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All Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Ilmiah Kedokteran Wijaya Kusuma Journal of Dentomaxillofacial Science Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Abdi Masyarakat Indonesia

Jenny Sunariani

Department Of Oral Biology, Faculty Of Dental Medicine, Universitas Airlangga

Author-ID : 3196457

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Medicine & Pharmacology Public Health

Published : 12 Documents Claim Missing Document

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Changes of the sweet taste sensitivity due to aerobic physical exercise Ni Luh Putu Ayu Wardhani; Anis Irmawati; Jenny Sunariani
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 1 (2011): March 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Sweet taste is a pleasant sensation. Sweet taste is mostly consumed and fancied by many people. Physiologically, glucose is body's source of energy, but if over used it can be affected to the body's metabolism. This can be worsen if the person's not doing a healthy lifestyle. One way to implement a healthy lifestyle is by doing physical exercises. Purpose: The aim of this study was to determine changes in sensory sensitivity of sweet taste due to aerobic physical exercise. Methods: This study was conducted on subjects aged 20 to 30 years. The subjects did aerobic exercise using 80% load of MHR. The measurement sensitivity of the senses of the sweet taste was done for three times before the subject take aerobic physical exercise, four weeks after doing aerobic physical exercise, and eight weeks after doing aerobic physical exercise. Results: There was significant difference towards sensitivity of sweet taste sense before doing aerobic physical exercise, 4 week after doing the aerobic physical exercise, and 8 week after doing aerobic physical exercise. Conclusion: Aerobic physical exercise during eight weeks increase sweet taste sensitivity.Latar belakang: Rasa manis memberikan sensasi yang menyenangkan. Rasa manis merupakan jenis rasa yang paling banyak dikonsumsi dan disukai oleh sekelompok orang. Secara fisiologis, glukosa bisa berperan sebagai sumber energi, namun apabila dikonsumsi secara berlebihan dapat menimbulkan efek patologis. Hal ini dihubungkan dengan individu yang mempunyai gaya hidup yang tidak sehat. Salah satu cara yang bisa dilakukan untuk membiasakan gaya hidup sehat adalah dengan latihan fisik (olah raga). Tujuan: Penelitian ini bertujuan untuk membuktikan adanya perubahan sensitivitas indera kecap rasa manis setelah melakukan latihan fisik aerobik. Metode: Penelitian ini melibatkan subyek laki-laki, berusia 20–30 tahun. Subjek melakukan latihan fisik aerobik dengan intensitas sebesar 80% maximal heart rate. Sensitivitas indera kecap rasa manis diukur 3 kali, yaitu sebelum melakukan latihan fisik aerobik, dan 4 serta 8 minggu setelah latihan fisik aerobik. Hasil: Terdapat perbedaan yang signifikan pada sensitivitas indera kecap rasa manis sebelum 4 dan 8 minggu sesudah latihan fisik aerobik. Kesimpulan: Latihan fisik aerobik selama 8 minggu menyebabkan peningkatan sensitivitas indera kecap rasa manis.

