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All Journal Jurnal Sain Veteriner e-GIGI Medali Jurnal : Media Dental Intelektual Indonesian Journal of Biotechnology ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dentino: Jurnal Kedokteran Gigi Denta: Jurnal Kedokteran Gigi Cakradonya Dental Journal Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas
Anggun Feranisa
Departemen Biologi Oral, Fakultas Kedokteran Gigi, Universitas Islam Sultan Agung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Evaluation of Physical Stability of Phaleria Macrocarpa’s Leaf Extract Formulated in Nanoemulgel Rosa Pratiwi; Anggun Feranisa; Elsa Yuliana Sukmawati
Denta Journal Kedokteran Gigi Vol 17 No 1 (2023): February
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v17i1.2

Abstract

Background: Phaleria macrocarpa’s leaf contains alkaloids, saponins, phenols, tannins, and flavonoids which have antioxidant, anti-inflammatory, and antibacterial activities. The nanoemulgel preparation was chosen because it can penetrate well and quickly into the mucosa thereby increasing absorption. Physical stability tests need to be carried out to ensure the quality, safety and benefits of the gel meet the expected specifications and stable during storage. Objective: This study aims to determine which concentration has the most stable physical stability of pH and viscosity which were observed for 28 days. Materials and Methods: This was an experimental laboratory design, with 30 preparation divided into 3 groups, group of 30%, 40%, and 50% concentration preparation of nanoemulgel leaves of Phaleria macrocarpa. which were tested for pH tests and viscosity tests for 28 days which was observed every 7 days in climatic chamber. The pH and viscosity tests among groups were compared and analyzed by the Repeated Anova and Pos Hoc test. Results: Average pH test and viscosity test 30% concentration with the average baseline and h+28 pH values were 5,02 and 4,97 and the baseline and h+28 viscosity values were 1610 cPas and 1520 cPas. The results of the average concentration of 50% pH value at baseline = 4,65 and h+28 = 4,60. The mean baseline viscosity value=1290 cPas and h+28=1170 cPas. The results of the post-Wilcoxon test showed p>0.05 in the 30% concentration group for pH and viscosity tests showed that there was no significant difference in pH and viscosity values at a concentration of 30%, It means the pH value and viscosity of the 30% concentration preparation of nanoemulgel were relatively constant from baseline to h+28. Conclusion: It can be concluded that the pH and viscosity test of the preparation of nanoemulgel leaves of Phaleria macrocarpa at a concentration of 30% was the most stable pH and viscosity compared to concentrations of 40% and 50%.
Co-Authors Adhiatarika Rismadianti Adisty Restu Poetri Anjani, Fabela Artha Arimurni, Dewa Ayu Arlina Nurhapsari Aulia Rohmania Benni Benyamin Dewi Monica Elsa Yuliana Sukmawati Erna Dwi Agustin Firda Yanuar Syafaat Hilda Ismail, Hilda Indriastanti, Rikha Millania Murtikasari Muchaeroni, Isa Anshori Niken Satuti Nur Handayani Nur Istighfah, Jafifah Mega Nurinaya, Fatati Rahmawati Sri Praptiningsih Recita Indraswary Rizki Amalina Rochman Mujayanto Ronny Martien Rosa Pratiwi, Rosa S. Sismindari Sari, Mona Setiabudi, Deny Shafia, Arina Sheilia Siwi Pranantri Silvi Anggraini Suryono Suryono Trijoko . Yusril Yusuf