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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmiah Kesehatan Jember Medical Journal (JMJ)
M. Ihwan Narwanto
Fakultas Kedokteran Universitas Jember
Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

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Mesenchymal Stem Cell Therapy to Reduce the Neurological Deficit of Chronic Ischemic Stroke Patients: A Systematic Review nita, surya; Narwanto, Muhammad Ihwan; Yuli Hermansyah; Cholis Abrori; Novan Krisno Adji
Jember Medical Journal Vol. 3 No. 2 (2024): .
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jembermedicaljournal.v3i2.943

Abstract

Current ischemic and hemorrhagic stroke treatments are limited by a narrow golden period and lack of regenerative benefits, so stem cell therapy emerges as an ideal candidate for functional recovery in stroke patients. Stem cell therapy, still being studied, is expected to repair ischemic areas damaged by stroke to restore their physiological functions and reduce neurological deficits in chronic stroke patients. This study aimed to determine the therapeutic efficacy of MSCs in reducing neurological deficits in chronic ischemic stroke patients. We conducted a systematic review. We searched PubMed, Cochrane Library, Science Direct, and Springer Link from inception until December 2022 for cohort studies dealing with mesenchymal stem cell therapy for patients with ischemic stroke. The citation-searching method in this study collected 1,038 articles using the advanced searching method and 8 articles using the citation-searching method, bringing the total number of articles to 1,046. The exclusion criteria used were articles with systematic reviews and meta-analyses and articles that were not accessible in full text. Based on the results of a systematic review study conducted, the conclusion that can be drawn is that MSCs therapy has proven effective in reducing neurological deficits in chronic ischemic stroke patients in terms of the decreased NIHSS score. 
Neurodegenerative and Neurobehavioral Symptoms in Jember Agricultural Workers Caused by Oxidative Stress and Neurotransmitter Disturbance Narwanto, Muhammad Ihwan; Purwandhono, Azham; Sofiana, Kristianningrum Dian; Febianti, Zahrah; Jauhani, Muhammad Afiful; Kusumastuti, Inke; Putri, Elvia Rahmi Marga
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3508

Abstract

Increased use of pesticides can have detrimental health consequences, one of which is chronic neurotoxicity. The symptoms include degenerative and neurobehavioral issues. Chronic neurotoxicity occurs through oxidative stress, inflammation, and neurotransmitter disturbances. This study aimed to determine chronic neurotoxicity and test malondialdehyde and cholinesterase levels as neurotoxicity biomarkers among agricultural workers in Wuluhan, Jember, Indonesia. The 60-person research sample was divided into two groups: agricultural and non-agricultural workers. The interview utilized a mini-mental score examination, Chan's questionnaire, and the Patient Health Questionnaire to analyze the cognitive impairment, Parkinsonism, and depressive symptoms. The examination of serum malondialdehyde levels was performed using the TBARS method and cholinesterase levels by photometric kinetic method at a biochemistry laboratory from October to November 2022. Results showed cognitive impairment and depressive symptoms in agricultural workers, as well as high levels of malondialdehyde and low cholinesterase levels. This study concludes the presence of chronic pesticide neurotoxicity among agricultural workers in Jember, Indonesia, and that malondialdehyde and cholinesterase levels might serve as biomarkers of pesticide-induced neurotoxicity.
Co-Authors Azham Purwandhono Chikita R Hanifati Cholis Abrori, Cholis Desie Dwi Wisudanti Elvia Rahmi Marga putri Ida Srisurani Wiji Astuti Jauhani, Muhammad Afiful K Dian Sofiana Kristianningrum Dian Sofiana Kristianningrum Sofiana Kusumastuti, Inke Masruroh Rahayu Masruroh Rahayu, Masruroh Moch. Aris Widodo Muhammad Afiful Jauhani Muhammad Haikal Supriyadi Natasha Amelia Nita, Surya Novan Krisno Adji Nurdiana Nurdiana Nurdiana Nurdiana Pipiet Wulandari Pranika, Hafidh Restu Prasetia Aji Ramadhan Putri, Elvia Rahmi Marga Setyawati Soeharto Setyawati Soeharto, Setyawati Shera Nadhila Setyo Bisono Siti Jamalia Syadza Salsabila Yuli Hermansyah Yuli Hermansyah Zahrah Febianti Zahrah Febianti