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All Journal Folia Medica Indonesiana Jurnal Farmasi Klinik Indonesia Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Syntax Literate: Jurnal Ilmiah Indonesia JURNAL FARMASIMED (JFM) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Insan Farmasi Indonesia Berkala Penelitian Hayati Caring : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Komunitas
Toetik Aryani
Department Of Clinical Pharmacy, Faculty Of Pharmacy, Airlangga University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Diabetes Support Groups Improve Patient’s Compliance and Control Blood Glucose Levels Izzah, Zamrotul; Suprapti, Budi; Aryani, Toetik; Budiatin, Aniek S.; Rahmadi, Mahardian; Hapsari, Pharmasinta P.; Ramadiani, Fathia; Shinta, Dewi W.; Andarsari, Mareta R.
Indonesian Journal of Clinical Pharmacy Vol 2, No 3 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (562.142 KB)

Abstract

Providing information is not enough to improve diabetic patient’s compliance and achieve goals of therapy. Patient’s good awareness as well as emotional and social supports from family and community may play an important role to improve their compliance and clinical outcomes. Therefore, diabetes support groups were developed and each support group consisted of two pharmacists, two nurses, diabeticpatients and their family members. A total of 70 type 2 diabetic patient’s were enrolled and randomized into support group 1 and support group 2. Patients in the group 1 received information leaflets only, while patients in the group 2 received pharmacist counselling and information leaflets at each meeting. Patient’s awareness of diabetes and compliance with medications were assessed by a short questionnaire at baseline and final follow-up. Blood glucose and cholesterol levels were also evaluated in both groups.At the end of study, the overall patient’s awareness and compliance improved by 61.5%. The random and fasting blood glucose levels decreased over than 30% in the group 2 and around 14% in the group 1. This study reveals that collaboration between health care professionals and community in the diabetes support group might help diabetic patients to increase their knowledge and compliance with the diabetes therapy as well as glycaemic control.Key words: Diabetes, group awareness program, pharmacist, patient counselling Kelompok Dukungan terhadap Diabetes Meningkatkan Kepatuhan dan Kontrol Kadar Glukosa Darah PasienMenyediakan informasi tidak cukup untuk meningkatkan kepatuhan pasien diabetes dan mencapai tujuan terapi. Kesadaran pasien serta dukungan emosional dan sosial dari keluarga dan masyarakat dapat memainkan peran penting untuk meningkatkan kepatuhan dan hasil klinis. Oleh karena itu, kelompok pendukung diabetes dikembangkan dan masing-masing kelompok pendukung terdiri atas dua apoteker, dua perawat, pasien diabetes dan anggota keluarga mereka. Sebanyak 70 pasien diabetes tipe 2 yang terdaftar dan acak ke dalam kelompok dukungan 1 dan kelompok dukungan 2. Pasien dalam kelompok 1 menerima selebaran informasi saja, sedangkan pasien di kelompok 2 menerima konseling dari apoteker dan informasi diabetes pada setiap pertemuan. Kesadaran Pasien diabetes dan kepatuhan dengan obat dinilai oleh kuesioner singkat pada awal dan akhir. Kadar glukosa darah dan koleste-rol juga dievaluasipada kedua kelompok. Pada akhir penelitian, kesadaran dan kepatuhan pasien secara keseluruhan meningkat 61,5%. Kadar glukosa darah acak dan puasa menunjukkan penurunan 30% pada kelompok 2 dansekitar 14 % pada kelompok 1. Penelitian ini mengungkapkan bahwa kolaborasi antara profesional perawatan kesehatan dan masyarakat dalam kelompok pendukung diabetes dapat membantu pasien diabetesuntuk meningkatkan pengetahuan dan kepatuhan mereka dengan terapi diabetes serta kontrol glikemik. Kata kunci: Diabetes, program penyadaran kelompok, apoteker, konseling pasien
Effect of Attapulgite on the Oral Bioavailability of Ciprofloxacin Izzah, Zamrotul; Gratia, Veronica; Aryani, Toetik; Suharjono, Suharjono
Indonesian Journal of Clinical Pharmacy Vol 2, No 2 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.014 KB)

