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EFEK PEMBERIAN EKSTRAK DAUN Carica pubescens TERHADAP JUMLAH LIMFOSIT TIKUS Sprague dawley YANG DIINDUKSI AZOXYMETHANE : STUDI DI LABORATORIUM PENELITIAN DAN PENGUJIAN TERPADU 4 UNIVERSITAS GADJAH MADA Maharani Shofa Yudina; Ainun Rahmasari Gumay; Muflihatul Muniroh
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latarbelakang: Inflamasi merupakan salah satu faktor yang berperan penting dalam patofisiologi kanker kolorektal. Daun Carica pubescens yang mengandung flavonoid berpotensi sebagai agen preventif kanker kolorektal. Tujuan: Mengetahui efek pemberian ekstrak daun Carica pubescens terhadap jumlah limfosit tikus Sprague dawley yang diinduksi azoxymethane. Metode: randomized post test control group design yang menggunakan 25 ekor tikus Sprague dawley jantan. Kontrol normal (K1) diinjeksi NaCl fisiologi. Kontrol sakit (K2) diinjeksi Azoxymethane satu kali seminggu selama dua minggu. Kelompok P1, P2, dan P3 diinjeksi Azoxymethane dan diberi ekstrak daun Carica pubescens dosis 100 mg/kgBB, 200 mg/kgBB, dan 400 mg/kgBB. Untuk analisis data digunakan One-Way Anova dan uji Post-Hoc. Hasil: Jumlah limfosit kelompok K2 (3100/μl±200,00) signifikan lebih tinggi daripada K1 (5460/μl±1647,1; p=0,000). Jumlah limfosit kelompok P1 (3260/μl±746,9) lebih rendah secara signifikan dibandingkan dengan kelompok K2 (p=0,001), P2 (5080/μl±630,0; p=0,004 ) dan P3 (4680/μl±476,4; p=0,020). Kesimpulan: Pemberian ekstrak daun Carica pubescens menyebabkan penurunan jumlah limfosit tikus Sprague dawley yang diinduksi azoxymethane.Kata Kunci: Carica pubescens, limfosit, inflamasi, kanker kolorektal

THE EFFECT OF HONEY PINEAPPLE JUICE (Ananas comosus var. cayenne) ON TOOTH ENAMEL HARDNESS Fadiah Annisa Safirah; Gunawan Wibisono; Ainun Rahmasari Gumay; Muflihatul Muniroh
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: The habit of drinking juice containing high acid in a certain time affects tooth erosion by inducing the dissolvement of enamel hydroxyapatite crystal. Honey pineapple juice is known to have a high acid content and lower pH. However, there have been no reports of honey pineapple juice on tooth enamel hardness. Aim: To determine the effect of honey pineapple juice on tooth enamel hardness. Methods: This study used an experimental laboratory design with a pre- and post-test group design. Twenty-four post extraction maxillary or mandible premolars were divided into 4 treatment groups; where each group was immersed in honey pineapple juice for 30, 60, 90 and 120 minutes. The pH of honey pineapple juice was determined in the early treatment. The hardness test was carried out before and after the treatment using Vickers Hardness Tester with a load of 100 grams for 15 seconds. Data analysis used Wilcoxon and Kruskal Wallis test. Results: The results showed a significant differences in tooth enamel hardness before and after immersion honey pineapple juice for 30 min (p = 0.028), 60 min (p = 0.028), 90 min (p = 0.028), and 120 min (p = 0.046). There was no significant difference in the mean of tooth enamel hardness at each immersion times (p = 0.985). Conclusions: Consumption of honey pineapple juice has an effect on reducing tooth enamel hardness that could be started in a short time consumption.

PENGARUH LATIHAN SKIPPING RUTIN TERHADAP MEMORI JANGKA PENDEK DEWASA MUDA Qonita Nur Qolby; Muflihatul Muniroh; Nani Maharani
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 1 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar Belakang: Skipping merupakan olahraga aerob yang telah dikenal sebagai permainan dalam masyarakat. Olahraga aerob jangka pendek dapat meningkatkan fungsi kognitif, salah satunya memori jangka pendek. Namun demikian, efek rutin atau jangka panjang dari olahraga ini terhadap memori jangka pendek belum pernah diteliti.Tujuan: Mengetahui pengaruh latihan skipping rutin terhadap memori jangka pendek kelompok dewasa muda.Metode: Penelitian quasi eksperimental dengan metode pre-test dan post-test unequivalent group. Subjek penelitian adalah mahasiswa Fakultas Kedokteran Universitas Diponegoro (n=40) berusia 18-22 tahun yang dipilih secara purposive sampling menjadi kelompok perlakuan dan kontrol. Penelitian ini menggunakan Scenery Picture Memory Test untuk pengambilan data memori jangka pendek pre-test dan post-test yang dilanjutkan analisis menggunakan uji t berpasangan, t tidak berpasangan, Wilcoxon dan Mann-Whitney.Hasil: Terdapat peningkatan bermakna pada nilai memori jangka pendek (p=0,000) setelah perlakuan latihan skipping rutin selama 8 minggu, dengan rerata 18,00 ± 3,08 menjadi 21,60 ± 1,67. Peningkatan yang bermakna ini tidak ditemukan pada kelompok kontrol (p=0,189). Rerata selisih pre-test dan post-test nilai memori kelompok perlakuan lebih tinggi dibandingkan kelompok kontrol (p=0,008).Kesimpulan: Latihan skipping rutin dapat meningkatkan fungsi memori jangka pendek pada dewasa muda.

