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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Obstetrics & Gynecology Science Excellent Midwifery Journal
M. Fidel Ganis Siregar
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Journal : Majalah Kedokteran Nusantara The Journal Of Medical School

 1 
Kadar estradiol serum pada wanita menopause dengan dan tanpa sindroma vasomotor di RSUP H Adam Malik dan RS Jejaring Fakultas Kedokteran Universitas Sumatera Utara Medan Tri Sugeng Hariadi; M. Fidel Ganis Siregar; Hanudse Hartono; Makmur Sitepu; M. Rhiza Z. Tala; Cut Adeya Adella
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background: Physiologic changes from the reproductive to non reproductive phase is characterized by a gradual decline in estrogen levels. In menopausal women decline of estrogen levels can causes various complaints, one of which is the vasomotor syndromeAim: This study was conducted to determine estradiol serum levels in menopausal women with and without vasomotor syndrome and estradiol serum levels in menopausal women based on severity degrees (mild, moderate, and severe).Metode: This analytical cross sectional study involved 60 women, 34 women with vasomotor syndrome and 26 women with non vasomotor syndrome. Serum estradiol levels in every groups were checked. Data were statistically analysed using Anova and Spearmen correlation tests (p<0.05; CI 95%).Results : Non vasomotor syndrome estradiol serum mean rank was significantly higher than vasomotor syndrome estradiol serum mean rank (17.5 vs 47,5 pg/mL). Mean estradiol levels of menopausal vasomotor syndrome subjects based on severity degrees for mild, moderate, and severe degrees are 25.80 ± 2.34 pg/ml; 15.58 ± 2.64 pg/ml; and 11,80 pg/ml (P<0.05). Age, menopausal age, and menopausal length was significantly negatively correlated with estradiol levels with r values of -0.859, - 0.830, and -0.880, respectively. Body Mass Index (BMI) was significantly positively correlated with estradiol levels with a r value of 0.699Conclusion: Serum estradiol levels were lower in vasomotor syndrome women than non vasomotor women. There is significantly differed serum estradiol levels based on severity degress. More severe degrees of vasomotor syndrome will make lowerv serum estradiol levels. Subject characteristics were also significantly associated with serum estradiol levels in menopausal women. Key Words : Menopause, vasomotor syndrome, serum estradiol.
Kadar Kortisol Saliva Sebagai Penanda Gangguan Gejala Menopause pada Paramedis Poli Rawat Jalan Usia Perimenopause di Rumah Sakit Umum Pusat Haji Adam Malik Medan Yufi Permana; M. Fidel Ganis Siregar; Syamsul A. Nasution; Sanusi Piliang; Muldjadi Affendy; Yostoto B. Kaban
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 48, No 1 (2015): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction :The premenopausal period is characterized as a decline in estrogen levels that consequently result in disturbing symptoms. One noted significant factor in this period is the psychological state, a condition that is closely related to cortisol levels. Stress is known to be a product of the neuroendocrine system. As a product of tbis mechanism, cortisol is frequently used as a biomarker to study stress. Currently, menopausal symptoms are diagnosed based on present complaints, which tends to be subjective, consequently, a biomarker is required to diagnose menopausal disturbances. Method :This analytic, diagnostic, cross sectional study was conducted in the General Hiospital of Haji Adam Malik Medan, and enrolled paramedics working at the out patient clinic from March until April 2015. All subjects were asked to fill a Menopause Rating Scale (MRS), the results of which were then associated with obtained salivary cortisol levels. Results :Salivary cortisol levels was significantly associated with menopausal disturbances with p< 0.01. Salivary cortisol also significantly differed based on each MRS scores with p=0.008. A cut-off value of 9.52 ng/ml was obtained, with specificity and sensitivity values of 85 and 77%, respectively. Conclusion :Salivary cortisol testing as a marker for menopausal disturbances obtained a marker of 9.52 ng/mL with specificity and sensitivity values of 85 and 77%, respectively. Key words :Salivary cortisol, menopausal disturbances, Menopause Rating Scale
Co-Authors Binarwan Halim CUT ADEYA ADELLA, CUT ADEYA Hanudse Hartono Ichwanul Adenin Irwin Lamtota Lumbanraja Johanes Cornelius Mose Leo Jumadi Simanjuntak Letta Sari Lintang M. Rhiza Z. Tala Makmur Sitepu, Makmur Muldjadi Affendy Sanusi Piliang Sarma N Lumbanraja Sarma Nursani Lumbanraja Syamsul A. Nasution Tri Sugeng Hariadi Yostoto B. Kaban Yufi Permana