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All Journal Jurnal Gizi dan Pangan SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Indonesian Journal of Cardiology Amerta Nutrition Indonesian Journal of Pharmacology and Therapy
Astika Widy Utomo, Astika Widy
Department Of Pharmacology And Therapeutic, Faculty Of Medicine Diponegoro University, Semarang, Indonesia
Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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UBI JALAR UNGU GORENG ATAU KUKUS DOSIS BERTINGKAT TERHADAP GULA DARAH TIKUS WISTAR Matondang, Asri Rizqi; Tarigan, Clara Vica Rudangta; Sihombing, Maria Anna; Defie, Rhory; Siringoringo, Ester Theresia; Utomo, Astika Widy
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.752 KB) | DOI: 10.14710/dmj.v6i2.18565

Abstract

Indonesia merupakan negara keempat yang memiliki jumlah penderita diabetes melitus (DM) terbanyak di dunia. Salah satu yang terpenting bagi penderita DM adalah pengendalian kadar glukosa darah. Ubi jalar ungu merupakan salah satu jenis umbi-umbian yang memiliki indeks glikemik yang lebih rendah sehingga tidak meningkatkan glukosa darah secara signifikan dan juga karena adanya antosianin yang memiliki manfaat untuk menurunkan kadar gula darah yang kadarnya dapat bergantung dari cara pengolahannya. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ubi jalar ungu yang dikukus dan digoreng terhadap kadar gula darah tikus wistar. Penelitian eksperimental dilakukan pada bulan April hingga Mei 2017 di Laboratorium Hewan Coba Fakultas Kedokteran Undip. Pemilihan sampel diperoleh secara random sampling. Sebelum diberi perlakuan terlebih dahulu tikus diinjeksi aloksan monohidrat lalu perlakuan diberikan selama empat minggu. Pengukuran gula darah dilakukan setiap akhir minggu. Analisis data menggunakan Post-hoc Mann-whitney dengan nilai signifikansi p<0,05. Didapatkan hasil yang signifikan di minggu ke-2, ke-3, dan ke-4 pada kelompok kukus 13,5 gram/kgBB dan juga di minggu ke-2 dan ke-3 pada kelompok goreng 6,75 gram/kgBB. Dengan demikian, pengolahan yang berbeda memberikan dosis optimal yang juga berbeda terhadap kadar gula darah tikus wistar.
Utilization of banana (Musa paradisiaca L.) peel as pectin source as antidiarrheal on castor oil-induced diarrheal Wistar rats model Martin Adhitya Subagio; Cecilia Noviyanti Salim; Qorina Putri Srisantoso; Yora Nindita; Astika Widy Utomo; Nani Maharani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.066 KB) | DOI: 10.19106/JMedSci005202202001

Abstract

Banana (Musa paradisiaca L.) peel, locally name pisang raja, contains a high concentration of pectin which is used as antidiarrheal to absorb irritants and increase stool consistency. However, it’s use to increase the stool consistency has not been studied, yet. The study aimed to investigate the effect banana peel extract (BPE) administration on stool consistency of diarrheal rat model. It was an experimental study with a post-test only control group design. Thirty male Wistar rats were induced diarrhea with castor oil and then randomized into five groups. Group I as positive control group was given attapulgite at dose of 124 mg/kg BW. Group II as negative control was given 0.5 mL of 1% tween 80. Group III, IV and V as treatment group were give BPE at different doses of 100, 200 and 400 mg/kg BW, respectively.T he stool consistency was measured every hour for 4 h by weighing fresh and dry stool weight and then the water content was calculated. Data analysis was conducted using one-way ANOVA and LSD post hoc test. Significantly different in stool consistency between Group III, IV, and V compared to Group II (p<0.05) and between groups Group III and IV compare to Group I (p<0.05) were observed. However, there was no significantly different between group V compared to Group I (p=0.149).In conclusion, BPE can increase the stool consistency of castor oil-induced diarrhea rats. The BPE at the dose of 400 mg/kg BW has similar effect to attapulgite.
DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN Wafi Banadzir Resya; Novi Kusumaningrum; Santoso Jaeri; Astika Widy Utomo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30029

