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All Journal HAYATI Journal of Biosciences Pharmaciana: Jurnal Kefarmasian Biopropal Industri Jurnal Ilmiah Manuntung FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmako Bahari Jurnal Farmasi Sains dan Praktis Riset Informasi Kesehatan Borneo Journal of Pharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

Harry Noviardi

Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Author-ID : 1428873

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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POTENSI SENYAWA BULLATALISIN SEBAGAI INHIBITOR PROTEIN LEUKOTRIEN A4 HIDROLASE PADA KANKER KOLON SECARA IN SILICO Noviardi, Harry; Fachrurrazie, Fachrurrazie
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 5, No 2 (2015): Vol 5 No 2 Desember 2015
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.935 KB)

ABSTRAK Kanker kolon merupakan jenis kanker yang dapat menyebabkan kematian. Salah satu penyebabnya adalah pertumbuhan Leukotrien A4 hidrolase yang tidak terkontrol. Leukotrien A4 hidrolase dapat dijadikan target terapi dalam menekan pertumbuhan sel kanker. Bullatalisin merupakan senyawa turunan asetogenin yang memiliki potensi inhibitor terhadap Leukotrien A4 hidrolase. Penelitian ini bertujuan menentukan potensi Bullatalisin sebagai inhibitor secara in silico berdasarkan energi bebas Gibbs (∆G), tetapan inhibisi, interaksi ikatan hidrogen serta Root Mean Deviation Square (RMSD). Penelitian dilakukan secara komputasi menggunakan metode molecular docking.Berdasarkan pada hasil analisis visualisasi interaksi docking, menunjukkan adanyainteraksi ikatan antara Bullatalisin dan residu asam amino dari kantung aktif Leukotrien A4 hidrolase. Selain itu nilai energi bebas Gibbs, tetapan inhibisi dan RMSD dari Bullatalisin tidak berbeda secara signifikan dibandingkan dengan ligan standar. Oleh karena itu, Bullatalisin diprediksi berpotensi sebagai inhibitor Leukotrien A4 hidrolase. Kata kunci: bullatalisin, docking, in silico, kanker kolon, leukotrien A4 hidrolase

SITOTOKSISITAS EKSTRAK ETANOL 70% KULIT JENGKOL (ARCHIDENDRON JIRINGA (JACK). I.C. NIELSEN) TERHADAP PENGHAMBATAN SEL KANKER PAYUDARA MCF-7 DAN KANKER SERVIKS HELA Noviardi, Harry; Ratu, Antonius Padua; Tri R, Diah Ajeng
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.555 KB)

Jengkol (Archidendron jiringa (Jack).I.C. Nielsen) skin for this belongs to the organic wastes that do not provide economic value. Compounds of natural ingredients on the Jengkol Skin among others, alkaloids, flavonoids, tannins, saponins, and triterpenoids. Some of the molecular structures of the compound are thought to potentially in inhibiting the growth of cancer cells. This research aimed to determine the cytotoxicity effect of 70% ethanol extract of Jengkol Skin as anticancer. Jengkol Skin was macerated in ethanol 70% then extract was concentrated with a rotary vacuum evaporator and water bath. Cytotoxicity test was carried out using cells MCF-7 (breast cancer) and HeLa cells (cervical cancer) based upon the method of MTT assay. The parameter was the value measured inhibition concentration (IC50). Extracts of the Jengkol Skin showed activity against cytotoxicity MCF-7 cells with IC50 values of 51.76 ?g/mL and for the IC50 value of HeLa cells 39.618 ?g/mL. IC50 values of the cell were less than 100 ?g/mL, indicated categories of potential cytotoxicity. The Jengkol Skin extract could be used as anticancer agents.

