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All Journal Jurnal Kesehatan WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Cendekia Journal of Pharmacy Jurnal Insan Farmasi Indonesia Jurnal Farmasi Komunitas Eduvest - Journal of Universal Studies Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Bambang Subakti Zulkarnain
Department Of Clinical Pharmacy, Faculty Of Pharmacy Airlangga University, Surabaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Effect of Dual Antiplatelet Post Percutaneous Coronary Intervention On Aggregation of Platelet In Myocardial Infarction Patients With Diabetes Mellitus and Non Diabetes Mellitus Rahmawati, Yessi Asli; Yogiarto, Mohammad; Zulkarnaen, Bambang Subakti
Indonesian Journal of Pharmacy Vol 29 No 1, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.699 KB) | DOI: 10.14499/indonesianjpharm29iss1pp44

Abstract

To analyze the differences in the effect of dual antiplatelet post PCI on the percentage of aggregation in myocardial infarction patients with DM and non DM. Percentage of aggregation were analyzed using light transmission aggregometry (LTA) before loading dose, after PCI, and after maintenance dose of dual antiplatelet (aspirin 100mg and clopidogrel 75mg). Total 22 patients were participated in this study divided into 10 and 12 patients in diabetic and non diabetic group. Percentage of aggregation after taking dual antiplatelet maintenace dose decrease significantly in both group (p=0.006 in diabetic group and p=0.002 in non diabetic group). Mean reduction of percentage of aggregation in diabetic group (3.30±2.91%) is less than non diabetic group (6.83±5.97%). Statistical analysis shows that the mean reduction of percentage of aggregation between two groups were not significantly different (p>0.05). Mean percentage of aggregation after dual antiplatelet maintenance dose was higher in diabetic group and mean reduction of percentage of aggregation was higher in non diabetic group, although statistically in both group it is not significantly different.
The Effect of 20-20-20 Rule Dissemination and Artificial Tears Administration in High School Students Diagnosed with Computer Vision Syndrome Bambang Subakti Zulkarnain; Aniek Setiya Budiatin; Toetik Aryani; Rozalina Loebis
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1105.748 KB) | DOI: 10.22146/jpkm.54121

Abstract

Computers and gadgets are modern tools for assisting Senior High School students’ work. However, using gadgets more than 2 hours a day may cause computer vision syndrome (CVS), which can interfere with academic activities. CVS main symptom is dry eyes. CVS could be prevented by applying the 20-20-20 rule and artificial tears. A total of 100 students from two public high schools in Kediri with 50 students from each school were selected for this community service. All students diagnosed with CVS participated in the dissemination of 20-20-20 rule and artificial tear administration. The pre-test and post-test scores, the Tear Break Up Time Test (TBUT) and the Ocular Disease Surface Index (OSDI) were measured within two weeks. TBUT and OSDI are parameters for measuring dry eye. Likewise, interviews were conducted to assess the adherence to the 20-20-20 rule and artificial tea administration. The results showed the knowledge level increased (p <0.0001). Most students understood 20-20-20 rule and how to administer artificial tears correctly. However, the adherence to both methods was approximately 50%. There was an improvement in the TBUT (p <0.0001) for dry eyes but not for OSDI (p> 0.05). Applying the 20-20-20 rule and artificial tears could be used for CVS treatment.
Pivotal role reelin signaling pathway in the development of tolerance to morphine-induced antinociception Bambang Subakti Zulkarnanin; Junaidi Khotib
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.119 KB) | DOI: 10.14499/indonesianjpharm0iss0pp157-164

