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All Journal Jurnal Kesehatan WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Cendekia Journal of Pharmacy Jurnal Insan Farmasi Indonesia Jurnal Farmasi Komunitas Eduvest - Journal of Universal Studies Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Bambang Subakti Zulkarnain
Department Of Clinical Pharmacy, Faculty Of Pharmacy Airlangga University, Surabaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Profile of Prophylactic Antibiotics in Cesarean Sections with Occurrence of Infection: Literature Review Asfarina, Hairunnisyah; Zulkarnain, Bambang Subakti
Eduvest - Journal of Universal Studies Vol. 5 No. 6 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i6.50136

Abstract

Caesarean section is a surgical procedure that requires the use of prophylactic antibiotics throughout its implementation. Providing prophylactic antibiotics before surgery can reduce the risk of postoperative infections. The most common short-term complications of a caesarean section are wound infections. This research aims to ascertain the profile of prophylactic antibiotic use in caesarean section patients and to review the incidence of infections. The method used is a literature review. A total of eleven papers met the inclusion criteria for review. Based on the results of the article review, all of the research conducted were randomised controlled trial (RCT) studies. Randomised controlled trials (RCTs) are the gold standard for assessing the benefits of a treatment. Cefazolin, the first-generation cephalosporin antibiotic, is the most commonly used antibiotic for patients undergoing caesarean section. This aligns with the recommendations in the guideline. The highest prevalence of post-cesarean section infections is wound infections, with a percentage of 11.8% or 437 caesarean section patients. The most common microbiological pattern causing these infections is Staphylococcus aureus.
Exploring Side Effects of Warfarin in Outpatients at Tertiary Hospital in Indonesia Zahra Oviary Satryo, Fatimatuz; Wahyuni, Dewi; Suprapti, Budi; Putri Nilamsari, Wenny; Yusuf Alsagaff, Mochamad; Makmuroh Nurul Qomar Purnamawati, Dewi; Subakti Zulkarnain, Bambang
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.142-150

Abstract

Background: Patients with atrial fibrillation, venous thromboembolism, valvular disease, cardioembolic stroke, and acute myocardial infarction are prescribed the oral anticoagulant warfarin to treat thrombi. To guarantee its efficacy and safety, anticoagulants must be closely monitored. Furthermore, warfarin has a narrow therapeutic index, which increases the risk of side effects, particularly in the early stages of treatment. Objective: This study aimed to analyze the incidence of warfarin side effects in outpatients at Dr. Soetomo General Hospital. Methods: A retrospective cross-sectional design was adopted for outpatients at the Cardiology Department of Dr. Soetomo General Hospital from March to May 2023. Data were collected on the incidence of side effects in outpatients who received warfarin for a minimum of one month through an interview process. Other data, including age, sex, duration of warfarin therapy, comorbidities, and INR at the last scan, were extracted from medical records. The Chi-Square test was used to examine the data. Results: The results showed that 88 patients (42.7%) had side effects of bleeding (126 events). These included gum bleeding (22.3%), hematoma (20.4%), melena (7.7%), menometrorrhagia (2.4%), epistaxis (1.9%), hematuria (1.5%), hematemesis (1.0%), hemoptysis (1.0%), spontaneous venous bleeding  (1.0%), hematochezia (0.5%), hemostasis during blood sampling  (0.5%), tongue bleeding  (0.5%), and subconjunctival bleeding  (0.5%). Conclusion: The incidence of side effects during warfarin treatment was high, accounting for approximately 42.7% of cases. Furthermore, one patient experienced more than one side effect.
Efficacy of Ticagrelor Monotherapy in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: a Systematic Review Nur Arifana, Erlita; Subakti Zulkarnain, Bambang
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.174-194

