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All Journal Jurnal Kesehatan Folia Medica Indonesiana WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Cendekia Journal of Pharmacy Jurnal Farmasi Komunitas Jurnal Sains dan Kesehatan

Bambang Subakti Zulkarnain

Department Of Clinical Pharmacy, Faculty Of Pharmacy Airlangga University, Surabaya

Author-ID : 3305385

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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The Effect of Dual Antiplatelet Post Percutaneous Coronary Intervention On Aggregation of Platelet In Myocardial Infarction Patients With Diabetes Mellitus and Non Diabetes Mellitus Rahmawati, Yessi Asli; Yogiarto, Mohammad; Zulkarnaen, Bambang Subakti
Indonesian Journal of Pharmacy Vol 29 No 1, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

To analyze the differences in the effect of dual antiplatelet post PCI on the percentage of aggregation in myocardial infarction patients with DM and non DM. Percentage of aggregation were analyzed using light transmission aggregometry (LTA) before loading dose, after PCI, and after maintenance dose of dual antiplatelet (aspirin 100mg and clopidogrel 75mg). Total 22 patients were participated in this study divided into 10 and 12 patients in diabetic and non diabetic group. Percentage of aggregation after taking dual antiplatelet maintenace dose decrease significantly in both group (p=0.006 in diabetic group and p=0.002 in non diabetic group). Mean reduction of percentage of aggregation in diabetic group (3.30Â±2.91%) is less than non diabetic group (6.83Â±5.97%). Statistical analysis shows that the mean reduction of percentage of aggregation between two groups were not significantly different (p>0.05). Mean percentage of aggregation after dual antiplatelet maintenance dose was higher in diabetic group and mean reduction of percentage of aggregation was higher in non diabetic group, although statistically in both group it is not significantly different.

The Effect of 20-20-20 Rule Dissemination and Artificial Tears Administration in High School Students Diagnosed with Computer Vision Syndrome Bambang Subakti Zulkarnain; Aniek Setiya Budiatin; Toetik Aryani; Rozalina Loebis
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Computers and gadgets are modern tools for assisting Senior High School students’ work. However, using gadgets more than 2 hours a day may cause computer vision syndrome (CVS), which can interfere with academic activities. CVS main symptom is dry eyes. CVS could be prevented by applying the 20-20-20 rule and artificial tears. A total of 100 students from two public high schools in Kediri with 50 students from each school were selected for this community service. All students diagnosed with CVS participated in the dissemination of 20-20-20 rule and artificial tear administration. The pre-test and post-test scores, the Tear Break Up Time Test (TBUT) and the Ocular Disease Surface Index (OSDI) were measured within two weeks. TBUT and OSDI are parameters for measuring dry eye. Likewise, interviews were conducted to assess the adherence to the 20-20-20 rule and artificial tea administration. The results showed the knowledge level increased (p <0.0001). Most students understood 20-20-20 rule and how to administer artificial tears correctly. However, the adherence to both methods was approximately 50%. There was an improvement in the TBUT (p <0.0001) for dry eyes but not for OSDI (p> 0.05). Applying the 20-20-20 rule and artificial tears could be used for CVS treatment.

Pivotal role reelin signaling pathway in the development of tolerance to morphine-induced antinociception Bambang Subakti Zulkarnanin; Junaidi Khotib
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The huge endogenous macromolecule protein responsible for controlling migration and dendritic growth of developing neurons, reelin, has recently been proposed that its signaling pathway modulates synaptic plasticity in the adult rodent brain. This study was carried out to investigate the pivotal role of the reelin signaling pathway in the development of tolerance to morphine induced antinociception. There was evidence that repeated intracerebroventricular administration of reelin’s monoclonal antibody, the competitive inhibitor to reelin – apolipoprotein receptor E2 recombinant, and disabled1 (Dab1) protein inhibitor – MG132, resulted in the inhibition to the development of antinociception tolerance to morphine administration. Furthermore, chronic in vivo administration with morphine caused significance increase of the immunoreactivity (IR) for phosphorylated-Dab1 in the thalamus. These data suggested that persistent activation of reelin signaling pathway due to chronic administration of morphine may be responsible for the development of tolerance to morphine-induced antinociception.Key words: Morphine tolerance, Neuronal plasticity, Opioid receptor, Reelin signalling pathway

Faktor yang Berhubungan dengan Long-term COVID-19: Studi Observasi Cross-Sectional di Indonesia Arina Dery Puspitasari; Nanda Ardianto; Lily Aina; Eunice Marlene Sicilia Kundiman; Fatimatuz Zahra Oviary Satryo; Melinda Putri Amelia Rachman; Fauzul Meiliani; Pharmasinta Putri Hapsari; Bambang Subakti Zulkarnain; Alfian Nur Rosyid; Tamara Nur Budiarti; Brigitta Dhyah Kunthi Wardhani
WMJ (Warmadewa Medical Journal) Vol 7 No 1 (2022): May 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.1.4784.33-39