Abstract

The huge endogenous macromolecule protein responsible for controlling migration and dendritic growth of developing neurons, reelin, has recently been proposed that its signaling pathway modulates synaptic plasticity in the adult rodent brain. This study was carried out to investigate the pivotal role of the reelin signaling pathway in the development of tolerance to morphine induced antinociception. There was evidence that repeated intracerebroventricular administration of reelin’s monoclonal antibody, the competitive inhibitor to reelin – apolipoprotein receptor E2 recombinant, and disabled1 (Dab1) protein inhibitor – MG132, resulted in the inhibition to the development of antinociception tolerance to morphine administration. Furthermore, chronic in vivo administration with morphine caused significance increase of the immunoreactivity (IR) for phosphorylated-Dab1 in the thalamus. These data suggested that persistent activation of reelin signaling pathway due to chronic administration of morphine may be responsible for the development of tolerance to morphine-induced antinociception.Key words: Morphine tolerance, Neuronal plasticity, Opioid receptor, Reelin signalling pathway
EVALUATION OF COVID-19 VACCINE EFFECTIVENESS AMONG HEALTHCARE WORKERS USING CASCADE ANALYSIS Bambang Subakti Zulkarnain; Eunice Marlene Sicilia Kundiman; Lily Aina; Nanda Ardianto; Fauzul Meiliani; Melinda Putri Amelia Rachman; Fatimatuz Zahra Oviary Satryo; Pharmasinta Putri Hapsari; Arina Dery Puspitasari; Alfian Nur Rosyid; Tamara nUR Budiarti
Jurnal Kesehatan Vol 15 No 2 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i2.27553

Abstract

Background: Healthcare workers in Indonesia have been prioritized for vaccination. Nevertheless, fully vaccinated healthcare workers are still at risk of being infected with COVID-19, but will be less likely to develop severe symptoms, be hospitalized or be at risk for death as compared to those who have not been vaccinated. Objectives: This study aims to analyze the incidence of COVID-19 in fully vaccinated healthcare workers. Methods: This cross-sectional study was conducted in 2021. All healthcare workers who have been fully vaccinated, have recovered from COVID-19 (2-4 weeks after vaccination) and able to complete a questionnaire were the participants. The collected data was then analyzed using the cascade method. Results: Based on the 529 collected questionnaires, by using the cascade analysis conclude that the percentage of healthcare workers who have been fully vaccinated was 99%, healthcare workers who have been fully vaccinated and then infected with COVID-19 was 14%, healthcare workers who have been fully vaccinated, infected with COVID-19 and hospitalized was 4%, healthcare workers who have been fully vaccinated, exposed to COVID-19, hospitalized and experienced the long-haul effect of COVID-19 was 0%. Discussion: Health workers are still at risk of being confirmed by COVID-19, because have high risk of being exposed in the workplace. The risk of being confirmed and severity are also influenced by age, gender and comorbidities. Conclusions: Complete vaccinations of healthcare workers did not reduce their risk of being infected with COVID-19, however, it can reduce the severity and the risk of the long-haul effects.
Faktor yang Berpengaruh terhadap Kesehatan Mental Karyawan Non Kesehatan ketika Kembali Bekerja saat Pandemi COVID-19 Alfiyah Hasanah; Alvita Raniah Aisyah Putri; Aranza Khoirina Audrey Abbas; Cici Aisyah Putri Rogahang; Cladita Pamungkas Putri; Clarissa Budiman; Desi Ratu Puspita; Erviana; Bambang Subakti Zulkarnain; Febria Rossa Alba; Hana Rizqi Ghaesani; Misbahul Munir; Nurul Khikmiyah; Paulina Ari Damayanti; Rebecca Ferida Octaviani
Jurnal Farmasi Komunitas Vol. 10 No. 1 (2023): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v10i1.32895

