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All Journal MODUL Nexus Biomedika Journal of Epidemiology and Public Health Jurnal Ilmu Manajemen Indonesian Journal of Global Health research
Muvida Muvida
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Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Efek Nefroprotektor Ekstrak Biji Mahoni (Swietenia mahagoni (L.) Jacq.) terhadap Kerusakan Histologis Sel Ginjal Mencit (Mus musculus) yang Diinduksi Parasetamol Muvida, Muvida; Muthmainah, .; Sari, Yulia
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Seed extract of Swietenia mahagoni (L.) Jacq. contains saponins, flavonoids, alkaloids, terpenoids, steroids, and tannins that may exhibit significant protection of kidney cells from free radicals. In present study, Swietenia mahagoni was evaluated for its nephroprotector effect on paracetamol-induced kidney cells histological damage in mice (Mus musculus).   Methods: This research used experimental laboratory studies with post test only controlled group design. Samples were 28 male Swiss webster mice (2-3 months old) weighing + 20 g and divided into 4 groups, 7 mice each group. Sampling technique in this research was incidental sampling. The negative control group (KK (-)) and the positive control group (KK (+)) of mice were administered aquadest for 14 days. The first treatment group (KP1) and the second group treatment (KP2) of mice were administered mahagony seed extract with the dose of 11,2 mg/20 g and 22,4 mg/20 g body weight of mice for 14 days, respectively. Paracetamol was administered to groups of KK (+), KP1, dan KP2 on the 12th, 13th, and 14th day. On day-15th, mice were sacrificed and their kidneys were taken and stained with hematoxilin eosin (HE) for histological study. The kidney cells histological features were assessed based on quantifying of pyknosis, karyorrhexis, and karyolysis. Data were analyzed with the One-Way ANOVA test (α = 0.05) and Post Hoc Multiple Comparisons LSD test (α = 0.05). Results: The mean of kidney cells histological damage in mice for KK (-), KK (+), KP1 and KP2 were 9.57 + 0.701; 28.93 + 1.698; 9.28 + 0.873 and 27.79 + 1.651, respectively. Result of statistic analysis showed that there were significant differences of kidney cells damage score between KK (-) – KK (+), KK (-) – KP2, KK (+) – KP1, KP1 – KP2, and non significant differences between KK (-) – KP1 and KK (+) – KP2. Conclusions: Swietenia mahagoni (L.) Jacq. seed extract showed nephroprotector effect against paracetamol-induced kidney cells histological damage in mice. Keywords: mahagony seed extract, nephroprotector, kidney cells histological damage
Do Community Health Centers Have Contextual Effect on the Risk of Recurrence in Patient with Tuberculosis? A Multilevel Evidence from Surakarta, Central Java Muvida, Muvida; Widyaningsih, Vitri; Murti, Bhisma
Journal of Epidemiology and Public Health Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Community Health Centers play­ed an important role in tuber­culosis con­trol. Ho­w­ever, Community Health Centers’ con­tex­tual effect toward tuberculosis recurrence has not yet been discovered. The study aims to analyze socio-demography and clinical factors of first tuber­culosis episode and Community Health Centers’ contextual effect toward tuber­culosis recurrence.Subjects and Method: It was analytic obser­vational study with case control approach. The study was conducted in the city of Sura­kar­ta, Central Java, from December 2019 up to January 2020. Sample collection toward 204 tuberculosis patients who had completed their treatment or were confirmed cured, were con­duc­ted by using simple random sampling at individual level and stratified random sampling at community health centers level. The de­pen­dent variable was tuber­culosis recurrence. The independent variables were family income, le­vel of education, BCG vaccination status, smo­­­­king history, initial bac­terio­logical test, weight gain, DM, and COPD. The data were collected through medical record and interview. The data were analyzed by using multi­level multiple logistic regression with Stata 13.Results: In individual