SITOTOKSISITAS KOMBINASI EKSTRAK DAUN PETAI CINA DAN KULIT JENGKOL TERHADAP SEL KANKER PAYUDARA DAN SERVIKS (Cytotoxicity of Petai Cina Leaves and Jengkol Pods Combinations Against Breast Cancer Cells and Cervix) Harry Noviardi; Sitaresmi Yuningtyas; Dwi Suwarni
Biopropal Industri Vol 10, No 2 (2019)
Publisher : Balai Riset dan Standardisasi Industri Pontianak

Petai cina (Leucaena leucocephala (Lam.) De Wit) and jengkol (Archidendron jiringa (Jack) I.C.Nielsen) are leguminous plants that contain alkaloids, flavonoids, saponins, tannins and triterpenoids which potential to be anticancer. This study aimed to determine the synergic effect of petai cina leaves extract and jengkol pods combination based on its cytotoxicity value. The extraction used maceration method with 70% ethanol solvent. Comparison of the combination of petai cina leaves extract and jengkol pods were 1:0, 0:1, 1:1, 1:3, 1:5, 1:7 and 1:9. The cytotoxicity method used MTT assay with MCF-7 breast cancer cell culture and cervical HeLa. Inhibition valueconcentration (IC50) used as parameter. The combination with ratio 1:0, 0:1, 1:1, 1:3, 1:5, 1:7 and 1:9 showed cytotoxicity activity against MCF-7 cells with IC50 values respectively 102.56; 51.76; 37.35; 28.57; 11.69; 7.5 and 1.92 µg/mL while on HeLa cells 137.65; 39.62; 20.91; 14.46; 9.34; 7.28 and 1.86 µg/mL. Based on the National Cancer Institute (NCI), all comparisons classified as potential cytotoxicity except ratio1: 1 on MCF-7 cancer cells which considered as moderate since IC50 values were more than 30 µg/mL.Keywords: cytotoxicity, HeLa, jengkol pods, petai cina leaves, MCF-7ABSTRAKPetai cina (Leucaena leucocephala (Lam.) de Wit) dan jengkol (Archidendron jiringa (Jack) I.C.Nielsen) merupakan tumbuhan suku polong-polongan yang mengandung senyawa bahan alam seperti alkaloid, flavonoid, saponin, tanin dan triterpenoid. Senyawa bahan alam tersebut berpotensi sebagai antikanker. Kombinasi ekstrak bahan alam memiliki kelebihan terkait sinergisitas dibandingkan dengan ekstrak tunggal. Uji sitotoksisitas digunakan untuk mendeteksi potensi senyawa antikanker. Tujuan penelitian ini adalah untuk menentukan efek sinergis dari kombinasi ekstrak daun petai cina dan kulit jengkol berdasarkan pada nilai sitotoksisitasnya. Proses ekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Perbandingan kombinasi ekstrak daun petai cina dan kulit jengkol yang digunakan secara berturut-turut yaitu 1:0, 0:1, 1:1, 1:3, 1:5, 1:7 dan 1:9. Metode sitotoksisitas yang digunakan adalah MTT assay dengan kultur sel kanker payudara MCF-7 dan serviks HeLa. Parameter yang diukur adalah nilai inhibition concentration (IC50). Kombinasi ekstrak daun petai cina dan kulit jengkol dengan perbandingan 1:0, 0:1, 1:1, 1:3, 1:5, 1:7 dan 1:9 menunjukkan aktivitas sitotoksisitas terhadap sel MCF-7 dengan nilai IC50 secara berturut-turut sebesar 102,56; 51,76; 37,35; 28,57; 11,69; 7,5 dan 1,92 µg/mL sedangkan pada sel HeLa 137,65; 39,62; 20,91; 14,46; 9,34; 7,28 dan 1,86 µg/mL. Berdasarkan kriteria sitotoksisitas National Cancer Institute (NCI) semua perbandingan termasuk dalam kategori sitotoksisitas potensial, kecuali perbandingan 1:1 pada sel kanker MCF-7 termasuk dalam kategori sitotoksisitas sedang karena nilai IC50 lebih dari 30 µg/mL. Oleh sebab itu, kombinasi ekstrak daun petai cina dan kulit jengkol dapat digunakan sebagai agen antikanker yang memberikan efek sinergis lebih baik dari pada ekstrak tunggal.Kata kunci: daun petai cina, HeLa, kulit jengkol, MCF-7, sitotoksisitas

OPTIMASI WAKTU INKUBASI PRODUKSI BAHAN MINUMAN PROBIOTIK DARI UMBI GARUT (Maranta arundinacea L.) OLEH Lactobacillus fermentum SEBAGAI ANTIHIPERKOLESTEROLEMIA Harry Noviardi; Sitaresmi Yuningtyas; Vira Yuniar
Biopropal Industri Vol 11, No 1 (2020)
Publisher : Balai Riset dan Standardisasi Industri Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36974/jbi.v11i1.5846

