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All Journal Journal of Dentistry Indonesia Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Jurnal Material Kedokteran Gigi
Elly Munadziroh
Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Characterization of Fresh Bovine Amnion Membrane Combined with Hydroxyapatite as Candidate Scaffold for Alveolar Bone Tissue Engineering Octarina, Octarina; Munadziroh, Elly
Journal of Dentistry Indonesia Vol. 31, No. 3
Publisher : UI Scholars Hub

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Abstract

Objective: This research aims to analyze the characteristics of a BAM-HA biocomposite with ratios of 4:1 and 4:2. Methods: This research is an in vitro laboratory experiment that starts by grinding fresh BAM to produce amnion slurry and then, adding HA powder to the slurry and carrying out freeze-drying on the slurry. Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscope-Energy dispersive X-ray (SEM-EDX) tests are used to analyze the characteristics of the BAM-HA biocomposite. Results: The FTIR test results showed that the BAM-HA biocomposite had amide functional groups I, II, III, A, B, OH, CO32-, and PO43-. SEM test results showed revealed different types of pores on the surface of the biocomposite with ratios of 4:1 and 4:2. The elements C, O, Na, Mg, Si, P, CL, Ca, and Nb were found in the BAM-HA biocomposite following testing by SEM-EDX. Conclusion: Based on the research results, this research has succeeded in combining BAM-HA. The ratio BAM-HA 4:2 has the potential as a scaffold for alveolar bone tissue.
The characteristics of swelling and biodegradation tests of bovine amniotic membrane-hydroxyapatite biocomposite Agustantina, Titien Hary; Munadziroh, Elly; Yuliati, Anita; Bahtiar, Muhammad Riza Hafidz; Octarina; Salma, Rizki Fauziah; Meyranti, Ajeng Putri; Razak, Fathilah Abdul
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p172-177

Abstract

Background: A good biocomposite is a structure that can provide opportunities for cells to adhere, proliferate, and differentiate. It is affected by the characteristics of a material. As bone tissue regeneration occurs, biomaterials must have a high swelling ability and low biodegradability. The high swelling capability will have a larger surface area that can support maximal cell attachment and proliferation on the biocomposite surface, which accelerates the regeneration process of bone defects. Purpose: The study aimed to analyze the characteristics of swelling and biodegradation of bovine amniotic membrane-hydroxyapatite (BAM-HA) biocomposite with various ratios. Methods: The BAM-HA biocomposite with a ratio of 30:70, 35:65, and 40:60 (w/w) was synthesized using a freeze-dry method. The swelling test was done by measuring the initial weight and final weight after being soaked in phosphate-buffered saline for 24 hours and the biodegradation test was done by measuring the initial weight and final weight after being soaked in simulated body fluid for seven days. Results: The swelling percentage of BAM-HA biocomposite at each ratio of 30:70, 35:65, and 40:60 (w/w) was 303.90%, 477.94%, and 574.19%. The biodegradation percentage of BAM-HA biocomposite at each ratio of 30:70, 35:65, and 40:60 was 9.43%, 11.05%, and 12.02%. Conclusion: The BAM-HA biocomposite with a ratio of 40:60 (w/w) has the highest swelling percentage while the 30:70 (w/w) ratio has the lowest percentage of biodegradation.
The compressive strength and static biodegradation rate of chitosan-gelatin limestone-based carbonate hydroxyapatite composite scaffold Rianti, Devi; Purnamasari, Alqomariyah Eka; Putri, Rifayinqa Ruyani; Salsabilla, Noor Zain; Faradillah; Munadziroh, Elly; Agustantina, Titien Hary; Meizarini, Asti; Yuliati, Anita; Syahrom, Ardiyansyah
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p160-165

Abstract

Background: One of the main components in tissue engineering is the scaffold, which may serve as a medium to support cell and tissue growth. Scaffolds must have good compressive strength and controlled biodegradability to show biological activities while treating bone defects. This study uses Chitosan-gelatin (C–G) with good flexibility and elasticity and high-strength carbonate hydroxyapatite (CHA), which may be the ideal scaffold for tissue engineering. Purpose: To analyze the compressive strength and static biodegradation rate within various ratios of C–G and CHA (C–G:CHA) scaffold as a requirement for bone tissue engineering. Methods: The scaffold is synthesized from C–G:CHA with three ratio variations, which are 40:60, 30:70, and 20:80 (weight for weight [w/w]), made with a freeze-drying method. The compressive strengths are then tested. The biodegradation rate is tested by soaking the scaffold in simulated body fluid for 1, 3, 7, 14, and 21 days. Data are analyzed with a one-way ANOVA parametric test. Results: The compressive strength of each ratio of C–G:CHA scaffold 40:60 (w/w), 30:70 (w/w), and 20:80 (w/w), consecutively, are 4.2 Megapascals (MPa), 3.3 MPa, 2.2 MPa, and there are no significant differences with the p= 0.069 (p>0.05). The static biodegradation percentage after 21 days on each ratio variation of C–G:CHA scaffold 40:60 (w/w), 30:70 (w/w), and 20:80 (w/w) is 25.98%, 24.67%, and 20.64%. One-way ANOVA Welch test shows the result of the p-value as p<0.05. Conclusion: The compressive strength and static biodegradation of the C–G:CHA scaffold with ratio variations of 40:60 (w/w), 30:70 (w/w), and 20:80(w/w) fulfilled the requirements as a scaffold for bone tissue engineering.
Co-Authors Agni Febrina Pargaputri Anita Yuliati Asti Meizarini Bahtiar, Muhammad Riza Hafidz David David Devi Rianti Ekowati Handharyani Faradillah Fitria Rahmitasari Geneva Ariesta Indah Listiana Kriswandini Intan Fajrin Arsyada Meyranti, Ajeng Putri Moh. Basroni Rizal Niken Pristianingrum Octarina Octarina Pargaputri, Agni Febrina Purnamasari, Alqomariyah Eka Putri, Rifayinqa Ruyani Razak, Fathilah Abdul Retno Indrawati Roestamadji Retno Pudji Rahayu Salma, Rizki Fauziah Salsabilla, Noor Zain Soebagio Syahrom, Ardiyansyah Titien Hary Agustantina Wibowo, Artdhea Regita