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All Journal Jurnal Anestesiologi Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Majalah Anestesia dan Critical Care Jurnal Plastik Rekonstruksi Indonesian Journal of Anesthesiology and Reanimation (IJAR) Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Majalah Anestesia & Critical Care (MACC) Jurnal Sehat Indonesia (JUSINDO) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Jurnal Komplikasi Anestesi
Sugiarto, Adhrie
Departemen Anestesiologi Dan Terapi Intensif, Fakultas Kedokteran Universitas Indonesia – RSUPN Nasional Dr. Cipto Mangunkusumo, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Antifungal Therapy for Complicated Intra-Abdominal Infection: A Case Report Mega Halida; Vera Irawany; Adhrie Sugiarto
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 2 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.537

Abstract

Complicated intra-abdominal infection (cIAI) is a serious condition characterized by the extension of infection beyond the gastrointestinal tract into the peritoneal cavity and is associated with high morbidity and mortality. Management of cIAI requires a comprehensive approach, including prompt diagnosis, adequate source control, and appropriate antimicrobial therapy. This case report describes the role of antifungal therapy in the management of cIAI in a critically ill patient with multiple risk factors for invasive fungal infection. A 52-year-old woman with a history of cervical cancer treated with radiotherapy and chronic hemodialysis presented with abdominal pain, nausea, vomiting, and inability to tolerate oral intake. Diagnostic evaluation revealed obstructive ileus and necrotic ileal tissue requiring exploratory laparotomy and intestinal resection. Postoperatively, the patient was admitted to the intensive care unit and received broad-spectrum antibiotics combined with fluconazole as empirical antifungal therapy. Clinical and laboratory improvements were observed during intensive care management, leading to stabilization and subsequent transfer to a high-dependency unit. This case highlights the importance of considering antifungal therapy in healthcare-associated intra-abdominal infections, particularly among immunocompromised and critically ill patients at risk of Candida infection. Early recognition, adequate source control, and individualized antimicrobial selection remain essential for optimizing patient outcomes.
Co-Authors Aditya Wardhana Agustina Haloho Ahmad Irfan Aivi Mujono Alatas, Anas Aldy Heriwardito Amir S Madjid Amir S Madjid Anas Alatas Andi Ade Wijaya Ramlan Anggara Gilang Dwiputra Arief Cahyadi Arifin Arifin Asri C. Adisasmita Auerkari, Aino Nindya Avisa Cetta Cresma Dita Aditianingsih Dita Aditianingsih Eko Setijanto Hafidz, Noor Haloho, Agustina Br Harijanto, Eddy Heni Pujiastuti Hunter Design Nainggolan Inge Permadhi Jefferson Hidayat Jefrey Tuhulele, Norman Rabker Karseno Dibyosubroto, Iradewi Luther Holan Parasian Madeline Marpaung Manggala, Sidharta Kusuma Mega Ayu M Marina S.A Mega Halida Mohamad Rachadian Ramadan Mufaza, Uyun Muhammad Husni Thamrin Noor Hafidz Nugraha, Taufiqo Peni Yulia Nastiti Perdana, Aries Purwoko Purwoko Putri, Regina Prima Rahmah, Herlina Ratna Farida Soenarto Riyadh Firdaus Rosdiana, Prita Rudyanto Sedono Septian Adi Permana Setiadi, Bakti Shendy Meike Sari Supriyadi, Eddo Tantri, Aida THARIQAH SALAMAH, THARIQAH Vera Irawany Yoan Devina Zahrina, Fadiah Zulkifli