Abstract

As a result, this drug-drug interaction may reduce ciprofloxacin bioavailability. This study was aimed to determine the effect of attapulgite on the bioavailability of a single orally-administered ciprofloxacin. Six New Zealand white rabbits received each of the following treatments in a randomized, three-way crossover sequence, separated by a 7-day washout period: (i) ciprofloxacin (23 mg/kgBW) alone; (ii) ciprofloxacin (23 mg/kgBW) given simultaneously with attapulgite (28 mg/kgBW); (iii) ciprofloxacin(23 mg/kgBW) given 2 hours after attapulgite (28 mg/kgBW). Blood samples (1 mL) were collected from the marginal ear vein up to 240 minutes postdose. The plasma concentrations of ciprofloxacin were determined by a validated high-performance liquid chromatography method. The maximum concentration and oral bioavailability (AUC0-240 min) of ciprofloxacin were significantly decreased by 49% and 32% when administered concomitantly with attapulgite (p<0.001). Attapulgite appeared to have no significant effect on the bioavailability of ciprofloxacin when administered 2 hours before ciprofloxacin. In conclusion, the oral bioavailability of ciprofloxacin is markedly reduced when administered concomitantly with attapulgite. This drug-drug interaction may decrease clinical efficacy and promote microbial resistance to ciprofloxacin. However, the interaction could be minimized by separating the adminsitration of these drugs at least 2 hours.Key words: Attapulgite, bioavailability, ciprofloxacin, drug-drug interactionPengaruh Atapulgit pada Ketersediaan Hayati Siprofloksasin OralKemampuan absorpsi atapulgit dapat menghambat absorpsi siprofloksasin pada pemberian per oral. Sebagai hasilnya, interaksi obat-obat ini dapat menurunkan ketersediaan hayati siprofloksasin. Penelitian ini bertujuan untuk  mendeterminasi efek atapulgit pada ketersediaan hayati obat siprofloksasin yang diberikan secara oral. Sebanyak 7 kelinci putih Selandia Baru menerima perlakuan secara random dengan desain three-way crossover sequence, yang dipisahkan dengan periode washout 7 hari. (i) siprofloksasin (23 mg/kgBB); (ii) siprofloksasin (23 mg/kgBB) diberikan secara simultan dengan atapulgit (28 mg/kgBB); (iii) siprofloksasin (23 mg/kgBB) diberikan 2 jam setelah pemberian atapulgit (28 mg/kgBB. Sampel darah (1 mL) dikumpulkan pada marginal ear vein setelah 240 menit pemberian obat. Konsentrasi siprofloksasin plasma dihitung dengan metode kromatografi cair kinerja tinggi tervalidasi. Konsentrasi maksimum dan ketersediaan hayati oral (AUC0-240 min) siprofloksasin secara signifikan berkurang 49% dan 32% ketika dikombinasikan bersamaan dengan atapulgit (p< 0,001). Atapulgit tidak memiliki pengaruh signifikan pada ketersediaan hayati ketika diberikan 2 jam sebelum siprofloksasin. Ketersediaan hayati siprofloksasin berkurang secara signifikan ketika diberikan bersamaan dengan pemberian atapulgit. Interaksi obat dengan obat ini dapat mengurangi efikasi obat dan meningkatkan resistensi mikrob terhadap siprofloksasin. Namun, interaksi dapat dikurangi dengan pemberian obat pada jarak waktu minimal 2 jam.Kata kunci: Atapulgit, interaksi obat dengan obat, ketersediaan hayati, siprofloksasin
Diabetes Support Groups Improve Patient’s Compliance and Control Blood Glucose Levels Zamrotul Izzah; Budi Suprapti; Toetik Aryani; Aniek S. Budiatin; Mahardian Rahmadi; Pharmasinta P. Hapsari; Fathia Ramadiani; Dewi W. Shinta; Mareta R. Andarsari
Indonesian Journal of Clinical Pharmacy Vol 2, No 3 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (562.142 KB)