Abstract

Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous gland of the skin which can cause depression and anxiety. IL-23 is a cytokine that is involved in autoimmune diseases, including acne vulgaris. IL-23 affects the differentiation process of Th17 which further produces IL-17, an important component in the pathogenesis of acne vulgaris. IL-17 plays a significant role in the grade of skin damage caused by the inflammation process.Objective: To find out differences in IL-23 serum levels and the grade of AV severity in women.Methods: An observational study with a cross-sectional design approach conducted from June until October 2020 in 15 women with AV aged 15-25 years old, not consuming anti-inflammatory drugs, antibiotics, retinoid group of drugs and free from other inflammatory diseases. Subjects were divided into three groups based on the AV severity grade: specifically mild (n=5), moderate (n=5) and severe (n=5). Subjects had venous blood taken for IL-23 serum content by the ELISA method. Data on IL-23 serum content in the three groups were tested using the One-Way ANOVA method to determine the differenceResults: Average age from the 3 groups was 21 (17-23 ) years old. The results showed that there is no significant difference in IL-23 rate from the 3 groups of AV severities (p=0,490).Conclusion: : There is no significant difference of IP-23 rate between the 3 groups of AV severites in women. 
The effect of chronic usage of Renin-Angiotensin-Aldosterone System Blocking Agents on Incidence of Contrast-Induced Nephropathy in patients with Diabetes Mellitus and Renal Insufficiency. A Restropesctive Cohort Study astika widy utomo; dwi aris agung nugrahaningsih; iwan dwiprahasto
Jurnal Kardiologi Indonesia Vol 40 No 1 (2019): Indonesian Journal of Cardiology: January-March 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i1.920

Abstract

Background: This study was to investigate the effect of long term use of Renin-Angiotensin-Aldosterone System(RAAS) blocking agents on the incidence of Contrast-Induced Nephropathy(CIN) on patients with Diabetes Mellitus(DM) and renal insufficiency underwent Percutaneous Coronary Intervention (PCI). Methods:A total 281 of subjects were included in this study and divided into two groups based on prior use of RAAS blocking agents (RAAS +, n = 146; RAAS -, n = 135). CIN was defined as an increase of ≥25% in creatinin over baseline value 48-72 hours after PCI. Result: Total incidence of CIN was 14,95%. There was no difference in the incidence of CIN between 2 study groups (p = 0,952) and relatif risk for CIN was 1,02. Left Ventricular ejection Fraction (LVEF) ≤ 40 % (OR 2,300; 95% CI 1,028 – 5,143; p = 0,043), anemia (OR 2,628; 95% CI 1,274 – 5,422; p = 0,009) and Glomerular Filtration rate (GFR) pre PCI ≤ 60 mL/menit (OR 2,782; 95% CI 1,293 – 5,987; p = 0,009) were important predictors of CIN. Conclusion: Long term use of RAAS blocking agents do not increase the incidence of CIN on patients with DM and renal insufficiency underwent PCI.
Acute Toxicity Test of Soursop Leaves (Annona muricata) on Liver and Kidney of Switzerland Mice Utomo, Astika Widy; Susilaningsih, Neni; Armalina, Desy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.764 KB) | DOI: 10.30659/sainsmed.v6i2.600

Abstract

Introduction: The soursoup leaves extract (Annona muricata) has widely been used as traditional medicine for cancer. No studies have been conduct to investigate the safety of the extract. Objectives: The purpose of the study was to investigate the acute oral toxicity test of soursoup leaves extract (Annona muricata) on Swiss mice’s liver and kidney.Methods: Twenty four mice were divided into 4 groups. Group I was control group, while group II-IV was given soursoup leaves extract as single dose orally via sonde. The mice were obsereved until day 7 to determine the LD50 and at the end were terminated to collect the liver and kidney. The organs later were made into histopathology slides. The slides read with light microscope. The data analyzed with ANOVA and was considered significant at p<0.05.Results: All mice were alive during the 7 days observation and no mice showing the toxic spectrum after the dosing. Microscopically, no damage on the liver and kidney organ among the groups.Conclusion: The LD50 of soursoup leaves extract is more than 2000 mg/kgBW. This result indicate that the extract is practically non toxic and do not damage the liver and kidney.
The Effect of Green Tea Leaf Extract on Spatial Memory Function and Superoxyde Dismutase Enzyme Activity in Mice with D-galactose Induced Dimentia Gumay, Ainun Rahmasari; Bakri, Saekhol; Utomo, Astika Widy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): June 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.137 KB) | DOI: 10.30659/sainsmed.v8i1.1050