Long-term COVID-19 could occur in COVID-19 patients, affecting the patient's quality of life, and becoming a problem for public health. However, information is rarely on factors associated with the occurrence of long COVID-19 cases. This study analyzed factors associated with long-term COVID-19. The study was an observational cross-sectional, conducted in August 2021. The data were collected through a Google form questionnaire distributed to COVID-19 survivors in Indonesian. They must be aged more than 17 years to meet the inclusion criteria, while those with incomplete data were excluded. The data were processed by using SPSS 21 with an ordinal regression test in which an alpha level was 5%. As many as 101 from 16 men (15.8%) and 85 women (84.2%) were obtained. Comorbid status (p-value = 0.001) and duration of treatment (p-value = 0.034 and 0.015) had a significant association with the occurrence of long-term COVID-19. Meanwhile, age, gender, occupation, type of care, and vaccination status were not likely associated with long-term COVID-19. COVID-19 patients with comorbidity and a long duration of treatment are more likely to experience long-term COVID-19. Keywords: COVID-19, long-term COVID-19, factor, public health

EVALUATION OF COVID-19 VACCINE EFFECTIVENESS AMONG HEALTHCARE WORKERS USING CASCADE ANALYSIS Bambang Subakti Zulkarnain; Eunice Marlene Sicilia Kundiman; Lily Aina; Nanda Ardianto; Fauzul Meiliani; Melinda Putri Amelia Rachman; Fatimatuz Zahra Oviary Satryo; Pharmasinta Putri Hapsari; Arina Dery Puspitasari; Alfian Nur Rosyid; Tamara nUR Budiarti
Jurnal Kesehatan Vol 15 No 2 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i2.27553

Background: Healthcare workers in Indonesia have been prioritized for vaccination. Nevertheless, fully vaccinated healthcare workers are still at risk of being infected with COVID-19, but will be less likely to develop severe symptoms, be hospitalized or be at risk for death as compared to those who have not been vaccinated. Objectives: This study aims to analyze the incidence of COVID-19 in fully vaccinated healthcare workers. Methods: This cross-sectional study was conducted in 2021. All healthcare workers who have been fully vaccinated, have recovered from COVID-19 (2-4 weeks after vaccination) and able to complete a questionnaire were the participants. The collected data was then analyzed using the cascade method. Results: Based on the 529 collected questionnaires, by using the cascade analysis conclude that the percentage of healthcare workers who have been fully vaccinated was 99%, healthcare workers who have been fully vaccinated and then infected with COVID-19 was 14%, healthcare workers who have been fully vaccinated, infected with COVID-19 and hospitalized was 4%, healthcare workers who have been fully vaccinated, exposed to COVID-19, hospitalized and experienced the long-haul effect of COVID-19 was 0%. Discussion: Health workers are still at risk of being confirmed by COVID-19, because have high risk of being exposed in the workplace. The risk of being confirmed and severity are also influenced by age, gender and comorbidities. Conclusions: Complete vaccinations of healthcare workers did not reduce their risk of being infected with COVID-19, however, it can reduce the severity and the risk of the long-haul effects.

Sodium Hyaluronate Eye Drops for College Students with Computer Vision Syndrome in Indonesia Bambang Subakti Zulkarnain; Rozalina Loebis; Toetik Aryani
Folia Medica Indonesiana Vol. 58 No. 4 (2022): December
Publisher : Universitas Airlangga

Highlights: Computer vision syndrome (CVS) that causes dry eyes becomes a health problem for college students. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS. Abstract: The use of computers and mobile devices is increasing. Computers and mobile devices help our daily work or study. However, prolonged use of them may cause computer vision syndrome (CVS). Nowadays, CVS becomes a health problem for everyone working with computers or mobile devices including college students because it causes dry eyes. It may disrupt reading, doing professional work, or using a computer which is important for college students to complete academic tasks. Sodium hyaluronate can be used to overcome the dry eye problem due to CVS. To assess the effectiveness of sodium hyaluronate eyedrops on students suffering from CVS, pre- and post-administration of sodium hyaluronate was measured for two weeks. Inclusion criteria for this study were college students aged 20-35 years, using a computer for >2 hours a day, not using nonsteroidal anti-inflammatory drugs (NSAIDs), not consuming drugs, or having a disease that affects tear production and bearing no pregnancy. Parameters assessed include tear break-up time using the Tear Break-Up Time (TBUT) test, tear production using the Schirmer I test, the number of clinically subjective symptoms, and Ocular Surface Disease Index (OSDI) scores. Data were analyzed using student paired t-tests or Wilcoxon Rank Test. There were statistically significant differences before and after the TBUT (4.4 vs 6.7 seconds; p<0.0001); the Schirmer I Test (4 vs 6 mm; p<0.05), and the number of clinically subjective symptoms (3 vs 0 clinically subjective symptoms; p<0.0001). The OSDI scores did not show statistical differences before and after administration of sodium hyaluronate (27 vs 21; p>0.05), but there was a positive impact from moderate to mild dry eye. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.