Abstract

Pandemi COVID-19 telah menyebabkan sebagian orang merasa khawatir atau takut berlebihan hingga menimbulkan kecemasan dan ketakutan. Kecemasan merupakan hal wajar yang dialami setiap manusia, dimana seseorang merasa ketakutan yang tidak jelas,seperti saat pandemi COVID-19 sebagai wabah yang membawa dampak termasuk korban. Terlebih banyaknya informasi yang belum akurat menambah dampak psikis termasuk stres dan kecemasan. Penelitian ini bertujuan mengetahui hubungan karakteristik demografi dengan tingkat stres dan kecemasan pada karyawan non kesehatan yang kembali bekerja di kantor setelah work from home. Studi observasional dilakukan dengan menggunakan kuesioner survei PSS (Perceived Stress Scale) dan GAD-7 (General Anxiety Disorder-7). Sampel diambil menggunakan metode accidental sampling dengan kriteria inklusi karyawan non kesehatan yang bekerja di kantor dan sudah kembali bekerja secara luring dengan intensitas kerja minimal 3 hari dalam seminggu. Terdapat 145 responden yang berpartisipasi pada penelitian ini. Uji korelasi pearson dilakukan untuk menganalisis hubungan antara karakteristik demografi terhadap stress dan kecemasan. Data demografi mencakup usia, jenis kelamin, pendidikan terakhir, status pernikahan, pekerjaan, jumlah jam kerja, pendapatan, riwayat COVID-19, vaksinasi, dan persepsi terhadap COVID-19. Terdapat hasil yang bermakna antara tingkat stres dengan usia dan pendidikan (p<0,05).. Kesehatan mental berupa stres dan kecemasan pada penelitian ini dipengaruhi oleh usia, dan tingkat pendidikan. Promosi kesehatan yang berfokus pada kesehatan mental perlu untuk dilakukan.
ANALISIS EFEK SAMPING KANAMISIN DAN KAPREOMISIN TERHADAP FUNGSI GINJAL PADA PASIEN TB RO DI RSUD DR. SOETOMO Syefi Nuraeni Fitriana; Bambang Subakti Zulkarnain; Herri Yulimanida
Cendekia Journal of Pharmacy Vol 7, No 1 (2023): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v7i1.195

Abstract

Tingginya efek samping dan lamanya terapi pengobatan TB resisten menjadi kendala utama dalam keberhasilan terapi TB resisten. Salah satu efek samping obat yang serius dan dapat mengancam jiwa adalah gangguan ginjal. Kanamisin dan kapreomisin merupakan obat TB MDR yang dapat menyebabkan efek samping gangguan ginjal. Penelitian ini bertujuan untuk mengetahui insidensi efek samping hipokalemia dan nefrotoksik pada pasien TB MDR, berapa lama onsetnya, dan bagaimana cara pengatasannya. Pengambilan data dilakukan secara retrospektif dari rekam medis pasien di poli rawat jalan TB MDR RSUD dr. Soetomo Surabaya selama periode Januari 2018-Juni 2020. Didapatkan 183 rekam medis pasien dan yang memenuhi kriteria inklusi sebanyak 112 rekam medis. Efek samping yang diteliti adalah hipokalemia dan nefrotoksik yang dianalisis berdasarkan kadar kalium dan serum kreatinin. Hasil penelitian menunjukkan efek samping terhadap gangguan ginjal lebih banyak ditemukan pada kelompok pasien yang menggunakan kapreomisin dibandingkan pada kelompok pasien yang menggunakan kanamisin, yaitu hipokalemia 70,45% dan nefrotoksik 30,23% pada kelompok kapreomisin, sedangkan pada kelompok kanamisin hipokalemia 38,24% dan nefrotoksik 20,29%.
Risk Factor Analysis of Adverse Effects of Kanamycin and Capreomycin on Kidney Function in Multidrug-Resistant TB Patients Bambang Subakti Zulkarnain; Syefi Nuraeni Fitriana; Herri Yulimanida
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 2 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i22023.202-209

Abstract

Background: Multidrug-Resistant TB treatment's high side effects and long duration are barriers to successful TB therapy. Various side effects such as age, gender, body weight, comorbidities, and drug dose can cause severe side effects, including impaired renal function (nephrotoxic). Objectives: This study aimed to analyze the risk factors of side effects of the failure of kanamycin and capreomycin therapy that can cause impaired renal function in Multidrug-Resistant TB patients. Methods: Data were collected retrospectively by searching and recording the medical records of Multidrug-Resistant TB patients at the Multidrug-Resistant TB Polyclinic. There were 183 patients at Dr Soetomo Hospital who met the inclusion criteria. Results: There was a significant relationship between gender in the kanamycin group and the appearance of side effects of renal impairment (p= 0.035). There was no effect of age, comorbid diseases, body weight, and dose of drug administration on the side effects of kanamycin and capreomycin in treating Multidrug-Resistant TB on impaired renal function (nephrotoxic). However, nephrotoxic side effects in elderly patients were more common in the kanamycin group (p=0.001). Conclusion: Gender affects the side effects of kanamycin and capreomycin in treating Multidrug-Resistant TB in nephrotoxic patients.  In addition, stricter supervision of the use of kanamycin in elderly patients (>40 years) to minimize the incidence of side effects of impaired renal function in the treatment of Multidrug-Resistant TB.
Efektivitas Deferasirox pada Pasien Thalasemia Mayor: Artikel Review: Efficacy of Deferasirox for Thalassemia Mayor: Review Article Naksa Garnida Arfie; Bambang Subakti Zulkarnaen; Sudarmanto Sudarmanto
Jurnal Sains dan Kesehatan Vol. 4 No. 3 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i3.1159

