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All Journal Jurnal Natur Indonesia Chimica et Natura Acta Asian Journal of Aquatic Sciences Unri Conference Series: Community Engagement Narra J Makara Journal of Science
Yuana Nurulita
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Jurnal Natur Indonesia

 1 
Penapisan Aktivitas dan Senyawa Antidiabetes Ekstrak Air Daun Dandang Gendis (Clinacanthus nutans) Nurulita, Yuana; Dhanutirto, Haryanto; Soemardji, Andreanus A.
Jurnal Natur Indonesia Vol 10, No 2 (2008)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.499 KB) | DOI: 10.31258/jnat.10.2.98-103

Abstract

An investigation of the antidiabetic activity of Aqueous Extract and its fractions from a different polarity solvent:ethanol, ethyl acetate, and n-hexane of Dandang Gendis Leaves (Clinacanthus nutans Lindau) on Mile SwissWebster Mice has been carried out. The effect of aqueous extract of dose of 50, 100, and 150 mg/kg BW wastested on glucose serum level of alloxan induced that mice. Its fractions were tested by glucose tolerance method.Aqueous extract (150 mg/kg BW) significantly decreased blood glucose serum level (pd”0,05) that had the sameeffect as oral glibenclamide (0,65 mg/kg BW) administrated once a day for 9 days. Aqueous extract that wasfractionated has 5 fraction. Fraction of ethanol extract that was insoluble in ethyl acetate at a dose of 100 mg/kgBW was the most active fraction, that significantly (p<0,05) decreased blood glucose serum level of mice atglucose tolerance method of 18,4% in 3 hours after 2 g/kg BW of glucose administration. Thin layer chromatography(TLC) of that fraction ethanol 95%-chloroform 9:2 as eluent gave 5 spots under ultraviolet ray and showed spesificcompounds by qualitative test. Spot 1 (steroid) gave Rf 0,14; spot 2 and spot 3 that gave Rf 0,53 and 0, 67 wereflavonoid, spot 4 (triterpenoid) gave Rf 0,77; and spot 5 (chlorophyll) gave Rf 0,89. This research show that this plantcan used for hipoglicemic traditional medicine.
Sintesis dan Uji Antibakteri Senyawa Bromo Kalkon Piridin Jasril, Jasril; Teruna, Hilwan Yuda; Zamri, Adel; Alfatos, Darian; Yuslinda, Elka; Nurulita, Yuana
Jurnal Natur Indonesia Vol 14, No 3 (2012)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.23 KB) | DOI: 10.31258/jnat.14.3.172-175

Abstract

Three pyridine chalcones including (Z)-1-(4-bromophenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1), (Z)-1-(4-bromophenyl)-3- (pyridin- 3-yl)prop-2-en-1-one (2) and (Z)-1-(4-bromophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (3) were synthesized by aldol condensation reactions from pyridinecarbaldehyde with 4-bromoacetophenone. In antibacterial assay, compound 3 exhibited strong activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli with the inhibition zone of 19.9; 19.5, and 17.5 mm, respectively.
Co-Authors Adel Zamri Amalia, Aisyah Sabrina Andi Dahliaty Andi Dahliaty Andreanus A. Soemardji Apriyola, Nadya Darian Alfatos Dewi Anggraini Elka Yuslinda Feliatra Haryanto Dhanutirto Hendra, Rudi Hilwan Yuda Teruna Jasril Jasril Jufrizal Syahri Maya Savira Narasswati, Nungki Nenci, Nuryani Oktavia, Rani Saryono Saryono Sri Helianty suraya, nabella Titania Tjandrawati Nugroho Wardana, Rexi Dwi Yuharmen, Yuharmen Yum Eryanti Zona Octarya