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All Journal Bionatura Farmaka INDONESIAN JOURNAL OF PHARMACY ALCHEMY Jurnal Penelitian Kimia Majalah Farmasetika Journal of Global Pharma Technology ETHOS: Jurnal Penelitian dan Pengabdian kepada Masyarakat
Resmi Mustarichie
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Journal of Global Pharma Technology

 1 
Determination of Potential Compounds of Stevia Leaves (Stevia rebaudiana Bertoni) Against DPP4 as Candidates for Antidiabetic Drugs Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Diabetes mellitus is a metabolic disorder due to abnormalities in insulin secretion, insulin action, or both. Around 200 million people worldwide suffer from diabetes, most of which is type 2 diabetes. One of the targets of diabetes treatment is the DPP-4 enzyme which works to degrade incretin from the body. Sitagliptin, a DPP-4 inhibitor that has been approved for the treatment of type 2 diabetes. Besides using synthetic drugs, a biochemical compound can also be used for diabetes therapy, one of which is stevia leaf. This research was conducted to select compounds contained in stevia leaves based on their interaction with DPP4 in silico. The purpose of this study was to determine potential compounds from stevia leaves to be a candidate for antidiabetic drugs. Tests were carried out on DPP4 inhibitors, namely sitagliptin, and 10 compounds contained in stevia leaves. The results showed that there were three potential compounds namely isosteviol, steviol, and steviolmonoside. Testing the Lipinski's rule of five and pre-ADMET parameters implied that the three compounds had the potential to be used as candidates for antidiabetic drugs. Keywords: Stevia leaf, Stevia rebaudiana, Diabetes mellitus, DPP4, Molecular modeling.
Molecular Modeling of Anti-Alopecia Compounds Found in Sauropus Androgynus Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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People in the village of Mak Kemas, Malaysia use the katuk leaves (Sauropus androgynus) to prevent anti-alopecia. It was thought that katuk leaves have secondary metabolites which could accelerate the growth of new hair. The objective of this study was to determine the molecular modeling of compounds contained in katuk leaves (Sauropus androgynous) providing docking and ADMET information in silico as anti-alopecia drugs. In this study, receptors were used (PDB code: 4K7A) derived from protein data banks (http://www.rscb.org/pdb) and visualized with Discovery Studio and tested 10 compounds that had the potential as ligands to prevent baldness. Molecular modeling of bioactive compounds was carried out by molecular docking computation using AutodockTools 1.5.6 and Pre-Admet to determine absorption, distribution, and toxicity. The results were an amino acid residue that showed the place-bound to the receptor, inhibitory constant (Ki), and free energy bonds (∆ G). Of the 11 compounds studied, 3 were 5-Alpha-Dihydrotestosterone; Finasteride; and Pyrene interacts well so that it could prevent baldness. From the results of docking and pre-admet that had been done, it concluded that the compounds contained in katuk leaves could be used as candidates for anti-alopecia drugs.Keywords: Anti-alopecia, ADMET, In-silico, Katuk Leaf, Sauropus androgynus.
Molecular Docking of The Potential Compound from Cocoa Shells (Theobroma cacao L.) Against Androgen Receptor as Anti-Alopecia Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The determination of the components of the cocoa shells compounds that have anti-alopecia activity have not been reported, so the molecular docking approach is a very effective alternative before further testing is carried out. This study aimed to determine the potential compound components against androgen receptor targets as anti-alopecia drugs. Molecular docking used ChemDraw Ultra 12.0, Chem3D Pro 12.0, Biovia Discovery Studio 2016 Client®, and Autodock Tools 4.2, as well as to determine the pharmacokinetic properties and toxicity of drug ingredients with Pre-ADMET. It was found that that the components of the cocoa peel compound had the potential to act as anti-alopecia drugs, namely chlorogenic acid, epicatechin, and catechins with the value of the free energy binding (ΔG) and the inhibition constant (Ki) respectively (-7.87 kcal/mol; 1.70 µM)> (-6.48 kcal/mol; 17.65 µM)> (-6.36 kcal/mol; 21.91 µM) with the crucial amino acid residue formed was GLN 858. The pharmacokinetics (plasma protein binding) of epicatechin and catechin were excellent compared to chlorogenic acid and minoxidil because it could penetrate the plasma membrane when interacting. While the toxicity test, the components of chlorogenic acid, epicatechin, and catechin compounds were mutagenic, and only chlorogenic acid was carcinogenic. The study concluded chlorogenic acid, epicatechin, and catechin compounds from the cocoa shells were promising candidates for anti-alopecia drugs to be developed further targeting androgen receptors. It was consistent with the molecular docking results, which showed that ΔG and Ki's values were excellent compared to minoxidil. The pre-ADMET results also showed that the epicatechin and catechin compounds components could penetrate the plasma membrane when given topically compared to minoxidil. Keywords: Alopecia, Cocoa shells, Theobroma cacao, Molecular docking, Androgen receptor.