PERBANDINGAN EFEK OLAHRAGA INDOOR DAN OUTDOOR TERHADAP TINGKAT STRES MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS DIPONEGORO Aditya Dwiki Adiono; Yuriz Bakhtiar; Yuswo Supatmo; Muflihatul Muniroh; Titis Hadianti
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar Belakang: Stres merupakan salah satu reaksi atau respons psikologis manusia saat dihadapkan pada hal-hal yang telah melampaui batas untuk dihadapi. Olahraga yang teratur dapat menurunkan insiden dan keparahan gangguan suasana hati yang berkaitan dengan stres. Aktivitas olahraga dapat dilakukan di indoor (dalam ruangan) dan outdoor (luar ruangan).Tujuan: Mengidentifikasi perbedaan antara tingkat stres olahraga indoor ataupun olahraga outdoor.Metode: Penelitian ini adalah penelitian kuasi-eksperimental dengan desain pre-test and post-test sample group design. Sampel penelitian adalah mahasiswa Fakultas Kedokteran Universitas Diponegoro berusia 18-22 tahun (n=40). Dikelompokkan menjadi: kelompok perlakuan olahraga indoor (n=20) yang melakukan olahraga di dalam gedung olahraga dan kelompok perlakuan olahraga outdoor (n=20). Penelitian dilaksanakan selama 6 minggu. Skor tingkat stres diukur sebelum dan sesudah perlakuan menggunakan kuesioner Depression, Anxiety and Stress Scale (DASS-42). Analisis statistik yang digunakan adalah uji t-tidak berpasangan dan uji min rerata.Hasil: Rerata tingkat stres (skor DASS) sebelum dan sesudah perlakuan olahraga indoor mengalami penurunan secara tidak bermakna dari rerata 17,5 menjadi 14,8 (p=0,214). Rerata tingkat stres (skor DASS) sebelum dan sesudah perlakuan olahraga outdoor mengalami penurunan secara bermakna dari rerata 20,2 menjadi 11,2 (p=0,000). Selisih penurunan tingkat stres (skor DASS) sebelum dan sesudah antara kedua kelompok secara statistik tidak bermakna (p=0,095) walaupun kelompok olahraga outdoor didapatkan selisih skor yang lebih tinggi dibanding kelompok olahraga indoor (2,7 vs 9,0).Simpulan: Penurunan skor tingkat stres pada kelompok olahraga outdoor lebih baik dibanding kelompok olahraga indoor tapi tidak bermakna .

PERBEDAAN NILAI ARUS PUNCAK EKSPIRASI SEBELUM DAN SESUDAH LATIHAN SKIPPING PADA DEWASA MUDA Haningtyas Endah Putriani; Endang Ambarwati; Muflihatul Muniroh
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 1 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar Belakang: Fungsi paru dapat ditingkatkan dengan latihan aerobik dan parameter fungsi paru yang mudah digunakan adalah APE (Arus Puncak Ekspirasi). Skipping adalah salah satu contoh latihan aerobik yang mudah dilakukan dengan alat yang sederhana. Skipping tidak tergantung pada cuaca dan waktu sehingga dapat menjadi salah satu alternatif latihan yang cocok untuk diterapkan pada masyarakat terutama dengan rutinitas yang padat.Tujuan: Membuktikan adanya perbedaan nilai APE sebelum dan sesudah latihan skipping pada dewasa muda.Metode: Desain penelitian yang digunakan adalah eksperimental dengan rancangan comparison group pre-test dan post-test design. Subjek penelitian berjumlah 40 mahasiswa Fakultas Kedokteran Universitas Diponegoro yang dipilih secara purposive sampling. Subjek dibagi menjadi kelompok kontrol dan perlakuan, terdiri dari 10 laki-laki dan 10 perempuan pada setiap kelompok. Kelompok perlakuan melakukan latihan skipping 3 kali perminggu selama 8 minggu sementara kelompok kontrol melakukan aktivitas sehari-hari seperti biasa. APE diukur dengan menggunakan mini wright peak flow meter. Analisis statistik menggunakan uji t berpasangan untuk menganalisis APE sebelum dan sesudah latihan skipping, uji Wilcoxon untuk menganalisis perbedaan APE pada kelompok kontrol, serta uji Mann-Whitney untuk menganalisis selisih APE antar kelompok dan antar jenis kelamin.Hasil: Terdapat peningkatan APE yang bermakna (p=0.000) setelah melakukan latihan skipping dan perbedaan APE yang bermakna jika dibandingkan dengan kelompok kontrol (p=0.000). Peningkatan APE kelompok perlakuan pada laki-laki lebih besar dibandingkan dengan perempuan (p=0.538).Kesimpulan: Latihan skipping meningkatkan APE pada dewasa muda.

