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All Journal VA Jurnal Pendidikan Teknik Mesin Jurnal Ilmiah Mahasiswa FEB Biomedika JURNAL BIOLOGI INDONESIA Forest and Society PREPOTIF : Jurnal Kesehatan Masyarakat FOCUS: Journal of Social Studies JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Didik Prasetyo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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PENGARUH EKSTRAK PROPOLIS TERHADAP PENINGKATAN EKSPRESI p21, EKSPRESI PROTEIN Bax DAN INDUKSI APOPTOSIS PADA KULTUR SEL KANKER KOLON (CELL LINE WiDr) Prasetyo, Didik; Maryono, Suradi; Purwanto, Bambang
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4342

Abstract

Kanker kolorektal merupakan kanker ketiga terbanyak dengan lebih dari 1 juta kasus setiap tahunnya dan salah satu kanker dengan mortalitas tertinggi di seluruh dunia. Radioterapi dan kemoterapi pada kanker relatif terbatas karena toksisitasnya yang tinggi dan efek samping yang bersifat merusak. Pengembangan propolis merupakan strategi baru untuk terapi adjuvan yang diharapkan meminimalkan efek samping terapi standar yang ada. Peran propolis pada keganasan terkait kemampuannya dalam menginduksi apoptosis dan aktivitas antiproliferasi. Penelitian in vitro, menunjukkan propolis memiliki aktivitas proapoptosis pada berbagai jenis sel kanker, meliputi : kanker laring, kanker paru, kanker pankreas, kanker tiroid, kanker payudara, kanker prostat dan glioma. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian propolis yang berasal dari Kerjo, Karanganyar, Indonesia terhadap aktivitas antiproliferasi, terkait peningkatan ekspresi p21 dan induksi apoptosis terkait peningkatan ekspresi protein bax pada kultur sel kanker kolon (cell line WiDr). Jenis penelitian ini, eksperimental laboratorik dengan post test with control group design. Penelitian menggunakan kultur sel WiDr (sel kanker kolon) dengan pemberian ekstrak etanol propolis (EEP). Pengamatan ekspresi p21 dan protein Bax dengan metode imunositokimia, sedangkan pengamatan induksi apoptosis dengan flowcytometry. Analisis statistik menggunakan uji Kruskall Wallis dilanjutkan Mann WhutneyU test. EEP cenderung menekan viabilitas sel WiDr dengan IC50 sebesar 140 μg/mL. EEP konsentrasi 70,140, 280 μg/mL mampu meningkatkan ekspresi p21 yang sebanding dengan peningkatan konsentrasi yang diberikan. EEP konsentrasi 70 μg/mL (1/2 IC50) paling efektif dalam menginduksi apoptosis dan meningkatkan ekspresi Bax pada sel WiDr. Peningkatan konsentrasi EEP mengakibatkan kematian sel WiDr ke arah nekrosis. Penelitian ini menunjukkan EEP mampu menekan viabilitas sel WiDr. Aktivitas ini kemungkinan terkait dengan kemampuannya dalam meningkatkan ekspresi p21 sebanding dengan peningkatan konsentrasi yang diberikan. EEP pada konsentrasi 70μg/mL mampu menginduksi apoptosis pada sel WiDr terkait dengan peningkatan ekspresi Bax. Peningkatan konsentrasi EEP konsentrasi 140 dan 280 μg/Ml mengakibatkan nekrosis sel WiDr. Kata kunci: EEP, p21, protein bax, cell line WiDr
Nest Stuctures in Bornean Orangutan Prasetyo, Didik; Utami, Sri Suci; Suprijatna, Jatna
JURNAL BIOLOGI INDONESIA Vol 8, No 2 (2012): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v8i2.3042