Arrowroot tuber is one of the potential plants that has a high nutritional content so it can be the source of nutrition for the growth of Lactobacillus fermentum bacteria for probiotic drink production. Arrowroot fermentation with L. fermentum is also known potentially reduce cholesterol level. The probiotics have the ability to absorb a number of cholesterol into cells. This research aimed to determine the optimum incubation time of the production of arrowroot tubers with antihypercholesterolemia activity for pribiotic drink. Arrowroot tuber fermentation was carried out using L. fermentum culture with varying incubation times of 4, 8 and 12 hours. The fermentation results were evaluated organoleptically (color, aroma, texture and taste), pH, total lactic acid, total lactic acid bacteria and alcohol content. In addition, anylisis of total cholesterol levels by in vivo were also tested. The decreasing of total cholesterol level by the fermented tuber with incubation time variations of 4, 8 and 12 hours, respectively, by 15.14%, 16.96% and 28.56%. The results showed that the highest reduction percentage of total cholesterol level is 12 hours incubation time with pH value of 5.25, total lactic acid bacteria 6.4 x 108CFU/mL. The total value of acquired lactic acid bacteria meets the standard for probiotic product. This indicates that the optimum incubation time for the production of probiotic arrowroot tubers as antihypercholesterolemia is 12 hours.Keywords: antihypercholesterolemic, arrowroot tuber, Lactobacillus fermentum, probioticABSTRAKUmbi garut merupakan salah satu tanaman potensial yang memiliki kandungan gizi tinggi sehingga dapat dijadikan sumber nutrisi bagi pertumbuhan bakteri Lactobacillus fermentum untuk pembuatan minuman probiotik. Fermentasi umbi garut dengan L. fermentum tersebut juga diketahui memiliki potensi untuk menurunkan kadar kolesterol. Hal ini disebabkan oleh kemampuan probiotik menyerap sejumlah kolesterol ke dalam sel. Penelitian ini bertujuan untuk menentukan waktu inkubasi optimum produksi bahan minuman probiotik dari umbi garut yang mempunyai aktivitas antihiperkolesterolemia. Fermentasi umbi garut dilakukan menggunakan kultur L. fermentum dengan variasi waktu inkubasi, yaitu 4, 8 dan 12 jam. Hasil fermentasi dievaluasi organoleptik (warna, aroma, tekstur dan rasa), pH, total asam laktat, total bakteri asam laktat dan kadar alkohol. Selain itu, dilakukan juga analisis penurunan kadar kolesterol total secara in vivo. Nilai persentase penurunan kadar kolesterol total oleh hasil fementasi umbi garut dengan variasi waktu inkubasi 4, 8 dan 12 jam secara berturut-turut sebesar 15,14%, 16,96% dan 28,56%. Hasil fermentasi umbi garut dengan nilai persentase penurunan kadar kolesterol total tertinggi adalah waktu inkubasi 12 jam dengan nilai pH 5,25; total asam laktat 1,56%, total bakteri asam laktat 6,4 x 108 CFU/mL. Nilai total bakteri asam laktat yang diperoleh memenuhi standar untuk produk probiotik. Oleh sebab itu, waktu inkubasi optimum produksi umbi garut probiotik sebagai antihiperkolesterolemia berada pada waktu 12 jam.Kata kunci: antihiperkolesterolemia, Lactobacillus fermentum, probiotik, umbi garut