Abstract

Providing information is not enough to improve diabetic patient’s compliance and achieve goals of therapy. Patient’s good awareness as well as emotional and social supports from family and community may play an important role to improve their compliance and clinical outcomes. Therefore, diabetes support groups were developed and each support group consisted of two pharmacists, two nurses, diabeticpatients and their family members. A total of 70 type 2 diabetic patient’s were enrolled and randomized into support group 1 and support group 2. Patients in the group 1 received information leaflets only, while patients in the group 2 received pharmacist counselling and information leaflets at each meeting. Patient’s awareness of diabetes and compliance with medications were assessed by a short questionnaire at baseline and final follow-up. Blood glucose and cholesterol levels were also evaluated in both groups.At the end of study, the overall patient’s awareness and compliance improved by 61.5%. The random and fasting blood glucose levels decreased over than 30% in the group 2 and around 14% in the group 1. This study reveals that collaboration between health care professionals and community in the diabetes support group might help diabetic patients to increase their knowledge and compliance with the diabetes therapy as well as glycaemic control.Key words: Diabetes, group awareness program, pharmacist, patient counselling Kelompok Dukungan terhadap Diabetes Meningkatkan Kepatuhan dan Kontrol Kadar Glukosa Darah PasienMenyediakan informasi tidak cukup untuk meningkatkan kepatuhan pasien diabetes dan mencapai tujuan terapi. Kesadaran pasien serta dukungan emosional dan sosial dari keluarga dan masyarakat dapat memainkan peran penting untuk meningkatkan kepatuhan dan hasil klinis. Oleh karena itu, kelompok pendukung diabetes dikembangkan dan masing-masing kelompok pendukung terdiri atas dua apoteker, dua perawat, pasien diabetes dan anggota keluarga mereka. Sebanyak 70 pasien diabetes tipe 2 yang terdaftar dan acak ke dalam kelompok dukungan 1 dan kelompok dukungan 2. Pasien dalam kelompok 1 menerima selebaran informasi saja, sedangkan pasien di kelompok 2 menerima konseling dari apoteker dan informasi diabetes pada setiap pertemuan. Kesadaran Pasien diabetes dan kepatuhan dengan obat dinilai oleh kuesioner singkat pada awal dan akhir. Kadar glukosa darah dan koleste-rol juga dievaluasipada kedua kelompok. Pada akhir penelitian, kesadaran dan kepatuhan pasien secara keseluruhan meningkat 61,5%. Kadar glukosa darah acak dan puasa menunjukkan penurunan 30% pada kelompok 2 dansekitar 14 % pada kelompok 1. Penelitian ini mengungkapkan bahwa kolaborasi antara profesional perawatan kesehatan dan masyarakat dalam kelompok pendukung diabetes dapat membantu pasien diabetesuntuk meningkatkan pengetahuan dan kepatuhan mereka dengan terapi diabetes serta kontrol glikemik. Kata kunci: Diabetes, program penyadaran kelompok, apoteker, konseling pasien
Effect of Attapulgite on the Oral Bioavailability of Ciprofloxacin Zamrotul Izzah; Veronica Gratia; Toetik Aryani; Suharjono Suharjono
Indonesian Journal of Clinical Pharmacy Vol 2, No 2 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.014 KB)

