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All Journal Jurnal Pendidikan dan Pemberdayaan Masyarakat Aceh Journal of Animal Science Jurnal Sains Teh dan Kina Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Oceana Biomedicina Journal JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Biomolecular and Health Science Journal Jurnal Sains dan Teknologi Peternakan Indonesian Journal of Applied Research (IJAR) OISAA Journal of Indonesia Emas
Reny Rosalina
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Aktifitas Antibakteri Ekstrak Jamur Endofit Mangga Podang (Mangifera indica L.) Asal Kabupaten Kediri Jawa Timur Reny Rosalina; Riska Surya Ningrum; Prima Agusti Lukis
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 35, No 3 (2018)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.006 KB) | DOI: 10.20884/1.mib.2018.35.3.757

Abstract

Jamur endofit merupakan salah satu mikroba endofit yang hidup di dalam jaringan tumbuhan dan diketahui dapat menghasilkan senyawa aktif yang mirip dengan tumbuhan inangnya. Penelitian ini bertujuan untuk mengetahui aktifitas antibakteri dari ekstrak media dan ekstrak jamur endofit yang berhasil diisolasi dari ranting mangga podang (Mangifera indica L.). Didapatkan empat jenis jamur endofit hasil isolasi yang kemudian dikultur menggunakan media padat Potato Dextrose Agar (PDA) kemudian dipindahkan ke media cair Potato Dextrose Broth (PDB). Setelah miselia tumbuh selama inkubasi, media dan biomassaa jamur dipisahkan dengan filtrasi vakum. Jamur yang telah dikeringkan dimaserasi menggunakan metanol, sedangkan media jamur diekstraksi menggunakan etil asetat. Ekstrak jamur dan ekstrak media kemudian diuji aktivitas terhadap bakteri Escherichia coli, Staphylococcus aureus, Salmonella thypi, dan Staphylococcus mutan menggunakan metode difusi cakram kertas. (Disk Diffusion Method). Kontrol negatif yang digunakan adalah aquades sedangkan sebagai pembanding adalah antibiotik ciprofloxacin dan kloramfenikol. Hasil penelitian menunjukan bahwa ekstrak jamur dan ekstrak media jamur memiliki aktifitas sebagai antibakteri dengan sensitifitas yang berbeda-beda. Ekstrak media jamur memiliki sensitifitas yang lebih tinggi terhadap beberapa macam bakteri dibandingkan dengan ekstrak yang diperoleh dari biomassa jamur.
Molecular Mechanism of Cholerae Toxin (ctx) in Causing Diarrhea Rian Ka Praja; Reny Rosalina
Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i2.16

Abstract

Vibrio cholerae is one of the pathogenic bacteria transmitted through contaminated food, especially contaminated seafood and beverages. V. cholerae produces cholerae toxin (ctx) which is encoded by the ctx gene located within its chromosome. This toxin has been recognized as one of the toxins responsible for cholera outbreaks. The mechanism of ctx gene expression is induced by environmental signals such as pH, osmolarity, temperature, bile, amino acids, and CO2. These signals will be a positive transcriptional factor to the ToxR gene that regulates the biogenesis of cholerae toxin. After cholerae toxin has been successfully expressed, V. cholerae uses a type II secretion (T2S) pathway to deliver cholerae toxin to the extracellular environment. Cholerae toxin consists of A and B subunits. The B subunit plays a role in attaching to the receptor Manosialosyl Ganglioside (GM1 ganglioside) and the Asubunit plays a role in catalyzing ADP-ribosylation of Gs (stimulatory) protein and turning them into active condition. The Gs protein will convert the inactive adenilate cyclase (AC) into active AC. The increase of AC activity will increase the cyclic adenosine 3'5'-monophosphate (cAMP) concentration along the cell membrane. The cAMP then causes theactive secretion of sodium (Na+), chloride (Cl-), potassium (K+), bicarbonate (HCO3-), and water (H2O) out of the cell into the intestinal lumen, resulting in large fluid losses and electrolyte imbalances.
Co-Authors Aisyah Hadi Ramadani Aisyah Ramadani Angella Ananda Saputra Anggita Ratri Pusporini Anita Alni, Anita Desy Yustiyani Didin Mujahidin Dwi Dianita Irawan I Dewa Made Sukrama I Wayan Muda Suta Arta Karin Alifia Rachmadani Lukis, Prima Agusti Ni Nengah Dwi Fatmawati Rian Ka Praja Rio Altha Reyzando Riska Surya Ningrum Rofiatun Solekha Setiyowati, Putri Ayu Ika Siti Zubaidah Sri Bintang Sahara Mahaputra Kusumanegara