Abstract

Struktur Sarang Orangutan Kalimantan. Nest-building techniques processes related partiesin choosing the trees, the basic building structure, making layers, and adding nest lockingsystem with accessories. There are Lacks of data about the pattern of the orangutan nest andonly van Schaik (1995) described four Variations of nest structure. By Following 22 orangutanswith instantaneous focal animal method, 19 vertical nest structures are found, and horizontallyvariations orangutan nest forming butterfly pattern. Tree species are Elaocarpus mastersiithat mostly used by Orangutan to build nest with type of branch direction and height of firstbranch as the Reasons. Nest was built in 5-9 meters height and they were seldom to rebuilt orreuse old nest. They seldom to develop their nest in the last fruit trees to avoid nightpredators.Kata Kunci: Orangutan, Struktur dan pola, sarang.
BUKIT NGEPON JATIROGO-TUBAN SEBAGAI INSPIRASI PENCIPTAAN KARYA SENI LUKIS PRASETYO, DIDIK
Jurnal Seni Rupa Vol 5, No 02 (2017): Volume 05 Nomor 02 Edisi Yudisium 2017
Publisher : Jurnal Seni Rupa

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Abstract

Bukit Ngepon adalah sebuah bukit di Desa Ngepon, Kec Jatirogo, Kab. Tuban. Walaupun sangat jauh dari pusat kota Tuban namun bukit tersebut sangat populer di mata masyarakat karena dalam area bukit tersebut terdapat wisata religi yaitu makam  Mbah Punjul dan situs Dadungawuk. Bukit Ngepon menyimpan banyak kekayaan alam, diantaranya adalah banyaknya pohon ental (pohon siwalan) dan karakter tanah yang berwarna merah kekuning-kuningan dan berpasir. Karena tanah tersebut bernilai ekonomi yang lumayan akibatnya terjadilah ekploitasi besar-besaran terhadap bukit Ngepon. Bukit yang semula hijau, rimbun dipenuhi tumbuh-tumbuhan dan berbentuk seperti sebuah mangkuk raksasa terbalik, kini berubah menjadi gersang penuh dengan kubangan-kubangan, terbentuk tebing-tebing yang curam dan rawan longsor akibat berpusatnya eksploitasi yang hanya di beberapa titik. Melihat perubahan bukit tersebut penulismerasa tertarik, hingga akhirnya penulis terinspirasi. Fokus penciptaan penulis adalah menciptakan karya seni lukis yang bersumber dari inpirasi bukit Ngepon Jatirogo-Tuban. Metode penciptaan dimulai dari ide penciptaan, penentuan tema, gaya, media, teknik, hingga eksekusi karya. Hasil berupa empat buah karya seni lukis yang terinspirasi dari bukit Ngepon Jatirogo-Tuban.  Kata kunci: seni lukis, bukit Ngepon , Kabupaten Tuban  
NEST STUCTURES IN BORNEAN ORANGUTAN Prasetyo, Didik; Utami, Sri Suci; Suprijatna, Jatna
JURNAL BIOLOGI INDONESIA Vol 8, No 2 (2012): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v8i2.3042

Abstract

Struktur Sarang Orangutan Kalimantan. Nest-building techniques processes related partiesin choosing the trees, the basic building structure, making layers, and adding nest lockingsystem with accessories. There are Lacks of data about the pattern of the orangutan nest andonly van Schaik (1995) described four Variations of nest structure. By Following 22 orangutanswith instantaneous focal animal method, 19 vertical nest structures are found, and horizontallyvariations orangutan nest forming butterfly pattern. Tree species are Elaocarpus mastersiithat mostly used by Orangutan to build nest with type of branch direction and height of firstbranch as the Reasons. Nest was built in 5-9 meters height and they were seldom to rebuilt orreuse old nest. They seldom to develop their nest in the last fruit trees to avoid nightpredators.Kata Kunci: Orangutan, Struktur dan pola, sarang.
PENGEMBANGAN MEDIA PERAGA PADA KOMPETENSI MENGIDENTIFIKASI SISTEM INTERMITTENT WIPER Prasetyo, Didik; Wahyudi, Wahyudi
Jurnal Pendidikan Teknik Mesin Vol 19, No 1 (2019)
Publisher : Jurusan Teknik Mesin, Fakultas Teknik, Universitas Negeri Semarang

