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All Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Journal of Dental Medicine Jurnal Abdi Masyarakat Indonesia International Journal of Science and Society (IJSOC) International Journal of Health and Medicine
Indeswati Diyatri
Departemen Biologi Oral Fakultas Kedokteran Gigi Universitas Airlangga Surabaya, Indonesia
Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Differences Post-extraction Collagen-density of Wistar-rat With Aerobic and Anaerobic Interval-training Oki, Aqsa Sjuhada; Diyatri, Indeswati; Wibawa, Kadek Gede Putra
Indonesian Journal of Dental Medicine Vol. 2 No. 2 (2019): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v2i2.2019.32-34

Abstract

Background: Tooth extraction is extracting teeth from alveolar bone. In the world, tooth loss is a disease that affects the function and aesthetics oral cavity, it causes 7.5 million Disability-Adjusted Life Year (DALY). Tooth extraction rate in Indonesia is around 24% in 2013 and 19% in 2018. Sports is one of the activities that can help accelerate wound healing after tooth extraction, this study examine differences in collagen density after tooth extraction of Wistar rats given aerobic and anaerobic interval training. Objective: To prove differences in post-extraction collagen density of Wistar Rat (Rattus norvegicus) with aerobic and anaerobic interval training. Method: Wistar rats were divided into 3 groups, control group (K) rat were soaked in a bucket with tap water as high as the rat soles with a duration of 50% of maximum swimming ability (KRM), aerobic interval (P1) 3% load swim test with duration of  3 sets 50 % KRM exercise and 25% KRM rest, anaerobic interval P2 load 6% duration 80% KRM exercise and rest with 4 sets. All groups were observed on the 3rd and 7th day post extraction. Data were analyzed using Kruskal-Wallis and continued with Post-hoc test to test differences between groups. Results: There was only significant difference in collagen thickness between groups K(3) and K7, and another groups had not significant difference. Conclusion: there unsignificant differences in collagen density after tooth extraction in Wistar rats (Rattus norvegicus) with aerobic and anaerobic interval training.
Epigallocatechin gallate Mucoadhesive Gingival Patch as Potential Biomaterial to Regulate Macrophage and Lymphocyte Cells in Periodontitis: A Review Sidarningsih, Sidarningsih; Diyatri, Indeswati; Pratiwi, Reinaya Tifa; Nabilla, Jihan Hijriya; Yuliati, Yuliati; Ridwan, Rini Devijanti
Indonesian Journal of Dental Medicine Vol. 5 No. 1 (2022): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v5i1.2022.32-36

Abstract

Background: Periodontitis is a periodontal disease that affects more than 743 million peopleworldwide and causes damage to the periodontal ligament and alveolar bone. One of the bacteriathat can cause periodontitis is Porphyromonas gingivalis (P.gingivalis). P. gingivalis has virulence factors that can damage the periodontal tissue. Treatment of periodontitis is in the form of non- surgical therapy such as scaling and root planning and some cases, doxycycline can be given as adjunctive therapy after scaling and root planing. Epigallocatechin gallate (EGCG) is one of the catechins found in green tea and has anti-bacterial properties. Purpose: The study aimed to describe the potency of the mucoadhesive gingival patch with EGCG green tea against the number of macrophage cells and lymphocyte cells during periodontitis through narrative review. Review: Mucoadhesive gingiva patch loaded with EGCG has the advantages such as maintaining drug bioavailability, non-invasive, and optimizing drug distribution. Using a mucoadhesive gingiva patch with EGCG can reduce macrophage and lymphocyte cells by inhibiting lipopolysaccharide, a virulence factor of P. gingivalis. Inhibited lipopolysaccharide will inhibit pro-inflammatory cytokines such as TNF-α and IL-6. Macrophage and lymphocyte cells will reduce due to the inhibition of pro inflammatory cytokines. Conclusion: Mucoadhesive gingiva patch with EGCG green tea potentially to decreased macrophage and lymphocyte cells in periodontitis.
The Influence of Vitamin K Levels on Blood Coagulation Factors After Tooth Extraction in Hemophilia Patients Indeswati Diyatri; Muhammad Hibban Qadhafi; Haura Destina Anandhiyah; Muhamad Nabil Rabbani
International Journal of Health and Medicine Vol. 2 No. 1 (2025): January : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i1.224

