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FORMULATION AND CHARACTERIZATION EFFERVESCENT TABLETS OF GAMBIER LEAF EXTRACT (Uncaria gambier Roxb) Putra, I Gusti Ngurah Agung Windra Wartana; Rismayanti Putri, Putu; Wintariani, Ni Putu; Suryaningsih, Ni Putu Aryati
Journal Pharmaceutical Science and Application Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2024.v06.i01.p04

Background: Gambier, also known as the term (Uncaria gambier Roxb), is a plant that has long been cultivated in Indonesia. The components of flavonoid compounds in gambier plants have been widely reported as antioxidants. Using the gambier plant will be more accessible and more practical if it is made in dosage form, one of which is in the form of effervescent tablets. Objective: To determine the physical and chemical characteristics of effervescent tablets of gambier leaf extract (Uncaria gambier Roxb). Methods: Descriptive design, which includes phytochemical screening research, extract quality test, physical and chemical characteristics test of effervescent tablets formulation. Results: Positive gambier leaf extracts contain flavonoid compounds, alkaloids, tannins, and saponins. The average weight uniformity test of the tablet is 1.57 ± 0.02 grams, the average tablet thickness test of the tablet is 0.5±0 cm while a tablet's average diameter is 1.6±0 cm, the fragility test obtained <1%, the average hardness test of the tablet is 4.34±0.02 kg, the solubility time of the tablet obtaining is 1.6 ±0.4 minutes and tablets pH is 5.5±0.2. Conclusion: It is possible to draw the conclusion that the positive gambier leaf extract includes flavonoid components, alkaloids, tannins, and saponins based on the findings of the data previously gathered. The quality test of gambier leaf extract is already qualified, and the test of the characteristics of the physical and chemical properties produced is suitable based on Pharmacopeia Indonesia Standard. Keywords: Gambier; Extract; Tablet Effervescent

OPTIMIZATION OF GUMITIR FLOWER EXTRACT (TAGETES ERECTA L.) SUNSCREEN CREAM : SIMPLEX LATTICE DESIGN METHOD Putra, I Gusti Ngurah Agung Windra Wartana; Septiari, I Gusti Ayu Agung
Journal Pharmaceutical Science and Application Vol 5 No 2 (2023): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i02.p06

Background: Sunscreen cream is used to protect the skin from the bad effects of sunlight. Making a good sunscreen cream requires paying attention to the composition of the constituent compounds to obtain a standardized cream formquality. Formula optimization is carried out in each cream formulation, including to produce of Gumitir flower extract sunscreen cream. Objective: The aim of this research is to produce an optimum formula for Gumitir flower extract sunscreen cream. Methods: The method used in this research is the Simplex Lattice Design optimization method to find the optimum base between stearate acid cream base and triethanolamine. Results: Optimization results show that variations in stearic acid and triethanolamine cream bases influence the physical properties of viscosity and adhesiveness of sunscreen cream preparations, with stearic acid as the dominant factor influencing viscosity. Conclusion: The conclusion obtained from this research is that the optimum formula for Gumitir flower extract sunscreen cream was obtained with a base composition of 13.5% stearic acid and 2.5% triethanolamine. Keywords: Optimization; Gumitir; Extract; Sunscreen

The Cultural, Pharmacological, and Spiritual Significance of Tri Ketuka in Balinese Healing and Yoga Sugata, I Made; Ayu Kartika, I Gusti Agung; Puspita Apsari , Dewi; Windra Wartana Putra, I Gusti Ngurah Agung
Jurnal Kajian Bali (Journal of Bali Studies) Vol. 15 No. 2 (2025): Symbolism in Balinese Rituals
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JKB.2025.v15.i02.p13

This study delves into the cultural, pharmacological, and spiritual significance of Tri Ketuka, a traditional Balinese polyherbal formulation composed of Acorus calamus, Cryptocarya massoy, and Allium sativum, as documented in classical Usadha manuscripts. These three plants are not only known for their therapeutic properties but also for their symbolic role in promoting balance and holistic well-being within Balinese healing and yoga traditions. This qualitative study employed document analysis to investigate the use of Tri Ketuka in both healing rituals and yoga-based practices, particularly the Jala Neti nasal cleansing technique. The analysis is supported by illustrative testimonial evidence from users. The findings underscore the medicinal, spiritual, and cultural value of Tri Ketuka, affirming its relevance in both traditional and modern wellness contexts. The study also highlights the potential for integrating Balinese traditional medicine into contemporary healthcare as part of alternative and complementary therapies.

