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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Heart Science Journal JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Global Pharma Technology Folia Medica Indonesiana
Budi Susetyo Pikir
Departemen Kardiologi Dan Kedokteran Vaskuler, Fakultas Kedokteran –RSUD Dr. Soetomo. Kelompok Peneliti Sel Punca – Institut Penyakit Tropik, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : The Indonesian Biomedical Journal

 1 
Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease Mochammad Yusuf Alsagaff; Budi Susetyo Pikir; Mochammad Thaha; Hendri Susilo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1241

Abstract

BACKGROUND: Chronic kidney disease (CKD) is often associated with an increased risk of cardiovascular disease. Cardiovascular disease in CKD can be affected by oxidative stress and inflammation. The oxidative stress can affect arterial stiffness, especially in patients with CKD, which will increase the risk of cardiovascular disease. This study aimed to explain the correlation between total antioxidant capacity (TAC) and 8-hydroxydeoxyguanosine (8-OHdG) with carotid-femoral pulse wave velocity (cf-PWV) in patients with CKD.METHODS: Forty-three CKD patients was included in this cross-sectional study. TAC was measured from serum samples by colorimetric method and 8-OHDG was measured from urine by enzyme-linked immunoassay method. cf-PWV was measured by Doppler ultrasound as a diagnostic tool for arterial stiffness.RESULTS: Significant correlations were found between age, estimated glomerular filtration rate (e-GFR), Hemoglobin A1C (HbA1C), serum creatinine, cystatin-C, and severity of CKD with urinary 8-OHdG levels. Serum creatinine, cystatin-C, severity of CKD, age, high-density lipoprotein (HDL), e-GFR, and HbA1C also had significant correlations with serum TAC levels. Other significant correlations between e-GFR, HbA1C, serum creatinine, cystatin-C, and severity of CKD with cf-PWV were also obtained. A significant negative correlation was obtained between serum TAC and cf-PWV with moderate levels of correlation coefficient (r=-0.504).CONCLUSION: There was a negative correlation between TAC and cf-PWV, but there was no significant correlation between 8-OHdG and cf-PWV in patients with CKD.KEYWORDS: chronic kidney disease, total antioxidant capacity, 8-hydroxydeoxyguanosine, carotid-femoral pulse wave velocity
The Role of Klotho G395A Gene Polymorphism in Atherosclerotic Cardiovascular Disease and Mortality Risk Scores in Non-dialysis Chronic Kidney Disease Hendri Susilo; Budi Susetyo Pikir; Mochammad Thaha; Mochamad Yusuf Alsagaff; Satriyo Dwi Suryantoro; Citrawati Dyah Kencono Wungu; David Setyo Budi; Laurentius Andre; Cennikon Pakpahan
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1975

Abstract

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis. We investigated the role of the klotho G395A gene polymorphism and plasma klotho level in the ten-year risk of atherosclerotic cardiovascular disease (ASCVD) and CVD mortality in CKD patients.METHODS: We used the PCR-CTPP assay method to genotype klotho G395A single nucleotide polymorphism (SNP) in 72 non-dialysis CKD patients. The klotho level was determined using the enzyme-linked immunoassay (ELISA) method. Path analysis was used to determine the relationship between the klotho G395A SNP, plasma klotho level, ASCVD risk score, and CVD mortality risk score.RESULTS: Our results showed that the GA genotype had lower plasma klotho levels than the GG genotype (path coefficient=-0.185, p=0.000). There was a significant negative correlation between plasma klotho level and the ASCVD risk score (r=-0.243, p=0.040), but no significant correlation was found between plasma klotho level and the CVD mortality risk score (r=-0.145, p=0.225). Path analysis showed that plasma klotho level had a significant negative direct effect on ASCVD risk score (path coefficient=-0.272, p=0.000) and an indirect effect on CVD mortality risk score (path coefficient=0.187, p=0.005).CONCLUSION: Klotho G395A SNP might reduce lower plasma klotho levels, which increased ASCVD and CVD mortality risk scores in non-dialysis CKD patients. However, other risk factors such as age, CKD stages, hypertension, and smoking should be taken into consideration. Therefore, large-scale genetic association studies with adjusted variables could be conducted in various ethnic groups for a more robust result.KEYWORDS: klotho, single nucleotide polymorphism, cardiovascular disease, chronic kidney disease
Co-Authors , Irma Maghfirah Andrianto Annisa Trissatharra Arnindita, Jannatin Nisa Bambang Purwanto Budi Bakti Dharmadjati Budi Utomo David Setyo Budi Dharmadjati, Budi Bakti Fita Triastuti Hendri Susilo Ilma Alfia Isaridha Imam Mahbub Zam Zami Irma Maghfirah Isaridha, Ilma Alfia Jannatin Nisa Arnindita Laurentius Andre Mochamad Yusuf Alsagaff MOCHAMMAD THAHA Mochammad Yusuf Alsagaff Mohammad Satya Bhisma Mulyanto Mulyanto Pakpahan, Cennikon Pudji Lestari Putra, Rendra Mahardhika Rendra Mahardhika Putra Rizka Amalia Romi Ermawan, Romi Setiabudi, Narendra Arya Sinta Dwi Juniar Suryantoro, Satriyo Dwi Widjiati , Widjiati Wungu, Citrawati Dyah Kencono Yudi Her Oktaviono, Yudi Her