Faktor yang Berpengaruh terhadap Kesehatan Mental Karyawan Non Kesehatan ketika Kembali Bekerja saat Pandemi COVID-19 Alfiyah Hasanah; Alvita Raniah Aisyah Putri; Aranza Khoirina Audrey Abbas; Cici Aisyah Putri Rogahang; Cladita Pamungkas Putri; Clarissa Budiman; Desi Ratu Puspita; Erviana; Bambang Subakti Zulkarnain; Febria Rossa Alba; Hana Rizqi Ghaesani; Misbahul Munir; Nurul Khikmiyah; Paulina Ari Damayanti; Rebecca Ferida Octaviani
Jurnal Farmasi Komunitas Vol. 10 No. 1 (2023): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v10i1.32895

Pandemi COVID-19 telah menyebabkan sebagian orang merasa khawatir atau takut berlebihan hingga menimbulkan kecemasan dan ketakutan. Kecemasan merupakan hal wajar yang dialami setiap manusia, dimana seseorang merasa ketakutan yang tidak jelas,seperti saat pandemi COVID-19 sebagai wabah yang membawa dampak termasuk korban. Terlebih banyaknya informasi yang belum akurat menambah dampak psikis termasuk stres dan kecemasan. Penelitian ini bertujuan mengetahui hubungan karakteristik demografi dengan tingkat stres dan kecemasan pada karyawan non kesehatan yang kembali bekerja di kantor setelah work from home. Studi observasional dilakukan dengan menggunakan kuesioner survei PSS (Perceived Stress Scale) dan GAD-7 (General Anxiety Disorder-7). Sampel diambil menggunakan metode accidental sampling dengan kriteria inklusi karyawan non kesehatan yang bekerja di kantor dan sudah kembali bekerja secara luring dengan intensitas kerja minimal 3 hari dalam seminggu. Terdapat 145 responden yang berpartisipasi pada penelitian ini. Uji korelasi pearson dilakukan untuk menganalisis hubungan antara karakteristik demografi terhadap stress dan kecemasan. Data demografi mencakup usia, jenis kelamin, pendidikan terakhir, status pernikahan, pekerjaan, jumlah jam kerja, pendapatan, riwayat COVID-19, vaksinasi, dan persepsi terhadap COVID-19. Terdapat hasil yang bermakna antara tingkat stres dengan usia dan pendidikan (p<0,05).. Kesehatan mental berupa stres dan kecemasan pada penelitian ini dipengaruhi oleh usia, dan tingkat pendidikan. Promosi kesehatan yang berfokus pada kesehatan mental perlu untuk dilakukan.

Predicting Factors for COVID-19 Infection: A Cross-Sectional Study in Indonesia Pharmasinta Putri Hapsari; Lily Aina; Nanda Ardianto; Eunice Marlene Sicilia Kundiman; Fatimatuz Zahra Oviary Satryo; Melinda Putri Amelia Rachman; Fauzul Meiliani; Farah Meutia; Arina Dery Puspitasari; Bambang Subakti Zulkarnain; Alfian Nur Rosyid; Tamara Nur Budiarti; Brigitta Dhyah Kunthi Wardhani; Dhieo Kurniawan
WMJ (Warmadewa Medical Journal) Vol 8 No 1 (2023): May 2023
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.8.1.5329.34-40

COVID-19 cases in Indonesia still remain a concern, particularly for public health. Several factors, such as gender, age, comorbidity, occupation, and vaccination status, might influence COVID-19 infection. Individuals who have many predicting factors have a higher risk of being infected by COVID-19. Other studies have not yet shown the significance of predicting factors for COVID-19 infection in Indonesia. The study explored the association between the predicting factors and COVID-19 infection in Indonesia. The study used a cross-sectional method with a population of all Indonesian communities. It was conducted in August 2021 by distributing a Google Form questionnaire in Indonesia. By a saturated sampling of the population in Jawa, Sumatera, Sulawesi, Kalimantan, and Papua, 776 Indonesians were selected; they were aged > 17 years and voluntarily completed the questionnaires. whereas respondents with incomplete data were excluded from this study. The data were analyzed using a binary logistic regression test in SPSS (version 21.0). The respondents include 134 men (17.3%) and 642 women (82.7%). The binary logistic regression analysis showed that COVID-19 infection was more common among respondents who were non-health-care workers (p 0.001) and less common among those who had been fully vaccinated (p 0.001). The COVID-19 infection was significantly associated with occupation and vaccination status. Keywords: COVID-19 Infection, Predicting Factors, Public Health, Health-Care Worker, COVID-19 Vaccination, Comorbidity