Abstract

As a result, this drug-drug interaction may reduce ciprofloxacin bioavailability. This study was aimed to determine the effect of attapulgite on the bioavailability of a single orally-administered ciprofloxacin. Six New Zealand white rabbits received each of the following treatments in a randomized, three-way crossover sequence, separated by a 7-day washout period: (i) ciprofloxacin (23 mg/kgBW) alone; (ii) ciprofloxacin (23 mg/kgBW) given simultaneously with attapulgite (28 mg/kgBW); (iii) ciprofloxacin(23 mg/kgBW) given 2 hours after attapulgite (28 mg/kgBW). Blood samples (1 mL) were collected from the marginal ear vein up to 240 minutes postdose. The plasma concentrations of ciprofloxacin were determined by a validated high-performance liquid chromatography method. The maximum concentration and oral bioavailability (AUC0-240 min) of ciprofloxacin were significantly decreased by 49% and 32% when administered concomitantly with attapulgite (p<0.001). Attapulgite appeared to have no significant effect on the bioavailability of ciprofloxacin when administered 2 hours before ciprofloxacin. In conclusion, the oral bioavailability of ciprofloxacin is markedly reduced when administered concomitantly with attapulgite. This drug-drug interaction may decrease clinical efficacy and promote microbial resistance to ciprofloxacin. However, the interaction could be minimized by separating the adminsitration of these drugs at least 2 hours.Key words: Attapulgite, bioavailability, ciprofloxacin, drug-drug interactionPengaruh Atapulgit pada Ketersediaan Hayati Siprofloksasin OralKemampuan absorpsi atapulgit dapat menghambat absorpsi siprofloksasin pada pemberian per oral. Sebagai hasilnya, interaksi obat-obat ini dapat menurunkan ketersediaan hayati siprofloksasin. Penelitian ini bertujuan untuk  mendeterminasi efek atapulgit pada ketersediaan hayati obat siprofloksasin yang diberikan secara oral. Sebanyak 7 kelinci putih Selandia Baru menerima perlakuan secara random dengan desain three-way crossover sequence, yang dipisahkan dengan periode washout 7 hari. (i) siprofloksasin (23 mg/kgBB); (ii) siprofloksasin (23 mg/kgBB) diberikan secara simultan dengan atapulgit (28 mg/kgBB); (iii) siprofloksasin (23 mg/kgBB) diberikan 2 jam setelah pemberian atapulgit (28 mg/kgBB. Sampel darah (1 mL) dikumpulkan pada marginal ear vein setelah 240 menit pemberian obat. Konsentrasi siprofloksasin plasma dihitung dengan metode kromatografi cair kinerja tinggi tervalidasi. Konsentrasi maksimum dan ketersediaan hayati oral (AUC0-240 min) siprofloksasin secara signifikan berkurang 49% dan 32% ketika dikombinasikan bersamaan dengan atapulgit (p< 0,001). Atapulgit tidak memiliki pengaruh signifikan pada ketersediaan hayati ketika diberikan 2 jam sebelum siprofloksasin. Ketersediaan hayati siprofloksasin berkurang secara signifikan ketika diberikan bersamaan dengan pemberian atapulgit. Interaksi obat dengan obat ini dapat mengurangi efikasi obat dan meningkatkan resistensi mikrob terhadap siprofloksasin. Namun, interaksi dapat dikurangi dengan pemberian obat pada jarak waktu minimal 2 jam.Kata kunci: Atapulgit, interaksi obat dengan obat, ketersediaan hayati, siprofloksasin
The Effect of 20-20-20 Rule Dissemination and Artificial Tears Administration in High School Students Diagnosed with Computer Vision Syndrome Bambang Subakti Zulkarnain; Aniek Setiya Budiatin; Toetik Aryani; Rozalina Loebis
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1105.748 KB) | DOI: 10.22146/jpkm.54121

Abstract

Computers and gadgets are modern tools for assisting Senior High School students’ work. However, using gadgets more than 2 hours a day may cause computer vision syndrome (CVS), which can interfere with academic activities. CVS main symptom is dry eyes. CVS could be prevented by applying the 20-20-20 rule and artificial tears. A total of 100 students from two public high schools in Kediri with 50 students from each school were selected for this community service. All students diagnosed with CVS participated in the dissemination of 20-20-20 rule and artificial tear administration. The pre-test and post-test scores, the Tear Break Up Time Test (TBUT) and the Ocular Disease Surface Index (OSDI) were measured within two weeks. TBUT and OSDI are parameters for measuring dry eye. Likewise, interviews were conducted to assess the adherence to the 20-20-20 rule and artificial tea administration. The results showed the knowledge level increased (p <0.0001). Most students understood 20-20-20 rule and how to administer artificial tears correctly. However, the adherence to both methods was approximately 50%. There was an improvement in the TBUT (p <0.0001) for dry eyes but not for OSDI (p> 0.05). Applying the 20-20-20 rule and artificial tears could be used for CVS treatment.
EFFECT OF DIABETES TRAINING PROGRAM ON KNOWLEDGE AND ASSESSMENT SKILL AMONG GERIATRIC WORKER COMMUNITY IN SURABAYA Zamrotul Izzah; Mahardian Rahmadi; Dewi Wara Shinta; Toetik Aryani; Aniek Setiya Budiatin
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 2 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.808 KB) | DOI: 10.20473/jlm.v1i2.2017.56-60