Abstract

Background: Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) prevents ischemic events. However, prolonged therapy increases the risk of bleeding. In this context, an antithrombotic strategy is applied to post-PCI patients by discontinuing aspirin and maintaining P2Y12 receptor monotherapy. Currently, patients with ACS treated with the single antiplatelet agent ticagrelor prefer to apply DAPT for 1 to a few months to open blocked arteries. Objectives: This systematic review aimed to evaluate the clinical efficacy of transitioning high-bleeding-risk patients to ticagrelor monotherapy following a three-month course of DAPT. Methods: A systematic literature review based on the PRISMA statement was conducted to review articles on DAPT, PCI, ticagrelor monotherapy, and high bleeding risk (HBR). The article search was conducted using Internet search databases, including PubMed and ScienceDirect, published between January 2014 and December 2024. Results: Six studies met the inclusion criteria and were included in the analysis. Clinical outcomes were assessed over a follow-up period of up to one year, including endpoints such as all-cause mortality, myocardial infarction, stent thrombosis, stroke, and target vessel revascularization. The secondary endpoints included major adverse cardiovascular and cerebrovascular events (MACCE), significant bleeding defined by Bleeding Academic Research Consortium (BARC) types 2, 3, or 5, and net adverse clinical events (NACE). Conclusion: the use of ticagrelor monotherapy after 3 months of dual antiplatelet therapy is expected to assist healthcare professionals in considering the risk-benefit of single therapy for patients after percutaneous coronary intervention.
Benefit dan Side Effect dari Penggunaan Profilaksis Aspirin Low Dose pada Pasien High Risk Stroke Zulkarnain, Bambang Subakti; Puspitasari, Eka Octaviana
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 15, No 1 (2024): Januari-Maret 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15102

Abstract

Cardiovascular disease is a disease with disorders of the heart and blood vessels such as coronary heart disease, heart failure, hypertension and stroke. Aspirin or acetylsalicylic acid is recommended in the primary prevention of cardiovascular disease in adult patients who are at risk of having a heart attack in the next ten years or are also at risk of stroke. Low doses of acetylsalicylic acid (75-162 mg) have anti-platelet aggregation activity and reduce the risk of arterial blockages. The use of low-dose acetylsalicylic acid as a secondary prevention measure has been reported to reduce the risk of Major Adverse Cardiovascular Events (MACE), but is also associated with an increased risk of bleeding in patients. The review aimed to determine the benefit and risk profile of low-dose ASA therapy. The method used in making this review was a narrative review. The results of the review showed that low-dose aspirin had been shown to increase the risk of bleeding. Regarding the benefits and risks, the use of low-dose aspirin must be based on the individual condition of the sufferer. Patients with a low risk of bleeding, and those aged 40 -59 years can consider using low dose aspirin. It was concluded that the use of acetylsalicylic acid carries a risk of bleeding.Keywords: acetylsalicylic acid; low dose; cardiovascular; bleeding ABSTRAK Penyakit kardiovaskular adalah penyakit dengan gangguan pada jantung dan pembuluh darah seperti penyakit jantung koroner, gagal jantung, hipertensi, dan stroke. Aspirin atau asam asetilsalisilat direkomendasikan dalam pencegahan utama penyakit kardiovaskular pada pasien dewasa yang beresiko mengalami serangan jantung dalam sepuluh tahun mendatang atau juga risiko kejadian stroke. Asam asetilsalisilat dosis rendah (75-162 mg) mempunyai aktivitas antiagregasi platelet dan menurunkan resiko sumbatan pada arteri. Penggunaan asam asetilsalisilat dosis rendah sebagai tindakan pencegahan sekunder dilaporkan menurunkan resiko Major Adverse Cardiovascular Events (MACE), namun juga dikaitkan dengan meningkatnya resiko pendarahan pada pasien. Review bertujuan untuk mengetahui profil manfaat dan resiko terapi ASA dosis rendah. Metode yang digunakan dalam pembuatan review ini adalah tinjauan naratif. Hasil review menunjukkan bahwa aspirin dosis rendah terbukti dapat meningkatkan risiko perdarahan. Sehubungan dengan manfaat dan risikonya, penggunaan aspirin dosis rendah harus berdasarkan kondisi individu penderita. Pasien dengan risiko perdarahan yang rendah, dan usia 40 -59 tahun dapat dipertimbangkan dalam penggunaan aspirin dosis rendah.  Disimpulkan bahwa penggunaan asam asetilsalisilat berisiko pada terjadinya perdarahan.Kata kunci: asam asetilsalisilat; dosis rendah; kardiovaskular; perdarahan 
Analysis of changes in the serum level nt-probnp after ace inhibitors therapy in patients with heart failure Hartoto, Halla Hisan; Zulkarnain, Bambang Subakti; Aminuddin, Muhammad
Folia Medica Indonesiana Vol. 52, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