Effect of IL-1 and gustducin expression change on bitter taste during fever Jenny Sunariani
Dental Journal (Majalah Kedokteran Gigi) Vol. 41 No. 2 (2008): June 2008
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Homeostatic changes in the body, such as fever, cause inflammation, whose one of its impacts is the sense of bitterness inside the mouth. It implies in the reduction of appetite, which may finally result in the reduction of physical condition due to the inadequacy of food intake. It causes the inhibition of healing process, which reduces working productivity. The objective of this study was to identify the mechanism of bitterness due to inflammation, as proved locally in the taste buds of Wistar rats. This study was carried out experimentally using post-test only control design in experimental animals of male Wistar strain Rattus norvegicus. The animals were divided into two groups. First group served as control, while the second group received treatment with Salmonella typhimurium 0.5 ml/kg BW. Blood sample and tongue incision were taken from the animals. IL-1 was counted, and tongue incision was used for immunohistochemical staining for the variables of gustducin. Data were analyzed using Kolmogorov-Smirnov test for data normality, and followed with comparative test. The discriminant analysis was also done to find the discriminant variable. It was found that there was an increase of biological response of signaling transduction of bitterness in taste buds, as indicated from the increase of gustducin in treatment group or in inflammatory fever condition as compared to control group (p < 0.05), but no change of concertation at IL-1 significan whenever there was any change of concertation by unfolding its mechanism. Further studies can be recommended to find the way to inhibit this sense of bitterness. The results are intended to overcome homeostatic disorder in the body to prevent loss of appetite, so that physical endurance can be maintained. It concluded that there is no increase of serum IL-1 expression in fever, but there is a significanly increase of taste buds gustducin. Further studies should focus on gustducin cellular role in other factors that play a role in taste buds signal transduction, either in homeostatic condition or in the condition of homeostatic disorder.

The effect of Hegu acupoint stimulation in dental acupuncture analgesia Fransiskus Andrianto; Jenny Sunariani; Theresia Indah Budhy S
Dental Journal (Majalah Kedokteran Gigi) Vol. 40 No. 1 (2007): March 2007
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

In daily life, dental treatments are often related with oral pain sensation which needs anesthesia procedures. Sometimes local anesthetics can not be used because patients have hypersensitive reaction or systemic diseases which may lead to complications. Stimulating acupoint, such as Hegu activates hypothalamus and pituitary gland to release endogenous opioid peptide substances that reduce pain sensitivity. The aim of the study was to determine Hegu acupoint stimulation effect on the pain sensitivity reduction in maxillary central incisor gingiva. The laboratory experimental research was conducted on 12 healthy male Wistar rats (3 months old, weights 150–200 grams). All rat samples received the same treatments and adapted within 1 month. The research was done in pre and post test control group design. 40-Volt electro-stimulation was done once on the maxillary central incisor gingiva prior to the bilateral Hegu acupoint stimulation, then followed by 3 times electro-stimulation with 3 minutes intervals. The pain scores were obtained based on the samples’ contraction in each electro-stimulation. The responses were categorized into 5 pain scores and statistically analyzed using Wilcoxon Test. The results showed that Hegu acupoint stimulation lowered the pain scores significantly (p < 0.05). Hegu acupoint stimulation could reduce the pain sensitivity in maxillary central incisor gingiva. Therefore, the use of acupuncture analgesia in dental pain management can be considered in the future.

Changes in taste sensation of sour, salty, sweet, bitter, umami, and spicy, as well as levels of malondialdehyde serum in radiographers Agniz Nur Aulia; Jenny Sunariani; Ester Arijani Rachmat
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 2 (2016): June 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Radiation used for any purpose certainly contains potential danger to humans. Radiographers are given a task, authority, and responsibility by the competent authority to conduct radiography and imaging in health services unit. Some researcheson the effects of radiation on cancer patients show that radiation can cause an increase in bitterness and metal taste [in cancer patients] leading to discomfort in the oral cavity. In body, free radicals then can cause lipid peroxidation process. Lipid peroxidation is an oxidative destruction of polyunsaturated fatty acid producing malondialdehyde (MDA). Purpose: This study aimed to determine the effects of radiation on changes in the taste sensation of sour, salty, sweet, bitter, umami, and spicy as well as the levels of MDA serum in radiographers. Method: This study was an observational laboratory research using post- test control design. Samples were selected using simple random sampling technique. The samples were seven radiographers who have been working for five years in the laboratory and radiographic units in Surabaya. Result: Based on the results of statistical tests, it showed that there were no differences in the sensitivity of all tastes between the groups tested. Moreover, the results also depicted considerable value for the sour taste was 0.550, the saltiness was 0.775, the sweetness was 0.294, the bitter taste was 0.065, the umami taste was 0.705, and the spicy taste was 0.319 (p>0.05). However, the dramatic increase was higlighted in levels of MDA serum with a significant value of 0.065 (p>0.005). Conclusion. There were no changes in the sensitivity of sour, salty, sweet, bitter, umami, and spicy tastes, but there was a significant increased in level of MDA serum in the radiographers compared to the control group.