Abstract

The prevalence of diabetes mellitus (DM) is higher among other degenerative diseases in Surabaya, Indonesia. Providing information is not sufficient to improve diabetic patients’ compliance and achieve goals of its therapy. Patients’ good awareness as well as emotional and social supports from community plays an important role to improve their compliance and clinical outcomes. Therefore, diabetes training program was delivered to geriatric worker community to improve their knowledge on DM and assessment skill to check the blood glucose level of geriatric diabetic patients. A total of 20 female workers were enrolled in the program. They received a series of lectures on diabetes and its management and gained practical skill on using the self-check blood glucose test. A validated questionnaire was administered to all workers at baseline and at final follow-up to assess knowledge and practice. The overall workers’ awareness increased over than 100%. After finishing the program, all workers joined a diabetic counseling program for geriatric patients in their community. Glucose levels were evaluated from their patients to assess the outcome of the counseling program. The random and fasting blood glucose levels decreased around 31% and 14%, consecutively. This study reveals that diabetes training program for geriatric community workers is beneficial to control blood glucose levels. AbstrakDiabetes melitus (DM) merupakan penyakit degeneratif yang memiliki prevalensi lebih tinggi di antara penyakit degeneratif lainnya di Surabaya, Indonesia. Pemberian informasi saja masih dirasakan belum cukup untuk memperbaiki tingkat kepatuhan pasien diabetes dan mencapai tujuan terapi. Kesadaran pasien serta dukungan emosional dan sosial dari masyarakat berperan penting untuk meningkatkan kepatuhan dan hasil terapi. Oleh karena itu, program pelatihan diabetes dilakukan kepada komunitas pekerja lanjut usia (lansia) untuk meningkatkan pengetahuan mereka tentang penyakit DM dan ketrampilan dalam pemeriksaan kadar glukosa darah. Sebanyak 20 orang pekerja perempuan ikut serta sebagai peserta dalam program ini. Mereka menerima serangkaian materi tentang penyakit DM dan pengelolaannya, serta mendapatkan praktek keterampilan untuk menggunakan tes glukosa darah secara mandiri. Sebagai evaluasi kegiatan, kuesioner diberikan kepada peserta pada awal dan akhir kegiatan. Kesadaran pekerja secara keseluruhan meningkat lebih dari 100%. Setelah akhir kegiatan, semua peserta bergabung dengan program konseling diabetes untuk pasien lansia di komunitas mereka. Tingkat glukosa dievaluasi dari pasien mereka untuk menilai hasil program konseling. Tingkat glukosa darah acak dan puasa menurun sekitar 31% dan 14%, berturut-turut. Studi ini mengungkapkan bahwa program pelatihan diabetes untuk pekerja komunitas lansia ini sangat bermanfaat untuk mengendalikan kadar glukosa darah di komunitas.
PENGUJIAN VALIDASI ANALISIS KADAR ANDROGRAFOLID SECARA KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) DENGAN ELUASI GRADIEN TERHADAP EKSTRAK HERBA SAMBILOTO (ANDROGRAPHIS PANICULATA NESS) Toetik Aryani
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 11 No 1 (2005): December 2005
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/463

