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Pengaruh Pemberian Aspartam terhadap Kadar Low-Density Lipoprotein dan High-Density Lipoprotein pada Tikus Wistar Diabetes Melitus Diinduksi Aloksan Revivo Rinda Pratama; Eti Yerizel; Rahmatini Rahmatini
Jurnal Kesehatan Andalas Vol 3, No 3 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i3.172

Abstract

AbstrakAspartam telah disetujui oleh FDA untuk dikonsumsi. Konsumsi pemanis buatan ini menggunakan dosis ADI (Acceptable Daily Intake) yaitu 50 mg/kgBB. Individu dengan diabetes melitus kemungkinan menjadi antusias terhadap adanya aspartam. Aspartam dapat mempengaruhi metabolisme profil lipid. Tujuan dari penelitian ini adalah mengetahui pengaruh pemberian aspartam terhadap kadar LDL dan HDL tikus diabetes melitus diinduksi aloksan. Ini merupakan penelitian eksperimental dengan randomized post test only control group design. Subjek penelitian adalah 15 ekor tikus Wistar jantan yang dibagi menjadi tiga kelompok, yaitu kelompok kontrol negatif, kelompok kontrol positif, dan kelompok perlakuan. Masing-masing kelompok terdiri dari lima (5) ekor tikus. Pemberian aspartam (dosis 315 mg/kgBB tikus) diberikan kepada kelompok perlakuan selama empat (4) minggu. Hasil penelitian menunjukkan bahwa pemberian aspartam pada tikus diabetes melitus diinduksi aloksan berpengaruh terhadap penurunan kadar LDL dan peningkatan kadar HDL. Kadar LDL pada kelompok kontrol positif adalah 30 ± 2 mg/dl, pada kelompok perlakuan adalah 24 ± 2 mg/dl. Sedangkan kadar HDL pada kelompok kontrol positif adalah 19 ± 1 mg/dl, pada kelompok perlakuan adalah 22 ± 1 mg/dl. Terdapat perbedaan yang bermakna pada kadar LDL dan HDL antara kelompok kontrol positif dengan kelompok perlakuan. Kesimpulan hasil penelitian ini adalah pemberian aspartam pada tikus diabetes melitus diinduksi aloksan berpengaruh terhadap penurunan kadar LDL dan peningkatan kadar HDL.Kata kunci: aspartam, diabetes melitus, LDL, HDLAbstractAspartame has been approved by the FDA for consumption. Consumption of artificial sweeteners is using ADI (Acceptable Daily Intake) dose which is 50 mg/kg. Individuals with diabetes mellitus would likely be enthusiastic consumers of aspartame. Aspartame can influence the metabolism of lipid profile. The purpose of this study was to determine the effect of aspartame on levels of LDL and HDL at rats with diabetes mellitus induced by alloxan. The research is experimental research with randomized post test only control group design. The subjects were 15 male Wistar rats those were divided into three groups: a negative control group, a positive control group, and the treated group. Each group consists of five (5) male rats. Administration of aspartame (dose of 315 mg/kg rat) was administered to the treatment group for four (4) weeks. The results showed that administration of aspartame in rats with diabetes mellitus induced by alloxan was influenced the decreased in LDL levels and increased in HDL levels. The LDL levels in positive control group was 30 ± 2 mg/dl, in the treatment group was 24 ± 2 mg/dl. While the levels of HDL in positive control group was 19 ± 1 mg/dl, in the treatment group was 22 ± 1 mg/dl. There is a significant difference in the levels of LDL and HDL between the positive control group with the treatment group. The conclusion of this research are the administration of aspartame in rats with diabetes mellitus induced by alloxan influenced the decreased in LDL levels and increased in HDL levels.Keywords: aspartame, diabetes mellitus, LDL, HDL
Edukasi Dan Skrining Tingkat Pengetahuan Tentang Bahaya NAPZA Dan Alkohol Bagi Remaja Di Masjid Maryam Ranah Pratama, Revivo Rinda; Amelia, Rinita; Wahyuni, Sri; Zainun, Zukhri; Amran, Rika; Chan, Zamsari
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 2 (2024): April
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i2.834

