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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Farmako Bahari Pharmaceutical Sciences and Research (PSR) Jurnal Sains dan Teknologi Farmasi Indonesia
Ilma Nugrahani
Fakultas Farmasi Universitas Pancasila Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health

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Journal : Pharmaciana: Jurnal Kefarmasian

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The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Nugrahani, Ilma; Aulia, Winni Nur
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.896 KB) | DOI: 10.12928/pharmaciana.v8i1.8227

Abstract

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the method’s performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.  
The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Ilma Nugrahani; Winni Nur Aulia
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.896 KB) | DOI: 10.12928/pharmaciana.v8i1.8227

Abstract

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the method’s performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.  
Co-Authors Abdillah, Muhammad Nur Aditya Aditya Andreanus Andaja Soemardji Andy Susbandiyah Ifada Astrini, Dwie Asyarie, Sukmadjaja Belda Nurmeyna Benny Permana Cintya Nurul Apsari Dea Dwi Puspita Debora Ronauli Dwie Astrini Hasan Rahmat Hasan Rahmat, Hasan Hidehiro Uekusa Humairoh, Rosnaini Irda Fidriany Joshita Djajadisastra Joshita Djajadisastra, Joshita Kartawinata, Tutus Gusdinar Marlia Singgih Wibowo Melvia Sundalian N.S, Sundani Ningsih, Listia Nurmeyna, Belda Okky D. Putra Okky Dwichandra Putra Pusparani Krisnamurthi Putra, Okky D. Rachmat Mauludin Ratna A. Utami Rozana Oktaviary Slamet Ibrahim Slamet Ibrahim Slamet Ibrahim Slamet Ibrahim Slamet Ibrahim Surantaatmadja Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sundani Noerono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Triyadi Hendra Wijaya Tutus Gusdinar Kartawinata Utami, Ratna A. Wibowo, Marlia Singgih Winni Nur Auli