ISOLASI SENYAWA ANTIOKSIDAN EKSTRAK ETANOL BUAH BISBUL ( Diospyros discolor Willd.) Harry Noviardi; Antonius Padua Ratu; Amanda Feby Safitri
Jurnal Farmamedika (Pharmamedika Journal) Vol 3 No 2 (2018): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Free radicals are the one form of reactive oxygen compounds, which could disrupt the production of DNA, lipid layer on the cell wall, affecting blood vessels, and the production of prostaglandins. Therefore, it takes antioxidants because its ability to inhibit free radicals by means of donating one electron on free radicals. Synthetic antioxidant compounds often have side effects is not good, so much sought after alternative antioxidants from natural ingredients, one of which is bisbul fruit (Diospyros discolor Willd.). Based on research, bisbul fruit has a strong antioxidant activity. The purpose of this study was to isolate the active compound bisbul fruit extracts which had antioxidant activity. The isolation method used thin layer chromatography method and chromatography columns, continued using FTIR spectroscopy method and LC- MS, while the antioxidant activity using the DPPH method. The results obtained had antioxidant activity IC50 53.51 ppm. The spectrum of FTIR spectroscopy was obtained that the compounds had a hydroxyl group which could be assumed as a phenol or alcohol. While the results of the LC-MS spectrum of compounds having a molecular mass of (m+H+) 631.95 m/z. The results showed extract the ethanol bisbul fruit had a strong antioxidant activity and possibility compound antioxidants was Goshonoside F4

FORMULASI DAN AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER DARI EKSTRAK ETANOL BIJI MANGGA HARUM MANIS ( Mangifera indica L.) TERHADAP Escherichia coli DAN Staphylococcus aureus Harry Noviardi; Herson Cahaya Himawan; Rina Anggraeni
Jurnal Farmamedika (Pharmamedika Journal) Vol 3 No 1 (2018): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Mangifera indica L. is a plant that has antibacterial activity. One of the plant‟s parts that has antibacterial activity on mango is the seed. Natural antibacterial content in the form of tannins contained in ethanol extract of Harum Manis mango seed is considered being effective towards Escherichia coli and Staphylococcus aureus bacteria, which are the main cause bacteria in diarrhea and other skin infections. The objective of this study is to obtain a good and effective formulation to remove Escherichia coli and Staphylococcus aureusbacteria in order to produce natural hand- made antiseptic gel preparations. The diameter of clear zone produced by gel preparation of hand sanitizer ethanol extract of mango seed on Escherichia coli bacteria with gel concentration of 2; 2.5 and 5% respectively - 10.86, 1.74, and 13.15 mm, while on a positive control, it is 7.47 mm. On the other hand, the diameter of clear zone in Staphylococcus aureus with gel concentration of 2; 2.5 and 5% respectively - 10.14, 10.58, and 12.83 mm, while on the positive control, it is 7.43 mm. Based on Anovaone way test followed by Duncan test show a significant difference (significant effect) between the concentration. It can be concluded that the preparation of 70% ethanol extract gel having antibacterial effectiveness towards Escherichia coli and Staphylococcus aureus and effective gel preparation evaluation results are at 2,5% concentration

PERBANDINGAN INHIBISI BRUSEIN D TERHADAP PROTEIN NFKB PADA SEL KANKER PANKREAS SECARA FLEKSIBEL DAN RIGID DOCKING Harry Noviardi; Armi Wulanawati; Muhammad Sholehuddin malik Ibrohim
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Pancreatic cancer is a malignant tumor types are particularly deadly. Patients with pancreatic cancer are generally treated with chemoradiotherapy and gemcitabine, but still provide a good clinical outcome. This study aims to determine the ratio of the potential of bruceine D as inhibitors of protein NFĸB transcription of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions are flexible and rigid docking. Based on the analysis docking, docking flexibly deliver better results than rigid. Additionally, bruceine D provides the potential for better inhibition than gemcitabine.

PERBANDINGAN INHIBISI α-MANGOSTIN, β-MANGOSTIN, DAN γ-MANGOSTIN TERHADAP PROTEIN AKT-KINASE PADA SEL KANKER PANKREAS SECARA MOLECULAR DOCKING Harry Noviardi; Armi Wulanawati; Muhamad Sholehuddin Malik Ibrohim
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

The mangosteen pericarp contains a class of compounds called xanthones, including α-mangostin, β-mangostin, and, γ-mangostin. Mangosteen products have become popular natural medicine. cancer is a malignant tumor types are particularly deadly caused by proliferative effects to inhibit apoptosis cell. Akt protein is considered to be the key downstream effector of reducing apoptosis. This study aims to determine the ratio of the potential of α-mangostin, β-mangostin, γ-mangostin as inhibitors of Akt protein of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions. The computationally study using molecular docking method.Based on the analysis docking, γ-mangostin provides the potential for better inhibition than gemcitabine.