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Abstract

Tujuan penelitian ini untuk menguji kelayakan peraga sistem intermittent wiper sebagai media pembelajaran dan mengetahui peningkatan penguasaan materi pada mahasiswa setelah belajar menggunakan peraga sistem intermittent wiper. Metode penelitian yang digunakan adalah metode penelitian dan pengembangan dengan model pengembangan ADDIE. Pengambilan data dilakukan dengan menggunakan instrumen lembar validasi ahli untuk penilaian kelayakan peraga dan instrumen soal pilihan ganda untuk penguasaan mahasiswa. Analisis kelayakan peraga dilakukan dengan membandingkan skor yang diperoleh dari validator ahli dengan kriteria kevalidan media peraga yang telah ditetapkan. Sedangkan analisis peningkatan penguasaan materi dilakukan dengan membandingkan hasil pretest dan posttest pada kelompok maupun kelompok kontrol. Hasil penelitian didapatkan bahwa media peraga sistem intermittent wiper tersebut memenuhi kriteria “Layak” sehingga dapat digunakan sebagai media pembelajaran. Selain itu, analisis hasil belajar menunjukkan bahwa terjadi peningkatan hasil belajar pada kelompok eksperimen setelah diberikan pembelajaran menggunakan alat peraga sistem intermittent wiper. Hal ini ditunjukkan dengan skor rata-rata saat pretest sebesar 38 yang meningkat menjadi 66,871 saat posttest. Dengan demikian, pada kelompok eksperimen terjadi peningkatan hasil belajar sebesar 28,871 atau meningkat 75,98%.
Population Status of Tapanuli Orangutan (Pongo tapanuliensis) within the Renewable Energy Development and its Management Implications Prasetyo, Didik; Hadiprakarsa, Yokyok; Kuswanda, Wanda; Sugardjito, Jito
Forest and Society Vol. 5 No. 2 (2021): NOVEMBER
Publisher : Forestry Faculty, Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24259/fs.v5i2.13529

Abstract

To protect Tapanuli orangutan it is essential to understand the actual situation. It has been studied 15% of its population live outside the protected area facing a density disruption due to forest conversion. Several best management practices have been created and tested for different natural concession types. Yet, the main objective to reduce the impact and increase wildlife survival is far away from the goal. To improve our understanding of the species survival within ongoing project construction, we conducted population density monitoring prior- to post-construction time frames within the hydroelectric dam project. Also, we carried out spatial analysis to understand the land cover change and orangutan’s suitable habitat distribution. This study found that during high construction activities, orangutans were avoiding the threat sources, and returned when the disturbances reduced. These findings indicated orangutans are ecology flexible and have the capability to increase its survival, although the company’s involvement is crucial to facilitate the successes. Our study is based on indirect observation, and spatial modeling, which may lead to an uncertain conclusion. Further research on orangutan ecology and behavior is prioritized.
Analisis Hukum Terhadap Wanprestasi dalam Proyek Konstruksi yang Melibatkan Pihak Perorangan: Studi Kasus Pembangunan Guesthouse. Prasetyo, Didik; Putranto, Rahmat Dwi; Harvelian, Agnes
FOCUS Vol 5 No 2 (2024): FOCUS: Jurnal Ilmu Sosial
Publisher : Neolectura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37010/fcs.v5i2.1692

