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All Journal Jurnal Farmamedika (Pharmamedica Journal) Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Medical Sains : Jurnal Ilmiah Kefarmasian

Antonius Padua Ratu

Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Author-ID : 3460221

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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ISOLASI SENYAWA ANTIOKSIDAN EKSTRAK ETANOL BUAH BISBUL ( Diospyros discolor Willd.) Harry Noviardi; Antonius Padua Ratu; Amanda Feby Safitri
Jurnal Farmamedika (Pharmamedika Journal) Vol 3 No 2 (2018): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Free radicals are the one form of reactive oxygen compounds, which could disrupt the production of DNA, lipid layer on the cell wall, affecting blood vessels, and the production of prostaglandins. Therefore, it takes antioxidants because its ability to inhibit free radicals by means of donating one electron on free radicals. Synthetic antioxidant compounds often have side effects is not good, so much sought after alternative antioxidants from natural ingredients, one of which is bisbul fruit (Diospyros discolor Willd.). Based on research, bisbul fruit has a strong antioxidant activity. The purpose of this study was to isolate the active compound bisbul fruit extracts which had antioxidant activity. The isolation method used thin layer chromatography method and chromatography columns, continued using FTIR spectroscopy method and LC- MS, while the antioxidant activity using the DPPH method. The results obtained had antioxidant activity IC50 53.51 ppm. The spectrum of FTIR spectroscopy was obtained that the compounds had a hydroxyl group which could be assumed as a phenol or alcohol. While the results of the LC-MS spectrum of compounds having a molecular mass of (m+H+) 631.95 m/z. The results showed extract the ethanol bisbul fruit had a strong antioxidant activity and possibility compound antioxidants was Goshonoside F4

Uji Aktivitas Ekstrak Etanol 70% dan Etil Asetat Daun Sukun (Artocarpus altilis (Park.) Fosberg Sebagai Inhibitor Tirosinase. Herson Cahaya Himawan; Antonius Padua Ratu; Maya Miani
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Melanin is a substance that gives brown or blackish brown on the skin. Tyrosinase is the main enzyme in biosynthesis of melanin. Utilization of breadfruit leaves based chemical compounds therein such as flavonoids and tannins which are derivates of phenol.Then tested of tyrosinase inhibitory activity.The purpose of this study was to determine the power of inhibition of tyrosinase at ethanol extracts 70% and ethyl acetate extracts of leaves of breadfruit. Acquisition of extraction by maceration, subsequently evaporated by means of separation (rotary vacuum evaporator). Maserate were obtained for a each standard series of concentration 2000; 1000; 500; 250; 125; 62,5; 31,25; 15,63 ppm and kojic acid as positive control with concentration 500; 250; 125; 62,5; 31,25; 15,63 ppm, then each sample tested the inhibitory activity of tyrosinase.Based on the results of the study for the highest tyrosinase inhibitory activity shown by ethyl acetate extract of leaves of breadfruit, because it value smaller IC50 than ethanol extracts 70% of leaves ofbreadfruit. The value IC50 the ethyl acetate extract was 245,43 ppm, while the value IC50 the is 3143,21 ppm. However the activity of tyrosinase inhibition of ethanol extracts 70% and ethyl acetate extract of leaves of breadfruit was lower than kojic acid as positive control that has a value IC50 is 19,36 ppm, because the smaller the value IC50 The greater power inhibition of tyrosinase.

UJI ANTIOKSIDAN EKSTRAK AIR DAN EKSTRAK ETANOL DAGING DAN KULIT BUAH BLEWAH (Cucumis melo L.) Antonius Padua Ratu; Herson Cahaya Himawan; M. Rio Radhi
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 1 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

High content of sitrulin can contribute to oxidative stress as a free radical scavenger. Plants from the Cucurbitaceae family are found in high quantities of Citrulline. One of Cucurbitaceae family is cantaloupe (Cucumis melo L.) The purpose of this study was to determine the antioxidant activity which is optimal in the flesh and rind cantaloupe against extraction methods. The method was used maceration with the ethanol and water, methods of digestion and decocta only with water solvent. The high antioxidant activity was shown by ethanol extract cantaloupe was rind maceration method (583.19 mg/L). In the water extract, rind maceration method of cantaloupe provides antioxidant activity (722.17 mg/L) were significantly different (P<0,05) than the water solvent digestion method and decocta method. However, the antioxidant activity of the flesh and rind extract from cantaloupe is lower than vitamin C.