Abstract

Andrographolide of Andrographis paniculata Nees have been isolated and determined Extraction was carried out by maceration with ethanol as solvent. The concentration of Andrographolide was determined by HPLC method. The eluation was carried by out gradiently using methanol: water as an eluent and UV spectrophotometer at maks 228 as detector. The result of HPLC analysis are selectivity >1.2–1.5; r was 0.9937; precision was KV < 10%; accuracy > 90%; DL was 0.075; QL was 0.50 and PW < F table. Andrographolide content of Andrographis paniculata Nees from Banyuwangi was 6.25%, Kediri was 14.69% and Surabaya was 6.83%
Efektivitas Penggunaan Layanan Telefarmasi di Era Pandemi COVID-19 dari Perspektif Masyarakat Abdul Farid; Adelia Firdausy; Alifia Sulaiman; Dewi Simangunsong; Febi Sulistyani; Frizca Varianti; Kevin Ong; Livia Kristiany; Nancy Mustika; Natasha Febiani; Salsabela Komalasari; Salsabila Salsabila; Sherin Azzahra; Yasmin Zulfah; Toetik Aryani
Jurnal Farmasi Komunitas Vol. 9 No. 2 (2022): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v9i2.32924

Abstract

Pandemi COVID-19 di Indonesia pertama kali diumumkan pada Maret 2020. Kasus COVID-19 yang terus meningkat mendorong pemerintah untuk menetapkan berbagai macam kebijakan untuk menekan angka positif COVID-19 seperti penerapan protokol kesehatan, physical distancing, dan Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM). Pandemi COVID-19 telah menimbulkan berbagai masalah kesehatan, salah satunya yaitu terhambatnya pelayanan kefarmasian. Oleh karena itu, penerapan telefarmasi di kalangan masyarakat dapat menjadi sebuah pelayanan alternatif demi mengurangi tendensi interaksi aktif secara langsung antara apoteker dengan pasien. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan layanan telefarmasi di era pandemi COVID-19 dari perspektif masyarakat. Penelitian ini merupakan penelitian Cross-Sectional dengan instrumen berupa kuesioner yang disebar secara online melalui google form. Pengambilan sampel dilakukan secara accidental sampling dengan kriteria inklusi masyarakat umum berusia 15-65 tahun yang berdomisili di Pulau Jawa.  Berdasarkan hasil survei  terhadap 243 responden, 90 responden (37,03%) pernah menggunakan telefarmasi dan dari 90 responden tersebut semuanya (100%) merasa terbantu dengan adanya pembelian obat secara online, 56 responden (62,2%) menyatakan pelaksanaan pemantauan terapi obat melalui telefarmasi berjalan dengan efektif, 58 responden  (64,4%) menyatakan pelaksanaan pemantauan efek samping obat berjalan dengan efektif, dan 72 responden (80%) dapat memahami Informasi obat yang diberikan. Hal ini menunjukkan bahwa  penggunaan telefarmasi di era pandemi COVID-19 efektif dari perspektif masyarakat. Namun, pemahaman dan minat masyarakat terkait telefarmasi masih kurang sehingga penggunaannya masih cukup rendah di masyarakat. Untuk itu perlu dilakukan promosi kesehatan terkait telefarmasi agar masyarakat lebih mengenal telefarmasi dan dapat memaksimalkan penggunaanya di era pandemi COVID-19.
Sodium Hyaluronate Eye Drops for College Students with Computer Vision Syndrome in Indonesia Bambang Subakti Zulkarnain; Rozalina Loebis; Toetik Aryani
Folia Medica Indonesiana Vol. 58 No. 4 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (967.669 KB) | DOI: 10.20473/fmi.v58i4.6704

