’ diagnotic method, scientists developed LAMP as new nucleic acid amplification method.Discussion: There are various experiments used to develop LAMP as infectious diseases diagnostic method compared to PCR. The results are LAMP more sensitive, specific, rapid, and inexpensive than PCR.Conclusion: Both PCR and LAMP can be used as molecular diagnostic tools.LAMP prefer to used as infectious disease diagnostic method in poor anddeveloping countries.

BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT EFFECT ON IL-10 EXPRESSION IN ORAL ULCER Arina Shafia; Rochman Mujayanto; Anggun Feranisa
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

PEMBUATAN GEL HIDROKSIAPATIT CANGKANG KERANG-SIMPING (Amusium pleuronectes) DAN PENGARUHNYA SETELAH APLIKASI DI LESI WHITE-SPOT EMAIL GIGI Rizki Amalina; Dewi Monica; Anggun Feranisa; Firda Yanuar Syafaat; Mona Sari; Yusril Yusuf
Cakradonya Dental Journal Vol 13, No 2 (2021): Agustus 2021
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v13i2.23527

Masalah kesehatan gigi tertinggi di Indonesia adalah karies yaitu rusaknya jaringan keras gigi. Pencegahan karies dapat dilakukan dengan meningkatkan remineralisasi. Cangkang kerang-simping merupakan limbah industri kaya kalsium yang dapat menjadi prekursor hidroksiapatit yaitu kristal penyusun gigi. Penelitian ini bertujuan untuk mensintesis gel hidroksiapatit dari cangkang kerang- simping dan mengetahui pengaruh gel hidroksiapatit terhadap remineralisasi email gigi. Metode penelitian merupakan eksperimental laboratoris 2 tahap. Pertama adalah sintesis hidroksiapatit dan evaluasi fisikokimia menggunakan SEM-EDX dan XRD. Hidroksiapatit kemudian dibuat menjadi sediaan gel dan diuji secara organoleptik. Tahap kedua adalah penelitian pre dan post-test control group design menggunakan 16 sampel gigi premolar satu rahang atas post ekstraksi yang terbagi menjadi 2 kelompok yaitu kelompok gel hidroksiapatit 20%, dan kelompok kontrol. Uji kekerasan email gigi menggunakan Vickers microhardness tester sebanyak 2 kali, yaitu sebelum dan setelah aplikasi gel. Hasil menunjukkan bahwa hidroksiapatit cangkang kerang simping berukuran nano, berbentuk granular dengan rasio molar Ca:P 3,22. Konsistensi gel hidroksiapatit homogen, sedikit berbau dan berwarna putih krem. Pada hasil uji kekerasan email terdapat perbedaan signifikan sebelum dan sesudah aplikasi (p0,05) dan terdapat signifikansi perbedaan peningkatan kekerasan antar kelompok (p0,05). Peningkatan kekerasan email kelompok gel hidroksiapatit lebih tinggi daripada kelompok kontrol. Kesimpulannya adalah gel hidroksiapatit cangkang kerang-simping berpotensi sebagai agen remineralisasi email gigi

Differences In Surface Hardness of Nanohybrid Composite Resin after Immersion In Variant Of Yakult Probiotic Drink Nurinaya, Fatati; Benyamin, Benni; Feranisa, Anggun; Muchaeroni, Isa Anshori
Jurnal Medali Vol 6, No 2 (2024): Media Dental Intelektual September 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.6.2.91-96

Background: A probiotic drink is an acidic drink. Each type of probiotic drink has different contents. Differences in the surface hardness of composite resin can be caused by the content and pH which damages the bonds of the composite resin which causes a decrease in the hardness of the composite resin. This study aims to determine the difference in surface hardness of nanohybrid composite resin after soaking in the Original and Light Yakult probiotic drinksMethod: The type of the study was laboratory experimental study with post-test design with 2 treatment group. The samples used in this study were FiltexTM Z250 XT nanohybrid composite resin with 32 specimens with a length of 12 mm, width of 2 mm, and thickness of 2 mm. Samples were divided into 2 groups, group A soaked in the Original variant of Yakult and group B soaked in Light variant of Yakult. Samples were soaked for 24 hours in the incubator. Surface hardness of the samples was measued after treatment using Micro Vickers Hardness TesterResult: The results of soaking according to Vickers measurement were tested statistically using the Independent-T Test. The results of the study showed the difference in surface hardness of nanohybrid composite resin after soaking in the Original variant of Yakult and Light variant of Yakult (P<0,05) with an average hardness of 45.81 in Original variant of Yakult and 50.43 in Light variant of YakultConclusion: it can be concluded that soaking in the Original Yakult probiotic drink reduces the surface hardness of composite resin compared to Light Yakult.

The Effectiveness Of Black Cumin Nanoemulsion Gel Concentration 10% And 15% On Staphylococcus Aureus Biofilm Thickness (In Vitro) Praptiningsih, Rahmawati Sri; Feranisa, Anggun; Amalina, Rizki; Nur Istighfah, Jafifah Mega
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.136-145

Background: Periodontal disease is a disease that often occurs in the oral cavity with prevalence in Semarang City increasing in 2016 by 67.18% to 89.53%. One of the causes of periodontal disease is the buildup of Stapylococcus aureus bacterial biofilm during the initial colonization of the tooth pellicle formation. One herbal ingredient that can be used as an antibacterial is black cumin (Nigella sativa). Gel nanoemulsion technology has the advantage of increasing material stability. This research aims to determine the effectiveness of black cumin gel nanoemulsion on the growth of Stapylococcus aureus biofilm thickness. Methods:The treatment group consisted of black cumin gel nanoemulsion with a concentration of 10% and a concentration of 15% and the control group, namely 0.2% chlorhexidine and distilled water. Stapylococcus aureus biofilm thickness was measured using an ELISA-reader. Statistical tests were carried out using the One Way Anova test. Results: The average thickness of Stapylococcus aureus with the addition of black cumin gel nanoemulsion with a concentration of 15% was the lowest, namely 0.046, while the thickness of Stapylococcus aureus with the addition of distilled water was the highest, namely 0.158. The One Way Anova test obtained a significance figure of 0.000 (p<0.05) so it could be concluded that there were significant differences in the 4 Stapylococcus aureus thickness test groups.Conclusion: Black cumin gel nanoemulsion concentrations of 10% and 15% have antibacterial properties which can reduce the thickness of Stapylococcus aureus biofilm.