ANALISIS EFEK SAMPING KANAMISIN DAN KAPREOMISIN TERHADAP FUNGSI GINJAL PADA PASIEN TB RO DI RSUD DR. SOETOMO Syefi Nuraeni Fitriana; Bambang Subakti Zulkarnain; Herri Yulimanida
Cendekia Journal of Pharmacy Vol 7, No 1 (2023): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v7i1.195

Tingginya efek samping dan lamanya terapi pengobatan TB resisten menjadi kendala utama dalam keberhasilan terapi TB resisten. Salah satu efek samping obat yang serius dan dapat mengancam jiwa adalah gangguan ginjal. Kanamisin dan kapreomisin merupakan obat TB MDR yang dapat menyebabkan efek samping gangguan ginjal. Penelitian ini bertujuan untuk mengetahui insidensi efek samping hipokalemia dan nefrotoksik pada pasien TB MDR, berapa lama onsetnya, dan bagaimana cara pengatasannya. Pengambilan data dilakukan secara retrospektif dari rekam medis pasien di poli rawat jalan TB MDR RSUD dr. Soetomo Surabaya selama periode Januari 2018-Juni 2020. Didapatkan 183 rekam medis pasien dan yang memenuhi kriteria inklusi sebanyak 112 rekam medis. Efek samping yang diteliti adalah hipokalemia dan nefrotoksik yang dianalisis berdasarkan kadar kalium dan serum kreatinin. Hasil penelitian menunjukkan efek samping terhadap gangguan ginjal lebih banyak ditemukan pada kelompok pasien yang menggunakan kapreomisin dibandingkan pada kelompok pasien yang menggunakan kanamisin, yaitu hipokalemia 70,45% dan nefrotoksik 30,23% pada kelompok kapreomisin, sedangkan pada kelompok kanamisin hipokalemia 38,24% dan nefrotoksik 20,29%.

Risk Factor Analysis of Adverse Effects of Kanamycin and Capreomycin on Kidney Function in Multidrug-Resistant TB Patients Bambang Subakti Zulkarnain; Syefi Nuraeni Fitriana; Herri Yulimanida
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 2 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i22023.202-209

Background: Multidrug-Resistant TB treatment's high side effects and long duration are barriers to successful TB therapy. Various side effects such as age, gender, body weight, comorbidities, and drug dose can cause severe side effects, including impaired renal function (nephrotoxic). Objectives: This study aimed to analyze the risk factors of side effects of the failure of kanamycin and capreomycin therapy that can cause impaired renal function in Multidrug-Resistant TB patients. Methods: Data were collected retrospectively by searching and recording the medical records of Multidrug-Resistant TB patients at the Multidrug-Resistant TB Polyclinic. There were 183 patients at Dr Soetomo Hospital who met the inclusion criteria. Results: There was a significant relationship between gender in the kanamycin group and the appearance of side effects of renal impairment (p= 0.035). There was no effect of age, comorbid diseases, body weight, and dose of drug administration on the side effects of kanamycin and capreomycin in treating Multidrug-Resistant TB on impaired renal function (nephrotoxic). However, nephrotoxic side effects in elderly patients were more common in the kanamycin group (p=0.001). Conclusion: Gender affects the side effects of kanamycin and capreomycin in treating Multidrug-Resistant TB in nephrotoxic patients. In addition, stricter supervision of the use of kanamycin in elderly patients (>40 years) to minimize the incidence of side effects of impaired renal function in the treatment of Multidrug-Resistant TB.

Co-Authors Alfiyah Hasanah Alvita Raniah Aisyah Putri Aranza Khoirina Audrey Abbas Arina Dery Puspitasari Arina Dery Puspitasari Brigitta Dhyah Kunthi Wardhani Brigitta Dhyah Kunthi Wardhani Budiatin, Aniek Setiya Cici Aisyah Putri Rogahang Cladita Pamungkas Putri Clarissa Budiman Desi Ratu Puspita Dhieo Kurniawan Erviana Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Farah Meutia Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Febria Rossa Alba Hana Rizqi Ghaesani Heri Yulimanida Herri Yulimanida Herri Yulimanida Junaidi Khotib Lily Aina Lily Aina Lily Aina Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Misbahul Munir Naksa Garnida Arfie Nanda Ardianto Nanda Ardianto Nanda Ardianto Nurul Khikmiyah Paulina Ari Damayanti Pharmasinta Putri Hapsari Rebecca Ferida Octaviani Rosyid, Alfian Nur Rozalina Loebis Sudarmanto Sudarmanto Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Tamara Nur Budiarti Tamara Nur Budiarti Tamara nUR Budiarti Toetik Aryani Yessi Rahmawati Yogiarto, Mohammad

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