The decrease of fibroblasts and fibroblast growth factor-2 expressions as a result of X-ray irradiation on the tooth extraction socket in Rattus novergicus Fatma Yasmin Mahdani; Intan Nirwana; Jenny Sunariani
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 2 (2015): June 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Wound healing involves cellular, molecular, physiological, and biochemical processes as responses to tissue damage. For instance, when a failure during tooth extraction occurs, radiographic examination, X-rays, is required. X-rays as an enforcer diagnosis can damage DNA chain, resulting in cell death and inhibition of wound healing process. Purpose: This research aims to analyze fibroblasts cell number and fibroblast growth factor-2 (FGF-2) expressions during wound healing process after tooth extraction as a result of X-ray irradiation. Methods: There were three research groups, each consisting of ten rats. Incisor tooth extraction was performed on the left lower jaw, and then X-ray examination was conducted at certain irradiation doses, namely 0 mSv, 0.08 mSv, and 0.16 mSv. Those animals were sacrificed on day 3, and on day 7 after the extraction, histopathology and immunohistochemistry examinations were conducted to determine fibroblast cell number and FGF-2 expressions. Data obtained were then analyzed by oneway ANOVA and Tukey HSD tests. Results: The number of fibroblasts decreased significantly in the group with the irradiation dose of 0.16 mSv applied on day 7 after the extraction (p <0.05). Similarly, the number of FGF-2 expressions decreased significantly in the group with the irradiation dose of 0.16 mSv applied on days 3 and 7 after the extraction (p <0.05). Conclusion: X-ray irradiation at a dose of 0.16 mSv can inhibit the healing process of tooth extraction wound due to the decreasing of fibroblasts cell number and FGF-2 expressions.

VEGF expression and new blood vessel after dental X-ray irradiation on fractured tooth extraction wound Niluh Ringga Woroprobosari; Jenny Sunariani; Eha Renwi Astuti
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 3 (2015): September 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background:Dental X-ray has an important role in dentistry. Complication case such as tooth fracture extraction requires this examination to determine the appropriate treatment measures. Dental X-ray can also cause a negative impact to the body at cellular and even molecular level. Purpose: The aim of this study was to evaluate the decrease of vascular endothelial growth factor (VEGF) expression and new blood vessels number caused by dental X-ray irradiation on fractured tooth extraction wound on day 3 and 7 after extraction. Method: We used 30 wistar rats which was randomly divided into 6 groups. Each rat’s central insisive of left mandible was fractured and then extracted after or without X-ray irradiation. Group KA and KB were control groups without irradiation. Group P1 A and P1 B were treatment groups with 0.08 mSv irradiation dose. Group P2 A and P2 B were treatment groups with 0.16 mSv irradiation dose. The subject from group KA, P1 A, and P2 A were sacrficed and sockets were collected at day 3. The subject from group KB, P1 B, and P2 B were sacrficed and sockets were collected at day 7. Socket were processed and painted with hematoxylin eosin and immunohistochemistry, then observed with a microscope. Data processing was performed with SPSS 16 through one way anova test and post hoc Tukey test HS. Result: The lowest means expression of VEGF and the number of new blood vessels on the day 3 was found in P2 A group, and the highest found in the KA group. The lowest means expression of VEGF and the number of new blood vessels on the day 7 was found in P2 B group, and the highest found in the KB group. Conclusion: Dental X-ray irradiation dose of 0.08 mSv and 0.16 mSv causes decrease of VEGF expression and new blood vessels in the wound fractured tooth extraction in day 3 and day 7 post-extraction.