Abstract

In the realm of construction, contracts form the fundamental basis of projects involving multiple parties with clear responsibilities and obligations. This research explores a case of breach of contract (wanprestasi) in a construction project involving an individual, which not only caused financial and reputational harm to other parties involved but also compromised the integrity and quality of the project. The legal framework governing construction services and contracts, including Article 1 paragraph (3) of Law Number 2 of 2017 concerning Construction Services, sets the ground for understanding obligations and rights under Indonesian civil law. The methodology employed in this study is a qualitative analysis, focusing on the application of legal principles, relevant regulations, and real-life practices related to cases of breach of contract using literature reviews and case document analysis. This approach has allowed for an in-depth understanding of the legal norms and the actual enforcement of laws in similar situations. The findings reveal that the specific breaches included not meeting agreed specifications and delays in project completion, which are deemed as wanprestasi under Article 1243 of the Indonesian Civil Code. These violations stem from poor project management, opaque fund usage, and unilateral decisions by the executing party, highlighting the need for stringent legal enforcement and protection for the aggrieved parties. Keywords: Construction Law, Breach of Contract, Legal Enforcement, Project Management, Civil Law
GAMBARAN PASIEN NOISED INDUCED HEARING LOSS : LITERATURE REVIEW Prasetyo, Didik; Nasruddin, Hermiaty; Alimah, Yarni
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.44092

Abstract

Gangguan pendengaran akibat kerja adalah hilangnya sebagian atau seluruh pendengaran secara permanen, dapat terjadi pada salah satu atau kedua telinga karena terpaparnya kebisingan terus menerus di tempat kerja. Gangguan pendengaran akibat bising (noise induced hearing loss/NIHL) adalah penurunan pendengaran atau tuli akibat bising yang melebihi nilai ambang batas (NAB) dengar di lingkungan kerja. Global Burden Disease tahun 2010, menyatakan bahwa sekitar 1-3 milyar orang telah mengalami gangguan pendengaran akibat bising, dimana merupakan kasus yang menduduki peringkat ke-13 sebagai penyebab disabilitas. Dampak yang dapat dirasakan oleh pekerja dengan NIHL ini dapat berupa gangguan fisiologi (penurunan fungsi pendengaran, sakit kepala dan iritasi telinga), gangguan psikologis (penurunan konsentrasi konsentrasi, rasa tidak nyaman, mudah lelah, cepat marah, dan mengalami gangguan tidur), serta gangguan komunikasi. Tujuan dari tinjauan literatur ini adalah untuk mengetahui gambaran pasien noised induced hearing loss. Menggunakan metode literature review dengan prinsip Diagram Alur PRISMA. Artikel atau jurnal ilmiah diunduh dari PubMed, Portal Garuda, dan Google Scholar dengan standar SINTA IV dan V. Kata kunci dalam pencarian artikel ini yaitu gambaran, pasien dan noised induced hearing loss. Didapatkan 105 artikel dalam hasil pencarian. Semua artikel diseleksi berdasarkan kriteria inklusi diperoleh  10 artikel penelitian yang akan di telaah. Hasil penelitian menunjukkan bahwa usia, jenis kelamin, masa kerja, durasi paparan bising, intensitas bising, merokok dan konsumsi alkohol adalah salah satu gambaran yang ditemukan pada pasien noised induced hearing lloss.
Real-Life Situation Of Bile Duct Injury Management: Challenges And Lessons From A Tertiary Care Center Pramana, Triyanta Yuli; Adhyaksari, Apriliana; Lee, See Young; Ratanachu-ek, Thawee; Ranty, Stefanus Satrio; Prasetyo, Ari; Darmayani, Aritantri; Prasetyo, Didik; Notonugroho, Anung
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025143-153

