Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung E-Prodenta Journal of Dentistry Indonesian Journal of Community Empowerment
Pargaputri, Agni Febrina
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Pengaruh nystatin topikal dan terapi oksigen hiperbarik terhadap jumlah makrofag pada tikus oral candidiasis kondisi imunosupresi Syarifah Fatimatuzzahra; Pargaputri, Agni Febrina; Dwi Andriani; Isidora Karsini
E-Prodenta Journal of Dentistry Vol 7 No 2 (2023)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2023.007.02.7

Abstract

Latar belakang: Kandidiasis oral merupakan infeksi jamur pada rongga mulut yang sebagian besar disebabkan oleh jamur jenis Candida. Limfosit berperan sebagai pertahanan utama host dalam melawan infeksi jamur pada permukaan mukosa dan epidermis. Penggunaan obat antijamur nystatin efektif untuk pengobatan infeksi jamur, sedangkan terapi oksigen hiperbarik diketahui sebagai salah satu terapi adjuvant dalam mengeliminasi infeksi jamur, sehingga pemberian kombinasi nystatin dan terapi oksigen hiperbarik diharapkan dapat berpengaruh pada sel limfosit dalam melawan infeksi jamur. Tujuan: Membuktikan pengaruh nystatin kombinasi terapi oksigen hiperbarik terhadap jumlah limfosit pada tikus model kandidiasis oral imunosupresi. Metode: Tikus strain Wistar sebanyak 25 ekor dibagi menjadi 5 kelompok: K1 (tikus sehat), K2 (tikus model kandidiasis oral imunosupresi), K3 (tikus model kandidiasis oral imunosupresi diberi nystatin topikal), K4 (tikus model kandidiasis oral imunosupresi diberi terapi oksigen hiperbarik), dan K5 (tikus model kandidiasis oral imunosupresi diberi kombinasi nystatin topikal dan terapi oksigen hiperbarik). Tikus pada K2, K3, K4, dan K5 diimunosupresi dengan deksametason peroral selama 14 hari. Candida albicans dioleskan pada dorsum linguae tikus untuk menginduksi kandidiasis. Nystatin topikal 0,5 cc diberikan pada K3 dan K5, terapi oksigen hiperbarik 2,4 ATA diberikan pada K4 dan K5 selama 5 hari. Jumlah limfosit pada lidah tikus diamati menggunakan mikroskop pembesaran 400x. Hasil: Uji statistik Post-Hoc LSD menunjukkan perbedaan yang bermakna pada kelompok K1 dibandingkan K2, K2 dibandingkan dengan K1, K3, K4, dan K5, sedangkan pada kelompok K3, K4, dan K5 tidak terdapat perbedaan bermakna. Kesimpulan: Kombinasi nystatin dan terapi oksigen hiperbarik berpengaruh pada peningkatan jumlah limfosit model oral kandidiasis imunosupresi.
Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats Pargaputri, Agni Febrina; Wahjuningsih, Endah; Andriani, Dwi
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3569

Abstract

The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active substances, promoting pathological processes. This study aimed to evaluate the correlation between the number of Kupffer cells and liver parenchymal cell damages in immunosuppressed, drug-induced rats. The study was conducted from July to December 2019 at the Oral Biology Laboratory of the Faculty of Dentistry and the Biochemical Laboratory of the Faculty of Medicine at Universitas Hang Tuah Surabaya. Twelve healthy male Wistar rats were divided into two groups: Healthy (H) and Immunosuppressed Drug-Induced (ID) groups. Immunosuppression was induced using dexamethasone (0.5 mg/day/rat), administered orally for 14 days, combined with tetracycline (1%/day/rat). Liver samples from all rats were examined for Kupffer cell count and parenchymal cell damages were assessed using a light microscope with 400x magnification. Results revealed a significant difference in the number of Kupffer cells and liver parenchymal cell damages between the H and ID groups (p<0.05). Pearson correlation analysis indicated a significant correlation between Kupffer cell number and parenchymal cell damages (p=0.000). Continuous administration of immunosuppressive drugs may activate Kupffer cells, leading to damage of liver parenchymal cells. In conclusion, the infiltration of Kupffer cells is associated with liver parenchymal cell damages, mediated by various factors in the immunosuppressed drug-induced rat model.
PENGARUH TRAINING OF TRAINER KESEHATAN GIGI DAN MULUT PADA GURU DAN ORANG TUA TERHADAP PERUBAHAN PERILAKU MENGGOSOK GIGI SISWA SISWI SDIT AL-USWAH Pargaputri, Agni Febrina; Andriani, Dwi; Parisihni, Kristanti; Priambodo, Nur Tsurayya; Saptaswari, Dianty; Elidasari, Monika; Fauzia, Bunga; Mulawarmanti, Dian; Sari, Rima Parwati; Kusumawardani, Chaterina Diyah Nanik; Setianingtyas, Dwi; Prananingrum, Widyasri; Nafi'ah; Laihad, Fanny M.; Teguh, Paulus Budi
MAJU : Indonesian Journal of Community Empowerment Vol. 1 No. 6 (2024): MAJU : Indonesian Journal of Community Empowerment, November 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/ss5x9x45

Abstract

Oral and dental health is an essential aspect of general health that must be maintained from an early age. This study aims to evaluate the impact of the Training of Trainer (ToT) program on dental and oral health for teachers and parents on changing tooth brushing behavior among students at SDIT Al-Uswah Surabaya. The methods used include surveys, training, evaluations, and observations of a tooth-brushing calendar filled out over 21 days. The results showed an increase in knowledge among teachers and parents, as well as positive changes in students' habits of brushing their teeth twice daily. These results highlight the importance of the role of teachers and parents in supporting dental and oral health promotion for children, which is expected to reduce the risk of dental caries in the future.
Co-Authors Dian Mulawarmanti, Dian Dwi Andriani Dwi Andriani, Dwi Dwi Setianingtyas Elidasari, Monika Elly Munadziroh Endah Wahjuningsih, Endah Fauzia, Bunga Isidora Karsini Kristanti Parisihni Kusumawardani, Chaterina Diyah Nanik Laihad, Fanny M. Nafi'ah Priambodo, Nur Tsurayya Retno Indrawati Roestamadji Rima Parwati Sari, Rima Parwati Saptaswari, Dianty Syarifah Fatimatuzzahra Widyasri Prananingrum