Anti-Dandruff Activities of Ethanol Extract and Water, N-Hexan, Ethyl Acetate Fractions of Key Lime (Citrus Aurantifolia) Leaves Against Malassezia Furfur Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The objective of this research was to determine the Anti-dandruff characteristic of ethanol extract and its fractions of key-lime leaves (Citrus aurantifolia L) against the fungus Malassezia furfur. C. Aurifolia leaves were collected from villagers' vegetable crops in Kendari, Southeast Sulawesi, Eastern Indonesia. It was macerated with ethanol 96%, rotary evaporated till viscous extract was obtained. The extract was analyzed its phytochemical substances and tested its Minimum Inhibitory Concentration (MIC). The extract was fractionated using ethyl acetate and n-hexane. Both ethanol extract and its fractions were tested their anti-dandruff activity using the fungus Malassezia furfur. DMSO was used as negative control and ketoconazole 1% as a positive control. All data were statistically analyzed. Phytochemical screening found that key-lime leaves contained flavonoids, polyphenols, saponins, steroids & triterpenoids, and tannin. The results showed that key-lime leaf extract was able to inhibit the activity of the Malassezia furfur fungus, the inhibition zones of the extract were 1% (6.0 mm), 4% (7.55mm), 8% (8.44 mm), 16% (9.9 mm), and 29% (16.7) mm) which was slightly greater than 1% ketoconazole as a positive control. The higher the concentration of lime leaf extract, the greater the inhibitory power against the Malassezia furfur fungus. Statistical data shows that the fraction of key-lime leaf had the best antifungal effect shown by the ethyl acetate fraction. The study concluded that either ethanol extract or its fractions of c.aurantifolia leaves has anti-dandruff activity against M. furfur. The ethyl acetate fraction was found to have a better activity compared to n-hexane and water fractions. This finding could be useful to elucidate the compound which is responsible for this action. Keywords: Citrus aurantifolia, Anti-dandruff, MIC, Malassezia furfur, Ethanol extract.
Antiseptic White Honey Liquid Soap Formulation and its Effectiveness against Nosocomial Infections Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa Multiresisten (PaMR) are the main bacteria that cause nosocomial infections. Prevention of MRSA and PaMR transmission can be done by maintaining a clean body through the use of antiseptic bath soap that is sensitive to this bacterium. This study aimed to carry out a white honey antiseptic liquid soap formula that could be useful for killing MRSA and PaMR bacteria. This research was based on laboratory research on white honey as an antiseptic derived from natural ingredients. Organoleptic examination, pH, viscosity, consistency, antibacterial effectiveness for 56 days of storage, then from the evaluation results of the formula was best done a hedonic test. Statistical calculations with fixed random block complete design models were applied for a conclusion of evaluation tests. The results of the test activity of the liquid shower soap showed that all three formulations had activity against the MRSA and PaMR bacteria. Growth Inhibitory Concentration Minimum preparation of antiseptic liquid bath soap was 12.5% w/v. Antiseptic liquid soap with a concentration of 12.5% had a phenol coefficient of 0.4167 for MRSA bacteria and 0.9 for PaMR bacteria. The comparative test results showed that the best formula (F2) activity was 0.859: 1 against MRSA and 0.7167: 1 against PaMR compared to liquid bath soap in the market. The test results showed that the best liquid bath soap formula based on stability and the lowest GICM value was white honey antiseptic liquid soap with a concentration of 12.5% w/v.Keywords: Antiseptic bath soap, Nosocomial infections, White Honey, Methicillin-Resistant Staphylococcus aureus (MRSA), Multiresistent Pseudomonas aeruginosa (PaMR).