UJI ANTIOKSIDAN EKSTRAK PIGMEN KAROTENOID DAN SITRULIN PADA KULIT BUAH BLEWAH (Cucumis melo L.) SECARA IN VITRO (METODE DPPH) Antonius Padua Ratu; Nadia Fahmi Silabi; Padmono Citroreksoko
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Antioxidants stabilize free radicals with a complete the lack of electrons from free radicals and inhibiting the chain reaction of free radical formation. The purpose this research is to determine the amount of the antioxidant potential of the cantaloupe skin extracts and the effect of different test result of pigment carotene and citrulline in skin cantaloupe extracts to the extraction stage. Cantaloupe skin with drying and without drying treatment is gradually extracted using three solvents (petroleum ether-acetone-water). The highest antioxidant activity shown by extracts water without drying treatment (667.30 mg / L), which was significantly different (P <0.05) with acetone and petroleum ether (996.65 and 2368.26 mg / L). Treatment with drying only on petroleum ether extract (1607.28 mg / L), which provides activity compared with acetone and water (2871.54 and 2290.75 mg / L). However, cantaloupe skin extract antioxidant activity was lower compared with β-carotene and vitamin C. Treatment without drying also give the highest pigments carotenoid shown by extracts aceton (β-caroten 11,32 mg/L, lycopene 0,29 mg/100g) and level of citrulline in water extracts (29,91 mg/L). The difference of effect in simplisia treatment and solvent on the activity of antioxidants and pigments carotenoid levels were significantly different (P <0.05), whereas the levels of citrulline in the simplisia treatment was not significantly different for solvent acetone and significantly different (P <0.05) for solvent petroleum ether and water.

ANALISIS SENYAWA SITRULIN EKSTRAK AIR DAN EKSTRAK ETANOL DAGING DAN KULIT BUAH BLEWAH (Cucumis melo L.) Antonius Padua Ratu; Herson Cahaya Himawan; M. Rio Radhi
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Data from the United States Department of Agriculture (USDA) National Nutrient database, that cantaloupe contains amino acids of 0.8 grams / 100 grams. One of the amino acids found in cantaloupe is citrulline which can contribute to oxidative stress as a free radical scavenger. The purpose of this study was to obtain the optimal content of citrulline compound in the flesh and skin of blewah to the method of extraction. The method used is the maceration method with ethanol and water solvent, digestion and dekokta method only with water solvent. Quantitatively, sitrulin is obtained by acid hydrolysis and is reacted with a specific reagent which is 3% diacetyl monoxime in a hot temperature. The reading of the result using the maximum wavelength spectrophotometer is 488 nm. The highest content of citrulline compound was shown by decocta method of aquatic leather water extract (7.72 g / 100g). The citrulline content was significantly different (P <0.05) on the difference in other extraction methods.

AKTIVITAS ANTIHIPERGLIKEMIA REBUSAN DAUN KERSEN (Mutingia calabura L.) DAN DAUN TEH HIJAU (Camellia sinensis) SERTA KOMBINASINYA PADA MENCIT JANTAN Antonius Padua Ratu; Lilik Sulastri; Novriani Debora Siregar
Jurnal Farmamedika (Pharmamedika Journal) Vol 7 No 1 (2022): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v7i1.129

Hiperglikemia adalah kondisi tubuh mengalami peningkatan kadar glukosa darah melebihi batas normal. Daun kersen (Mutingia calabura L.) dan daun teh hijau (Camellia sinensis (L.) Kuntze) memiliki aktivitas antihiperglikemia. Metode yang digunakan yaitu maserasi dan rebusan. Ekstrak etanol dan rebusan dilakukan uji fitokimia setelah itu kelompok ekstrak etanol dan rebusan tunggal maupun kombinasinya diujikan ke mencit jantan. Penelitian ini bertujuan untuk mengetahui kelompok yang memberi aktivitas penurunan kadar glukosa dari ekstrak, rebusan tunggal daun kersen dan daun teh hijau maupun kombinasinya dibandingkan dengan kontrol positif. Hasil uji fitokimia dari ekstrak etanol dan rebusan daun kersen serta daun teh hijau menunjukan hasil positif untuk alkaloid, flavonoid, saponin, tanin. Pemberian perlakuan dan induksi sukrosa dilakukan selama 28 hari, pengukuran penurunan kadar glukosa darah mencit pada hari pertama dengan interval waktu 1 jam, 2 jam dan 3 jam dilanjutkan pengukuran tiap 1 minggu sekali 3 jam setelah perlakuan. Penurunan tersebar pada rebusan kersen tunggal (R1) dan penurunan terbesar kombinasi daun kersen dan daun teh (3:1) (R5). Penurunan rata-rata kontrol positif (akarbosa) 60,45%, rebusan daun kersen (R1) 51,62%, kombinasi rebusan 3:1 (R5) 53,44%.

Co-Authors Amanda Feby Safitri Anisya Dwi Shakil Eko Mugiyanto Harry Noviardi Herson Cahaya Himawan Lilik Sulastri M. Rio Radhi Maya Miani Nadia Fahmi Silabi Novriani Debora Siregar Padmono Citroreksoko Silvi Nurafni Siska Fitri Herdiyanti Wirasti

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