BNP secreted by left ventricle as response to wall stress in patient with heart failure. Elevated concentration of NT-pro-BNP correlate with severity of heart failure across all stages of the condition and left ventricle ejection fraction in patient. Several clinical trials have demonstrated that neurohormonal modulation on the RAAS decreases NT-proBNP level and results in favorable outcomes. One of the drug used for blocked RAAS system is ACE inhibitor, decrease of NT-proBNP level show response to therapy include therapy with ACE inhibitors. To analize changes in the levels serum NT-proBNP levels after ace inhibitor therapy in patients with heart failure and monitoring creatinine serum. This study was a observational, prospective, non-randomized trial involving patient age 21-75 years, with NYHA class II-III HF, using ACE inhibitor therapy plus other therapy maximum 3 months before study without ARB or beta blocker. We compared serum NT-pro-BNP and creatinin serum parameters before and after two months treatment with ACE inhibitor. This study conducted in cardiovascular ambulatory patient dr. Soetomo hospital Surabaya. Between August-November 2015, 13 patient (38-63 years, 6 woman, 7 men) include in this study. The mean baseline level of NT-proBNP is 2166.92±1236.73 pg/ml, and creatinin serum 1.023±0.601 mg/dL. The NT-pro-BNP were significantly decreased after two months of treatment with ACE inhibitors 1508.23±651 pg/mL (p=0.025), there were no significant differences creatinin serum between two groups 0.951±0.0365 mg/dL (p=0.111). The results demonstrated the benefits of ACE inhibitor on the neurohormonal profile in patients with HF. If necessary we could measure NT-proBNP level to support prognosis data and monitoring effectivity therapy especially ACE inhibitor which had antiremodelling effect towards patients with HF.
Analysis of change in nt-probnp after angiotensin receptor blocker (arb) therapy in patient with heart failure Dewi, Intan Kusuma; Aminuddin, Muhammad; Zulkarnain, Bambang Subakti
Folia Medica Indonesiana Vol. 52, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