Abstract

Background: Oxidative stress and inflammation play an important role in pathogenesis of brain aging and neurodegenerative diseases such as Alzheimer. Green tea has been shown to have antioxidant, anti-inflammatory, anticancer, and neuroprotective activity.Objectives: to determine the effect of green tea extract on spatial memory function and superoxide dismutase enzyme activity in mice with D-galactose induced dementiaMethods: An experimental study using "post test only control group design". Twenty male BALB/c Mice aged 6-8 weeks were divided into 4 groups. Negative control group (NG) was induced by subcutaneous injection of D-galactose (150 mg/kg BW) once daily for 6 weeks. GT-90, GT-270, GT-540 were induced by D-galactose and orally administered with 90, 270, and 540 mg/kg BW of green tea extract once daily for 6 weeks. The spatial memory functions were assessed using Morris water maze and SOD enzyme activities were evaluated using ELISA. One-way Anova and Kruskal-Wallis were used for statistical analysis. Results: mean percentage of latency time in the GT-90 (35.29 (SD= 2.69)%), GT-270 (35.28 (SD= 2.62)%), and GT-540 (35.62 (SD=5.05)%) were significantly higher compared to that of NG (20.38 (SD = 3.21)%), p <0.05). SOD enzyme activity in the GT-270 (0.78 (SD = 0.07) U/ml) was significantly higher compared to that of NG (0.51 (SD = 0.01) U ml), p= 0.004).Conclusion: Green tea extract may improve spatial memory function and the activity of superoxide dismutase enzyme in mice with D-galactose induced dementia.
Effect of Mangosteen Peel Extract on SGOT and SGPT in Rats Fed Reused Cooking Oil Widyastuti, Esti; Maharani, Nani; Utomo, Astika Widy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): December 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (995.324 KB) | DOI: 10.30659/sainsmed.v9i2.2286

Abstract

Background: Free radicals that enter the body due to consumption of reused cooking oil can cause liver cell damage. Mangosteen peel extract (Garcinia mangostana L) is known to contain mangostin as an ntioxidant. However, it is not known whether it can repair liver damage.Objective: To deter mine the ef fect of mangosteen peel extract on the levels of SGOT and SGPT of Wistar rats fed with reused cooking oil.the ef fect of mangosteen peel extract on the levels of SGOT and SGPT of Wistar rats fed with reused cooking oil.Methods: This study was a tr ue experimental study with post-test only controlled group design. Twenty four male Wistar rats were randomly divided into 4 groups randomly. The CN-G group was given the standard diet, the MJ-G group was given a standard diet and cooking oil, the MJM- 400 group was given standard diet, reused cooking oil, and mangosteen peel extract at a dose of 400 mg/KgBW, and the MJM-800 group was fed with a standard, reused cooking oil, and mangosteen peel extract at 800mg/KgBW. The treatment was car ried out for 28 days, and then continued with examination of reused cooking oil, and mangosteen peel extract at 800mg/KgBW. The treatment was car ried out for 28 days, and then continued with examination of SGOT and SGPT levels using the Inter national Federation of Clinical Chemistr y (IFCC) method without Pyridoxal Phosphate 37ºC.Results: Kr uskal Walis test showed that SGOT and SGPT levels showed no signif icant dif ferences between groups (p = 0.197 and 0.063, respectively).Conclusion: administration of mangosteen (Garcinia mangostana L) peel extract did not af fect SGOT levels, even tended to increase SGPT levels in ratsinduced by cooking oil.
The Immunomodulatory Effect of Cinnamon (Cinnamomum Burmanii) Bark Extract On the C-Reactive Protein (CRP) Level, Leukocyte Count and Leukocyte Type Count of Wistar Rats Exposed to Staphylococcus Aureus Utomo, Astika Widy; Retnoningrum, Dwi; Gumay, Ainun Rahmasari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (854.958 KB) | DOI: 10.30659/sainsmed.v11i1.4907

Abstract

Introduction: Bacterial infection induces inflammation in human body. This process produceshumoral and cellular immune responses. Cinnamomum burmaniigrows very vast in Indonesia and contains cinnamaldehyde known to have an anti-inflammatory effect.Objective: To prove the effect of C. burmanii bark extract on CRP level, leukocyte count and differential blood count.Methods: Aposttest-only controlled group design with 25 Wistar Rats divided into 5 groups was employed. The CN-G group was giventhe standard feed, the CP-G group was given the standard feed and levamisole 2.5 mg/KgBW, while the CBE-100, CBE-200, and CBE-400 groups were respectively given the standard feed and cinnamon bark extract 100 mg/kgBW, 200 mg/KgBW and 400 mg/KgBW. The treatmentswereconducted for 7 consecutive days.On day 8, all rats were injected with the suspense of S. aureus intraperitoneally. The blood wasthen drawn on day 9, followed with CRP level measurement using the ELISA method. The total leukocyte count and differential blood count weremanually measured.Results: There is no significant difference in the value of CRP level (One Way ANOVA; p = 0.749) with the total counts of leukocytes(p=0.685), monocytes (p=0.769), and eosinophil(p=0.123) between groups. The neutrophils and lymphocytes of CBE-100 group aresignificantly differentfrom the other groups.Conclusion: C. burmanii extract has a potential benefit as immunomodulator. 
The use of herbal medicines in patients with type-2 diabetes mellitus in Indonesia Utomo, Astika Widy; Annisaa, Eva; Antari, Arlita Leniseptaria; Armalina, Desy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (866.994 KB) | DOI: 10.30659/sainsmed.v13i1.13487

