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All Journal Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Paediatrica Indonesiana Oceana Biomedicina Journal
Hidajat, Boerhan
Department Of Child Health, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo Regional General Hospital, Jl. Prof. Dr. Moestopo No 6-8, Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method Adiwinoto, Ronald Pratama; Sustini, Florentina; Hardiono, Hardiono; Widodo, Agung Dwi Wahyu; Hidajat, Boerhan; Hadi, Usman
Oceana Biomedicina Journal Vol 1, No 2 (2018): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (546.601 KB) | DOI: 10.30649/obj.v1i2.17

Abstract

Rational empirical antimicrobial therapy is an important component of sepsis patient management. This study aimed to assess the rationality of empirical antimicrobial therapy in patients diagnosed with sepsis admitted in intermediate care ward of internal medicine department (RPI) of Dr. Soetomo General Hospital from January 2016 to July 2017. Medical records of 91 patients diagnosed with sepsis were collected and studied retrospectively in period from July 2017 to November 2017. 91 (85.05%) medical records from 107 sepsis patients were evaluated. Cultures and antimicrobial sensitivity tests were carried out in 21 (23.07%) patients. 14 patients yielded positive culture results, 9 of which were MDRO positive with ESBL as resistant marker. Empirical antibiotic therapies for these patients were reviewed according to Gyssens method.73 (80.2%) of 91 patients were deemed receiving appropriate empirical antibiotic therapies. Ceftriaxone IV injection as monotherapy or combination therapy were the most common empirical antibiotic therapies (82 in 91 patients, 90.1%), despite local microbiologic flora and antibiogram show most pathogens were resistant to ceftriaxone. Mortality rate in this study was high, 92.3% (84 patients died) despite rational empirical antibiotic therapies were high. This study concluded that empirical antibiotic therapies in sepsis patients according to guidelines adopted in Soetomo General Hospital, albeit deemed rational, was no longer appropriate according to local antibiogram issued by microbiological department of Soetomo General Hospital. Keywords: Empirical Antibiotics Therapy, Gyssens criteria, Intermediate Care Ward, Sepsis, Septic Shock
PARENT’S STRATEGY TO ATTRACT CHILDREN TO EAT, FEEDING DURATION, AND ITS RELATION TO WEIGHT FOR AGE Z-SCORE IN CHILDREN Masayu Ramadhani Polanunu; Nanda Hudawarrahmah; Hartojo Hartojo; Meta Herdiana Hanindita; Nur Aisiyah Wijaya; Siti Nurul Hidayati; Roedi Irawan; Boerhan Hidajat
Media Gizi Indonesia Vol. 15 No. 1 (2020): JURNAL MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v15i1.27-30

Abstract

Appropriate feeding practices are critical for gaining and maintaining nutrition and development in children. Previous study in feeding practices indicated that inappropriateness in feeding practices had consequences in children’s growth and development. This study aimed to determine corelation between parents strategy to attract children to eat and feeding duration to weight for age z-score in children. This was a simple random sampling, cross-sectional study and held on April to June 2016 in Dr. Soetomo Hospital and Husada Utama Hospital, Surabaya, Indonesia. Subjects in this study were children from 6 to 24 months. Feeding practice determined by interview with children’s parents which consisted parent’s strategy to attract children to eat, feeding duration, and then children were measured weight for age z-score using WHO chart. Statistical analysis used Spearman correlation test. Thirty children were enrolled, 50% were male, with median age 16.5 months (6-24 months). Parents strategy to attract children to eat (53.3% talking, 30% playing and 16.7% watching television) had correlated signifi cantly with weight for age (r= 0.35, p= 0.028). Meanwhile, 56.7% children with feeding duration more than 30 minutes and 43.3% children with time feeding duration less than 30 minutes. Feeding duration had no correlation with weight for age in children (r=-0.32, p=0.43). We conclude from this study that parents strategy to attract children to eat had signifi cant correlation to weight for age but feeding duration had no correlation with weight for age. This study implied that strategy to attract children to eat is necessity in children physical development. Meanwhile, feeding duration has no signifi cant implication. We recommended children must be persuaded as part of parents strategy in order to attract them to eat.
Zinc Administration Affects Bronchial Mucosal NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β of Zinc-deficient Rats Reza Gunadi Ranuh; Andy Darma; Alpha Fardah Athiyyah; Ergia Latifolia; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Ferry Sandra; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1041