Pengaruh Variasi Konsentrasi Trietanolamin Terhadap Sifat Fisika Dan Kimia Sediaan Krim Ekstrak Etanol 96% Daun Dadap (Erythrina Subumbrans) Bernof, Boren Feren; Putra, I Gusti Ngurah Agung Windra Wartana; Artini, Ni Putu Rahayu
Bali International Scientific Forum Vol. 6 No. 2 (2025): Bali International Scientific Forum
Publisher : Bali International University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34063/bisf.v6i2.335

Latar belakang: Salah satu jenis kosmetik perawatan yaitu krim. Krim ada dua tipe yaitu krim tipe minyak dalam air (M/A) dan tipe air dalam minyak (A/M). Trietanolamin (TEA) merupakan senyawa sabun yang terbentuk melalui transplantasi asam lemak dan produk trietanol teknis yang mengandung 10-15% dietanolamin dan 5% monoetanolamin. Trietanolamin berfungsi untuk menetralkan asam lemak, menyesuaikan buffer pH, solubilizes minyak dan bahan-bahan lain yang tidak benar-benar larut dalam air. Tujuan: untuk mengetahui pengaruh variasi konsentrasi trietanolamin terhadap sifat fisika dan kimia pada sediaan krim ekstrak etanol 96% daun dadap (Erythrina Subumbrans) dan mengetahui pada konsentrasi trietanolamin berapa menghasilkan sifat fisika dan kimia krim yang baik. Metode: Rancangan Acak Lengkap (RAL) yaitu Formulai krim dengan variasi konsentrasi trietanolamin. Penelitian dilaksanakan di Laboratorium Farmasetika Universitas Bali Internasional pada bulan Juli sampai Agustus 2022. Hasil: sediaan krim uji tipe krim yaitu M/A, stabil, homogen, rata-rata nilai viskositas yaitu 9.768 cPs ± 12,000, 7.948 cPs ± 18,330, dan 6.164 cPs ± 36,661, nilai daya sebar 5,53 cm ± 0.015, 6,140 cm ± 0.020, dan 6,600cm ± 0.010, nilai daya lekat 7,233 ± 0,153, 6,567 ± 0,153, dan 5,300 ± 0,100, nilai pH 6,167 ± 0,021), 6,377 ± 0,025, dan 6,690 ± 0,030. Kesimpulan: Terdapat pengaruh variasi konsentrasi trietanolamin terhadap sifat fisika dan kimia pada sediaan krim ekstrak etanol 96% daun dadap (Erythrina Subumbrans) yaitu pada uji viskositas, daya sebar, daya lekat dan pH. Konsentrasi trietanolamin yang menghasilkan sifat fisika dan kimia yang baik pada krim yaitu 4%.

The Cultural, Pharmacological, and Spiritual Significance of Tri Ketuka in Balinese Healing and Yoga Sugata, I Made; Ayu Kartika, I Gusti Agung; Puspita Apsari , Dewi; Windra Wartana Putra, I Gusti Ngurah Agung
Jurnal Kajian Bali (Journal of Bali Studies) Vol. 15 No. 2 (2025): Symbolism in Balinese Rituals
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JKB.2025.v15.i02.p13

This study delves into the cultural, pharmacological, and spiritual significance of Tri Ketuka, a traditional Balinese polyherbal formulation composed of Acorus calamus, Cryptocarya massoy, and Allium sativum, as documented in classical Usadha manuscripts. These three plants are not only known for their therapeutic properties but also for their symbolic role in promoting balance and holistic well-being within Balinese healing and yoga traditions. This qualitative study employed document analysis to investigate the use of Tri Ketuka in both healing rituals and yoga-based practices, particularly the Jala Neti nasal cleansing technique. The analysis is supported by illustrative testimonial evidence from users. The findings underscore the medicinal, spiritual, and cultural value of Tri Ketuka, affirming its relevance in both traditional and modern wellness contexts. The study also highlights the potential for integrating Balinese traditional medicine into contemporary healthcare as part of alternative and complementary therapies.

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