Correlation between working position of dentists and malondialdehyde concentration with musculoskeletal complaints Hari Wibowo; Titiek Berniyanti; Jenny Sunariani
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 1 (2017): March 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Musculoskeletal complainst of dentists have become common issues in dentistry since the awkward positions during treating the patients; such as position of a dentist who bends towards the patient, moving abruptly, twisting the body from a side to another side. All those movements are done several times in long term. Such high level of activity without sufficient recovery time may lead to an oxidative stress, so it will affect on the musculoskeletal and concentration of malondialdehyde (MDA) in blood. Purpose: To identify the correlation between malondialdehyde concentration on the risk of musculoskeletal complaint on dentist with working position of maxilla dental patching at community health center(Puskesmas) in Surabaya. Method: The type of research conducted was observational analytics using cross sectional approach. Sampling technique utilized in this research was cluster random sampling techniquewith the total samples of 19. Result: From data analysis result using Spearman correlation test, it was found that there was a significant correlation between working position and musculoskeletal complaint using Spearman correlation test and the p value obtained was<0.05. This research also found that there was a significant correlation between malondialdehyde concentration and musculoskeletal complaint using Pearson correlation test and the p value obtained was <0.05. Conclusion: There is a significant correlation between working positions of dentists and there is a significant correlation between working position and malondialdehydeconcentration with the musculoskeletal complaints.

The effect of capsicum frutescens-l to transient receptor potential vinaloid-1, toll like receptors (tlr-4) and interleukin 1 beta (il-1Î²) on periodontitis Jenny Sunariani; Latief Mooduto; Yuliati Yuliati
Journal of Dentomaxillofacial Science Vol. 2 No. 2 (2017): (Available online: 1 August 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v2i2.527

Objective: Indonesia has many kinds of useful herbs, which are often used as species such as chili, pepper or cayenne pepper (Capsicum frutescens L). Previous study showed topical capsaicin can be used as a therapy to cure pain due to inflammation. Small concentrations of capsaicin can attenuate cytokines in the inflammatory process. Capsaicin studies in animal model showed activation of the transient receptor potential vanilloid-1. Capsaicin can decrease various cytokines such as IL-6, IL-12, IL-1Î², and increase IL-10. Capsaicin is a natural agonist for transient receptor potential vanilloid-1. The aim of this study is to prove the effect of capsaicin on transient receptor potential vanilloid-1 expression and TNF-Î± and TLR-4 toward pain.Material and Methods: An experimental laboratory research used animal model Wistar male rats (Rattus novegicus) induced with Aggregatibacter actinomycetemcomitans serotype b and green chili extract (Capsicum frutescens L.) with a dose of 0.0912 mg/kg/day was applied to surface of the gingiva on maxillary first molar for 7 days. An immunohistochemical examination was conducted to see the density of transient receptor potential vanilloid-1, and the expression of TLR-4 and IL-1Î² in the mucosal tissues of the oral cavity.Results: There were significant differences in the applications of Capsicum frutescens L. with increasing of TRPV ligand-1 and IL-1Î² (p < 0.05), while the TLR-4 (p > 0.05) showed a significant difference to TRPV-1 and IL-1Î². There is no significant difference to TLR-4.Conclusion: Capsaicin can increase TRPV-1 and decrease IL-1Î² but did not affect the TLR-4. Capsaicin can be used to decrease pain and accelerate healing process in periodontitis.