level, the preventive factor toward tuberculosis recurrence among other were high income (OR= 0.24; 95% CI= 0.06 up to 0.92; p= 0.037), high level of educa­tion (OR= 0.18; 95% CI= 0.04 up to 0.84; p= 0.029), BCG vaccination status (OR= 0.11; 95% CI= 0.02 up to 0.67; p= 0.017), and high weight gain (OR= 0.06; 95% CI= 0.01 up to 0.28; p< 0.001). Meanwhile, the independent predictors toward tuberculosis recurrence (OR= 7.11; 95% CI= 1.65 up to 30.64; p= 0.009) and diabetes mellitus (OR= 10.85; 95% CI= 2.13 up to 55.29; p= 0.004). In the level of Community Health Centers, high ratio between health workers/ tuberculosis patients significantly cor­related with lower tuberculosis (OR= 0.01; 95% CI< 0.01 up to 0.44; p= 0.016). Community health Centers had contextual effect toward tuberculosis re­currence with Intra-Class Cor­relation (ICC) by 38.67%.Conclusion: Factors in individual and com­munity health centers level may affect tuber­culosis recurrence. Community Health Centers has contextual effect toward tuberculosis re­cur­rent.Keywords: Tuberculosis recurrence, tuber­culosis, predictor, Community Health Center, multi­­level analysisCorrespondence: Muvida. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Su­ta­­mi No. 36 A, Surakarta 57126, Central Java. Email: muvida­md@­gmail.com. Mobile: +628­965­1­4­­50435.Journal of Epidemiology and Public Health (2020), 5(1): 65-78https://doi.org/10.26911/jepublichealth.2020.05.01.07
Efek Nefroprotektor Ekstrak Biji Mahoni (Swietenia mahagoni (L.) Jacq.) terhadap Kerusakan Histologis Sel Ginjal Mencit (Mus musculus) yang Diinduksi Parasetamol Muvida Muvida; . Muthmainah; Yulia Sari
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Seed extract of Swietenia mahagoni (L.) Jacq. contains saponins, flavonoids, alkaloids, terpenoids, steroids, and tannins that may exhibit significant protection of kidney cells from free radicals. In present study, Swietenia mahagoni was evaluated for its nephroprotector effect on paracetamol-induced kidney cells histological damage in mice (Mus musculus). Methods: This research used experimental laboratory studies with post test only controlled group design. Samples were 28 male Swiss webster mice (2-3 months old) weighing + 20 g and divided into 4 groups, 7 mice each group. Sampling technique in this research was incidental sampling. The negative control group (KK (-)) and the positive control group (KK (+)) of mice were administered aquadest for 14 days. The first treatment group (KP1) and the second group treatment (KP2) of mice were administered mahagony seed extract with the dose of 11,2 mg/20 g and 22,4 mg/20 g body weight of mice for 14 days, respectively. Paracetamol was administered to groups of KK (+), KP1, dan KP2 on the 12th, 13th, and 14th day. On day-15th, mice were sacrificed and their kidneys were taken and stained with hematoxilin eosin (HE) for histological study. The kidney cells histological features were assessed based on quantifying of pyknosis, karyorrhexis, and karyolysis. Data were analyzed with the One-Way ANOVA test (? = 0.05) and Post Hoc Multiple Comparisons LSD test (? = 0.05). Results: The mean of kidney cells histological damage in mice for KK (-), KK (+), KP1 and KP2 were 9.57 + 0.701; 28.93 + 1.698; 9.28 + 0.873 and 27.79 + 1.651, respectively. Result of statistic analysis showed that there were significant differences of kidney cells damage score between KK (-) KK (+), KK (-) KP2, KK (+) KP1, KP1 KP2, and non significant differences between KK (-) KP1 and KK (+) KP2. Conclusions: Swietenia mahagoni (L.) Jacq. seed extract showed nephroprotector effect against paracetamol-induced kidney cells histological damage in mice. Keywords: mahagony seed extract, nephroprotector, kidney cells histological damage
Pengaruh Kemudahan Transaksi, Kualitas Produk, Dan Promosi Terhadap Keputusan Pembelian Secara Online (Studi Kasus Pada Konsumen Market Place Shopee Ternate) Subhan, Subhan; Muvida, Muvida; Hidayanti, Ida E.
Jurnal Ilmu Manajemen Vol 12, No 1 (2022): Jurnal Ilmu Manajemen
Publisher : Universitas muhammadiyah palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/jimn.v12i1.4559

