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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro
Ainun Rahmasari Gumay, Ainun Rahmasari
Department Of Physiology, Faculty Of Medicine, Diponegoro University, Semarang, Indonesia
Health Professions Medicine & Pharmacology

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The Immunomodulatory Effect of Cinnamon (Cinnamomum Burmanii) Bark Extract On the C-Reactive Protein (CRP) Level, Leukocyte Count and Leukocyte Type Count of Wistar Rats Exposed to Staphylococcus Aureus Utomo, Astika Widy; Retnoningrum, Dwi; Gumay, Ainun Rahmasari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (854.958 KB) | DOI: 10.30659/sainsmed.v11i1.4907

Abstract

Introduction: Bacterial infection induces inflammation in human body. This process produceshumoral and cellular immune responses. Cinnamomum burmaniigrows very vast in Indonesia and contains cinnamaldehyde known to have an anti-inflammatory effect.Objective: To prove the effect of C. burmanii bark extract on CRP level, leukocyte count and differential blood count.Methods: Aposttest-only controlled group design with 25 Wistar Rats divided into 5 groups was employed. The CN-G group was giventhe standard feed, the CP-G group was given the standard feed and levamisole 2.5 mg/KgBW, while the CBE-100, CBE-200, and CBE-400 groups were respectively given the standard feed and cinnamon bark extract 100 mg/kgBW, 200 mg/KgBW and 400 mg/KgBW. The treatmentswereconducted for 7 consecutive days.On day 8, all rats were injected with the suspense of S. aureus intraperitoneally. The blood wasthen drawn on day 9, followed with CRP level measurement using the ELISA method. The total leukocyte count and differential blood count weremanually measured.Results: There is no significant difference in the value of CRP level (One Way ANOVA; p = 0.749) with the total counts of leukocytes(p=0.685), monocytes (p=0.769), and eosinophil(p=0.123) between groups. The neutrophils and lymphocytes of CBE-100 group aresignificantly differentfrom the other groups.Conclusion: C. burmanii extract has a potential benefit as immunomodulator. 
Co-Authors Aprita Hanung Astika Widy Utomo, Astika Widy Bagaskara Yogatama Blezeinsky, Faradilla Nadya Chikita Dian Rahma Saphira Darmawati Ayu Indraswari Edwin Basyar Eka Meyliana Sugeng Erni Erni Eva Susanty Purba Fadiah Annisa Safirah Fanti Saktini Hardian Hardian Irene Andriani Halim Maharani Shofa Yudina Mahardika Budjana Sultan Ilham Muflihatul Muniroh Muflihatul Muniroh Muhammad Mufaiddudin Nurwijayanti Retnoningrum, Dwi Saekhol Bakri, Saekhol Salma Yasmine Azzahara Yuriz Bakhtiar