Abstract

Kegiatan ini bertujuan untuk meningkatkan pengetahuan siswa SMP dan SMA mengenai bahaya dan dampak NAPZA dan Alkohol bagi remaja, mengetahui tingkat pengetahuan dan sikap siswa terhadap NAPZA dan Alkohol, memberikan edukasi terkait resiko pemakaian NAPZA dan Alkohol dalam kesehatan dan psikososial. Metode pelaksanaan pengabdian masyarakat ini adalah melalui penyuluhan dan pemberian kuesioner skrining tingkat pengetahuan dan sikap remaja terhadap NAPZA dan Alkohol pada remaja SMP dan SMA yang sedang mengikuti Pesantren Ramadhan di Masjid Maryam Ranah Padang. Hasil pelaksanaan program adalah terlaksananya penyuluhan dan edukasi mengenai NAPZA dan Alkohol serta dampaknya dalam masyarakat dari aspek kesehatan dan psikososial dan laporan kegiatan serta dokumentasi dan publikasi.
GAMBARAN TINGKAT KETERGANTUNGAN NIKOTIN PADA ROKOK ELEKTRONIK DIKALANGAN MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS BAITURRAHMAH Aryaldy Zulkarnaini; Vina Triseptiana; Reno Sari Caniago; Revivo Rinda Pratama; Fauzi Rahmat Dani
Nusantara Hasana Journal Vol. 3 No. 5 (2023): Nusantara Hasana Journal, October 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i5.1286

Abstract

Cigarettes are a product that contains addictive substances, which when used can cause dangerous impacts on the health of individuals and society. With the rapid development of technology, currently a new style has emerged for smokers, namely electronic cigarettes. The substance that has the strongest addictive effect is nicotine. This addictive effect of nicotine is usually called Nicotine Dependence. Nicotine dependence or nicotine dependence is a condition where a person involves physical and psychological factors that make it difficult to stop using nicotine. Most of the largest use of electronic cigarettes is among young people of productive age, which if equated to students. This study aims to determine the level of nicotine dependence on electronic cigarettes among Baiturrahmah University medical faculty students. This research uses descriptive analysis with a cross-sectional method using primary data with a sample size of 56 respondents. Univariate data analysis is presented in the form of a frequency distribution. The results of the study showed that the majority of students at the Faculty of Medicine, Baiturrahmah University were smokers with a median age of 21 years, the majority were male (91.1%), started smoking electronically at the age of ≥16 years (91.1%), due to the influence of friends (66.1%), and with an economic level described by income/pocket money > 1 – 2 million (37.5%). The level of nicotine dependence was mostly in the moderate category as many as 30 people (53.6%). The level of nicotine dependence as measured by the Fagerstrom Test in University Medical Faculty students is in the moderate category.
PENINGKATAN RESIKO PRESBIKUSIS PADA PASIEN LANSIA HIPERTRIGLISERIDEMIA DI RSI SITI RAHMAH Elsa Ardana; Triansyah, Irwan; Nilas Warlem; Ade Teti Vani; Aryaldy Zulkarnaini; Revivo Rinda Pratama
Nusantara Hasana Journal Vol. 4 No. 7 (2024): Nusantara Hasana Journal, December 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i7.1347

Abstract

Background: Presbycusis is a sensorineural hearing disorder that causes loss of hearing ability in old age. Dyslipidemia is a risk factor for presbycusis, namely an imbalance in lipids such as cholesterol, LDL, triglycerides and HDL. Excessive triglyceride levels will increase the risk of atherosclerosis. The formation of atherosclerotic plaque will result in thickening of the blood vessel walls and narrowing of the lumen, resulting in obstruction of blood flow and reducing oxygen transport which can cause ischemia in the cochlea and disrupt hearing function. Objective: Determine the relationship between increased triglyceride levels and presbycusis in elderly patients with dyslipidemia at RSI Siti Rahmah. Method: This type of research is analytical observational research using a case control design and the type of data used is primary and secondary data using consecutive sampling techniques. Results: Presbycusis was most commonly found in the 60-69 year age group (58,33%), presbycusis was mostly found in dyslipidemia elderly with increased triglyceride levels (75.0%), and the highest grouping of triglyceride levels was found in the high group (41,67%). There is a significant relationship between triglyceride levels in elderly patients with dyslipidemia and the incidence of presbycusis (P-value 0.001) and the OR calculation shows that elderly people with dyslipidemia with increased triglyceride levels are 6 times more at risk of experiencing presbycusis compared to elderly people without dyslipidemia. Conclusion: There is a significant relationship between increasing triglyceride levels and presbycusis in elderly with dyslipidemia at RSI Siti Rahmah
Stunting sebagai Ancaman Kualitas Sumber Daya Manusia: Perspektif Gizi, Lingkungan, dan Sosial Amran, Rika; Nurwiyeni; Pratama, Revivo Rinda; Wahyuni, Sri
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.234