Abstract

BACKGROUND: Risk of acute respiratory infections in children less than 5 years of age is up to 95%. Zinc deficiency is one of the main risk factors. This study aimed to explore the effect of zinc on the bronchial mucosae inflammatory status expressed by nuclear factor (NF)-κB p105/p50, NF-κB p65, interleukin (IL)-8, and IL-1β.METHODS: Twenty-four Wistar rats were divided into 4 groups: normal zinc diet group without zinc supplementation (Z1), normal zinc diet group with zinc supplementation (Z2), zinc deficient diet group without zinc supplementation (Z3), and zinc deficient diet group with zinc supplementation (Z4). NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β were measured by immunohistochemical staining.RESULTS: The inflammatory status of bronchial mucosae between Z1 and Z2 groups showed no difference (p=0.055). However, the inflammatory status of bronchial mucosae between Z3 and Z4 groups showed significant difference (p<0.01). Multivariate factorial design showed that zinc supplementation was beneficial when given to zinc deficient diet group with regard to decrease p-NF-κB p65, IL-8 and IL-1β levels (p<0.001) and increase dendritic cell (p=0.022).CONCLUSION: Zinc administration under conditions of zinc deficiency affects the inflammatory status, as shown by the decrease of p-NF-κB p65, IL-8 and IL-1β and the increase of NF-κB p105/p50.KEYWORDS: zinc, NF-κB, p105/p50, p65, IL-8, IL-1β, rat
Zinc Supplementation Effect on the Bronchial Cilia Length, the Number of Cilia, and the Number of Intact Bronchial Cell in Zinc Deficiency Rats Andy Darma; Alpha Fardah Athiyyah; Reza Gunadi Ranuh; Wiweka Merbawani; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.998

Abstract

BACKGROUND: Airway epithelium is the first line of defense against a variety of exposures. Inflammatory processes, hyperresponsiveness and zinc deficiency cause epithelial damage. Zinc is involved in apoptosis and microtubule formation. However, its role in the integrity of bronchial mucosa and cilia is unclear.METHODS: To assess the effect of zinc on the integrity of the bronchial epithelium, 24 male Rattus norvegicus strain Wistar rats were randomized into four experimental groups: normal zinc diet group without zinc supplementation, normal zinc diet group with 60 ppm zinc supplementation, zinc deficient diet group without zinc supplementation, and zinc deficient diet group with 120 ppm zinc supplementation. Bronchial mucosal integrity was measured with the number of epithelial cells, and the number and length of cilia.RESULTS: Number of cell in normal zinc diet group was 8.8±1.82, while it was only 8.1±1.08 in zinc deficient diet group (p<0.001). Number of cilia per cell was 4.6±1.08 in normal zinc diet group, compared to 4.0±0.79 in zinc deficient diet group (p<0.001). Ciliary length also differ by 7.68±0.66 μm in normal zinc diet group and only 5.16±0.91 μm in zinc deficient diet group (p<0.001).CONCLUSION: Zinc supplementation of the normal zinc diet group affected the length of bronchial cilia. Zinc supplementation of the zinc deficient diet group affected the integrity of the bronchial epithelium, which was shown by the number and length of cilia, and the number of epithelial cells.KEYWORDS: zinc, bronchial epithelial integrity, cilia length, number of cilia, epithelial cell 
Effects of zinc supplementation on nutritional status and cognition in children Retno Asih S; Endang Warsiki; Boerhan Hidajat
Paediatrica Indonesiana Vol 46 No 2 (2006): March 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.2.2006.64-70

Abstract

Background Zinc deficiency is common in children in develop-ing countries and data suggests the effects are detrimental towardschildren’s growth and neuropsychologic performance. Results ofmultiple studies which assess these effects have been inconsis-tent.Objective To evaluate the effects of zinc supplementation onnutritional status and cognition in children with zinc deficiency.Methods Forty-six stunted children aged 50-80 months with lowhair zinc levels were randomly assigned to receive either 7.5 mgelemental Zn or placebo twice a week for 3 months. Anthropom-etry and cognition were assessed at the beginning and the end ofthe supplementation period. Differences among both groups foranthropometry and cognition before and after supplementation wereanalyzed with paired t-test. A comparison of different anthropom-etry and cognition among the two groups were analyzed using theindependent t-test.Results There were no significant differences among baselinecharacteristics except on sex distribution.There was a significantdifference in weight for age between the zinc group and placebo[0.28 (SB 0.18) vs 0.09 (SB 0.14); P=0.0001]. Height incrementswere also greater in the zinc group [0.34 (SB 0.15) vs 0.02 (SB0.12); P=0.0001). There was no significant difference betweenweight for height. Intelligence quotient (IQ) measured by theStanford-Binnet test was slightly higher in the zinc group [2.26 (SB3.11) vs 2.00 (SB 2.81], but the difference was not significant ac-cording to sex.Conclusion Zinc supplementation produced highly positive re-sponses in weight for age and height for age increments in chil-dren with zinc deficiency compared with placebo. There was noeffect of zinc supplementation on weight for height index and noneon cognition measured by intelligence quotient (IQ)
Co-Authors Agung Dwi Wahyu Widodo Alpha Fardah Athiyyah Anang Endaryanto Andy Darma Endang Warsiki Ergia Latifolia Ferry Sandra Florentina Sustini Hanindita, Meta Herdiana Hardiono Hardiono, Hardiono Hartojo Hartojo I Gusti Made Reza Gunadi Ranuh Masayu Ramadhani Polanunu Nanda Hudawarrahmah Nur Aisiyah Wijaya Retno Asih S Retno Asih Setyoningrum Roedi Irawan Ronald Pratama Adiwinoto SITI NURUL HIDAYATI Sudarmo, Subijanto Marto Usman Hadi Wiweka Merbawani