The Effect of Red Algae (Eucheuma cottonii) Nanoemulgel on Cytokine Il-1 Beta Expression for Traumatic Ulcers Healing Feranisa, Anggun; Nurhapsari, Arlina; Indriastanti, Rikha; Amalina, Rizki
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol. 13 No. 2 (2024): November
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v13i2.23398

Red algae (Eucheuma cottonii) is a type of seaweed (Rhodophyceae). Eucheuma cottonii contains flavonoids and florotanin as an anti-inflammatory agent. The extracted red algae were formulated into nanoemulgel. This study aimed to determine the effect of red algae nanoemulgel (Eucheuma cottonii) in the expression of IL-1β cytokines on the healing of traumatic ulcers. The researcher applied true experimental research with a post-test-only control group design. This research was conducted by giving Eucheuma cottonii nanoemulgel concentrations of 20%, 35%, 50%, positive control, and negative control at the labial once a day, followed by evaluation using the IHC method. The results revealed that Eucheuma cottonii nanoemulgel extract affected the expression of IL-1β cytokines in healing traumatic ulcers by decreasing the amount of IL-1β cytokine expression. The results obtained a p-value of 0.05, which indicates a significant difference in the expression of the number of IL-1β cytokines in traumatic ulcers. This study concluded that the 20% Eucheuma cottonii extract nanoemulgel treatment group affected the amount of IL-1β by decreasing the expression of IL-1β cytokines. Nanoemulgel of 20% Eucheuma cottonii extract is considered effective as an anti-inflammatory material for traumatic ulcer healing.

EDUKASI PEMANFAATAN BAHAN ALAM UNTUK KEBERSIHAN GIGI PADA WARGA KELURAHAN KALIGAWE Praptiningsih, Rahmawati Sri; Feranisa, Anggun
Jurnal Pengabdian Masyarakat DentMas Vol 2, No 2 (2024): Desember 2024
Publisher : Faculty of Dentistry Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/dentmas.2.2.29-33

Background: Dental cavities or caries are ranked first in oral diseases in the world population. In Indonesia, RISKESDAS 2018 data shows that the greatest prevalence of caries is in the age groups of 5 years (93.4%), 12 years (68.8%), 15 years (68.1%), 35-44 years (92.1%) and 65-74 years (95.2%). Dental plaque control can use natural resources that are widely available in Indonesia. However, the proper use of natural materials and adequate knowledge of the advantages and disadvantages of each type of natural resource are very important for the success of dental plaque control in the community.Objective : This community service is to provide education about natural ingredients for dental health as well as the advantages and disadvantages of each ingredient to the Kaligawe Village community and provide education about oral health and the importance of maintaining dental hygiene to maintain oral homeostasis.Method: The methods used to increase community knowledge and awareness are counseling and interactive discussions.Result: The results of this community service include an increase in understanding and community interest.Conclusion: This educational activity has succeeded in increasing the knowledge and awareness of the Kaligawe Village community about the importance of dental hygiene and the use of natural substances.

The Effect Of Soybean Extract Nanoemulgel (Glycine max (L.) Merill) On The Number Of Fibroblasts In The Healing Process Of Traumatc Ulcers (In Vivo Study on White Wistar Rats) Anjani, Fabela Artha; Feranisa, Anggun; Pratiwi, Rosa
Jurnal Medali Vol 7, No 1 (2025): Media Dental Intelektual February 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.1.1-11

Background: Traumatic ulcers are a common oral lesioncharacterized by epithelial damage caused by trauma. They can healspontaneously within 7-10 days but may develop into chronic ulcers ifuntreated. Current treatments like hyaluronic acid gels are effective but costlyand can cause hypersensitivity reactions. This study aimed to analyze the effectof soybean extract (Glycine max (L.) Merill) formulated as a nanoemulgel onfibroblast proliferation during traumatic ulcer healing.Method: An in vivo study using male Wistar rats was conducted. Thirty ratswere divided into five groups: nanoemulgel soybean extract at concentrationsof 50%, 60%, and 70%, a positive control group (hyaluronic acid gel), and anegative control group (gel base). Treatments were applied daily for five days,after which fibroblast proliferation was evaluated histologically. Statisticalanalyses included Shapiro-Wilk, Levene's test, One-Way ANOVA, and Posthoc tests.Results: The 50% nanoemulgel soybean extract group showed the highestfibroblast count among treatment groups, indicating its potential in promotingulcer healing. However, hyaluronic acid gel outperformed other groups.Variability in nanoemulsion preparation likely influenced the fibroblast count.Conclusion: Nanoemulgel soybean extract demonstrates promising effects onfibroblast proliferation in traumatic ulcer healing, particularly at 50%concentration. Despite limitations in preparation, the results highlight itspotential as an alternative to conventional treatments. Further studies shouldoptimize the formulation and assess its toxicity.

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