Abstract

Background: Bile duct injury (BDI) is a serious complication of cholecystectomy, particularly with the widespread adoption of laparoscopic cholecystectomy (LC). Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. This study evaluates reallife clinical experiences in managing post-cholecystectomy BDIs in Central Java, Indonesia. We aim to discuss the prevention of BDI further and find out the most effective management and timing of interventions for BDI based on these analyses.Methods: Twenty-seven cases with iatrogenic BDI following cholecystectomy were classified according to BDI Strasberg classification, repair procedures, mortality and success rate procedures, onset of BDI, and timing of repair procedures. The correlation analyses were performed using the Contingency Coefficient Correlation Test.Results: Of the 27 patients, BDIs were detected in 33.3% of patients within two weeks of surgery. Major BDIs (Strasberg E) often required biliodigestive surgery, with variable outcomes. The overall mortality rate was 29.6%, mainly due to biliary sepsis. ERCP success was significantly associated with less severe BDI (p=0.018). This study stated that the type of previous cholecystectomy, timing of BDI diagnosis, and duration of BDI to repair procedures did not statistically influence mortality (p=0.822, p=0.551, p=0.958, respectively).Conclusion: Prevention of BDI is paramount, emphasizing surgical training, careful patient selection, and the critical view of safety technique. Early detection, multidisciplinary management tailored to the injury’s severity improve outcomes. While minimally invasive approaches are preferred for minor BDIs, major injuries necessitate surgical intervention by experienced hepatobiliary surgeons.
A 57-year-old woman with chronic hepatitis B and left hepatic nodularity unmasking intrahepatic hilar adenocarcinoma: A diagnostic case report Pramana, Triyanta Yuli; Gunawan, Timotheus A.; Prasetyo, Didik; Darmayani, Aritantri; Jati, Agus; Wasita, Brian
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art16

Abstract

Metastatic breast cancer involving the biliary tract is a rare case with an incidence rate of 1.49 per 100.000 persons. Chronic hepatitis B virus (HBV) infection is associated with tumor development and migration and promotes metastasis. While hepatocellular carcinoma is the most common primary liver cancer, cholangiocarcinoma is a rarer malignancy originating from epithelial cells in various parts of the bile ducts. Intraluminal adenocarcinoma of the common hepatic duct (CHD) is an exceptionally uncommon hepatic tumor. We reported that a 57-year-old female has been complaining of abdominal pain on the upper right side for 1 year, accompanied by nausea and icterus. The patient had a history of breast cancer in 1995 and chronic hepatitis B for 20 years on Tenovofir 1x300 mg. No abnormalities were found on physical examination. However, Magnetic Resonance Cholangiopancreatography (MRCP) revealed bilateral dilatation of the intrahepatic bile duct (IHBD), common hepatic duct (CHD), ductus cysticus, and common bile duct (CBD) distal to proximal, suggesting an intraluminal mass likely due to a tumor. A plastic stent was then placed, which reduced the lesion size. Immunohistochemistry (IHC) test confirmed adenocarcinoma, in which CK-7 and mammaglobin were positive, indicating metastatic breast cancer.. A thoracic MSCT revealed multiple lytic lesions in the T1, T7, T9–T12, and L2–L3 vertebral bodies. The patient was diagnosed with intraluminal adenocarcinoma of the CHD, representing metastatic Stage I triple-negative breast cancer with biliary, pulmonary, and osseous involvement, along with chronic hepatitis B. The chemotherapy regimen included carboplatin 370 mg and paclitaxel 260 mg, continued with Taceral 500 mg 2x3 in two weeks and Zometa every 6 weeks. Post-chemotherapy MRCP evaluation showed a solid intraluminal liver lobe lesion with partial obstruction. Metastatic adenocarcinoma of the CHD caused by breast cancer is a highly unusual clinical problem. In such cases, IHC plays a vital role in identifying the primary tumor site.
Co-Authors Adhyaksari, Apriliana Agnes Harvelian, Agnes Alimah, Yarni Ari Prasetyo Bambang Purwanto Brian Wasita Darmayani, Aritantri Gunawan, Timotheus A. Hadiprakarsa, Yokyok Jati, Agus Jito Sugardjito Lee, See Young Maryono, Suradi Nasruddin, Hermiaty Notonugroho, Anung Putranto, Rahmat Dwi Ranty, Stefanus Satrio Ratanachu-ek, Thawee Suprijatna, Jatna Suprijatna, Jatna Triyanta Yuli Pramana Unti Ludigdo Utami, Sri Suci Utami, Sri Suci Wahyudi Wahyudi Wanda Kuswanda