HUBUNGAN PENGETAHUAN, DUKUNGAN KELUARGA SERTA PERILAKU PENDERITA DIABETES MELITUS TIPE 2 TERHADAP KEJADIAN ULKUS KAKI DIABETES (Studi di Wilayah Kerja Puskesmas Ngesrep Semarang) Yunita Amilia; Lintang Dian Saraswati; Muflihatul Muniroh; Ari Udiyono
Jurnal Kesehatan Masyarakat (Undip) Vol 6, No 1 (2018): JANUARI
Publisher : Fakultas Kesehatan Masyarakat Universitas Diponegoro

The occurence of type 2 diabetes mellitus is one type of disease that continues to increase the number of sufferers. One of the most feared DM complications is diabetic foot ulcers. Diabetic foot ulcers are more common in people with type 2 diabetes mellitus. Diabetic foot ulcers can affect mental and physical health, but it also affects the quality of life. The purpose of this study was to determine the correlation between knowledge, family support and the behavior of diabetic mellitus patients type 2 diabetes against occurence of diabetic foot ulcers. This research uses tye analytic observation research type with cross-sectional study design with qualitative data analysis using Chi-Square test and simple random sampling method. The number of male and female respondents are 80 with aged 38-81 years who meet the entry criteria as research subjects. . Based on the result of bivariate analysis with chi-square test proved the relation between BMI (body mass index) (p = 0,02, POR = 0,235; 95% CI 0,074-0,741), behavior (p = 0,002; POR = 6,943; 95% CI 2,099-22,964), family support (p = 0.012; POR = 4,592; 95% CI 1,451-14,529); and knowledge (p = 0,004; POR = 6,111; 95% CI 1,828-20,434) with diabetic foot ulcers. While between age, sex, type of work, education level, family DM history, long suffering from DM, and smoking status is not related with the occurrence of diabetic foot ulcers. From this research can be concluded that the factors that influence the occurrence of diabetic foot ulcers are BMI (body mass index), behavior, family support and knowledge.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KADAR GULA DARAH PADA PENDERITA DIABETES MELITUS TIPE 2 DI RSUD K.R.M.T WONGSONEGORO SEMARANG Berkat Br Nababan; Lintang Dian Saraswati; Muflihatul Muniroh
Jurnal Kesehatan Masyarakat (Undip) Vol 6, No 1 (2018): JANUARI
Publisher : Fakultas Kesehatan Masyarakat Universitas Diponegoro

Indonesia with a growth of 152% or from 8.426.000 people in 2000 to 21.257.000 people in 2030. The proportion of cases of Type 2 DM in Semarang City Hospital in 2014 amounted to 1.83 percent and in 2015 3.22 percent of all Hospital in Semarang City . The purpose of this study to determine the factors associated with blood sugar levels in patients with Diabetes Mellitus type 2 in RSUD KRMT Wongsonegoro Semarang. The method of this research is analytic observational with cross sectional approach. This research is done by observation and interview method. The sampling technique used in this research is random sampling technique. The result of bivariate analysis showed that there was no significant correlation between food intake (p = 0,765), drug intake (p = 0,731), physical activity (p = 1,000), stress level (p = 0,094 ), family support (p = 0,453), and smoking status (p = 0,459) with blood glucose level in Type 2 DM patient. So, it can be concluded that nothing related to blood sugar level.