NT-proBNP is an inactive fragment of BNP secreted by stretched ventricle as response to wall stress in patients with heart failure. As a specific cardiac marker, elevated NT-proBNP correlates well with heart failure severity. The principle of heart failure therapy is modulation on neurohormonal activation. ARB can modulate neurohormon on RAA system, that result in decreasing NT-proBNP level and favorable outcomes. Reduction in NT-proBNP more than biologic variability (> 25%) shows a therapy response.This study was to analyze change of NT-proBNP after ARB therapy in ambulatory HF patients. This observational prospective study was carried from September to December 2015. Blood sampling was performed on patients who meet the inclusion criteria of the study at first visit and after 2 months therapy. NT-proBNP was measured by IMMULITE® as primary parameter and creatinin as secondary parameter. There are 14 patients met the inclusion criteria of the study (11 males and 3 females). ARB therapy used in patients were Valsartan (64%), Telmisartan (22%) and Candesartan (14%). After 2 months ARB therapy, a decrease in level of NT-proBNP with initial median 3092.5 (216 – 32112) pg/ml to 2135.5 (350 – 16172) pg/ml respectively were statistically significant (p=0.003). And the secondary parameter creatinin serum convert to eGFR shows a change in eGFR with initial median 73.33 (37.05 – 266.68) ml/minute to 81.04 (39.31 – 167.02) ml/minute respectively were statistically not significant (p=0.657). There were 7 patients (50%) have a decrease > 25%. In this study, we found that ARB therapy can change NT-proBNP level significantly after 2 months therapy.
Sodium Hyaluronate Eye Drops for College Students with Computer Vision Syndrome in Indonesia Zulkarnain, Bambang Subakti; Loebis, Rozalina; Aryani, Toetik
Folia Medica Indonesiana Vol. 58, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • Computer vision syndrome (CVS) that causes dry eyes becomes a health problem for college students. • Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS. Abstract: The use of computers and mobile devices is increasing. Computers and mobile devices help our daily work or study. However, prolonged use of them may cause computer vision syndrome (CVS). Nowadays, CVS becomes a health problem for everyone working with computers or mobile devices including college students because it causes dry eyes. It may disrupt reading, doing professional work, or using a computer which is important for college students to complete academic tasks. Sodium hyaluronate can be used to overcome the dry eye problem due to CVS. To assess the effectiveness of sodium hyaluronate eyedrops on students suffering from CVS, pre- and post-administration of sodium hyaluronate was measured for two weeks. Inclusion criteria for this study were college students aged 20-35 years, using a computer for >2 hours a day, not using nonsteroidal anti-inflammatory drugs (NSAIDs), not consuming drugs, or having a disease that affects tear production and bearing no pregnancy. Parameters assessed include tear break-up time using the Tear Break-Up Time (TBUT) test, tear production using the Schirmer I test, the number of clinically subjective symptoms, and Ocular Surface Disease Index (OSDI) scores. Data were analyzed using student paired t-tests or Wilcoxon Rank Test. There were statistically significant differences before and after the TBUT (4.4 vs 6.7 seconds; p<0.0001); the Schirmer I Test (4 vs 6 mm; p<0.05), and the number of clinically subjective symptoms (3 vs 0 clinically subjective symptoms; p<0.0001). The OSDI scores did not show statistical differences before and after administration of sodium hyaluronate (27 vs 21; p>0.05), but there was a positive impact from moderate to mild dry eye. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.
Faktor yang Berhubungan dengan Long-term COVID-19: Studi Observasi Cross-Sectional di Indonesia Arina Dery Puspitasari; Nanda Ardianto; Lily Aina; Eunice Marlene Sicilia Kundiman; Fatimatuz Zahra Oviary Satryo; Melinda Putri Amelia Rachman; Fauzul Meiliani; Pharmasinta Putri Hapsari; Bambang Subakti Zulkarnain; Alfian Nur Rosyid; Tamara Nur Budiarti; Brigitta Dhyah Kunthi Wardhani
WMJ (Warmadewa Medical Journal) Vol 7 No 1 (2022): May 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.1.4784.33-39

Abstract

Long-term COVID-19 could occur in COVID-19 patients, affecting the patient's quality of life, and becoming a problem for public health. However, information is rarely on factors associated with the occurrence of long COVID-19 cases. This study analyzed factors associated with long-term COVID-19. The study was an observational cross-sectional, conducted in August 2021. The data were collected through a Google form questionnaire distributed to COVID-19 survivors in Indonesian. They must be aged more than 17 years to meet the inclusion criteria, while those with incomplete data were excluded. The data were processed by using SPSS 21 with an ordinal regression test in which an alpha level was 5%. As many as 101 from 16 men (15.8%) and 85 women (84.2%) were obtained. Comorbid status (p-value = 0.001) and duration of treatment (p-value = 0.034 and 0.015) had a significant association with the occurrence of long-term COVID-19. Meanwhile, age, gender, occupation, type of care, and vaccination status were not likely associated with long-term COVID-19. COVID-19 patients with comorbidity and a long duration of treatment are more likely to experience long-term COVID-19. Keywords: COVID-19, long-term COVID-19, factor, public health
Predicting Factors for COVID-19 Infection: A Cross-Sectional Study in Indonesia Pharmasinta Putri Hapsari; Lily Aina; Nanda Ardianto; Eunice Marlene Sicilia Kundiman; Fatimatuz Zahra Oviary Satryo; Melinda Putri Amelia Rachman; Fauzul Meiliani; Farah Meutia; Arina Dery Puspitasari; Bambang Subakti Zulkarnain; Alfian Nur Rosyid; Tamara Nur Budiarti; Brigitta Dhyah Kunthi Wardhani; Dhieo Kurniawan
WMJ (Warmadewa Medical Journal) Vol 8 No 1 (2023): May 2023
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.8.1.5329.34-40