Abstract

In Indonesia, the use of herbal medicine as an alternative medicine is increasing. Herbal remedies are used as complementary medicine and self-medication. Diabetes mellitus requires treatment over the long term. This may contribute to the medication adherence problem. Consequently, many patients seek alternative treatments, such as herbal medications. The purpose of this study was to determine the use and type of herbal medicines among diabetic patients in Indonesia. A cross-sectional study with 190 respondents selected at random from multiple cities in Indonesia. A questionnaire was used to determine the most frequently used herbal medicine, the demographic profile of the patients, the health services, and the level of patient satisfaction with the use of herbal medicines. The participants were predominantly female (62.7%), housewives (39.5%), aged between 40 and 65 (84.5%), high school graduates (74.7%), and had low to moderate incomes (74.7%). The use of herbal medicine was 22%, and the combination of herbal medicine and prescription medication was 6%. Bitter leaves (10%), mangosteen peel (8.9%), insulin leaves (7.9%), mahkota dewa herbs (6.3%), and bitter melon are used as herbal or traditional medicines (4.7%). In terms of satisfaction, 28.7%, 40.9%, and 14.4% of respondents were quite satisfied, satisfied, and very satisfied with the use of herbal medicines, respectively. Herbal remedies are commonly used in alternative diabetes treatments. Bitter leaves are the most frequently used herb, with over half of respondents expressing satisfaction with the benefits of herbal medicine.
Healthcarepreneurship Training on Making Antibacterial Liquid Soap (Hand Soap) Made From Hibiscus rosa sinensis L. Extracts Antari, Arlita Leniseptaria; Saraswati, Indah; Annisaa, Eva; Utomo, Astika Widy; Ekawati, Nuraini; Kurniasari, Teny
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 2 (2024): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.89565

Abstract

Healthcare is one of the critical elements of infection prevention and control, one of which can be done by maintaining hand hygiene. Hand washing with soap and flowing water has long been considered a parameter of personal hygiene and is a simple way to reduce the transmission of infections, especially those caused by hand contact between individuals. However, it must still be done by paying attention to the time and the correct way to wash hands according to WHO standards. At this time, various hand soap products have emerged but are not antibacterial. Antibacterial ingredients used as soap base should not contain various kinds of chemicals that are harmful to the health of its users. Therefore, the use of natural ingredients can be an alternative to substitute chemical active substances. One that has been tested for its antibacterial properties is hibiscus flower (Hibiscus rosa sinensis L.). This activity began with presenting the results of the screening on hand washing habits carried out 2 weeks earlier. The next activity is the introduction to making antibacterial hand soap made from hibiscus extract through material presentation and empirical evidence of the potential of hibiscus as an antibacterial, as well as videos about the importance of maintaining hand hygiene through proper hand washing regularly. The activity is expected to make the healthcare UMKM know and understand that hibiscus flowers, which are widely available around their residence, can be used as raw material for making hand soap that has been produced so far, so as to minimize the use of chemical-based antibacterials. The hand soap product produced later became a collaborative product produced by the community, and then registered a patent with the number S00202120213 on November 17th, 2021.
Co-Authors Ahmad Syauqy Ainun Rahmasari Gumay, Ainun Rahmasari Antari, Arlita Leniseptaria Azizah, Arfianty Nur Batubara, Astriana Marta Binar Panunggal Cecilia Noviyanti Salim Defie, Rhory Desy Armalina Dwi Aris Agung Nugrahaningsih Ekawati, Nuraini Eva Annisaa Faradina, Amelia Haris, Nadia Husna Indah Saraswati Iwan Dwiprahasto Kurniasari, Teny Kurniawan, Muhammad Farhan Maharani, Mutiara Irma MARTHA ARDIARIA Martin Adhitya Subagio Masha, Tania Matondang, Asri Rizqi Nadia Husna Haris Nani Maharani Naufal, Haidar Satya Neni Susilaningsih Novi Kusumaningrum Nugroho, Trilaksana Nyoman Suci Widyastiti Qorina Putri Srisantoso Rachma Purwanti Retnoningrum, Dwi Saekhol Bakri, Saekhol Santoso Jaeri Saputra, Taufik Sihombing, Maria Anna Siringoringo, Ester Theresia Tarigan, Clara Vica Rudangta Trilaksana Nugroho Tsani, A. Fahmy Arif Wafi Banadzir Resya Widyastuti, Esti Yanti Ernalia Yora Nindita Yora Nindita Zulfa, Fairuz