GAMBARAN KUALITAS TIDUR PADA PENDERITA DIABETES MELITUS TIPE-2 DI WILAYAH KERJA PUSKESMAS NGESREP Tri Damayanti Simanjutak; Lintang Dian Saraswati; Muflihatul Muniroh
Jurnal Kesehatan Masyarakat (Undip) Vol 6, No 1 (2018): JANUARI
Publisher : Fakultas Kesehatan Masyarakat Universitas Diponegoro

Diabetes Mellitus type-2 is a condition when hyperinsulinemia happened but insulin could not bring glucose entering the tissues due to insulin resistance. Clinical symptoms experienced by patients with type-2 diabetes at night can reduce sleep quality. Puskesmas Ngesrep is a health center with the highest proportion of diabetes mellitus type 2 cases compared to other community health centers in Semarang city with percentage around 52.15%. This study aims to describe the quality of sleep in people with diabetes mellitus type 2 in the working area of Puskesmas Ngesrep. The Study design used is cross-sectional with 80 randomly selected samples which is assisted by sample frame listing. The result shows around 56,2% of people with diabetes mellitus type-2 have a bad sleep quality. People with age ≥ 60 years, work in shifts, smokers, and with BMI ≥ 30 Kg/m2, has a worse sleep quality. The people which use lights and cotton filled mattress even has worse sleep quality. Uncontrollable blood sugar level and high level of stress has stronger tendency to have bad quality of sleep. From this study, we can conclude that the sleep quality of people with type-2 diabetes in working area of Puskesmas Ngesrep is bad.

Association Between Stunting and Anemia Among Toddlers: Stratified by Characteristic of Family and Immunization Status in Mlonggo District, Jepara Regency Arwinda Nugraheni; Muflihatul Muniroh; Yora Nindita; Firdaus Wahyudi; Bambang Hariyana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i4.38561

Background: The risk of anemia in stunted toddlers is higher than in normal toddlers. There is limited research on anemia in children under 3 years old in the community and there is a need for supporting research to prove the possibility of controlling stunting and anemia together. Previous studies have shown that family characteristics and immunization status are associated with the stunting and anemia.Objective: This study aims to analyze the association between anemia and stunting in toddlers that are stratified by characteristics of family and Immunization status.Methods: This study used a cross-sectional design study and was conducted on September-October 2020 in the Mlonggo District, Jepara Regency. One hundred two respondents were selected by cluster random sampling technique. The questionnaire was applied to collect the data on stunting, anemia, immunization status, age, mother's occupation and education status, SCREEM score, and APGAR score. This study used the Chi-Square statistic test.Results: The anemia status was measured by the Hb meter. The characteristics of stunting status (stunting = 17.7%, no stunting= 82.3%), anemia status (Yes = 63.7%, No = 36.3%). The association between stunting and anemia was stratified by the child age (6-23 months) (PR=1.667; 95%; CI=1.103-2.519; P=0.123), employed mother (PR=1.593; 95%CI=1.265-2.005; P=0.154), incomplete and inappropriate immunization status (PR=1.636; 95%CI= 1.132-2.366; P=0.133) and highly internal family function; (PR=1.512; 95% CI=1.270-1.799; P=0.029).Conclusion: There was an association between stunting and anemia in toddlers from child age of 6-23 months, employed mother, incomplete and inappropriate immunization, and highly family function groups.

Analisis Faktor-Faktor yang mempengaruhi Ambulasi Dini Post ORIF pada Pasien Fraktur Femur Study Retrospektif Giat Wantoro; Muflihatul Muniroh; Henni Kusuma
Jurnal Akademika Baiturrahim Jambi Vol. 9 No. 2 (2020): September
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v9i2.273

Femur fracture is a loss of continuity of the femur, which can be caused by direct trauma to the thigh or pathological factors. The main treatment for fractures is ORIF. Implementation of early ambulation is important to prevent post ORIF complications. Objective: This study aims to analyze the factors that influence early ambulation post ORIF in femoral fracture patients. Methods: The study design was a cross-sectional retrospective approach with 82 respondents and data collection using medical record data. The independent variables are education, sex, age, hemoglobin, temperature, blood pressure, pain, fracture location, and time span of operation while the dependent variable is early ambulation. The test used in multivariate is logistic regression test. Results and discussion: Research shows education (p = 0,000), gender (p = 0.028), age (p = 0,000), Hb (p = 0.029), pain (p = 0.001), and location of the fracture (p = 0.007) , is an influential factor. The multivariate model found the fracture location to be the most influencing factor in post ORIF early ambulation in femur fracture patients with p = 0.023 and an OR value of 2.140. Conclusion: This study recommends that nurses first examine the factors that influence early ambulation, especially fracture location factors before providing post ORIF early ambulation interventions in femur fracture patients

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