Abstract

COVID-19 cases in Indonesia still remain a concern, particularly for public health. Several factors, such as gender, age, comorbidity, occupation, and vaccination status, might influence COVID-19 infection. Individuals who have many predicting factors have a higher risk of being infected by COVID-19. Other studies have not yet shown the significance of predicting factors for COVID-19 infection in Indonesia. The study explored the association between the predicting factors and COVID-19 infection in Indonesia. The study used a cross-sectional method with a population of all Indonesian communities. It was conducted in August 2021 by distributing a Google Form questionnaire in Indonesia. By a saturated sampling of the population in Jawa, Sumatera, Sulawesi, Kalimantan, and Papua, 776 Indonesians were selected; they were aged > 17 years and voluntarily completed the questionnaires. whereas respondents with incomplete data were excluded from this study. The data were analyzed using a binary logistic regression test in SPSS (version 21.0). The respondents include 134 men (17.3%) and 642 women (82.7%). The binary logistic regression analysis showed that COVID-19 infection was more common among respondents who were non-health-care workers (p 0.001) and less common among those who had been fully vaccinated (p 0.001). The COVID-19 infection was significantly associated with occupation and vaccination status. Keywords: COVID-19 Infection, Predicting Factors, Public Health, Health-Care Worker, COVID-19 Vaccination, Comorbidity
Co-Authors Abdul Rahem, Abdul Alfiyah Hasanah Alvita Raniah Aisyah Putri Ana Yuda Aranza Khoirina Audrey Abbas Arie Sulistyarini Arina Dery Puspitasari Asfarina, Hairunnisyah Brigitta Dhyah Kunthi Wardhani Brigitta Dhyah Kunthi Wardhani Budi Suprapti Budiatin, Aniek Setiya Chrismawan Ardianto Cici Aisyah Putri Rogahang Cladita Pamungkas Putri Clarissa Budiman Desi Ratu Puspita Dhieo Kurniawan Erviana Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Farah Meutia Farida Ifadotunnikmah Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Febria Rossa Alba Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hana Rizqi Ghaesani Hartoto, Halla Hisan Heri Yulimanida Hermansyah, Andi Herri Yulimanida Herri Yulimanida I NYOMAN WIJAYA Intan Kusuma Dewi Junaidi Khotib Lily Aina Lily Aina Lily Aina Mahardian Rahmadi Makmuroh Nurul Qomar Purnamawati, Dewi Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Misbahul Munir Muhammad Aminuddin, Muhammad Naksa Garnida Arfie Nanda Ardianto Nanda Ardianto Nanda Ardianto Nur Arifana, Erlita Nurul Khikmiyah Paulina Ari Damayanti Pharmasinta Putri Hapsari Puspitasari, Eka Octaviana Raden Mohamad Herdian Bhakti Rebecca Ferida Octaviani Rosyid, Alfian Nur Rozalina Loebis, Rozalina Sudarmanto Sudarmanto Sukorini, Anila Impian Sumarno . Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Syefi Nuraeni Fitriana Tamara nUR Budiarti Tamara Nur Budiarti Tamara Nur Budiarti Toetik Aryani Umi Athiyah WENNY PUTRI NILAMSARI, WENNY PUTRI Yessi Rahmawati Yogiarto, Mohammad Yuni Priyandani Yusuf Alsagaff, Mochamad Zahra Oviary Satryo, Fatimatuz