Abstract

Thalassemia is a heterogeneous grouping of genetic disorders resulting from decreased synthesis of the alpha or beta chains of hemoglobin. Anemia and iron overload are the main causes of morbidity and mortality due to thalassemia disease. Iron chelation has improved the survival and quality of life of patients with thalassemia major. Deferasirox (DFX) was developed as monotherapy for the treatment of transfusion iron overload. Search data in this literature study using an electronic database, namely Science Direct, Pubmed with the keywords thalassemia, deferasirox and efficacy. The search results obtained 1015 articles and 5 articles that matched the inclusion and exclusion criteria. The total patients in this study were 410 people from 5 countries. The results of the review article found that deferasirox was effective in reducing iron in the body as seen from the LIC (Liver Iron Concentration), T2* heart and serum ferritin in patients with thalassemia major.
Analisis Efek Samping Kanamisin dan Kapreomisin terhadap Fungsi Ginjal pada Pasien TB RO di RSUD Dr. Soetomo: Adverse Effect Analysis of Kanamicin and Capreomycin on Kidney Function in DR TB Patients at Dr. Soetomo Hospital Syefi Nuraeni Fitriana; Bambang Subakti Zulkarnain; Heri Yulimanida
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1174

Abstract

The high of adverse effect of resistant TB treatment and the long duration of the treatment is the main obstacle in the success of resistant TB therapy. One of the serious and life-threatening adverse effect of the treatment is nephrotoxic. Kanamycin and capreomycin are MDR TB drugs that can induce nephrotoxic and kidney disorder. This study aims to determine the incidence of hypokalemia and nephrotoxic induced by kanamycin and capreomycin, the onset of the kidney disorder, and its management. Data were collected retrospectively from the medical records of patients in the MDR TB outpatient clinic at Dr. Soetomo Hospital Surabaya during the period January 2018-June 2020. There were 183 patient medical records and only 112 medical records that met the inclusion criteria. The adverse effects studied were hypokalemia and nephrotoxicity which were analyzed based on potassium and creatinine serum levels. The result showed that adverse effect on kidney disorders were more common in the group of patients taking capreomycin than in the group of patients taking kanamycin. Hypokalemia were found 70.45% and nephrotoxicity were found 30.23% in the capreomycin group, while in the kanamycin group, hypokalemia were found 38.24% and nephrotoxicity were found 20.29%. Keywords: kanamycin, capreomycin, MDR TB, nephrotoxicity Abstrak Tingginya efek samping dan lamanya terapi pengobatan TB resisten menjadi kendala utama dalam keberhasilan terapi TB resisten. Salah satu efek samping obat yang serius dan dapat mengancam jiwa adalah gangguan ginjal. Kanamisin dan kapreomisin merupakan obat TB MDR yang dapat menyebabkan efek samping gangguan ginjal. Penelitian ini bertujuan untuk mengetahui insidensi efek samping hipokalemia dan nefrotoksik pada pasien TB MDR, berapa lama onsetnya, dan bagaimana cara pengatasannya. Pengambilan data dilakukan secara retrospektif dari rekam medis pasien di poli rawat jalan TB MDR RSUD dr. Soetomo Surabaya selama periode Januari 2018-Juni 2020. Didapatkan 183 rekam medis pasien dan yang memenuhi kriteria inklusi sebanyak 112 rekam medis. Efek samping yang diteliti adalah hipokalemia dan nefrotoksik yang dianalisis berdasarkan kadar kalium dan serum kreatinin. Hasil penelitian menunjukkan efek samping terhadap gangguan ginjal lebih banyak ditemukan pada kelompok pasien yang menggunakan kapreomisin dibandingkan pada kelompok pasien yang menggunakan kanamisin, yaitu hipokalemia 70,45% dan nefrotoksik 30,23% pada kelompok kapreomisin, sedangkan pada kelompok kanamisin hipokalemia 38,24% dan nefrotoksik 20,29%. Kata Kunci: kanamisin, kapreomisin, TB MDR, gangguan ginjal 
PENGARUH PELATIHAN TANGGAP TUBERKULOSIS DAN PENDAMPINGAN MINUM OBAT TERHADAP PENGETAHUAN KADER KESEHATAN DESA DI KECAMATAN BLUTO Rahem, Abdul; Wijaya, I Nyoman; Ifadotunnikmah, Farida; Rahmadi, Mahardian; Achmad, Gusti Noorrizka Veronika; Athiyah, Umi; Yuda, Ana; Zulkarnain, Bambang Subakti; Nugraheni, Gesnita; Ardianto, Chrismawan; Sumarno, Sumarno; Aryani, Toetik; Budiatin, Aniek Setiya; Hermansyah, Andi; Sulistyarini, Arie; Priyandani, Yuni; Sukorini, Anila Impian
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/s8534m26