Abstract

Hemophilia is a genetic disorder resulting from impaired blood clotting. This disorder can be caused by coagulation factor abnormalities due to a deficiency of clotting factors, including vitamin K. A lack of vitamin K disrupts the coagulation process, increasing the tendency for bleeding. This article aims to determine whether there is an influence of vitamin K levels on the blood clotting factors in hemophilia patients. Searching any information needed by analyzing kinds of papers of recent research from the year of 2014 until 2024. Online databases like PubMed, ScienceDirect, Google Scholar, Scopus, and ResearchGate are utilized by inserting relevant keywords, such as hemophilia, blood clotting factors, vitamin K deficiency and extraction. From 10 articles reviewed, a relationship was identified between vitamin K levels and blood clotting factors in hemophilia patients. Individuals with severe hemophilia experience bleeding episodes characterized by delayed onset, as well as bleeding into muscles, joints, and other internal structures, including the brain. Hemophilia is typically diagnosed through the identification of low or absent levels of FVIII:C or FIX:C. The genes encoding FVIII and FIX are located on the long arm of the X chromosome. Hemophilia A and B are the only hereditary clotting disorders inherited in a sex-linked recessive pattern. Vitamin K levels can influence the blood clotting factors in hemophilia patients, particularly those factors synthesized artificially.
Cytotoxicity of Turmeric Extract (Curcuma longa linn.) on BHK21 Fibroblast Cells Azzahra, Nadya Fithrie; Indrawati, Retno; Diyatri, Indeswati
International Journal of Science and Society Vol 6 No 1 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i1.1005

Abstract

Wound healing is the process of recovery from injury to stop bleeding, and fibroblasts play a crucial role in the healing process and contribute to the regeneration of periodontal tissue. Turmeric extract (Curcuma longa linn.) is an alternative treatment that uses natural ingredients with antibacterial, antioxidant, and anti-inflammatory properties. The aim of this study is to demonstrate the toxicity of turmeric extract (Curcuma longa linn.) on BHK21 fibroblast cells. Turmeric extract (Curcuma longa linn.) was administered at concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, and 0.78% to BHK-21 fibroblast cells, and its cytotoxicity was tested using the MTT Assay. The research results show that the percentage viability of fibroblast cells decreases successively with concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, and 0.78%, with the highest percentage at a turmeric extract concentration of 0.78% and the lowest at a concentration of 100%. The conclusion of this study is that turmeric extract (Curcuma longa linn.) is not cytotoxic to BHK-21 fibroblast cells at concentrations of 0.78%, 1.56%, and 3.12%.
Co-Authors Aqsa Sjuhada Oki Azzahra, Nadya Fithrie Diana Soesilo Dimas Rudianto Fardha Dyah Kusumaningrum Eha Renwi Astuti Fiory Dioptis Putriwijaya Haura Destina Anandhiyah Hesham Mohammed Al-Sharani Hutojo Djajakusuma Indah Listiana Kriswandini Intan Amalia Putri Keyona Laila Olivia Kinanti Nasywa Prajnasari Mahela Sefrian Luthfimaidah Markus Budi Rahardjo Moh. Malik Alhakim Mohammed Ahmed Al Junaid Mohammed Aljunaid Muhamad Nabil Rabbani Muhammad Hibban Qadhafi Nabilla, Jihan Hijriya Nastiti Faradilla Ramadhani Nova Andriani Hepitaria Pratiwi, Reinaya Tifa Retno Indrawati Roestamadji Rini Devijanti Ridwan Rinna Erlyawati Santoso Riski Rahayu Putri Rahmasari Salsabilla Syifa Sidarningsih Sidarningsih, Sidarningsih Tantiana Tantiana Titiek Berniyanti Tuti Kusumaningsih Wibawa, Kadek Gede Putra Wisnu Setyari Juliastuti Yeka Ramadhani Yuliati Yuliati -