Abstract

Previous studies in the field of consumer online purchasing decisions found that the ease of transaction, product quality and promotion factors determine the level of purchasing decisions. This study aims to determine the effect of ease of transaction, product quality and promotion on consumer purchasing decisions. This research is quantitative research using a survey approach in sampling. The population used in this study is the Shopee market place consumer in the city of Ternate. The technique used in sampling is purposive sampling method. A total of one hundred respondent data meets the criteria that have been set previously. The research instrument was tested first with validity and reliability tests to ensure that the questions were correct in measuring the independent and dependent variables. The analytical method used is multiple linear regression using the SPSS program. The results of this study indicate that the three independent variables studied, namely the ease of transactions, product quality and promotions, are proven to have a positive and significant influence on the purchase decision variable as the dependent variable.
INTERPOSITION AND COLOR CONTRAST AS DEPTH ASPECT: FROM 2D MEDIA TO 3D SPACE PRODUCTION Muvida, Muvida; Atmodiwirjo, Paramita; Paramita, Kristanti Dewi
MODUL Vol 23, No 2 (2023): MODUL vol 23 nomor 2 tahun 2023 ( 5 articles )
Publisher : architecture department, Engineering faculty, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/mdl.23.2.2023.68-75

Abstract

This study attempts to dismantle the depth aspects produced by two-dimensional (2D) media such as paintings. as the basis for the production of three-dimensional (3D) space. In particular, we argue that painting as artwork with a flat surface can be transformed into 3D space by incorporating depth aspects. Even though it has a flat surface, painting as a 2D medium has the impression of 3D space and volume, which can be circumvented by constructing the perception of depth. To explore the production of 3D space through depth aspects, four 2D paintings were analyzed to find out how the depth aspects were constructed. The analysis reveals the perception of depth technique through interposition as the depth cues within the arrangement of layers. The analysis also reveals the color contrast as additional aspect that strengthen the perception of depth. Both the interposition and the color contrast become the important aspects that create the perception of depth in the production of the 3D space.
Do Community Health Centers Have Contextual Effect on the Risk of Recurrence in Patient with Tuberculosis? A Multilevel Evidence from Surakarta, Central Java Muvida, Muvida; Widyaningsih, Vitri; Murti, Bhisma
Journal of Epidemiology and Public Health Vol. 5 No. 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Community Health Centers play
Intravenous Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke: Factors Affecting Clinical Outcomes Mustikasari, Hanif; Muvida, Muvida; Nugroho, Limawan Susilo
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6594

Abstract

Stroke is one of the leading causes of disability and death worldwide. Thrombolytic therapy using intravenous recombinant tissue plasminogen activator (rt-PA) is the recommended treatment. However, functional outcomes vary due to various factors. Objective: The aim of this study was to analyze the factors affecting clinical outcomes of acute ischemic stroke patients treated with intravenous rt-PA. Method: This research was a retrospective study with a total sample of 52 acute ischemic stroke patients who received intravenous rt-PA therapy. The research variable data were collected from medical records, then statistically analyzed and correlated with patient clinical outcomes. Data from medical records were collected based on inclusion and exclusion criteria, then statistically analyzed using STATA 13. Univariate analysis is presented in a list of categories according to the research variables determined by percentage (standard error). Bivariate analysis was tested using simple logistic regression and multivariate analysis using multiple logistic regression. Results: The results of this study showed that patient clinical outcomes are not significantly impacted by risk factors (age, gender, prior stroke history, comorbidities), COVID-19 vaccination, onset and severity of stroke, HCTS onset, dosage, or onset therapy. The side effects of intravenous rt-PA have a significant impact on patient clinical outcomes, including therapy response and discharge condition (p = 0.008, p < 0.05, and p = 0.012, OR 34.073 (95% CI 2.165 – 536.147)), but do not affect the length of hospital stay. Conclusions: In considering the other factors, the study indicates that patients experiencing adverse effects from intravenous rt-PA have worse clinical outcomes.
Co-Authors . Muthmainah . Muthmainah Bhisma Murti Hanif Mustikasari Hidayanti, Ida E. Kristanti Dewi Paramita Nugroho, Limawan Susilo Paramita Atmodiwirjo Subhan Subhan Tamaulina Br Sembiring Vitri Widyaningsih Yulia Sari