Abstract

Tuberculosis (TB) is one of the leading causes of death from infectious diseases worldwide. Indonesia ranks as the country with the second-highest number of TB cases after India. TB awareness training and medication adherence support for village health cadres are strategic steps to enhance their capacity in supporting TB treatment. This study aims to analyze the impact of TB awareness training and medication adherence support on improving the knowledge of village health cadres. A pre-experimental study with a pretest-posttest design was conducted involving 50 village health cadres in Bluto Subdistrict, Sumenep Regency. Data were collected using questionnaires administered before and after the training. Analysis was performed using the Mann-Whitney test. There was a significant increase in the knowledge scores of village health cadres regarding TB (pretest: 3.50 ± 1.65; posttest: 5.64 ± 2.70; p<0.05) and anti-TB drug side effects (pretest: 7.66 ± 4.07; posttest: 15.04 ± 3.11; p<0.05). The training also successfully enhanced the cadres' understanding of TB symptoms, prevention, and treatment, including drug side effects. TB awareness training and medication adherence support significantly improved the knowledge of village health cadres, making them more competent in supporting TB control efforts at the community level.
Co-Authors Abdul Rahem, Abdul Alfiyah Hasanah Alvita Raniah Aisyah Putri Ana Yuda Aranza Khoirina Audrey Abbas Arie Sulistyarini Arina Dery Puspitasari Asfarina, Hairunnisyah Brigitta Dhyah Kunthi Wardhani Brigitta Dhyah Kunthi Wardhani Budi Suprapti Budiatin, Aniek Setiya Chrismawan Ardianto Cici Aisyah Putri Rogahang Cladita Pamungkas Putri Clarissa Budiman Desi Ratu Puspita Dhieo Kurniawan Erviana Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Farah Meutia Farida Ifadotunnikmah Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Febria Rossa Alba Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hana Rizqi Ghaesani Hartoto, Halla Hisan Heri Yulimanida Hermansyah, Andi Herri Yulimanida Herri Yulimanida I NYOMAN WIJAYA Intan Kusuma Dewi Junaidi Khotib Lily Aina Lily Aina Lily Aina Mahardian Rahmadi Makmuroh Nurul Qomar Purnamawati, Dewi Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Misbahul Munir Muhammad Aminuddin, Muhammad Naksa Garnida Arfie Nanda Ardianto Nanda Ardianto Nanda Ardianto Nur Arifana, Erlita Nurul Khikmiyah Paulina Ari Damayanti Pharmasinta Putri Hapsari Puspitasari, Eka Octaviana Raden Mohamad Herdian Bhakti Rebecca Ferida Octaviani Rosyid, Alfian Nur Rozalina Loebis, Rozalina Sudarmanto Sudarmanto Sukorini, Anila Impian Sumarno . Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Tamara nUR Budiarti Tamara Nur Budiarti Tamara Nur Budiarti Toetik Aryani Umi Athiyah WENNY PUTRI NILAMSARI, WENNY PUTRI Yessi Rahmawati Yogiarto, Mohammad Yuni Priyandani Yusuf Alsagaff, Mochamad Zahra Oviary Satryo, Fatimatuz