PERAN KAPSAISIN PADA PENGHAMBATAN TERJADINYA KANKER Fery Setiawan; Arif Rahman Nurdianto; Rizal Fauzi Nurdianto; Heribertus Agustinus B Tena; Jenny Sunariani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 2 (2021): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v10i2.62

Kapsaisin (8-methyl-N-vanillyl-6-nonanenamide) adalah rasa pedas utama dalam batang cabai yang dikonsumsi secara umum. Fungsi utama kapsaisin adalah mengurangi rasa nyeri dan inflamasi neurogenik, selain itu juga memiliki efek anti-tumor. Reseptor kapsaisin dan substansi lain yang terkait dengan kapsaisin telah diidentifikasi dan dikloningkan. Reseptor ini adalah reseptor vaniloid subtipe 1 (VR-1), yang membentuk saluran kation non-selektif dalam membran plasma yang memediasi beberapa efek pleitropik. Kapsaisin dan substansi analog yang sejenis mempunyai efek anti-proliferatif dalam sel kanker manusia melalui induksi siklus sel fase G0/G1 sehingga proliferasi sel terhenti dan terjadi apoptosis pada beberapa sel yang mengalami transformasi. Kemampuan untuk menginduksi apoptosis merupakan aktivitas supresi plasma membran NADH-oksidoreduktase (PMOR), enzim yang mentransfer elektron dari sitoplasmik NADH melalui ko-enzim Q (ubikuinon) ke akseptor elektron eksternal, seperti oksigen. Selain menginduksi apoptosis melalui PMOR, kapsaisin juga menginduksi peningkatan p21, Bax, dan Poly ADP Ribose Polymerase (PARP). Mekanisme antitumor kapsaisin secara utama dengan melakukan stabilisasi dan aktivasi gen p53. Kapsaisin secara substansial memperpanjang siklus hidup p53 dan secara signifikan meningkatkan aktivitas transkripsional p53. PMOR diperkirakan terlibat dalam pengaturan pertumbuhan sel dan proliferasi dengan menjaga rasio NADH+/NADH yang sesuai dengan kebutuhan sel.

Molecular Toxicology of Organophosphate Poisoning Fery Setiawan; Arif Rahman Nurdianto; Heribertus Agustinus B Tena; Ahmad Yudianto; Jenny Sunariani; Achmad Basori; Acrivida Mega Charisma
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1596

The use of organophosphates (pesticides and other compounds to eradicate pests), currently, to increase the fulfillment of the population's consumption needs has a double-edged sword effect, on the one hand it can increase the need for food to be consumed by the population. The negative effect that can arise is the safety of organophosphate drugs which can contaminate the soil and water sources around the place where organophosphate drugs are used. The negative effects of organophosphates are associated with the effects of xenobiotics on humans who consume them. Xenobiotics are associated with toxicdynamic effects where organophosphates cause irreversible inhibition of the enzyme acetylcholinesterase (ACh). ACh is one of the main enzymes in the nervous system that terminates impulse conduction through the hydrolysis process of acetylcholine enzymes. Acetylcholinesterase is a specific molecular target of organophosphate pesticides. The inhibition of the Ach enzyme causes the inhibition of the acetylcholine enzyme which is normally always hydrolyzed by the Ach enzyme and is a specific biological marker of pesticide poisoning. Inhibition of ACh will cause the accumulation of the enzyme acetylcholine, resulting in negative effects of organophosphate poisoning which can lead to death. In this paper, the authors collect from various sources related to the study of molecular toxicology toxidynamic effects of drug safety and organophosphate poisoning. The results of this review article show that organophosphate poisoning is associated with irreversible inhibition of the acetylcholinesterase enzyme which results in death in the individual concerned.

Co-Authors Achmad Basori, Achmad Acrivida Mega Charisma Adikara, Tatang Santanu Agniz Nur Aulia Ahmad Yudianto Anis Irmawati Arif Rahman Nurdianto Arif Rahman Nurdianto Eha Renwi Astuti Ester Arijani Rachmat Fatma Yasmin Mahdani Fery Setiawan Fransiskus Andrianto Hari Wibowo Heribertus Agustinus B Tena Heribertus Agustinus B Tena Intan Nirwana, Intan Latief Mooduto, Latief Ni Luh Putu Ayu Wardhani Niluh Ringga Woroprobosari Nurdianto, Arif Rahman Rizal Fauzi Nurdianto Theresia Indah Budhy Sulisetyawati Titiek Berniyanti Yuliati

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