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All Journal Jurnal Kesehatan WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Cendekia Journal of Pharmacy Jurnal Farmasi Komunitas Jurnal Sains dan Kesehatan
Bambang Subakti Zulkarnain
Department Of Clinical Pharmacy, Faculty Of Pharmacy Airlangga University, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Analisis Efek Samping Kanamisin dan Kapreomisin terhadap Fungsi Ginjal pada Pasien TB RO di RSUD Dr. Soetomo: Adverse Effect Analysis of Kanamicin and Capreomycin on Kidney Function in DR TB Patients at Dr. Soetomo Hospital Syefi Nuraeni Fitriana; Bambang Subakti Zulkarnain; Heri Yulimanida
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1174

Abstract

The high of adverse effect of resistant TB treatment and the long duration of the treatment is the main obstacle in the success of resistant TB therapy. One of the serious and life-threatening adverse effect of the treatment is nephrotoxic. Kanamycin and capreomycin are MDR TB drugs that can induce nephrotoxic and kidney disorder. This study aims to determine the incidence of hypokalemia and nephrotoxic induced by kanamycin and capreomycin, the onset of the kidney disorder, and its management. Data were collected retrospectively from the medical records of patients in the MDR TB outpatient clinic at Dr. Soetomo Hospital Surabaya during the period January 2018-June 2020. There were 183 patient medical records and only 112 medical records that met the inclusion criteria. The adverse effects studied were hypokalemia and nephrotoxicity which were analyzed based on potassium and creatinine serum levels. The result showed that adverse effect on kidney disorders were more common in the group of patients taking capreomycin than in the group of patients taking kanamycin. Hypokalemia were found 70.45% and nephrotoxicity were found 30.23% in the capreomycin group, while in the kanamycin group, hypokalemia were found 38.24% and nephrotoxicity were found 20.29%. Keywords: kanamycin, capreomycin, MDR TB, nephrotoxicity Abstrak Tingginya efek samping dan lamanya terapi pengobatan TB resisten menjadi kendala utama dalam keberhasilan terapi TB resisten. Salah satu efek samping obat yang serius dan dapat mengancam jiwa adalah gangguan ginjal. Kanamisin dan kapreomisin merupakan obat TB MDR yang dapat menyebabkan efek samping gangguan ginjal. Penelitian ini bertujuan untuk mengetahui insidensi efek samping hipokalemia dan nefrotoksik pada pasien TB MDR, berapa lama onsetnya, dan bagaimana cara pengatasannya. Pengambilan data dilakukan secara retrospektif dari rekam medis pasien di poli rawat jalan TB MDR RSUD dr. Soetomo Surabaya selama periode Januari 2018-Juni 2020. Didapatkan 183 rekam medis pasien dan yang memenuhi kriteria inklusi sebanyak 112 rekam medis. Efek samping yang diteliti adalah hipokalemia dan nefrotoksik yang dianalisis berdasarkan kadar kalium dan serum kreatinin. Hasil penelitian menunjukkan efek samping terhadap gangguan ginjal lebih banyak ditemukan pada kelompok pasien yang menggunakan kapreomisin dibandingkan pada kelompok pasien yang menggunakan kanamisin, yaitu hipokalemia 70,45% dan nefrotoksik 30,23% pada kelompok kapreomisin, sedangkan pada kelompok kanamisin hipokalemia 38,24% dan nefrotoksik 20,29%. Kata Kunci: kanamisin, kapreomisin, TB MDR, gangguan ginjal 
Co-Authors Alfiyah Hasanah Alvita Raniah Aisyah Putri Aranza Khoirina Audrey Abbas Arina Dery Puspitasari Arina Dery Puspitasari Brigitta Dhyah Kunthi Wardhani Brigitta Dhyah Kunthi Wardhani Budiatin, Aniek Setiya Cici Aisyah Putri Rogahang Cladita Pamungkas Putri Clarissa Budiman Desi Ratu Puspita Dhieo Kurniawan Erviana Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Farah Meutia Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Febria Rossa Alba Hana Rizqi Ghaesani Heri Yulimanida Herri Yulimanida Herri Yulimanida Junaidi Khotib Lily Aina Lily Aina Lily Aina Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Misbahul Munir Naksa Garnida Arfie Nanda Ardianto Nanda Ardianto Nanda Ardianto Nurul Khikmiyah Paulina Ari Damayanti Pharmasinta Putri Hapsari Rebecca Ferida Octaviani Rosyid, Alfian Nur Rozalina Loebis, Rozalina Sudarmanto Sudarmanto Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Tamara Nur Budiarti Tamara Nur Budiarti Tamara nUR Budiarti Toetik Aryani Yessi Rahmawati Yogiarto, Mohammad