PENGARUH PERBANDINGAN SURFAKTAN DAN KO-SURFAKTAN TERHADAP KARAKTERISTIK DAN KESTABILAN MIKROEMULSI MINYAK ZAITUN (Olive oil) Devi Ratnasari; Harry Noviardi; Baiq Annisa Apriyanti A.R
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Olive oil is a compound known to have pharmacology activity, such as anticolesterol. Low solubility of olive oil lead to become low bioavailabilitas when given orally. Olive oil need to be formulations that could improve soulubility by making microemulsion. Microemulsion is an emulsion of oil in water (o/w) or water in oil (w/o) stable thermodynamically globul-size 0,1-1 μm. Type emulsion suitable for olive oil is oil in water (o/w) because it is intended for oral consumption. This research aimed to determine the comparison of the composition of the mixture of surfactants and co-surfactants in manufacture of microemulsi as well as test the stability. Microemulsion created by using tween 80 as surfactants and sorbitol as co-surfactants with a comparison of surfactants and co-surfactant (1:1, 2:1, 3:1, 4:1, 5:1). Microemulsion formed then evaluated organoleptis, types of density, size of globul, surface tension, viscosity and centrifugation. Evaluation results indicate the composition of surfactants and co-surfactants (5:1) has a size of globul (1,71 μm) and most low surface tension (40,8507 dyne/cm). Test of stability during 8 weeks at low, room, and high temperatures with parameter that was organoleptic, pH and viscosity. Stability test results shows that changes of pH and viscosity.

OPTIMASI WAKTU MASERASI SILDENAFIL SITRAT DALAM JAMU KUAT YANG BEREDAR DI BOGOR BARAT Harry Noviardi; Bina Lohita Sari; Muhamad Wildan Malik
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Herbal medicine is types traditional medicine that is consumed by people. One type of herbal medicine on the market is Jamu Kuat. According Indonesian Food and Drug Administration, herbal medicine can not contain chemical of drugs. But, Jamu Kuat on the market still found contain chemical of drug, that is sildenafil citrate. In previous research, analysis of sildenafil citrate in the Jamu Kuat has not been accompained by the optimization of extraction time.The aim of research is optimizing the time of maceration sildenafil citrate in Jamu Kuat circulating on the West Bogor. Sampling of Jamu kuat was used purpusive sampling. The sample macerated with constant stirring was used a magnetic stirrer with 560 rpm and analyzis with Thin Layer Chromatography and Spectrophotometry UV-Vis method. Results of the research show that there was 5 from 8 samples Jamu Kuat contained sildenafil citrate. Optimum times of maceration was 60-90 minutes in four samples, 120-150 minutes in one sample and contains sildenafil citrate 8.00-11.00% in four samples and 20.00-21.00% in one sample. The results was concluded there different optimal times for samples

Co-Authors Agustin, Lydia Ahmad Ben Amaliah, Putri Amanda Feby Safitri Antonius Padua Ratu Antonius Padua Ratu Armi Wulanawati Baiq Annisa Apriyanti A.R Ben, Ahmad Bina Lohita Sari Citroreksoko, Padmono Devi Ratnasari Devi Ratnasari Diah Ajeng Tri R Diah Ajeng Tri R Dwi Suwarni Dyah Iswantini Eem Masaenah Fachrurrazie Fachrurrazie Fachrurrazie, Fachrurrazie Freddy Arifta Nassel Herson Cahaya Himawan Kurniati Indraswari Lestari, Yunita Lydia Agustin Masaenah, Eem Meita Sari Mandiri Moh. Syarif Muhamad Sholehuddin Malik Ibrohim Muhamad Wildan Malik Muhammad Alfarabi Muhammad Fermadianto Muhammad Sholehuddin malik Ibrohim Nur Apriani Kartini Padmono Citroreksoko Patoni Patoni Patoni, Patoni Rina Anggraeni Rizky Ramadhan Setyanto Tri Wahyudi Sitaresmi Yuningtyas Sri Mulijani Sumiati, Triyani Tatik Khusniati Tri R, Diah Ajeng Tri R, Diah Ajeng Triyani Sumiati Utami, Mega Vira Yuniar

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