Abstract

Latar Belakang: Stunting merupakan kondisi gagal tumbuh kronis pada anak balita yang umumnya tampak nyata setelah usia dua tahun. Kondisi ini disebabkan oleh kekurangan gizi berkepanjangan serta dipengaruhi oleh berbagai faktor lingkungan, sosial, dan ekonomi, dan berdampak serius terhadap perkembangan fisik dan kognitif anak. Tujuan: Penelitian ini bertujuan untuk mendeskripsikan definisi, penyebab, metode penilaian, dampak, serta strategi pencegahan stunting, sekaligus menganalisis hubungan antara faktor ibu dan rumah tangga dengan kejadian stunting di Nagari Ampuan Lumpo, Sumatera Barat. Metode: Penelitian ini menggunakan desain analitik korelatif dengan pendekatan potong lintang (cross-sectional) pada bulan Agustus 2024. Sebanyak 60 balita usia 24–36 bulan menjadi responden. Data dikumpulkan menggunakan kuesioner terstruktur, dan status gizi dinilai berdasarkan indikator antropometri standar WHO. Analisis dilakukan untuk melihat hubungan antara stunting dengan jenis kelamin, berat badan lahir, tingkat pendidikan ibu, dan status sosial ekonomi. Hasil: Sebanyak 8,3% balita mengalami stunting. Tidak ditemukan hubungan yang bermakna antara status gizi dengan jenis kelamin, berat badan lahir, dan status sosial ekonomi (p > 0,05). Namun, terdapat hubungan bermakna antara tingkat pendidikan ibu dengan kejadian stunting (p < 0,005). Kesimpulan: Stunting merupakan masalah kesehatan masyarakat yang bersifat multidimensi. Pendidikan ibu terbukti berperan penting dalam pencegahan stunting. Oleh karena itu, intervensi yang terintegrasi melalui edukasi gizi, peningkatan akses layanan kesehatan, perbaikan sanitasi, dan perlindungan sosial sangat diperlukan, khususnya pada periode 1.000 hari pertama kehidupan.
Penyuluhan Mengenai Pentingnya Pengetahuan Mengenai Infeksi Menular Seksual Pada Ibu Hamil di RS Bayangkhara Padang : Pengabdian Primadella Fegita; Revivo Rinda Pratama
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.1640

Abstract

Adanya Penyuluhan dirasa sangat berarti untuk menambah pengetahuan para ibu hamil tentang penyakit yang mungkin diderita saat di masa kehamilannya.. Dari hasil observasi diketahui bahwa masih banyak ibu hamil yang mengalami infeksi seperti keputihan dimana keputihan ini sangat erat kaitannya dengan Infeksi Menular Seksual. Sehingga kegiatan ini dirasa sangat diperlukan untuk ibu hamil di RS Baynagkhara Padang. Kegiatan ini diikuti oleh 20 orang ibu hamil di RS Bayangkhara Padang. Metode yang digunakan dalam kegiatan penyuluhanini adalah penyampaian materi, serta presentasi. Dari hasil kegiatan yang dilaksanakan dapat dilihat indikator keberhasilan program yaitu meningkatnya pemahaman Ibu Hamil dari kuis yang diberikan di akhir penyuluhan
HUBUNGAN BURNOUT DENGAN KUALITAS TIDUR MAHASISWA TINGKAT AKHIR FAKULTAS KEDOKTERAN UNIVERSITAS BAITURRAHMAH Intan Sesri Winarni; Melya Susanti; Revivo Rinda Pratama
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1632

Abstract

Final-year medical students are often exposed to substantial academic demands, the obligation to complete a thesis, and the transition to professional practice. These conditions may trigger burnout, characterized by physical and psychological exhaustion resulting from chronic stress. Burnout can affect multiple aspects of life, particularly sleep quality, which plays a crucial role in maintaining cognitive function, physical health, and psychological well-being. This study aimed to evaluate the association between burnout and sleep quality among final-year medical students at the Faculty of Medicine, Universitas Baiturrahmah. An analytical observational study with a cross-sectional design was conducted. Primary data were collected from 55 respondents using questionnaires. Univariate analysis was presented in frequency distributions, while the chi-square test was employed to examine the association between variables. Among the participants, 33 students (60.0%) were identified as experiencing burnout, while poor sleep quality was reported in 41 students (74.5%). Statistical analysis demonstrated a significant association between burnout and sleep quality (p = 0.032; p < 0.05). Burnout is significantly associated with poor sleep quality among final-year medical students. These findings highlight the need for preventive strategies that integrate stress management and interventions targeting sleep quality.
GAMBARAN TINGKAT PENGETAHUAN IBU NIFAS TENTANG TANDA BAHAYA POSTPARTUM DI RSIA SITI HAWA PADANG Arief Rinaldy; Abdullah, Dessy; Revivo Rinda Pratama; Berri Rahmadhoni; Nofrina Putri Melati; Mashdarul Ma'arif
Nusantara Hasana Journal Vol. 3 No. 10 (2024): Nusantara Hasana Journal, March 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i10.1111