Abstract

Highlights: Computer vision syndrome (CVS) that causes dry eyes becomes a health problem for college students. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.   Abstract: The use of computers and mobile devices is increasing. Computers and mobile devices help our daily work or study. However, prolonged use of them may cause computer vision syndrome (CVS). Nowadays, CVS becomes a health problem for everyone working with computers or mobile devices including college students because it causes dry eyes. It may disrupt reading, doing professional work, or using a computer which is important for college students to complete academic tasks. Sodium hyaluronate can be used to overcome the dry eye problem due to CVS. To assess the effectiveness of sodium hyaluronate eyedrops on students suffering from CVS, pre- and post-administration of sodium hyaluronate was measured for two weeks. Inclusion criteria for this study were college students aged 20-35 years, using a computer for >2 hours a day, not using nonsteroidal anti-inflammatory drugs (NSAIDs), not consuming drugs, or having a disease that affects tear production and bearing no pregnancy. Parameters assessed include tear break-up time using the Tear Break-Up Time (TBUT) test, tear production using the Schirmer I test, the number of clinically subjective symptoms, and Ocular Surface Disease Index (OSDI) scores. Data were analyzed using student paired t-tests or Wilcoxon Rank Test. There were statistically significant differences before and after the TBUT (4.4 vs 6.7 seconds; p<0.0001); the Schirmer I Test (4 vs 6 mm; p<0.05), and the number of clinically subjective symptoms (3 vs 0 clinically subjective symptoms; p<0.0001). The OSDI scores did not show statistical differences before and after administration of sodium hyaluronate (27 vs 21; p>0.05), but there was a positive impact from moderate to mild dry eye. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.
Assessment of Antibiotic Use in ICU Patients with Pneumonia Using ATC/DDD as a Quantitative Analysis Method Mareta Rindang Andarsari; Zedny Norachuriya; Sarah Mahmudatun Nabila; Toetik Aryani; Alfian Nur Rosyid
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.138-145

Abstract

Background: Pneumonia is an infection of the lung tissue which is mainly caused by bacteria. High utilization and inappropriate use of antibiotics increase resistant bacteria, morbidity, mortality, and treatment cost. Quantitative evaluation becomes one of the indicators to assess the use of antibiotics which is one indicator of the quality of the antimicrobial resistance control program. Objective: This study aimed to evaluate the use of antibiotics an effort to increase the rationality of the use of antibiotics. Methods: This study was a retrospective observational study with a sampling method of time-limited sampling in Universitas Airlangga hospital from January until December 2019. Quantitatively using Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD). Result: The samples obtained were 68 severe pneumonia patients who met the inclusion criteria. From the result of the study, there were 13 types of antibiotics used for pneumonia therapy, and the three most used were Levofloxacin, Ceftriaxone, and Meropenem, with a total of all antibiotics 73.64 DDD/100 patients-days. Most useful is parenteral Levofloxacin at 21.92 DDD/100 patient-days, Ceftriaxone at 20.45 DDD/100 patient-days and Meropenem at 14.29 DDD/100 patient-days. Conclusion: The DDD value indicates high antibiotic usage, but high antibiotic use does not imply unreasonable drug use, so we must undertake a qualitative review of antibiotic use.
Co-Authors Abdul Farid Abdul Rahem, Abdul Adelia Firdausy Alifia Sulaiman Ana Yuda Andarsari, Mareta R. Aniek S. Budiatin Anik Rahmawati, Anik Arie Sulistyarini Astanti, Erika Bambang Subakti Zulkarnain Budi Suprapti Budiatin, Aniek S. Budiatin, Aniek S. Budiatin, Aniek Setiya Budiatin, Aniek Setiya Chrismawan Ardianto D. Puspitasari, Arina Dewi Simangunsong Dewi W. Shinta Dewi Wara Shinta Farida Ifadotunnikmah Fathia Ramadiani Febi Sulistyani Frizca Varianti Gesnita Nugraheni Gratia, Veronica Gusti Noorrizka Veronika Ahmad Hapsari, Pharmasinta P. Hermansyah, Andi I NYOMAN WIJAYA Izza, Zamrotul Kevin Ong Livia Kristiany Mahardian Rahmadi Mareta R. Andarsari Mareta Rindang Andarsari Mazidda, Sakinato Nafikhah, Wardah Zuhan Nancy Mustika Natasha Febiani Noorrizka V, Gusti Pharmasinta P. Hapsari Priyandani, Yuni Rahayu, Titik Puji Ramadiani, Fathia Ratri, Dinda MN Rosyid, Alfian Nur Rozalina Loebis, Rozalina Salsabela Komalasari Salsabila Salsabila Samirah Sarah Mahmudatun Nabila Sherin Azzahra Shinta, Dewi W. Suharjono, Suharjono Sukorini, Anila Impian Sumarno . Umi Athiyah, Umi Veronica Gratia Wahyu Utami, Wahyu Yasmin Zulfah Zamrotul Izzah Zedny Norachuriya Zulkamain, Bambang Subakti Zulkarnain, Bambang Subakti