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All Journal ACTA VETERINARIA INDONESIANA Pharmacon Sains Natural: Journal of Biology and Chemistry Pharmacology and Clinical Pharmacy Research Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Entomologi Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Patria : Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
MOERFIAH .
Pakuan University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Journal of Science Innovare

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The Effectiveness of Beetroot and Apple Juice Combination on Physical Endurance and Hemoglobin Levels in Sprague Dawley Rats Setiawan, Deni; Moerfiah, Moerfiah; Yulianita, Yulianita
Journal of Science Innovare Vol 7, No 2 (2024): Journal of Science Innovare, Volume 07 Number 02 2024
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jsi.v7i2.11303

Abstract

The present study investigates the stimulant and hematological effects of combined beetroot (Beta vulgaris L.) and apple (Malus pumila Mill.) juice on the physical endurance and hemoglobin (Hb) levels of Sprague Dawley rats. Adequate Hb concentration plays a critical role in oxygen transport and energy metabolism during physical activity. Thus, natural stimulant sources rich in bioactive compounds were evaluated as potential alternatives to synthetic energy supplements. Twenty-five male rats were divided into five treatment groups (n = 5): three groups receiving different ratios of beetroot and apple juice (1:1, 2:1, and 1:2), a negative control (CMC-Na 0.5%), and a positive control (caffeine 20 mg/200 g body weight). Stimulant activity was assessed using a rotarod endurance test, while Hb levels were measured by the Sahli method using a hemometer. The results demonstrated that the combined beetroot and apple juice significantly enhanced both endurance duration and hemoglobin concentration compared to the negative control (p 0.05). The optimal stimulant and hematopoietic effects were observed in the 2:1 beetroot-to-apple ratio, corresponding to doses of 5.6 g and 0.63 g per 200 g body weight, respectively. This combination yielded prolonged rotarod retention time and elevated Hb levels up to 18.5 g/dL, exceeding baseline and control values. The observed enhancement is attributed to the synergistic effects of bioactive constituents such as iron, potassium, flavonoids, and vitamin C, which facilitate oxygen transport, neuromuscular coordination, and erythropoiesis. These findings indicate that beetroot–apple juice exerts a physiological stimulant effect while improving hematological parameters without the adverse effects commonly associated with synthetic caffeine-based stimulants. This study highlights the potential of functional plant-based beverages as safe natural ergogenic aids for improving endurance and blood health.
Co-Authors - Affandi . Yulianita, . Achmad Supriadi Agus Ismanto Akhmad Rizali Auliya, Risa Bandung Sahari D Prasetyorini DAMAYANTI BUCHORI DENI SETIAWAN Deni Setiawan Dwi Ambarwati E Mulyati Effendi, E Mulyati ENRI AGUS SETIANI Erni Rustiani Hijib Sihabullah Indriani, Lusi Iyan Mulyana Lusi Agus Setiani Muhamad Nizar Zulfikar Muztabadihardja, - Najwa Rokhmah, Nisa Nina Herlina Pradana, Faisal Pungky Umi Sa’diyah Puspita Dewi, Santi Rangga Eka S. P Restu T. Purnama Sara Nurmala Septiani, Desi Sri Wardatun Supomo, Fira Diah Setiawaty Triastinurmiatiningsih, Triastinurmiatiningsih Winardiana, Yuda Yulianita, Yulianita Zunnita, Oktaviana