Abstract

The period of nifas (postpartum) is the recovery time of nine months of pregnancy as well as the birth process. This period of nifas lasts for about 6 weeks. This period occurs physiological and psychological changes, namely: physical changes, uterine involution and lochea expenditure, lactation / maternal milk expenditure, changes in other body systems and psychic changes. The purpose of the study is to find out the picture of the level of knowledge of mothers based on age, education, parity and occupation. The research method is descriptive quantitative with sample techniques i.e. total sampling. The number of samples of this study is 60 samples. The data was taken by way of a live interview with a questionnaire to respondents. Data is processed using SPSS in the form of tables. The results of the study were obtained the most at the age of 20-35 years a total of 52 people (86.7%) and have good knowledge at the age of > 35 years as many as 6 people (85.7%), The most high school education as many as 31 people (51.7%) and have a fairly good knowledge in college as many as 22 people (81.5%), The most parity < 2 children as many as 3 people (100%), as well as the most jobs not working as many as 37 people (61.7%) and have a fairly good knowledge of those who do not work as many as 30 people (81.1%). The results showed that the level of knowledge of mothers is mostly knowledgeable, this is influenced by several factors, namely age, education, parity and occupation factors.
Omphalocele Pratama, Revivo Rinda; Yanti, Roza Sri
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.98-103.2022

Abstract

Objective: Reporting a case of omphalocele.Method: Case report.Result:Acaseofa32years-oldwoman, diagnosedwithG2P1A0H134-35weeksofpretermpregnancy+ previous Cesaran Section + omphalocele + fetal distress. According to ultrasonography, biometric measurements of the fetus were: BPD: 8.5 cm, FL: 6.4 cm, HL: 5.2 cm, AC: 27.8 cm, AFI: 23.3 cm, there were no image of abdominal wall, but a membrane surrounding the abdomen was visible. From the USG examination, the conclusion was Omphalocele.ChromosomalanalysiswasdoneusingG-Comparativetechnic,withresult46,XY,which means the amount of the chromosomes was 46, and sex chromosomes were XY. There was no major structural defect. Mostly, the disorders causing these conditions are 13, 18 and 21 trisomy, and Beckwith-WiedemannSyndrome.Conclusion: Omphalocele is a genetic disorder marked by failure of the abdominal organs to return into the abdominal cavity. It requires thorough and accurate prenatal examinations to establish a diagnosis. Keywords: Omphalocele, prenatal diagnosis
Correlation between Glycated Hemoglobin Levels with Polycystic Ovary Syndrome Phenotypes and Metabolic Syndrome Yuad, Haviz; Pratama, Revivo Rinda
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.138-146.2022

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is one of the endocrine disorders that causes oligo-anovulation, clinical and biochemical signs hyperandrogenism and ovarian- specific morphological signs on ultrasound examination are common in women of reproductive age. Conditions of insulin resistance and hyperandrogenism accompanied by hypertension and obesity can lead to dyslipidemia that can meet the diagnostic criteria for the metabolic syndrome. The American Diabetes Association approved the examination of glycated hemoglobin (HbA1c) levels as a routine screening for impaired glucose tolerance and hyperglycemic conditions. Examination of HbA1c levels using the method Point of Care Test. Several studies have shown a direct correlation between elevated HbA1c levels and complications of PCOS, providing evidence that HbA1c plays a potential role in PCOS. This study aims to determine the correlation between HbA1c levels with PCOS phenotype and metabolic syndrome. Methods: The study used an analytical study with a cross sectional analytic study design, the number of samples was 52 respondents. The sample was using selected consecutive sampling and then analyzed for HbA1c levels using POCT, PCOS phenotype, and metabolic syndrome for univariate and bivariate. Results: The study with 52 respondents with PCOS patients, the results showed that the number of respondents with increased HbA1c levels was 17 (32.7%) respondents, most of the respondents with phenotype A were 30 (57.7%) respondents. The number of PCOS respondents with metabolic syndrome was 21 (40.4%) respondents. The results of statistical tests showed that correlation between the PCOS phenotype and HbA1c levels. The proportion of the incidence of metabolic syndrome was higher in respondents with phenotype A than phenotypes B, C, and D. The proportion of metabolic syndrome was higher in the category of elevated HbA1c levels compared to normal HbA1c levels, based on statistical tests there was a correlation between HbA1c levels and metabolic syndrome. Conclusion: There was an increase in HbA1c levels in PCOS patients in this study, which was 32.7% and most of the respondents were with phenotype A. Less than half of the respondents had metabolic syndrome. Statistically, there is a correlation between HbA1c levels and PCOS phenotype in PCOS patients and a correlation between HbA1c levels and metabolic syndrome in PCOS patients.