In-Silico Screening of Ranggap Bananas (Musa troglodytarum L) Compound Components against Dipeptidyl Peptidase 4 Receptors as Therapeutic Targets for Type 2 Diabetes Anredera cordifolia Leaves Sub-fraction as Anti-Hyperlipidemia Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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This study aimed to evaluate the anti-hyperlipidemic properties of the sub-fraction of the Binahong (Madeira vine, Anredera cordifolia) extract in male Wistar rats. The rats were given high-fat food every day for 3 months and pure cholesterol on weeks 0, 3, 7, and 11. Furthermore, Ethyl acetate sub-fraction of binahong leaves with 0, 12 mg/kg BW, and 0, 24 mg/kg BW doses were given orally for 3 weeks and observed for lipid profile on day 21. The result showed that sub-fractions of Madeira vine leaves decreased in triglyceride, cholesterol, and low-density lipoprotein (LDL) levels and did not influence the high-density lipoprotein level (HDL). Meanwhile, statin decreased total triglyceride, cholesterol, and the LDL level, and increased the HDL level. It concluded that Madeira vine sub-fraction with 0, 24 mg/kg BW dose presented improved results in the lipoprotein profile. Keywords: Binahong, Madeira vine, Anredera cordifolia, Hyperlipidemia, Ethyl acetate fraction.
Anti-Alopecia Activity and Compound Content of n-Hexane Fraction of Cyclea Barbata Leaves Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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One of the plants empirically used by the Pasemah tribe in South Sumatra, Indonesia,  as a hair grower is the green cincau (Indonesian) leaf (Cyclea barbata Miers.). Objective: The aim of this study was to determine the anti-alopecia activity and its compound content from the n-hexane fraction of the C. barbata leaves. Methods: Green grass jelly (C. barbata Miers.) Extracted with 96% ethanol and fractionated with water, n-hexane and ethyl acetate. The concentration of ethanol extract was diluted to 5%, 10%, 15%, 20% and 25% and all fractions were tested on rabbits by the modified Tanaka method. All data were analyzed statistically by ANOVA. Results: Test results showed that the ethanol extract of green grass jelly leaves had the activity of stimulating hair growth starting at a concentration of 15%. It was found that the n-hexane fraction had the best activity compared to other fractions and positive control (minoxidil 2%).Further tests using IR and LC-MS spectrophotometers found that the n-hexane fraction contained 1,4-dimethyl-1,2,3,6-tetrahydro-8H-pyrrolo[2’,3’:3,4]azepino[2,1-b]quinazolin-8-one. Conclusions: Ethanol extract and hexane fraction at concentrations of 15% and above were found to have anti-alopecia activity. The compound contained from the hexane fraction 1,4-dimethyl-1,2,3,6-tetrahydro-8H-pyrrolo[2’,3’:3,4]azepino[2,1-b]quinazolin-8-one] (C22H18N3O) which was thought to cause properties hair growth.Keywords: Hair loss, Anti-alopecia, Green grass jelly, Cyclea barbata Miers,  1,4-dimethyl-1,2,3,6-tetrahydro-8H-pyrrolo[2’,3’:3,4]azepino[2,1-b]quinazolin-8-one.
Co-Authors Abdul Kakhar Umar Agung Putu Surya Purna Kristyawan ALVIN AL BAIHAQI Anas Subarnas Astiningsih Diah Pravitasari Billy Dwi Saputra Diah Lia Aulifa DOLIH GOZALI Fadhlurrahman, Ahmad Fahim Frita Karisma Alvianita INGKA TISYA GARNISA IRBAH ARIFA Jopi Arpina Jutti Levita Kelutur, Faruk Jayanto Khoziah Ahmad, Khoziah Lusius Ari Wardoyo MAWAR DWI YULIANTI Moelyono Moektiwardoyo, Moelyono Monica Richelle Herdady Nyi Mekar Saptarini Rini Hendriani Riska Nurul Hidayah SILVI WULANDARI SRI INDRAYANI Supriyatna ., Supriyatna syafira aulia Syafrudin Purnama Sidiq, Syafrudin Purnama Tina Rostinawati Wiwiek Indriyati - YOVIA RIZKI ARRAHMAN Zakiatun Azma Amani